Early Immune Senescence in HIV Disease

Effros RB, Fletcher CV, Gebo K, et al.: Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis 2008, 47:542–553.

Teichmann J, Stephan E, Discher T, et al.: Changes in calciotropic hormones and biochemical markers of bone metabolism in patients with human immunodeficiency virus infection. Metabolism 2000, 49:1134–1139.

Kaplan RC, Kingsley LA, Sharrett AR, et al.: Ten-year predicted coronary heart disease risk in HIV-infected men and women. Clin Infect Dis 2007, 45:1074–1081

Ikezu T: The aging of human-immunodeficiency-virus-associated neurocognitive disorders. J Neuroimmune Pharmacol 2009, 4:161–162.

Desquilbet L, Margolick JB, Fried LP, et al.: Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr 2009, 50:299–306.

Pawelec G, Effros RB, Caruso C, et al.: T cells and aging (update february 1999). Front Biosci 1999, 4:D216–269.

Hunt PW, Brenchley J, Sinclair E, et al.: Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 2008, 197:126–133.

Appay V, Sauce D: Immune activation and inflammation in HIV-1 infection: causes and consequences. J Pathol 2008, 214:231–241.

Deeks SG, Phillips AN: HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ 2009, 338:a3172.

Piatak M Jr, Saag MS, Yang LC, et al.: High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993, 259:1749–1754.

Hardy AW, Graham DR, Shearer GM, Herbeuval JP: HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha. Proc Natl Acad Sci U S A 2007, 104:17453–17458.

Esser MT, Bess JW, Jr., Suryanarayana K, et al.: Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1. J Virol 2001;75:1152–1164.

Kuller LH, Tracy R, Belloso W, et al.: Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008, 5:e203.

Eggena MP, Barugahare B, Jones N, et al.: Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005, 174:4407–4414.

Giorgi JV, Lyles RH, Matud JL, et al.: Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr 2002, 29:346–355.

Czesnikiewicz-Guzik M, Lee WW, Cui D, et al.: T cell subset-specific susceptibility to aging. Clin Immunol 2008, 127:107–118.

Cheng X, Yu X, Ding YJ, et al.: The Th17/Treg imbalance in patients with acute coronary syndrome. Clin Immunol 2008, 127:89–97.

Huang MC, Liao JJ, Bonasera S, et al.: Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. Faseb J 2008, 22:2142–2150.

Caruso C, Candore G, Colonna-Romano G, et al.: Inflammation and life-span. Science 2005, 307:208–209; author reply 208–209.

Ginaldi L, De Martinis M, Monti D, Franceschi C: Chronic antigenic load and apoptosis in immunosenescence. Trends Immunol 2005, 26:79–84.

Linton PJ, Dorshkind K: Age-related changes in lymphocyte development and function. Nat Immunol 2004, 5:133–139.

Kelley CF, Kitchen CM, Hunt PW, et al.: Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clin Infect Dis 2009, 48:787–794.

Douek DC, McFarland RD, Keiser PH, et al.: Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396:690–695.

Lenschow DJ, Walunas TL, Bluestone JA: CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996, 14:233–258.

Spaulding C, Guo W, Effros RB: Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol 1999, 34:633–644.

Merino J, Martinez-Gonzalez MA, Rubio M, et al.: Progressive decrease of CD8high+ CD28+ CD57− cells with ageing. Clin Exp Immunol 1998, 112:48–51.

Brenchley JM, Karandikar NJ, Betts MR, et al.: Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003, 101:2711–2720.

Cao W, Jamieson BD, Hultin LE, et al.: Premature aging of T cells is associated with faster HIV-1 disease progression. J Acquir Immune Defic Syndr 2009, 50:137–147.

Valenzuela HF, Effros RB: Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol 2002, 105:117–125.

Gamberg J, Pardoe I, Bowmer MI, et al.: Lack of CD28 expression on HIV-specific cytotoxic T lymphocytes is associated with disease progression. Immunol Cell Biol 2004, 82:38–46.

Choremi-Papadopoulou H, Panagiotou N, Samouilidou E, et al.: CD28 costimulation and CD28 expression in T lymphocyte subsets in HIV-1 infection with and without progression to AIDS. Clin Exp Immunol 2000, 119:499–506.

Choi BS, Park YK and Lee JS. The CD28/HLA-DR expressions on CD4+T but not CD8+T cells are significant predictors for progression to AIDS. Clin Exp Immunol 2002, 127:137–144.

Desai SR, Usuga X, Martinson J, et al.: Immune senescence, activation and abnormal T cell homeostasis despite effective HAART, a hallmark of early aging in HIV. Presented at 16th Conference on Retroviruses and Opportunistic Infections. Montreal; February 8–11, 2009.

Bourgeois C, Hao Z, Rajewsky K, et al.: Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A 2008, 105:8691–8696.

Redelings MD, Sorvillo F, Mascola L: Increase in Clostridium difficile-related mortality rates, United States, 1999–2004. Emerg Infect Dis 2007, 13:1417–1419.

Cohen J: Retrovirus meeting. Back-to-basics push as HIV prevention struggles. Science 2008, 319:888.

Brenchley JM, Price DA, Schacker TW, et al.: Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365–1371.

Panda A, Arjona A, Sapey E, et al.: Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol 2009, 30:325–333.

Renshaw M, Rockwell J, Engleman C, et al.: Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 2002, 169:4697–4701.

Helenius M, Hanninen M, Lehtinen SK, Salminen A: Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J 1996, 318:603–608.

Hinojosa E, Boyd AR, Orihuela CJ: Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis 2009, 200:546–554.

van Duin D, Mohanty S, Thomas V, et al.: Age-associated defect in human TLR-1/2 function. J Immunol 2007, 178:970–975.

Stout-Delgado HW, Yang X, Walker WE, et al.: Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol 2008, 181:6747–6756.

Martinson J, Montoya CJ, Usuga X, et al.: Chloroquine modulates HIV-1 induced plasmacytoid dendritic cell IFNα: implication for T cell activation. Antimicrob Agent Chemother 2010, 54(2):871–881.

Hatano H, Delwart EL, Norris PJ, et al.: Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. J Virol 2009, 83:329–335.

Czeslick E, Struppert A, Simm A, Sablotzki A: E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes. Inflamm Res 2006, 55:511–515.

Connolly NC, Riddler SA, Rinaldo CR: Proinflammatory cytokines in HIV disease-a review and rationale for new therapeutic approaches. AIDS Rev 2005, 7:168–180.

Levy Y, Lacabaratz C, Weiss L, et al.: Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 2009, 119:997–1007.

Dagarag M, Evazyan T, Rao N, Effros RB: Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. J Immunol 2004, 173:6303–6311.

Fauce SR, Jamieson BD, Chin AC, et al.: Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol 2008, 181:7400–7406.