ERK implication in cell cycle regulation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Tập 1773 Số 8 - Trang 1299-1310 - 2007
Jean‐Claude Chambard1, Renaud LeFloch1, Jacques Pouysségur1, Philippe Lenormand1
1IBDC - Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer (Centre Antoine lacassagne 33 Avenue de volombrose 06189 NICE CEDEX 2 - France)

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Boulton, 1991, ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF, Cell, 65, 663, 10.1016/0092-8674(91)90098-J

Cooper, 1984, Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells, Mol. Cell Biol., 4, 30, 10.1128/MCB.4.1.30

Kohno, 1986, Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts, Biochem. J., 238, 451, 10.1042/bj2380451

Meloche, 1992, Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity, Mol. Endocrinol., 6, 845

Cook, 1996, Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells, Biochem. J., 320, 237

Kahan, 1992, Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition, J. Biol. Chem., 267, 13369

Tamemoto, 1992, Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells, J. Biol. Chem., 267, 20293

Vouret-Craviari, 1993, Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist, Biochem. J., 289, 209, 10.1042/bj2890209

Roovers, 2000, Integrating the MAP kinase signal into the G1 phase cell cycle machinery, BioEssays, 22, 818, 10.1002/1521-1878(200009)22:9<818::AID-BIES7>3.0.CO;2-6

Yamamoto, 2006, Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression, Curr. Biol., 16, 1171, 10.1016/j.cub.2006.04.044

Jones, 2001, Growth-factor-dependent mitogenesis requires two distinct phases of signalling, Nat. Cell Biol., 3, 165, 10.1038/35055073

Dikic, 1994, PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation, Curr. Biol., 4, 702, 10.1016/S0960-9822(00)00155-X

Traverse, 1994, EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor, Curr. Biol., 4, 694, 10.1016/S0960-9822(00)00154-8

Cagnol, 2006, Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death, Apoptosis, 11, 337, 10.1007/s10495-006-4065-y

Stanciu, 2002, Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line, J. Biol. Chem., 277, 4010, 10.1074/jbc.M104479200

Xiao, 2002, Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases, Cancer Res., 62, 3615

Tang, 2002, ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53, J. Biol. Chem., 277, 12710, 10.1074/jbc.M111598200

Hsu, 2005, Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells, J. Pharmacol. Exp. Ther., 313, 333, 10.1124/jpet.104.078808

Calcabrini, 2006, Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate, Carcinogenesis, 27, 1699, 10.1093/carcin/bgl044

Keyse, 1998, Protein phosphatases and the regulation of MAP kinase activity, Semin. Cell Dev. Biol., 9, 143, 10.1006/scdb.1997.0219

Pages, 1993, Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation, Proc. Natl. Acad. Sci. U. S. A., 90, 8319, 10.1073/pnas.90.18.8319

Dudley, 1995, A synthetic inhibitor of the mitogen-activated protein kinase cascade, Proc. Natl. Acad. Sci. U. S. A., 92, 7686, 10.1073/pnas.92.17.7686

Kamakura, 1999, Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus, J. Biol. Chem., 274, 26563, 10.1074/jbc.274.37.26563

Mody, 2001, Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway, FEBS Lett., 502, 21, 10.1016/S0014-5793(01)02651-5

Squires, 2002, Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1, Biochem. J., 366, 673, 10.1042/bj20020372

Davies, 2000, Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem. J., 351, 95, 10.1042/0264-6021:3510095

Fischer, 2005, The role of erk1 and erk2 in multiple stages of T cell development, Immunity, 23, 431, 10.1016/j.immuni.2005.08.013

Brunet, 1999, Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry, EMBO J., 18, 664, 10.1093/emboj/18.3.664

Formstecher, 2001, PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase, Dev. Cell, 1, 239, 10.1016/S1534-5807(01)00035-1

Gervais, 2006, Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15, Mol. Biol. Cell, 17, 3940, 10.1091/mbc.E06-06-0501

Graves, 2000, Regulation of carbamoyl phosphate synthetase by MAP kinase, Nature, 403, 328, 10.1038/35002111

Sigoillot, 2005, Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD, J. Biol. Chem., 280, 25611, 10.1074/jbc.M504581200

Lenormand, 1998, Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins, J. Cell Biol., 142, 625, 10.1083/jcb.142.3.625

Soloaga, 2003, MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14, EMBO J., 22, 2788, 10.1093/emboj/cdg273

Stefanovsky, 2006, Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling, Mol. Cell, 21, 629, 10.1016/j.molcel.2006.01.023

Stefanovsky, 2006, ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF, Biochemistry, 45, 3626, 10.1021/bi051782h

Waskiewicz, 1999, Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo, Mol. Cell Biol., 19, 1871, 10.1128/MCB.19.3.1871

Ueda, 2004, Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development, Mol. Cell Biol., 24, 6539, 10.1128/MCB.24.15.6539-6549.2004

Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016

Inoki, 2005, Signaling by target of rapamycin proteins in cell growth control, Microbiol. Mol. Biol. Rev., 69, 79, 10.1128/MMBR.69.1.79-100.2005

Ma, 2005, Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis, Cell, 121, 179, 10.1016/j.cell.2005.02.031

Roux, 2004, Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase, Proc. Natl. Acad. Sci. U. S. A., 101, 13489, 10.1073/pnas.0405659101

Lavoie, 1996, Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway, J. Biol. Chem., 271, 20608, 10.1074/jbc.271.34.20608

Weber, 1997, Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase, Biochem. J., 326, 61, 10.1042/bj3260061

Brown, 1998, Fos family members induce cell cycle entry by activating cyclin D1, Mol. Cell Biol., 18, 5609, 10.1128/MCB.18.9.5609

Burch, 2004, An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry, Mol. Cell Biol., 24, 4696, 10.1128/MCB.24.11.4696-4709.2004

Albanese, 1995, Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions, J. Biol. Chem., 270, 23589, 10.1074/jbc.270.40.23589

Preston, 2000, Apoptotic response to growth factor deprivation involves cooperative interactions between c-Fos and p300, Cell Death Differ., 7, 215, 10.1038/sj.cdd.4400637

Baluchamy, 2003, Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity, Proc. Natl. Acad. Sci. U. S. A., 100, 9524, 10.1073/pnas.1633700100

Balmanno, 1999, Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells, Oncogene, 18, 3085, 10.1038/sj.onc.1202647

Gille, 1995, ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation, EMBO J., 14, 951, 10.1002/j.1460-2075.1995.tb07076.x

Murphy, 2004, A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration, Mol. Cell. Biol., 24, 144, 10.1128/MCB.24.1.144-153.2004

Murphy, 2002, Molecular interpretation of ERK signal duration by immediate early gene products, Nat. Cell Biol., 4, 556, 10.1038/ncb822

Volmat, 2001, The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases, J. Cell Sci., 114, 3433

Seth, 1991, A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression, J. Biol. Chem., 266, 23521

Daksis, 1994, Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle, Oncogene, 9, 3635

Sherr, 1999, CDK inhibitors: positive and negative regulators of G1-phase progression, Genes Dev., 13, 1501, 10.1101/gad.13.12.1501

Keenan, 2001, Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase, J. Biol. Chem., 276, 22404, 10.1074/jbc.M100409200

Lents, 2002, Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2, J. Biol. Chem., 277, 47469, 10.1074/jbc.M207425200

Yoshida, 2003, Mice lacking a transcriptional corepressor Tob are predisposed to cancer, Genes Dev., 17, 1201, 10.1101/gad.1088003

Weitzman, 2000, JunD protects cells from p53-dependent senescence and apoptosis, Mol. Cell, 6, 1109, 10.1016/S1097-2765(00)00109-X

Wright, 1999, Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts, Proc. Natl. Acad. Sci. U. S. A., 96, 11335, 10.1073/pnas.96.20.11335

Roberts, 2002, Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis, Mol. Cell Biol., 22, 7226, 10.1128/MCB.22.20.7226-7241.2002

Walsh, 2003, Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx, Mol. Cancer Res., 1, 280

Palmer, 1998, A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1, EMBO J., 17, 5037, 10.1093/emboj/17.17.5037

Liu, 1999, Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2–cyclin B1 complexes, Mol. Cell. Biol., 19, 5113, 10.1128/MCB.19.7.5113

Yan, 2005, BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation, Oncogene, 24, 3285, 10.1038/sj.onc.1208492

Rahmouni, 2006, Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence, Nat. Cell Biol., 8, 524, 10.1038/ncb1398

Shapiro, 1998, Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen, J. Cell Biol., 142, 1533, 10.1083/jcb.142.6.1533

Zecevic, 1998, Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E, J. Cell Biol., 142, 1547, 10.1083/jcb.142.6.1547

Cha, 2004, Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies, Biochem. J., 378, 857, 10.1042/bj20031173

Hayne, 2004, MEK inhibition and phosphorylation of serine 4 on B23 are two coincident events in mitosis, Biochem. Biophys. Res. Commun., 321, 675, 10.1016/j.bbrc.2004.07.024

Willard, 2001, MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit, Cell. Signal., 13, 653, 10.1016/S0898-6568(01)00185-1

Franza, 1986, In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes, Cell, 44, 409, 10.1016/0092-8674(86)90462-9

Hirakawa, 1988, Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene, Proc. Natl. Acad. Sci. U. S. A., 85, 1519, 10.1073/pnas.85.5.1519

Samuels, 1993, Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase, Mol. Cell. Biol., 13, 6241, 10.1128/MCB.13.10.6241

Sewing, 1997, High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1, Mol. Cell. Biol., 17, 5588, 10.1128/MCB.17.9.5588

Woods, 1997, Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1, Mol. Cell. Biol., 17, 5598, 10.1128/MCB.17.9.5598

LaBaer, 1997, New functional activities for the p21 family of CDK inhibitors, Genes Dev., 11, 847, 10.1101/gad.11.7.847

Park, 2000, A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes, Mol. Biol. Cell, 11, 2915, 10.1091/mbc.11.9.2915

Touitou, 2001, A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome, EMBO J., 20, 2367, 10.1093/emboj/20.10.2367

Coleman, 2003, Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation, EMBO J., 22, 2036, 10.1093/emboj/cdg189

Alt, 2002, p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export, J. Biol. Chem., 277, 8517, 10.1074/jbc.M108867200

Haluska, 2006, Genetic alterations in signaling pathways in melanoma, Clin. Cancer Res., 12, 2301s, 10.1158/1078-0432.CCR-05-2518

Mirza, 2004, Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT, Mol. Cell. Biol., 24, 10868, 10.1128/MCB.24.24.10868-10881.2004

Yeh, 2004, A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells, Nat. Cell Biol., 6, 308, 10.1038/ncb1110

Yang, 2001, Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc, Oncogene, 20, 1688, 10.1038/sj.onc.1204245

O'Hagan, 2000, Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression, Genes Dev., 14, 2185, 10.1101/gad.827200

Medema, 2000, AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1, Nature, 404, 782, 10.1038/35008115

Stahl, 2002, The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2, J. Immunol., 168, 5024, 10.4049/jimmunol.168.10.5024

Hoshino, 1999, Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors, Oncogene, 18, 813, 10.1038/sj.onc.1202367

Davies, 2002, Mutations of the BRAF gene in human cancer, Nature, 417, 949, 10.1038/nature00766

Sebolt-Leopold, 1999, Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo, Nat. Med., 5, 810, 10.1038/10533

Karasarides, 2004, B-RAF is a therapeutic target in melanoma, Oncogene, 23, 6292, 10.1038/sj.onc.1207785

Solit, 2006, BRAF mutation predicts sensitivity to MEK inhibition, Nature, 439, 358, 10.1038/nature04304

Rinehart, 2004, Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer, J. Clin. Oncol., 22, 4456, 10.1200/JCO.2004.01.185

Kohno, 2006, Targeting the ERK signaling pathway in cancer therapy, Ann. Med., 38, 200, 10.1080/07853890600551037

Klein, 2006, The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer, Neoplasia, 8, 1, 10.1593/neo.05373

Fujioka, 2006, Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes, J. Biol. Chem., 281, 8917, 10.1074/jbc.M509344200

Lim, 2005, Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance, Cancer Cell, 8, 381, 10.1016/j.ccr.2005.10.014

Jordan, 2006, Cancer stem cells, N. Engl. J. Med., 355, 1253, 10.1056/NEJMra061808

Burdon, 1999, Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells, Dev. Biol., 210, 30, 10.1006/dbio.1999.9265

Burdon, 2002, Signalling, cell cycle and pluripotency in embryonic stem cells, Trends Cell Biol., 12, 432, 10.1016/S0962-8924(02)02352-8

Hoshino, 2001, Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1), J. Biol. Chem., 276, 2686, 10.1074/jbc.M006132200

Gysin, 2005, Pharmacologic inhibition of RAF→MEK→ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1, Cancer Res., 65, 4870, 10.1158/0008-5472.CAN-04-2848

Collisson, 2003, Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade, Cancer Res., 63, 5669