ESPEN guidelines on nutrition in cancer patients

Clinical Nutrition - Tập 36 Số 1 - Trang 11-48 - 2017
Jann Arends1, Patrick Bachmann2, Vickie E. Baracos3, Nicole Barthélémy4, Hartmut Bertz1, Federico Bozzetti5, Ken Fearon6, Elisabeth Hütterer7, Elisabeth Isenring8, Stein Kaasa9, Željko Krznarić10, Barry Laird11, Maria Larsson12, Alessandro Laviano13, Stefan Mühlebach14, Maurizio Muscaritoli13, Line Oldervoll9,15, Paula Ravasco16, Tora S. Solheim17,18, Florian Strasser19, M.A.E. de van der Schueren20,21, Jean‐Charles Preiser22
1Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
2Centre Régional de Lutte Contre le Cancer Léon Bérard, Lyon, France
3Department of Oncology, University of Alberta, Edmonton, Canada
4Centre Hospitalier Universitaire, Liège, Belgium
5University of Milan, Milan, Italy
6Western General Hospital, Edinburgh, United Kingdom
7Medical University of Vienna, Austria
8Bond University, Gold Coast, Australia
9Norwegian University of Science and Technology, Trondheim, Norway
10University Hospital Center and School of Medicine, Zagreb, Croatia
11Beatson West of Scotland Cancer Centre, Edinburgh, United Kingdom
12Karlstad University, Karlstad, Sweden
13University of Rome «La Sapienza», Roma, Italy
14University of Basel, Basel, Switzerland
15The Norwegian Heart and Lung Association (LHL), Oslo, Norway
16Faculty of Medicine, University of Lisbon, Lisbon, Portugal
17Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
18European Palliative Care Research Centre (PRC), Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Norway
19Oncological Palliative Medicine, Clinic Oncology/Hematology, Dept. Internal Medicine and Palliative Center, Cantonal Hospital St. Gallen, Switzerland
20HAN University of Applied Sciences, Nijmegen, Netherlands
21VU University Medical Center (VUmc), Amsterdam, Netherlands
22Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

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Preiser, 2011, ESPEN disease-specific guideline framework, Clin Nutr, 30, 549, 10.1016/j.clnu.2011.07.006

Andreyev, 1998, Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?, Eur J Cancer, 34, 503, 10.1016/S0959-8049(97)10090-9

Pressoir, 2010, Prevalence, risk factors and clinical implications of malnutrition in French comprehensive cancer centres, Br J Cancer, 102, 966, 10.1038/sj.bjc.6605578

Oh, 2011, Adipokines, insulin resistance, metabolic syndrome, and breast cancer recurrence: a cohort study, Breast Cancer Res, 13, R34, 10.1186/bcr2856

Flood, 2007, Elevated serum concentrations of insulin and glucose increase risk of recurrent colorectal adenomas, Gastroenterology, 133, 1423, 10.1053/j.gastro.2007.08.040

Arends, 2006, ESPEN guidelines on enteral nutrition: non-surgical oncology, Clin Nutr, 25, 245, 10.1016/j.clnu.2006.01.020

Arends, 2009, ESPEN guidelines on parenteral nutrition: non-surgical oncology, Clin Nutr, 28, 445, 10.1016/j.clnu.2009.04.011

Kushi, 2012, American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity, CA Cancer J Clin, 62, 30, 10.3322/caac.20140

August, 2009, A.S.P.E.N. clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation, J Parenter Enter Nutr, 33, 472, 10.1177/0148607109341804

Attar, 2012, Malnutrition is high and underestimated during chemotherapy in gastrointestinal cancer: an AGEO prospective cross-sectional multicenter study, Nutr Cancer, 64, 535, 10.1080/01635581.2012.670743

van Wayenburg, 2010, Weight loss in head and neck cancer patients little noticed in general practice, J Prim Health Care, 2, 16, 10.1071/HC10016

Hébuterne, 2014, Prevalence of malnutrition and current use of nutrition support in patients with cancer, J Parenter Enter Nutr, 38, 196, 10.1177/0148607113502674

Churm, 2009, A questionnaire study of the approach to the anorexia-cachexia syndrome in patients with cancer by staff in a district general hospital, Support Care Cancer, 17, 503, 10.1007/s00520-008-0486-1

Spiro, 2006, The views and practice of oncologists towards nutritional support in patients receiving chemotherapy, Br J Cancer, 95, 431, 10.1038/sj.bjc.6603280

Guyatt, 2008, Rating quality of evidence and strength of recommendations: Going from evidence to recommendations, BMJ, 336, 1049, 10.1136/bmj.39493.646875.AE

Guyatt, 2008, Rating quality of evidence and strength of recommendations GRADE: an emerging consensus on rating quality of evidence and strength of recommendations, BMJ, 336, 924, 10.1136/bmj.39489.470347.AD

Jaeschke, 2008, Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive, BMJ, 337, a744, 10.1136/bmj.a744

Guyatt, 2011, GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology, J Clin Epidemiol, 64, 380, 10.1016/j.jclinepi.2010.09.011

Kushner, 1995, Barriers to providing nutrition, Prev Med, 24, 546, 10.1006/pmed.1995.1087

DeLegge, 2013, State of nutrition support teams, Nutr Clin Prac, 28, 691, 10.1177/0884533613507455

Fearon, 2011, Definition and classification of cancer cachexia: an international consensus framework, Lancet Oncol, 12, 489, 10.1016/S1470-2045(10)70218-7

Jensen, 2010, Adult starvation and disease-related malnutrition: a proposal for etiology-based diagnosis in the clinical practice setting from the international consensus guideline committee, J Parenter Enter Nutr, 34, 156, 10.1177/0148607110361910

Muscaritoli, 2010, Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics, Clin Nutr, 29, 154, 10.1016/j.clnu.2009.12.004

Dechaphunkul, 2013, Crit Rev Oncol Hematol, 88, 459, 10.1016/j.critrevonc.2013.06.003

Martin, 2015, Diagnostic criteria for the classification of cancer-associated weight loss, J Clin Oncol, 33, 90, 10.1200/JCO.2014.56.1894

Baracos, 2013, Clinical outcomes related to muscle mass in humans with cancer and catabolic illnesses, Int J Biochem Cell Biol, 45, 2302, 10.1016/j.biocel.2013.06.016

Martin, 2013, Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index, J Clin Oncol, 31, 1539, 10.1200/JCO.2012.45.2722

Dewys, 1980, Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern cooperative oncology group, Am J Med, 69, 491, 10.1016/S0149-2918(05)80001-3

Jang, 2014, Simple prognostic model for patients with advanced cancer based on performance status, J Oncol Pract, 10, e335, 10.1200/JOP.2014.001457

Rossi-Fanelli, 1991, Effect of energy substrate manipulation on tumour cell proliferation in parenterally fed cancer patients, Clin Nutr, 10, 228, 10.1016/0261-5614(91)90043-C

Bossola, 2011, Does nutrition support stimulate tumor growth in humans?, Nutr Clin Pract, 26, 174, 10.1177/0884533611399771

Lacey, 2003, Nutrition care process and model: ADA adopts road map to quality care and outcomes management, J Am Diet Assoc, 103, 1061, 10.1016/S0002-8223(03)00971-4

Writing Group of the Nutrition Care Process/Standardized Language Committee, 2008, Nutrition care process part II: using the International Dietetics and Nutrition Terminology to document the nutrition care process, J Am Diet Assoc, 108, 1287, 10.1016/j.jada.2008.06.368

Muscaritoli, 2011, The “parallel pathway”: a novel nutritional and metabolic approach to cancer patients, Intern Emerg Med, 6, 105, 10.1007/s11739-010-0426-1

Correia, 2014, Evidence-based recommendations for addressing malnutrition in health care: an updated strategy from the feed M.E. Global Study Group, J Am Med Dir Assoc, 15, 544, 10.1016/j.jamda.2014.05.011

Meijers, 2014, Nutritional care; do process and structure indicators influence malnutrition prevalence over time?, Clin Nutr, 33, 459, 10.1016/j.clnu.2013.06.015

McMillan, 2013, The systemic inflammation-based glasgow prognostic score: a decade of experience in patients with cancer, Cancer Treat Rev, 39, 534, 10.1016/j.ctrv.2012.08.003

Pan, 2013, The impact of nutritional status, nutritional risk, and nutritional treatment on clinical outcome of 2248 hospitalized cancer patients: a multi-center, prospective cohort study in Chinese teaching hospitals, Nutr Cancer, 65, 62, 10.1080/01635581.2013.741752

Isenring, 2015, Which screening method is appropriate for older cancer patients at risk for malnutrition?, Nutrition, 31, 594, 10.1016/j.nut.2014.12.027

Geiker, 2012, Poor performance of mandatory nutritional screening of in-hospital patients, Clin Nutr, 31, 862, 10.1016/j.clnu.2012.03.006

http://www.healthcareimprovementscotland.org/our_work/patient_safety/improving_nutritional_care/nutritional_care_standards.aspx.

Baldwin, 2011, Simple nutritional intervention in patients with advanced cancers of the gastrointestinal tract, non-small cell lung cancers or mesothelioma and weight loss receiving chemotherapy: a randomised controlled trial, J Hum Nutr Diet, 24, 431, 10.1111/j.1365-277X.2011.01189.x

Baldwin, 2011, Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults, Cochrane Database Syst Rev, 9, CD002008

Ravasco, 2005, Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy, J Clin Oncol, 23, 1431, 10.1200/JCO.2005.02.054

Ravasco, 2005, Impact of nutrition on outcome: a prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy, Head Neck, 27, 659, 10.1002/hed.20221

Del Fabbro, 2011, Clinical outcomes and contributors to weight loss in a cancer cachexia clinic, J Palliat Med, 14, 1004, 10.1089/jpm.2011.0098

Gagnon, 2013, A prospective evaluation of an interdisciplinary nutrition-rehabilitation program for patients with advanced cancer, Curr Oncol, 20, 310, 10.3747/co.20.1612

Detsky, 1987, What is subjective global assessment of nutritional status?, J Parenter Enter Nutr, 11, 8, 10.1177/014860718701100108

Bauer, 2002, Use of the scored patient-generated subjective global assessment (PG-SGA) as a nutrition assessment tool in patients with cancer, Eur J Clin Nutr, 56, 779, 10.1038/sj.ejcn.1601412

Gabrielson, 2013, Use of an abridged scored patient-generated subjective global assessment (abPG-SGA) as a nutritional screening tool for cancer patients in an outpatient setting, Nutr Cancer, 65, 234, 10.1080/01635581.2013.755554

Isenring, 2010, Nutritional status and information needs of medical oncology patients receiving treatment at an Australian public hospital, Nutr Cancer, 62, 220, 10.1080/01635580903305276

Ribaudo, 2000, Re-validation and shortening of the functional assessment of anorexia/cachexia therapy (FAACT) questionnaire, Qual Life Res, 9, 1137, 10.1023/A:1016670403148

Aaronson, 1993, The european organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology, J Natl Cancer Inst, 85, 365, 10.1093/jnci/85.5.365

Stubbs, 2000, The use of visual analogue scales to assess motivation to eat in human subjects: a review of their reliability and validity with an evaluation of new hand-held computerized systems for temporal tracking of appetite ratings, Br J Nutr, 84, 405, 10.1017/S0007114500001719

Oken, 1982, Toxicity and response criteria of the Eastern cooperative oncology group, Am J Clin Oncol, 5, 649, 10.1097/00000421-198212000-00014

Yates, 1980, Evaluation of patients with advanced cancer using the Karnofsky performance status, Cancer, 45, 2220, 10.1002/1097-0142(19800415)45:8<2220::AID-CNCR2820450835>3.0.CO;2-Q

Bozzetti, 2009, Nutritional support and tumour growth in humans: a narrative review of the literature, Clin Nutr, 28, 226, 10.1016/j.clnu.2009.02.006

Knox, 1983, Energy expenditure in malnourished cancer patients, Ann Surg, 197, 152, 10.1097/00000658-198302000-00006

Dempsey, 1984, Energy expenditure in malnourished gastrointestinal cancer patients, Cancer, 53, 1265, 10.1002/1097-0142(19840315)53:6<1265::AID-CNCR2820530609>3.0.CO;2-2

Bosaeus, 2001, Dietary intake, resting energy expenditure in relation to weight loss in unselected cancer patients, Int J Cancer, 93, 380, 10.1002/ijc.1332

Cao, 2010, Resting energy expenditure and body composition in patients with newly detected cancer, Clin Nutr, 29, 72, 10.1016/j.clnu.2009.07.001

Hansell, 1986, Effects of hepatic metastases on resting energy expenditure in patients with colorectal cancer, Br J Surg, 73, 659, 10.1002/bjs.1800730828

Fredrix, 1991, Effect of different tumor types on resting energy expenditure, Cancer Res, 51, 6138

Moses, 2004, Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with N-3 fatty acids, Br J Cancer, 90, 996, 10.1038/sj.bjc.6601620

Gibney, 1997, Total energy expenditure in patients with small-cell lung cancer: results of a validated study using the bicarbonate-urea method, Metabolism, 46, 1412, 10.1016/S0026-0495(97)90140-2

Staal-van den Brekel, 1997, The effects of treatment with chemotherapy on energy metabolism and inflammatory mediators in small-cell lung carcinoma, Br J Cancer, 76, 1630, 10.1038/bjc.1997.608

Silver, 2007, Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low-dose induction chemotherapy, Head Neck, 29, 893, 10.1002/hed.20607

Cereda, 2007, Assessing energy expenditure in cancer patients: a pilot validation of a new wearable device, J Parenter Enter Nutr, 31, 502, 10.1177/0148607107031006502

Bencini, 2008, Total energy expenditure in patients with advanced solid tumours: a preliminary report, Nutr Ther Met, 26, 45

WHO, 1985

Schofield, 1985, Predicting basal metabolic rate, new standards and review of previous work, Hum Nutr Clin Nutr, 39, 5

Baracos, 2015, Skeletal muscle anabolism in patients with advanced cancer, Lancet Oncol, 16, 13, 10.1016/S1470-2045(14)71185-4

Nitenberg, 2000, Nutritional Support of the cancer patient: issues and dilemmas, Crit Rev Oncol Hematol, 34, 137, 10.1016/S1040-8428(00)00048-2

Barrera, 2002, Nutritional support in cancer patients, J Parent Enter Nutr, 26, 563

Baracos, 2006, Meeting the aminoacid requirements for protein anabolism in cancer cachexia, 631

Guadagni, 2009, Effects of inflammation and/or inactivity on the need for dietary protein, Curr Opin Clin Nutr Metab Care, 12, 617, 10.1097/MCO.0b013e32833193bd

Haran, 2012, Role and potential mechanisms of anabolic resistance in sarcopenia, J Cachexia Sarcopenia Muscle, 3, 157, 10.1007/s13539-012-0068-4

Deutz, 2014, Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN expert group, Clin Nutr, 33, 929, 10.1016/j.clnu.2014.04.007

Bauer, 2013, Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE study group, J Am Med Dir Assoc, 14, 542, 10.1016/j.jamda.2013.05.021

Eden, 1984, Glucose flux in relation to energy expenditure in malnourished patients with and without cancer during periods of fasting and feeding, Cancer Res, 44, 1718e24

Lindmark, 1986, Thermic effect and substrate oxidation in response to intravenous nutrition in cancer patients who lose weight, Ann Surg, 204, 628, 10.1097/00000658-198612000-00003

Pirat, 2009, Comparison of measured versus predicted energy requirements in critically ill cancer patients, Respir Care, 54, 487

Richards, 1993, Protein turnover in advanced lung cancer patients, Metabolism, 42, 291, 10.1016/0026-0495(93)90076-Z

MacDonald, 2015, Habitual myofibrillar protein synthesis is normal in patients with upper GI cancer cachexia, Clin Cancer Res, 21, 1734, 10.1158/1078-0432.CCR-14-2004

Bozzetti, 2013, Is the intravenous administration of amino acid adequate in cancer patients? A critical appraisal of literature, Clin Nutr, 32, 142, 10.1016/j.clnu.2012.10.017

Winter, 2012, Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia, Clin Nutr, 31, 765, 10.1016/j.clnu.2012.05.003

Martin, 2005, Dietary protein intake and renal function, Nutr Metab Lond, 2, 25, 10.1186/1743-7075-2-25

Cano, 2006, ESPEN guidelines on enteral nutrition: adult renal failure, Clin Nutr, 25, 295, 10.1016/j.clnu.2006.01.023

Tayek, 1986, Improved protein kinetics and albumin synthesis by branched chain aminoacid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial, Cancer, 58, 147, 10.1002/1097-0142(19860701)58:1<147::AID-CNCR2820580126>3.0.CO;2-I

Hunter, 1989, Branched chain amino acids as the protein component of parenteral nutrition in cancer cachexia, Br J Surg, 76, 149, 10.1002/bjs.1800760215

Deutz, 2011, Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food, Clin Nutr, 30, 759, 10.1016/j.clnu.2011.05.008

Kuhn, 2010, Glutamine as indispensable nutrient in oncology: experimental and clinical evidence, Eur J Clin Nutr, 49, 197, 10.1007/s00394-009-0082-2

Arcidiacono, 2012, Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms, Exp Diabetes Res, 2012, 789174, 10.1155/2012/789174

Waterhouse, 1971, Carbohydrate metabolism in subjects with cancer, Cancer Res, 31, 1273

Legaspi, 1987, Whole lipid and energy metabolism in the cancer patient, Metabolism, 36, 958, 10.1016/0026-0495(87)90132-6

Selberg, 1990, Palmitate turnover and its response to glucose infusion in weight-losing cancer patients, Clin Nutr, 9, 150, 10.1016/0261-5614(90)90047-V

Arbeit, 1984, Resting energy expenditure in controls and cancer patients with localized and diffuse disease, Ann Surg, 199, 292, 10.1097/00000658-198403000-00008

Shaw, 1987, Fatty acid and glycerol kinetics in septic patients and in patients with gastrointestinal cancer, Ann Surg, 205, 368, 10.1097/00000658-198704000-00005

Hansell, 1986, The oxidation of body fuel stores in cancer patients, Ann Surg, 204, 638, 10.1097/00000658-198612000-00004

Korber, 1999, Increased lipid utilization in weight-losing and weight-stable cancer patients with normal body weight, Eur J Clin Nutr, 53, 740, 10.1038/sj.ejcn.1600843

Vanek, 2012, A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products, Nutr Clin Pract, 27, 440, 10.1177/0884533612446706

Cabrero, 2002, Peroxisome proliferator-activated receptors and the control of inflammation, Curr Drug Targets Inflamm Allergy, 1, 243, 10.2174/1568010023344616

Zhao, 2004, Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation, J Am Coll Nutr, 23, 71, 10.1080/07315724.2004.10719345

Gamble, 1989, The Harvey Lectures, Series XLIII, 1946-1947: physiological information gained from studies on the life raft ration, Nutr Rev, 47, 199, 10.1111/j.1753-4887.1989.tb02838.x

Bloom, 1962, Inhibition of salt excretion by carbohydrate, Arch Intern Med, 109, 26, 10.1001/archinte.1962.03620130028004

Ferrannini, 1984, Renal handling of insulin in man, Contrib Nephrol, 43, 49

Rudman, 1975, Elemental balances during intravenous hyperalimentation of underweight adult subjects, J Clin Invest, 55, 94, 10.1172/JCI107922

Fan, 1989, Preoperative parenteral nutr ition in esophageal cancer: a prospective randomized clinical trial, Clin Nutr, 8, 23, 10.1016/0261-5614(89)90021-6

Bozzetti, 1990, Comparison of glucose versus fat solutions in cancer patients: a controlled cross-over study, Clin Nutr, 9, 325, 10.1016/0261-5614(90)90005-D

Gray, 1990, Can total parenteral nutrition reverse hypoalbuminemia in oncology patients?, Nutrition, 6, 225

Moser, 1994, Disorders of the neurohypophysis, pp1921

Steiner, 1998, Methods of hydration in palliative care patients, J Palliat Care, 14, 6, 10.1177/082585979801400202

Kerndt, 1982, Fasting: the history, pathophysiology and complications, West J Med, 137, 379

Bruera, 1992, Estimate of survival of patients admitted to a palliative care unit: a prospective study, J Pain Symptoms Manage, 7, 82, 10.1016/0885-3924(92)90118-2

Shenkin, 2006, The key role of micronutrients, Clin Nutr, 25, 1, 10.1016/j.clnu.2005.11.006

Giovannucci, 2010, Role of vitamin and mineral supplementation and aspirin use in cancer survivors, J Clin Oncol, 28, 4081, 10.1200/JCO.2009.27.3219

Mamede, 2011, The role of vitamins in cancer: a review, Nutr Cancer, 63, 479, 10.1080/01635581.2011.539315

Ströhle, 2010, Nutrition in oncology: the case of micronutrients (review), Oncol Rep, 24, 815, 10.3892/or.2010.815

Rock, 2012, Nutrition and physical activity guidelines for cancer survivors, CA Cancer J Clin, 62, 243, 10.3322/caac.21142

Biesalski, 2008, Mikronährstoffsupplemente bei onkologischen Patienten, Onkologe, 14, 45, 10.1007/s00761-007-1291-z

Zürcher, 2007, Antioxidanzien bei Krebs, Schweiz Z für Ernährungsmedizin, 4, 17

Norman, 2003, The role of dietary supplements during cancer therapy, J Nutr, 133, S3794

WHO/FAO: http://www.who.int/nutrition/topics/nutrecomm/en/.

EFSA: http://www.efsa.europa.eu/en/topics/topic/drv.

The Nordic Nutrition Recommendations: http://www.norden.org/en/theme/nordic-nutrition-recommendation.

Institute of Medicine: http://www.nap.edu/search/?topic=381&rpp=20&ft=1&term=Dietary+Reference+Intakes.

2015

Biesalski, 2009, Water, electrolytes, vitamins and trace elements –guidelines on parenteral nutrition, Chapter 7, Ger Med Sci, 7, 21

Akutsu, 2012, Are additional trace elements necessary in total parenteral nutrition for patients with esophageal cancer receiving cisplatin-based chemotherapy?, Biol Trace Elem Res, 150, 109, 10.1007/s12011-012-9513-7

Łuczyńska, 2013, Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European prospective investigation into Cancer and nutrition, Am J Clin Nutr, 98, 827, 10.3945/ajcn.112.054676

Drake, 2010, Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma, J Clin Oncol, 28, 4191, 10.1200/JCO.2010.28.6674

Arends, 2011, Vitamin D in oncology, Forsch Komplementmed, 18, 176, 10.1159/000330725

Zgaga, 2014, Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer, J Clin Oncol, 32, 2430, 10.1200/JCO.2013.54.5947

Rose, 2013, Blood levels of vitamin D and early stage breast cancer prognosis: a systematic review and meta-analysis, Breast Cancer Res Treat, 141, 331, 10.1007/s10549-013-2713-9

Bolland, 2014, The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: trial sequential meta-analysis, Lancet Diabetes Endocrinol, 2, 307, 10.1016/S2213-8587(13)70212-2

Autier, 2014, Vitamin D status and ill health: a systematic review, Lancet Diabetes Endocrinol, 2, 76, 10.1016/S2213-8587(13)70165-7

Horneber, 2012, How many cancer patients use complementary and alternative medicine: a systematic review and meta-analysis, Integr Cancer Ther, 11, 187, 10.1177/1534735411423920

Farina, 2014, Concomitant dietary supplement and prescription medication use is prevalent among US adults with doctor-informed medical conditions, J Acad Nutr Diet, 114, 1784, 10.1016/j.jand.2014.01.016

Bjelakovic, 2007, Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis, JAMA, 297, 842, 10.1001/jama.297.8.842

Lawson, 2007, Multivitamin use and risk of prostate cancer in the national institutes of health-AARP diet and health study, J Natl Cancer Inst, 99, 754, 10.1093/jnci/djk177

Ng, 2010, Multivitamin use is not associated with cancer recurrence or survival in patients with stage III colon cancer: findings from CALGB 89803, J Clin Oncol, 28, 4354, 10.1200/JCO.2010.28.0362

Ristow, 2009, Antioxidants prevent health-promoting effects of physical exercise in humans, Proc Natl Acad Sci U. S. A, 106, 8665, 10.1073/pnas.0903485106

The Alpha-Tocopherol, 1994, The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers, N Engl J Med, 330, 1029, 10.1056/NEJM199404143301501

Klein, 2011, Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT), JAMA, 306, 1549, 10.1001/jama.2011.1437

Kenfield, 2014, Selenium supplementation and prostate cancer mortality, J Natl Cancer Inst, 107, 360, 10.1093/jnci/dju360

Wang, 2014, Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians' Health Study II randomized trial, Am J Clin Nutr, 100, 915, 10.3945/ajcn.114.085480

Bozzetti, 2010, Nutritional support in patients with oesophageal cancer, Support Care Cancer, 18, S41, 10.1007/s00520-009-0664-9

Skipworth, 2007, Pathophysiology of cancer cachexia: much more than host-tumour interaction?, Clin Nutr, 26, 667, 10.1016/j.clnu.2007.03.011

Eaton, 2003, Teaching nutrition skills to primary care practitioners, J Nutr, 133, 563S

Brown, 2013, Using a wiki platform to promote guidelines internationally and maintain their currency: evidence-based guidelines for the nutritional management of adult patients with head and neck cancer, J Hum Nutr Diet, 26, 182, 10.1111/jhn.12036

Clutter Snyder, 2007, The diet quality index-revised: a tool to promote and evaluate dietary change among older cancer survivors enrolled in a home-based intervention trial, J Am Diet Assoc, 107, 1519, 10.1016/j.jada.2007.06.014

Isenring, 2013, Update of the evidence based guidelines for the nutritional management of patients receiving radiation therapy and/or chemotherapy, Nutr Diet, 70, 312, 10.1111/1747-0080.12013

Baldwin, 2012, Oral nutrition therapy in malnourished patients with cancer: a systematic review and meta-analysis, J Natl Cancer Inst, 104, 371, 10.1093/jnci/djr556

Bourdel-Marchasson, 2014, Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial, PLoS One, 9, e108687, 10.1371/journal.pone.0108687

Langius, 2013, Effect of nutrition therapy on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo)radiotherapy: a systematic review, Clin Nutr, 32, 671, 10.1016/j.clnu.2013.06.012

Halfdanarson, 2008, Does dietary counselling improve quality of life in cancer patients? A systematic review and meta-analysis, J Support Oncol, 6, 234

Ravasco, 2012, Individualized nutrition intervention is of major benefit to colorectal cancer patients: long-term follow-up of a randomized controlled trial of nutritional therapy, Am J Clin Nutr, 96, 1346, 10.3945/ajcn.111.018838

Huebner, 2014, Counseling patients on cancer diets: a review of the literature and recommendations for clinical practice, Anticancer Res, 34, 39

Arends, 2012, What we do not take as (sufficiently) true, Onkologie, 35, 12, 10.1159/000340026

Dansinger, 2005, Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial, JAMA, 293, 43, 10.1001/jama.293.1.43

Ye, 2015, Efficacy of and patient compliance with a ketogenic diet in adults with intractable epilepsy: a meta-analysis, J Clin Neurol, 11, 26, 10.3988/jcn.2015.11.1.26

Schmidt, 2011, Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: a pilot trial, Nutr Metab (Lond), 8, 54, 10.1186/1743-7075-8-54

Allen, 2013, Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts, Clin Cancer Res, 19, 3905, 10.1158/1078-0432.CCR-12-0287

Bozzetti, 2016, Toward a cancer-specific diet, Clin Nutr, 35, 1188, 10.1016/j.clnu.2015.01.013

Vidali, 2015, Mitochondria: the ketogenic diet–A metabolism-based therapy, Int J Biochem Cell Biol, 63, 55, 10.1016/j.biocel.2015.01.022

Nagamatsu, 1993, Expression of facilitative glucose transporter isoforms in human brain tumors, J Neurochem, 61, 2048, 10.1111/j.1471-4159.1993.tb07441.x

Haber, 1997, GLUT1 glucose transporter expression in benign and malignant thyroid nodules, Thyroid, 7, 363, 10.1089/thy.1997.7.363

Fukuzumi, 2000, Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma, Cancer Lett, 161, 133, 10.1016/S0304-3835(00)00613-3

Noguchi, 1999, Expression of facilitative glucose transporters in gastric tumors, Hepatogastroenterology, 46, 2683

Rudlowski, 2003, GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer, Am J Clin Pathol, 120, 691, 10.1309/4KYNQM5862JW2GD7

Macheda, 2005, Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer, J Cell Physiol, 202, 654, 10.1002/jcp.20166

Chang, 2000, Expression of the human erythrocyte glucose transporter in transitional cell carcinoma of the bladder, Urology, 55, 448, 10.1016/S0090-4295(99)00474-4

Palit, 2005, Expression of HIF-1alpha and Glut-1 in human bladder cancer, Oncol Rep, 14, 909

Elstrom, 2004, Akt stimulates aerobic glycolysis in cancer cells, Cancer Res, 64, 3892, 10.1158/0008-5472.CAN-03-2904

Ho, 2011, A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation, Cancer Res, 71, 4484, 10.1158/0008-5472.CAN-10-3973

Poff, 2013, The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer, PLoS One, 8, e65522, 10.1371/journal.pone.0065522

Rieger, 2014, ERGO: a pilot study of ketogenic diet in recurrent glioblastoma, Int J Oncol, 44, 1843, 10.3892/ijo.2014.2382

Arends, 2008, Malignant tumors – Transketolase-like 1 (TKTL 1) – ketogenic diet, Aktuel Ernahrungsmed, 33, 80, 10.1055/s-2007-986412

Breitkreutz, 2005, Effects of a high-fat diet on body composition in cancer patients receiving chemotherapy: a randomized controlled study, Wien Klin Wochenschr, 117, 685, 10.1007/s00508-005-0455-3

Raffaghello, 2008, Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy, Proc Natl Acad Sci U. S. A, 105, 8215, 10.1073/pnas.0708100105

Lee, 2012, Fasting cycles retard growth of tumors and sensitize a rage of cancer cell types to chemotherapy, Sci Transl Med, 4, 124ra27, 10.1126/scitranslmed.3003293

Safdie, 2012, Fasting enhances the response of glioma to chemo- and radiotherapy, PLoS One, 7, e44603, 10.1371/journal.pone.0044603

Caffa, 2015, Fasting plus tyrosine kinase inhibitors in cancer, Aging (Albany NY), 7, 1026, 10.18632/aging.100857

Laviano, 2012, Toxicity in chemotherapy–when less is more, N Engl J Med, 366, 2319, 10.1056/NEJMcibr1202395

Safdie, 2009, Fasting and cancer treatment in humans: a case series report, Aging (Albany NY), 1, 988, 10.18632/aging.100114

de Groot, 2015, The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study, BMC Cancer, 15, 652, 10.1186/s12885-015-1663-5

Corry, 2008, Randomized study of percutaneous endoscopic gastrostomy versus nasogastric tubes for enteral feeding in head and neck cancer patients treated with (chemo)radiation, J Med Imaging Radiat Oncol, 52, 503, 10.1111/j.1440-1673.2008.02003.x

Nugent, 2010, Nasogastric tube feeding and percutaneous endoscopic gastrostomy tube feeding in patients with head and neck cancer, J Hum Nutr Diet, 23, 277, 10.1111/j.1365-277X.2010.01047.x

Sheth, 2013, Enteral feeding in head and neck cancer patients at a UK cancer centre, J Hum Nutr Diet, 26, 421, 10.1111/jhn.12029

Bozzetti, 2014, The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a multi-centre observational study with prospective follow-up of 414 patients, Ann Oncol, 25, 487, 10.1093/annonc/mdt549

Brennan, 1994, A prospective randomized trial of total parenteral nutrition after major pancreatic resection for malignancy, Ann Surg, 220, 436, 10.1097/00000658-199410000-00003

Scolapio, 2002, Outcome of patients with radiation enteritis treated with home parenteral nutrition, Am J Gastroenterol, 97, 662, 10.1111/j.1572-0241.2002.05546.x

Klein, 1994, Nutrition support in patients with cancer: what do the data really show?, Nutr Clin Pract, 9, 91, 10.1177/011542659400900391

Staun, 2007, Management of intestinal failure in Europe. A questionnaire based study on the incidence and management, Dyn Med, 4, 6

Shaw, 2013, Home artificial nutrition in Switzerland: an epidemiological survey from 2005 to 2009, Ann Nutr Metab, 62, 207, 10.1159/000346485

Cotogni, 2013, Catheter-related complications in cancer patients on home parenteral nutrition: a prospective study of over 51,000 catheter days, J Parenter Enter Nutr, 37, 375, 10.1177/0148607112460552

Hearing, 2004, Refeeding syndrome, BMJ, 328, 908, 10.1136/bmj.328.7445.908

Mehanna, 2008, Refeeding syndrome: what it is, and how to prevent and treat it, BMJ, 336, 1495, 10.1136/bmj.a301

Marinella, 2009, Refeeding syndrome: an important aspect of supportive oncology, J Support Oncol, 7, 11

Walmsley, 2013, Refeeding syndrome: screening, incidence, and treatment during parenteral nutrition, J Gastroenterol Hepatol, 28, 113, 10.1111/jgh.12345

Sacks, 2009, Refeeding syndrome: awareness is the first step in preventing complications, J Support Oncol, 7, 19

Ahmed, 2011, Re-feeding syndrome in head and neck–prevention and management, Oral Oncol, 47, 792, 10.1016/j.oraloncology.2010.06.009

NICE. Nutrition support for adults: oral nutritiion support, enteral tube feeding and parenteral nutrition. NICE guidelines CG32. https://www.nice.org.uk/guidance/cg32.

Bozzetti, 2013, Nutritional support of the oncology patient, Crit Rev Oncol Hematol, 87, 172, 10.1016/j.critrevonc.2013.03.006

Ellershaw, 2003, Care of the dying patient: the last hours or days of life, BMJ, 326, 30, 10.1136/bmj.326.7379.30

Druml, 2016, ESPEN guideline on ethical aspects of artificial nutrition and hydration, Clin Nutr, 35, 545, 10.1016/j.clnu.2016.02.006

Ruggeri, 2013, Home artificial nutrition in advanced cancer patients, Tumori, 99, 218, 10.1177/030089161309900216

Orrevall, 2013, A national observational study of the prevalence and use of enteral tube feeding, parenteral nutrition and intravenous glucose in cancer patients enrolled in specialized palliative care, Nutrients, 5, 267, 10.3390/nu5010267

Fan, 2007, Parenteral nutrition prolongs the survival of patients associated with malignant gastrointestinal obstruction, J Parenter Enter Nutr, 31, 508, 10.1177/0148607107031006508

Staun, 2009, ESPEN guidelines on parenteral nutrition: home parenteral nutrition (HPN) in adult patients, Clin Nutr, 28, 467, 10.1016/j.clnu.2009.04.001

Jones, 2013, Exercise-oncology research: past, present, and future, Acta Oncol Stockh Swed, 52, 195, 10.3109/0284186X.2012.742564

Oldervoll, 2011, Physical exercise for cancer patients with advanced disease: a randomized controlled trial, Oncol, 16, 1649, 10.1634/theoncologist.2011-0133

Lowe, 2009, Physical activity as a supportive care intervention in palliative cancer patients: a systematic review, J Support Oncol, 7, 27

Speck, 2010, An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis, J cancer Surviv Res Pract, 4, 87

Stene, 2013, Effect of physical exercise on muscle mass and strength in cancer patients during treatment–a systematic review, Crit Rev Oncol/Hematol, 88, 573, 10.1016/j.critrevonc.2013.07.001

Fong, 2012, Physical activity for cancer survivors: meta-analysis of randomised controlled trials, BMJ, 344, e70, 10.1136/bmj.e70

Awad, 2012, Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer, Clin Nutr, 31, 74, 10.1016/j.clnu.2011.08.008

Antoun, 2010, Association of skeletal muscle wasting with treatment with sorafenib in patients with advanced renal cell carcinoma: results from a placebo-controlled study, J Clin Oncol, 28, 1054, 10.1200/JCO.2009.24.9730

Ferriolli, 2012, Physical activity monitoring: a responsive and meaningful patient-centered outcome for surgery, chemotherapy, or radiotherapy?, J Pain Symptom Manage, 43, 1025, 10.1016/j.jpainsymman.2011.06.013

Kortebein, 2007, Effect of 10 days of bed rest on skeletal muscle in healthy older adults, JAMA, 297, 1772, 10.1001/jama.297.16.1772-b

Yavuzsen, 2005, Systematic review of the treatment of cancer-associated anorexia and weight loss, J Clin Oncol, 23, 8500, 10.1200/JCO.2005.01.8010

Paulsen, 2014, Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial, J Clin Oncol, 32, 3221, 10.1200/JCO.2013.54.3926

Miller, 2014, Use of corticosteroids for anorexia in palliative medicine: a systematic review, J Palliat Med, 17, 482, 10.1089/jpm.2013.0324

Moertel, 1974, Corticosteroid therapy of preterminal gastrointestinal cancer, Cancer, 33, 1607, 10.1002/1097-0142(197406)33:6<1607::AID-CNCR2820330620>3.0.CO;2-V

Maltoni, 2001, High-dose progestins for the treatment of cancer anorexia-cachexia syndrome: a systematic review of randomised clinical trials, Ann Oncol, 12, 289, 10.1023/A:1011156811739

Lesniak, 2008, Effects of megestrol acetate in patients with cancer anorexia-cachexia syndrome–a systematic review and meta-analysis, Pol Arch Med Wewnętrznej, 118, 636

Ruiz Garcia, 2013, Megestrol acetate for treatment of anorexia-cachexia syndrome, Cochrane Database Syst Rev, 28, CD004310

Lambert, 2005, The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications, J Med Chem, 48, 5059, 10.1021/jm058183t

Pacher, 2006, The endocannabinoid system as an emerging target of pharmacotherapy, Pharmacol Rev, 58, 389, 10.1124/pr.58.3.2

Nelson, 1994, A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia, J Palliat Care, 10, 14

Cannabis-In-Cachexia-Study-Group, 2006, J Clin Oncol, 24, 3394, 10.1200/JCO.2005.05.1847

Jatoi, 2002, Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study, J Clin Oncol, 20, 567, 10.1200/JCO.20.2.567

Brisbois, 2011, Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial, Ann Oncol, 22, 2086, 10.1093/annonc/mdq727

Epstein, 2010, Taste disorders in cancer patients: pathogenesis, and approach to assessment and management, Oral Oncol, 46, 77, 10.1016/j.oraloncology.2009.11.008

Ripamonti, 1998, A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation, Cancer, 82, 1938, 10.1002/(SICI)1097-0142(19980515)82:10<1938::AID-CNCR18>3.0.CO;2-U

Lyckholm, 2012, A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders, J Pain Palliat Care Pharmacother, 26, 111, 10.3109/15360288.2012.676618

Strasser, 2008, Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study, Br J Cancer, 98, 300, 10.1038/sj.bjc.6604148

Lundholm, 2010, Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients: a randomized double-blind study, Cancer, 116, 2044, 10.1002/cncr.24917

Adachi, 2010, Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study, Gastroenterology, 138, 1312, 10.1053/j.gastro.2009.12.058

Temel, 2016, Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials, Lancet Oncol, 10.1016/S1470-2045(15)00558-6

Sinha-Hikim, 2004, Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment, J Clin Endocrinol Metab, 89, 5245, 10.1210/jc.2004-0084

Burney, 2012, Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia, J Clin Endocrinol Metab, 97, E700, 10.1210/jc.2011-2387

Chlebowski, 1986, Influence of nandrolone decanoate on weight loss in advanced non-small cell lung cancer, Cancer, 58, 183, 10.1002/1097-0142(19860701)58:1<183::AID-CNCR2820580131>3.0.CO;2-3

Loprinzi, 1999, Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia, J Clin Oncol, 17, 3299, 10.1200/JCO.1999.17.10.3299

Dobs, 2013, Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial, Lancet Oncol, 14, 335, 10.1016/S1470-2045(13)70055-X

Lundholm, 2007, Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning, Clin Cancer Res, 13, 2699, 10.1158/1078-0432.CCR-06-2720

Slater, 2000, Beta-hydroxy-bety-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength, Sports Med, 30, 105, 10.2165/00007256-200030020-00004

May, 2002, Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine, Am J Surg, 183, 471, 10.1016/S0002-9610(02)00823-1

Berk, 2008, A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122), Support Care Cancer, 16, 1179, 10.1007/s00520-008-0403-7

Alpers, 2006, Glutamine: do the data support the cause for glutamine supplementation in humans?, Gastroenterology, 130, S106, 10.1053/j.gastro.2005.11.049

DeBerardinis, 2007, Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proc Natl Acad Sci U. S. A, 104, 19345, 10.1073/pnas.0709747104

Huang, 2013, A proposed role for glutamine in cancer cell growth through acid resistance, Cell Res, 23, 724, 10.1038/cr.2013.15

Holecek, 2013, Side effects of long-term glutamine supplementation, J Parenter Enter Nutr, 37, 607, 10.1177/0148607112460682

McMillan, 1999, A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss, Br J Cancer, 79, 495, 10.1038/sj.bjc.6690077

Lai, 2008, Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract, Head Neck, 30, 67, 10.1002/hed.20662

Madeddu, 2012, Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome, Clin Nutr, 31, 176, 10.1016/j.clnu.2011.10.005

Goldberg, 1995, Pentoxifylline for treatment of cancer anorexia and cachexia? A randomized, double-blind, placebo-controlled trial, J Clin Oncol, 13, 2856, 10.1200/JCO.1995.13.11.2856

Del Fabbro, 2013, Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial, J Clin Oncol, 31, 1271, 10.1200/JCO.2012.43.6766

Jatoi, 2010, A placebo-controlled, double-blind trial of infliximab for cancer-associated weight loss in elderly and/or poor performance non-small cell lung cancer patients (N01C9), Lung Cancer, 68, 234, 10.1016/j.lungcan.2009.06.020

Reid, 2012, Thalidomide for managing cancer cachexia, Cochrane Database Syst Rev, 4, CD008664

Gordon, 2005, Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial, Gut, 54, 540, 10.1136/gut.2004.047563

Yennurajalingam, 2012, The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study, J Palliat Med, 15, 1059, 10.1089/jpm.2012.0146

Mantovani, 2010, Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia, Oncol, 15, 200, 10.1634/theoncologist.2009-0153

Wilkes, 2011, Poor tolerability of thalidomide in end-stage oesophageal cancer, Eur J Cancer Care Engl, 20, 593, 10.1111/j.1365-2354.2011.01255.x

Ando, 2013, Takahashi K.Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia, J Clin Oncol, 31, e69, 10.1200/JCO.2012.44.2020

Hirata, 2013, Favorable responses to tocilizumab in two patients with cancer-related cachexia, J Pain Symptom Manage, 46, e9, 10.1016/j.jpainsymman.2013.01.009

Bayliss, 2011, A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer, Expert Opin Biol Ther, 11, 1663, 10.1517/14712598.2011.627850

Solheim, 2013, Non-steroidal anti-inflammatory treatment in cancer cachexia: a systematic literature review, Acta Oncol, 52, 6, 10.3109/0284186X.2012.724536

Faber, 2013, Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial, Clin Nutr, 32, 338, 10.1016/j.clnu.2012.09.009

Wigmore, 1997, Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6, Clin Sci Lond, 92, 215, 10.1042/cs0920215

van der Meij, 2010, Oral nutritional supplements containing (N-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment, J Nutr, 140, 1774, 10.3945/jn.110.121202

Silva, 2012, Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients, Nutr Cancer, 64, 267, 10.1080/01635581.2012.643133

Mocellin, 2016, A systematic review and meta-analysis of the N-3 polyunsaturated fatty acids effects on inflammatory markers in colorectal cancer, Clin Nutr, 35, 359, 10.1016/j.clnu.2015.04.013

Finocchiaro, 2012, Effect of N-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study, Br J Nutr, 108, 327, 10.1017/S0007114511005551

Fearon, 2003, Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial, Gut, 52, 1479, 10.1136/gut.52.10.1479

van der Meij, 2012, Oral nutritional supplements containing N-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT, Eur J Clin Nutr, 66, 399, 10.1038/ejcn.2011.214

Murphy, 2011, Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy, Cancer, 117, 1775, 10.1002/cncr.25709

Trabal, 2010, Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition, Nutr Hosp, 25, 736

Sánchez-Lara, 2014, Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial, Clin Nutr, 33, 1017, 10.1016/j.clnu.2014.03.006

Murphy, 2011, Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer, Cancer, 117, 3774, 10.1002/cncr.25933

Gogos, 1998, Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial, Cancer, 82, 395, 10.1002/(SICI)1097-0142(19980115)82:2<403::AID-CNCR21>3.0.CO;2-1

Bruera, 2003, Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study, J Clin Oncol, 21, 129, 10.1200/JCO.2003.01.101

Jatoi, 2004, An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada collaborative effort, J Clin Oncol, 22, 2469, 10.1200/JCO.2004.06.024

Fearon, 2006, Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia, J Clin Oncol, 24, 3401, 10.1200/JCO.2005.04.5724

Dewey, 2007, Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia, Cochrane Database Syst Rev, 1, CD004597

Mazzotta, 2009, Anorexia-cachexia syndrome: a systematic review of the role of dietary polyunsaturated fatty acids in the management of symptoms, survival, and quality of life, J Pain Symptom Manage, 37, 1069, 10.1016/j.jpainsymman.2008.06.005

Ries, 2012, A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project, Palliat Med, 26, 294, 10.1177/0269216311418709

Colomer, 2007, N-3 fatty acids, cancer and cachexia: a systematic review of the literature, Br J Nutr, 97, 823, 10.1017/S000711450765795X

de Aguiar Pastore Silva, 2015, Omega-3 supplements for patients in chemotherapy and/or radiotherapy: a systematic review, Clin Nutr, 34, 359, 10.1016/j.clnu.2014.11.005

Clarke, 1990, Increased incidence of epistaxis in adolescents with familial hypercholesterolemia treated with fish oil, J Pediatr, 116, 139, 10.1016/S0022-3476(05)81666-X

EFSA Panel on Dietetic Products, 2012, Nutrition and Allergy (NDA). Scientific opinion on the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DH) and docosapentaenoic acid (DPA), EFSA J, 10, 2815, 10.2903/j.efsa.2012.2815

Pardini, 2006, Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents, Chem Biol Interact, 162, 89, 10.1016/j.cbi.2006.05.012

Hardman, 2004, N-3 fatty acids and cancer therapy, J Nutr, 134, 3427S

Serafini, 2010, Editorial: PGE2-producing MDSC: a role in tumor progression?, J Leukoc Biol, 88, 827, 10.1189/jlb.0510303

Haqq, 2015, Targeting pancreatic cancer using a combination of gemcitabine with the omega-3 polyunsaturated fatty acid emulsion, Lipidem™ Mol Nutr Food Res

Roodhart, 2011, Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids, Cancer Cell, 20, 370, 10.1016/j.ccr.2011.08.010

Daenen, 2015, Increased plasma levels of chemoresistance-inducing fatty acid 16:4(N-3) after consumption of fish and fish oil, JAMA Oncol, 1, 350, 10.1001/jamaoncol.2015.0388

Murphy, 2013, A fishy conclusion regarding N-3 fatty acid supplementation in cancer patients, Clin Nutr, 32, 466, 10.1016/j.clnu.2012.05.013

Bougnoux, 2009, Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial, Br J Cancer, 101, 1978, 10.1038/sj.bjc.6605441

Michael-Titus, 2014, Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?, Trends Neurosci, 37, 30, 10.1016/j.tins.2013.10.005

Coste, 2003, Neuroprotective effect of docosahexaenoic acid-enriched phospholipids in experimental diabetic neuropathy, Diabetes, 52, 2578, 10.2337/diabetes.52.10.2578

Ghoreishi, 2012, Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial, BMC Cancer, 12, 355, 10.1186/1471-2407-12-355

Elbarbary, 2016, ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: a randomized placebo-controlled study, Nutrition, 32, 41, 10.1016/j.nut.2015.06.010

Hiyama, 2009, Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract, J Gastroenterol Hepatol, 24, 537, 10.1111/j.1440-1746.2009.05780.x

Bruera, 1994, Comparison of the efficacy, safety, and pharmacokinetics of controlled release and immediate release metoclopramide for the management of chronic nausea in patients with advanced cancer, Cancer, 74, 3204, 10.1002/1097-0142(19941215)74:12<3204::AID-CNCR2820741220>3.0.CO;2-G

Bruera, 2000, A double-blind, crossover study of controlled-release metoclopramide and placebo for the chronic nausea and dyspepsia of advanced cancer, J Pain Symptom Manage, 19, 427, 10.1016/S0885-3924(00)00138-X

Russell, 1983, Delayed gastric emptying and improvement with domperidone in a patient with anorexia nervosa, Am J Psychiatry, 140, 1235, 10.1176/ajp.140.9.1235

Stacher, 1986, Oesophageal and gastric motility disorders in patients categorised as having primary anorexia nervosa, Gut, 27, 1120, 10.1136/gut.27.10.1120

Chial, 2002, Anorexia nervosa: manifestations and management for the gastroenterologist, Am J Gastroenterol, 97, 255, 10.1111/j.1572-0241.2002.05452.x

2003, 462

Raedsch, 2007, Assessment of the efficacy and safety of the phytopharmacon STW5 versus metoclopramide in functional dyspepsia – a retrolective cohort study, Z Gastroenterol, 45, 1041

Wlock, 2006, Domperidone – keeping abreast of the controversies, Brit Columbia Pharm Assoc Tablet, 15, 5

Gustafsson, 2012, Guidelines for perioperative care in elective colonic surgery: enhanced recovery after surgery (ERAS®) society recommendations, Clin Nutr, 31, 783, 10.1016/j.clnu.2012.08.013

Fearon, 2005, Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection, Clin Nutr, 24, 466, 10.1016/j.clnu.2005.02.002

Gustafsson, 2011, Perioperative nutritional management in digestive tract surgery, Curr Opin Clin Nutr Metab Care, 14, 504, 10.1097/MCO.0b013e3283499ae1

Ljungqvist, 2012, Jonathan E. Rhoads lecture 2011: insulin resistance and enhanced recovery after surgery, J Parenter Enter Nutr, 36, 389, 10.1177/0148607112445580

Hendry, 2009, Determinants of outcome after colorectal resection within an enhanced recovery programme, Br J Surg, 96, 197, 10.1002/bjs.6445

Beattie, 2000, A randomised controlled trial evaluating the use of enteral nutritional supplements postoperatively in malnourished surgical patients, Gut, 46, 813, 10.1136/gut.46.6.813

Mortensen, 2014, Consensus guidelines for enhanced recovery after gastrectomy: enhanced recovery after surgery (ERAS®) society recommendations, Br J Surg, 101, 1209, 10.1002/bjs.9582

Tyldesley, 1979, Prediction of operative morbidity and mortality by preoperative nutritional assessment, Surg Forum, 30, 80

The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group, 1991, Perioperative total parenteral nutrition in surgical patients, N Engl J Med, 325, 525, 10.1056/NEJM199108223250801

Marimuthu, 2012, A meta-analysis of the effect of combinations of immune modulating nutrients on outcome in patients undergoing major open gastrointestinal surgery, Ann Surg, 255, 1060, 10.1097/SLA.0b013e318252edf8

Odelli, 2005, Nutrition support improves patient outcomes, treatment tolerance and admission characteristics in oesophageal cancer, Clin Oncol R Coll Radiol, 17, 639, 10.1016/j.clon.2005.03.015

van den Berg, 2010, Comparison of the effect of individual dietary counselling and of standard nutritional care on weight loss in patients with head and neck cancer undergoing radiotherapy, Br J Nutr, 104, 872, 10.1017/S0007114510001315

Thiel, 1988, Malnutrition and the role of nutritional support for radiation therapy patients, Recent Results Cancer Res, 108, 205, 10.1007/978-3-642-82932-1_27

Nayel, 1992, Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation, Nutrition, 8, 13

Paccagnella, 2010, Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy, Support Care Cancer, 18, 837, 10.1007/s00520-009-0717-0

Nugent, 2013, Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy, Cochrane Database Syst Rev, 1, CD007904

Fietkau, 1991, Percutaneous endoscopically guided gastrostomy in patients with head and neck cancer, Recent Results Cancer Res, 121, 269, 10.1007/978-3-642-84138-5_31

Tyldesley, 1996, The use of radiologically placed gastrostomy tubes in head and neck cancer patients receiving radiotherapy, Int J Radiat Oncol Biol Phys, 36, 1205, 10.1016/S0360-3016(96)00434-8

Bozzetti, 1998, Nutritional support in patients with cancer of the esophagus: impact on nutritional status, patient compliance to therapy, and survival, Tumori, 84, 681, 10.1177/030089169808400614

Lee, 1998, Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck, Arch Otolaryngol Head Neck Surg, 124, 871, 10.1001/archotol.124.8.871

van den Berg, 2008, A prospective study on malnutrition and quality of life in patients with head and neck cancer, Oral Oncol, 44, 830, 10.1016/j.oraloncology.2007.11.002

Isenring, 2004, Nutrition intervention is beneficial in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area, Br J Cancer, 91, 447, 10.1038/sj.bjc.6601962

Khalid, 2006, A modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading, Int J Radiat Oncol Biol Phys, 64, 1432, 10.1016/j.ijrobp.2005.10.007

Isenring, 2007, Nutrition support using the American Dietetic Association medical nutrition therapy protocol for radiation oncology patients improves dietary intake compared with standard practice, J Am Diet Assoc, 107, 404, 10.1016/j.jada.2006.12.007

Elia, 2006, Enteral (oral or tube administration) nutritional support and eicosapentaenoic acid in patients with cancer: a systematic review, Int J Oncol, 28, 5

Cereda, 2014, The use of oral nutritional supplements in patients with head and neck cancer receiving (chemo)radiotherapy, Clin Nutr, 33, 370, 10.1016/j.clnu.2013.10.022

http://www.cancer.gov/about-nci/organization/ccct/steering-committees/nctn/head-neck.

Head and Neck Guideline Steering Committee. Evidence-based practice guidelines for the nutritional management of adult patients with head and neck cancer. Sydney: Cancer Council Australia. [Version URL: http://wiki.cancer.org.au/australiawiki/index.php?oldid=116710, cited 2016 Apr 18]. Available from: http://wiki.cancer.org.au/australia/COSA: Head_and_neck_cancer_nutrition_guidelines.

Marcy, 2000, Systematic percutaneous fluoroscopic gastrostomy for concomitant radiochemotherapy of advanced head and neck cancer: optimization of therapy, Support Care Cancer, 8, 410, 10.1007/s005200050010

Rabinovitch, 2006, Impact of nutrition support on treatment outcome in patients with locally advanced head and neck squamous cell cancer treated with definitive radiotherapy: a secondary analysis of RTOG trial 90-03, Head Neck, 28, 287, 10.1002/hed.20335

Lewis, 2014, Feeding tube use in patients with head and neck cancer, Head Neck, 36, 1789, 10.1002/hed.23538

Trotti, 2003, Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review, Radiother Oncol, 66, 253, 10.1016/S0167-8140(02)00404-8

Campos, 1990, Home enteral nutrition via gastrostomy in advanced head and neck cancer patients, Head Neck, 12, 137, 10.1002/hed.2880120208

Mekhail, 2001, Enteral nutrition during treatment of head and neck carcinoma, Cancer, 91, 1785, 10.1002/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.0.CO;2-1

Daly, 1984, Nutritional rehabilitation in patients with advanced head and neck cancer receiving radiation therapy, Am J Surg, 148, 514, 10.1016/0002-9610(84)90379-9

Cannaby, 2002, Nursing care of patients with nasogastric feeding tubes, Br J Nurs, 11, 366, 10.12968/bjon.2002.11.6.10127

Burkitt, 2011, Outcomes of percutaneous endoscopic gastrostomy and radiologically inserted gastrostomy in patienst with head and neck cancer: a systematic review, Br J Oral Maxillofac Surg, 49, 516, 10.1016/j.bjoms.2010.09.005

Paleri, 2014, Strategies to reduce long-term postchemoradiation dysphagia in patients with head and neck cancer: an evidence-based review, Head Neck, 36, 431, 10.1002/hed.23251

Wang, 2014, Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for patients with head and neck cancer: a systematic review, J Radiat Res, 22, 1

Gomes, 2015, Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances, Cochrane Database Syst Rev, 3, CD008096

Lees, 1997, Nasogastric and percutaneous endoscopic gastrostomy feeding in head and neck cancer patients receiving radiotherapy treatment at a regional oncology unit: a two year study, Eur J Cancer Care Engl, 6, 45, 10.1111/j.1365-2354.1997.tb00268.x

Fietkau, 2013, A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial, Cancer, 119, 3343, 10.1002/cncr.28197

Schindler, 2015, Dysphagia in head and neck cancer patients treated with radiotherapy and systemic therapies: literature review and consensus, Crit Rev Oncol Hematol, 96, 372, 10.1016/j.critrevonc.2015.06.005

Nguyen, 2006, Evolution of chronic dysphagia following treatment for head and neck cancer, Oral Oncol, 42, 374, 10.1016/j.oraloncology.2005.09.003

Savarese, 2003, Prevention of chemotherapy and radiation toxicity with glutamine, Cancer Treat Rev, 29, 501, 10.1016/S0305-7372(03)00133-6

Kozelsky, 2003, Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy, J Clin Oncol, 21, 1669, 10.1200/JCO.2003.05.060

Rotovnik Kozjek, 2011, Oral glutamine supplementation during preoperative radiochemotherapy in patients with rectal cancer: a randomised double blinded, placebo controlled pilot study, Clin Nutr, 30, 567, 10.1016/j.clnu.2011.06.003

Vidal-Casariego, 2014, Efficacy of glutamine in the prevention of acute radiation enteritis: a randomized controlled trial, J Parenter Enter Nutr, 38, 205, 10.1177/0148607113478191

Kucuktulu, 2013, The protective effects of glutamine on radiation-induced diarrhea, Support Care Cancer, 21, 1071, 10.1007/s00520-012-1627-0

Huang, 2000, Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial, Int J Radiat Oncol Biol Phys, 46, 535, 10.1016/S0360-3016(99)00402-2

Cerchietti, 2006, Double-blinded, placebo-controlled trial on intravenous L-alanyl-L-glutamine in the incidence of oral mucositis following chemoradiotherapy in patients with head-and-neck cancer, Int J Radiat Oncol Biol Phys, 65, 1330, 10.1016/j.ijrobp.2006.03.042

Tsujimoto, 2015, L-glutamine decreases the severity of mucositis induced by chemoradiotherapy in patients with locally advanced head and neck cancer: a double-blind, randomized, placebo-controlled trial, Oncol Rep, 33, 33, 10.3892/or.2014.3564

Coghlin Dickson, 2000, Effect of oral glutamine supplementation during bone marrow transplantation, J Parenter Enter Nutr, 24, 61, 10.1177/014860710002400261

Topkan, 2012, Influence of oral glutamine supplementation on survival outcomes of patients treated with concurrent chemoradiotherapy for locally advanced non-small cell lung cancer, BMC Cancer, 12, 502, 10.1186/1471-2407-12-502

Rubio, 2013, Oral glutamine reduces radiation morbidity in breast conservation surgery, J Parenter Enter Nutr, 37, 623, 10.1177/0148607112474994

Eda, 2016, The effects of enteral glutamine on radiotherapy induced dermatitis in breast cancer, Clin Nutr, 35, 436, 10.1016/j.clnu.2015.03.009

Pytlík, 2002, Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study, Bone Marrow Transpl, 30, 953, 10.1038/sj.bmt.1703759

Crowther, 2009, Systematic review and meta-analyses of studies of glutamine supplementation in haematopoietic stem cell transplantation, Bone Marrow Transpl, 44, 413, 10.1038/bmt.2009.41

Andreyev, 2011, “Pelvic radiation disease”: new understanding and new solutions for a new disease in the era of cancer survivorship, Scand J Gastroenterol, 46, 389, 10.3109/00365521.2010.545832

Andreyev, 2007, Gastrointestinal problems after pelvic radiotherapy: the past, the present and the future, Clin Oncol R Coll Radiol, 19, 790, 10.1016/j.clon.2007.08.011

Demers, 2014, A randomized double-blind controlled trial: impact of probiotics on diarrhea in patients treated with pelvic radiation, Clin Nutr, 33, 761, 10.1016/j.clnu.2013.10.015

Salminen, 1988, Preservation of intestinal integrity during radiotherapy using live Lactobacillus acidophilus cultures, Clin Radiol, 39, 435, 10.1016/S0009-9260(88)80296-4

Urbancsek, 2001, Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhoea, Eur J Gastroenterol Hepatol, 13, 391, 10.1097/00042737-200104000-00015

Delia, 2007, Use of probiotics for prevention of radiation-induced diarrhea, World J Gastroenterol, 13, 912, 10.3748/wjg.v13.i6.912

Giralt, 2008, Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial, Int J Radiat Oncol Biol Phys, 71, 1213, 10.1016/j.ijrobp.2007.11.009

Chitapanarux, 2010, Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients, Radiat Oncol, 5, 31, 10.1186/1748-717X-5-31

Wedlake, 2013, Systematic review: the efficacy of nutritional interventions to counteract acute gastrointestinal toxicity during therapeutic pelvic radiotherapy, Aliment Pharmacol Ther, 37, 1046, 10.1111/apt.12316

Gibson, 2014, Systematic review of agents for the management of gastrointestinal mucositis in cancer patients, Support Care Cancer, 21, 313, 10.1007/s00520-012-1644-z

Hamad, 2013, A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease, Clin Nutr, 32, 353, 10.1016/j.clnu.2013.02.004

Henson, 2013, Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy, Cochrane Database Syst Rev, 11, CD009896

Theis, 2010, Chronic radiation enteritis, Clin Oncol R Coll Radiol, 22, 70, 10.1016/j.clon.2009.10.003

Gavazzi, 2006, Role of home parenteral nutrition in chronic radiation enteritis, Am J Gastroenterol, 101, 374, 10.1111/j.1572-0241.2006.00438.x

Kalaiselvan, 2014, Radiation enteritis leading to intestinal failure: 1994 patient-years of experience in a national referral centre, Eur J Clin Nutr, 68, 166, 10.1038/ejcn.2013.251

Prado, 2007, Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity, Clin Cancer Res, 13, 3264, 10.1158/1078-0432.CCR-06-3067

Dy, 2013, Understanding, recognizing, and managing toxicities of targeted anticancer therapies, CA Cancer J Clin, 63, 249, 10.3322/caac.21184

Massicotte, 2013, Body composition variation and impact of low skeletal muscle mass in patients with advanced medullary thyroid carcinoma treated with vandetanib: results from a placebo-controlled study, J Clin Endocrinol Metab, 98, 2401, 10.1210/jc.2013-1115

Ross, 2004, Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers?, Br J Cancer, 90, 1905, 10.1038/sj.bjc.6601781

Meuric, 2012, SFNEP Oncology nutrition guidelines: when should individualized dietetic counselling be proposed?, Nutr Clin Metab, 26, 197, 10.1016/j.nupar.2012.10.006

Ligthart-Melis, 2013, Dietician-delivered intensive nutritional support is associated with a decrease in severe postoperative complications after surgery in patients with esophageal cancer, Dis Esophagus, 26, 587, 10.1111/dote.12008

Dobrila-Dintinjana, 2013, Nutritional support in patients with colorectal cancer during chemotherapy: does it work?, Hepato-Gastroenterol, 60, 475

De Waele, 2015, Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial, Appetite, 91, 298, 10.1016/j.appet.2015.04.049

Koretz, 2001, AGA technical review on parenteral nutrition, Gastroenterology, 121, 970, 10.1053/gast.2001.28031

Miyata, 2012, Randomized study of clinical effect of enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer, Clin Nutr, 31, 330, 10.1016/j.clnu.2011.11.002

Zaloga, 2006, Parenteral nutrition in adult inpatients with functioning gastrointestinal: assessment of outcomes, Lancet, 367, 1101, 10.1016/S0140-6736(06)68307-4

Li, 2009, Clinical trial: prophylactic intravenous alanyl-glutamine reduces the severity of gastrointestinal toxicity induced by chemotherapy–a randomized crossover study, Aliment Pharmacol Ther, 30, 452, 10.1111/j.1365-2036.2009.04068.x

Sun, 2012, Glutamine for chemotherapy induced diarrhea: a meta-analysis, Asia Pac J Clin Nutr, 21, 380

Sornsuvit, 2008, Pilot Study: effects of parenteral glutamine dipeptide supplementation on neutrophil functions and prevention of chemotherapy-induced side-effects in acute myeloid leukaemia patients, J Int Med Res, 36, 1383

Sayles, 2016, Oral glutamine in preventing treatment-related mucositis in adult patients with cancer: a systematic review, Nutr Clin Pract, 31, 171, 10.1177/0884533615611857

Wang, 2007, Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients, Oncologist, 12, 312, 10.1634/theoncologist.12-3-312

Urbain, 2013, Longitudinal follow-up of nutritional status and its influencing factors in adults undergoing allogeneic hematopoietic cell transplantation, Bone Marrow Transpl, 48, 446, 10.1038/bmt.2012.158

Urbain, 2013, Body mass index and bioelectrical impedance phase angle as potentially modifiable nutritional markers are independent risk factors for outcome in allogeneic hematopoietic cell transplantation, Ann Hematol, 92, 111, 10.1007/s00277-012-1573-4

Muscaritoli, 1998, Clinical and metabolic effects of different parenteral nutrition regimens in patients undergoing allogeneic bone marrow transplantation, Transplantation, 66, 610, 10.1097/00007890-199809150-00011

Mousavi, 2013, Impact of clinical pharmacist-based parenteral nutrition service for bone marrow transplantation patients: a randomized clinical trial, Support Care Cancer, 21, 3441, 10.1007/s00520-013-1920-6

Morishita, 2013, Relationship between corticosteroid dose and declines in physical function among allogeneic hematopoietic stem cell transplantation patients, Support Care Cancer, 21, 2161, 10.1007/s00520-013-1778-7

Dimeo, 1997, Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy, Blood, 90, 3390, 10.1182/blood.V90.9.3390

Dimeo, 1997, Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation, Cancer, 79, 1717, 10.1002/(SICI)1097-0142(19970501)79:9<1717::AID-CNCR12>3.0.CO;2-0

Knols, 2011, Effects of an outpatient physical exercise program on hematopoietic stem-cell transplantation recipients: a randomized clinical trial, Bone Marrow Transpl, 46, 1245, 10.1038/bmt.2010.288

Wiskemann, 2011, Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation, Blood, 117, 2604, 10.1182/blood-2010-09-306308

van Haren, 2013, Physical exercise for patients undergoing hematopoietic stem cell transplantation: systematic review and meta-analyses of randomized controlled trials, Phys Ther, 93, 514, 10.2522/ptj.20120181

Farias, 2013, Phase angle from BIA as a prognostic and nutritional status tool for children and adolescents undergoing hematopoietic stem cell transplantation, Clin Nutr, 32, 420, 10.1016/j.clnu.2012.09.003

Kramer, 2013, Validation of the grip test and human activity profile for evaluation of physical performance during the intermediate phase after allogeneic hematopoietic stem cell transplantation, Support Care Cancer, 21, 1121, 10.1007/s00520-012-1634-1

Seguy, 2012, Better outcome of patients undergoing enteral tube feeding after myeloablative conditioning for allogeneic stem cell transplantation, Transplantation, 94, 287, 10.1097/TP.0b013e3182558f60

Guièze, 2014, Enteral versus parenteral nutritional support in allogeneic haematopoietic stem-cell transplantation, Clin Nutr, 33, 533, 10.1016/j.clnu.2013.07.012

Tavakoli-Ardakani, 2013, Clinical effect of individualized parenteral nutrition vs conventional method in patients undergoing autologous hematopoietic SCT, Bone Marrow Transpl, 48, 958, 10.1038/bmt.2012.280

Trifilio, 2012, Questioning the role of a neutropenic diet following hematopoetic stem cell transplantation, Biol Blood Marrow Transpl, 18, 1385, 10.1016/j.bbmt.2012.02.015

Tomblyn, 2009, Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective, Biol Blood Marrow Transpl, 15, 1143, 10.1016/j.bbmt.2009.06.019

van Dalen, 2016, Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia, Cochrane Database Syst Rev, 4, CD006247

Gardner, 2008, Randomized comparison of cooked and noncooked diets in patients undergoing remission induction therapy for acute myeloid leukemia, J Clin Oncol, 26, 5684, 10.1200/JCO.2008.16.4681

Moody, 2006, Feasibility and safety of a pilot randomized trial of infection rate: neutropenic diet versus standard food safety guidelines, J Pediatr Hematol Oncol, 28, 126, 10.1097/01.mph.0000210412.33630.fb

Wilmore, 1999, Glutamine in the support of patients following bone marrow transplantation, Curr Opin Clin Nutr Metab Care, 2, 323, 10.1097/00075197-199907000-00013

Brown, 1998, Parenteral glutamine protects hepatic function during bone marrow transplantation, Bone Marrow Transpl, 22, 281, 10.1038/sj.bmt.1701321

Ziegler, 1992, Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study, Ann Intern Med, 116, 821, 10.7326/0003-4819-116-10-821

Uderzo, 2011, Glutamine-enriched nutrition does not reduce mucosal morbidity or complications after stem-cell transplantation for childhood malignancies: a prospective randomized study, Transplantation, 91, 1321, 10.1097/TP.0b013e31821ab959

Midtgaard, 2013, Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: a randomized, controlled trial, Ann Oncol, 24, 2267, 10.1093/annonc/mdt185

Holmes, 2005, Physical activity and survival after breast cancer diagnosis, JAMA, 293, 2479, 10.1001/jama.293.20.2479

Meyerhardt, 2006, Physical activity and survival after colorectal cancer diagnosis, J Clin Oncol, 24, 3527, 10.1200/JCO.2006.06.0855

Ballard-Barbash, 2012, Physical activity, biomarkers, and disease outcomes in Cancer survivors: a systematic review, J Natl Cancer Inst, 104, 1, 10.1093/jnci/djs207

Azrad, 2014, The association between adiposity and breast cancer recurrence and survival: a review of the recent literature, Curr Nutr Rep, 3, 9, 10.1007/s13668-013-0068-9

Gibson, 2014, Body mass index and risk of second obesity-associated cancers after colorectal cancer: a pooled analysis of prospective cohort studies, J Clin Oncol, 32, 4004, 10.1200/JCO.2014.56.8444

Pekmezi, 2011, Updated evidence in support of diet and exercise interventions in cancer survivors, Acta Oncol, 50, 167, 10.3109/0284186X.2010.529822

Kim, 2014, Impact of metabolic syndrome on oncologic outcome after radical gastrectomy for gastric cancer, Clin Res Hepatol Gastroenterol, 38, 372, 10.1016/j.clinre.2013.11.009

Ng, 2008, Second primary cancers: an overview, Hematol Oncol Clin North Am, 22, 271, 10.1016/j.hoc.2008.01.007

Demark-Wahnefried, 2008, Lifestyle interventions to reduce cancer risk and improve outcomes, Rev Am Fam Physician, 77, 1573

http://www.wcrf.org/.

Rock, 2005, Plasma carotenoids and recurrence-free survival in women with a history of breast cancer, J Clin Oncol, 23, 6631, 10.1200/JCO.2005.19.505

Chlebowski, 2006, Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study, J Natl Cancer Inst, 98, 1767, 10.1093/jnci/djj494

Pierce, 2007, Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial, JAMA, 298, 289, 10.1001/jama.298.3.289

Pierce, 2007, Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity, J Clin Oncol, 25, 2345, 10.1200/JCO.2006.08.6819

Wang, 2014, Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies, BMJ, 349, g4490, 10.1136/bmj.g4490

Gonzalez, 2006, Diet and cancer prevention: where we are, where we are going, Nutr Cancer, 56, 225, 10.1207/s15327914nc5602_14

Bradbury, 2014, Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC), Am J Clin Nutr, 100

Farvid, 2014, Willett WC5. Dietary protein sources in early adulthood and breast cancer incidence: prospective cohort study, BMJ, 348, g3437, 10.1136/bmj.g3437

Sinha, 2009, Meat intake and mortality: a prospective study of over half a million people, Arch Intern Med, 169, 562, 10.1001/archinternmed.2009.6

Boffetta, 2010, Fruit and vegetable intake and overall cancer risk in the European prospective investigation into cancer and nutrition (EPIC), J Natl Cancer Inst, 102, 529, 10.1093/jnci/djq072

Schrijvers, 2014, ESMO Clinical Practice Guidelines on palliative care: advanced care planning, Ann Oncol, 25, iii138, 10.1093/annonc/mdu241

Radbruch, 2009, White paper on standards and norms for hospice and palliative care in Europe: Part 1. Recommendations from the European association for palliative care, Eur J Palliat Care, 16, 278

Radbruch, 2010, White paper on standards and norms for hospice and palliative care in Europe: Part 2. Recommendations from the European association for palliative care, Eur J Palliat Care, 17, 22

Ferris, 2009, Palliative cancer care a decade later: accomplishments, the need, next steps—from the American society of clinical oncology, J Clin Oncol, 27, 3052, 10.1200/JCO.2008.20.1558

World Health Organization. Definition of palliative care. http://www.who.int/cancer/palliative/definition/en/.

Tong, 2009, The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients, Support Care Cancer, 17, 83, 10.1007/s00520-008-0472-7

Martin, 2010, Prognostic factors in patients with advanced cancer: use of the patient-generated subjective global assessment in survival prediction, J Clin Oncol, 28, 4376, 10.1200/JCO.2009.27.1916

Laird, 2013, Prognostic factors in patients with advanced cancer: a comparison of cliicopathological factors and the development of an inflammation-based prognostic system, Clin Cancer Res, 19, 5456, 10.1158/1078-0432.CCR-13-1066

Fearon, 2008, Cancer cachexia: developing multimodal therapy for a multidimensional problem, Eur J Cancer, 44, 1124, 10.1016/j.ejca.2008.02.033

Koretz, 2007, Do data support nutrition support? Part II. Enteral artificial nutrition, J Am Diet Assoc, 107, 1374, 10.1016/j.jada.2007.05.006

Bozzetti, 1989, Effects of artificial nutrition on the nutritional status of cancer patients, J Parenter Enter Nutr, 13, 406, 10.1177/0148607189013004406

Amano, 2013, Effect of nutritional support on terminally ill patients with cancer in a palliative care unit, Am J Hosp Palliat Care, 30, 730, 10.1177/1049909112469273

Lundholm, 2004, Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: effects on survival, metabolism, and founction, Cancer, 100, 1967, 10.1002/cncr.20160

Bozzetti, 2002, Quality of life and length of survival in advanced cancer patients on home parenteral nutrition, Clin Nutr, 21, 281, 10.1054/clnu.2002.0560

Soo, 2008, Use of parenteral nutrition in patients with advanced cancer, Appl Physiol Nutr Metab, 33, 102, 10.1139/H07-152

Cozzaglio, 1997, Outcome of cancer patients receiving home parenteral nutrition. Italian Society of Parenteral and Enteral Nutrition (S.I.N.P.E.), J Parenter Enter Nutr, 21, 339, 10.1177/0148607197021006339

Maltoni, 2005, Prognostic factors in advanced cancer patients: evidence-based clinical recommendations – a study by the Steering Committee of the European Association for Palliative Care, J Clin Oncol, 23, 6240, 10.1200/JCO.2005.06.866

Gripp, 2007, Survival prediction in terminally ill cancer patients by clinical estimates, laboratory tests, and self-rated anxiety and depression, J Clin Oncol, 25, 3313, 10.1200/JCO.2006.10.5411

Bruera, 2013, Parenteral hydration in patients with advanced cancer: a multicenter, double-blind, placebo-controlled randomized trial, J Clin Oncol, 31, 111, 10.1200/JCO.2012.44.6518

Del Río, 2012, Hydration and nutrition at the end of life: a systematic review of emotional impact, perceptions, and decisionmaking among patients, family, and health care staff, Psychooncology, 21, 913, 10.1002/pon.2099

Mallet, 2008, Ethical and legal aspects in nutrition, J Am Diet Assoc, 108, 873

Raijmakers, 2011, Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects, Ann Oncol, 22, 1478, 10.1093/annonc/mdq620

McCann, 1994, Comfort care for terminally ill patients. The appropriate use of nutrition and hydration, JAMA, 272, 1263, 10.1001/jama.1994.03520160047041

Good, 2008, Medically assisted hydration for adult palliative care patients, Cochrane Database Syst Rev

Cerchietti, 2000, Hypodermoclysis for control of dehydration in terminal-stage cancer, Int J Palliat Nurs, 6, 370, 10.12968/ijpn.2000.6.8.9060

Kang, 2013, Comprehensive approaches to managing delirium in patients with advanced cancer, Cancer Treat Rev, 39, 105, 10.1016/j.ctrv.2012.08.001

Prevost, 2012, Nutritional support and quality of life in cancer patients undergoing palliative care, Eur J Cancer Care, 21, 581, 10.1111/j.1365-2354.2012.01363.x

Bozzetti, 2003, Home total parenteral nutrition in incurable cancer patients: a therapy, a basic humane care or something in between?, Clin Nutr, 22, 109, 10.1054/clnu.2002.0629

Bozzetti, 2015, Development and validation of a nomogram to predict survival in incurable cachectic cancer patients on home parenteral nutrition, Ann Oncol, 26, 2335, 10.1093/annonc/mdv365