ER-associated Protein Degradation at Atomic Resolution

Ruggiano, 2014, ER-associated degradation: protein quality control and beyond, J. Cell Biol., 204, 869, 10.1083/jcb.201312042 Pohl, 2019, Cellular quality control by the ubiquitin-proteasome system and autophagy, Science, 366, 818, 10.1126/science.aax3769 Eldeeb, 2019, Physiological state dictates the proteasomal-mediated purging of misfolded protein fragments, Protein Pept. Lett., 27, 251, 10.2174/0929866526666191026111951 Bhattacharya, 2019, ER-associated degradation in health and disease - from substrate to organism, J. Cell Sci., 132, 10.1242/jcs.232850 Wu, 2018, Mechanistic insights into ER-associated protein degradation, Curr. Opin. Cell Biol., 53, 22, 10.1016/j.ceb.2018.04.004 Quan, 2008, Defining the glycan destruction signal for endoplasmic reticulum-associated degradation, Mol. Cell, 32, 870, 10.1016/j.molcel.2008.11.017 Wu, 2020, Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex, Science, 368, 1, 10.1126/science.aaz2449 Schoebel, 2017, Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3, Nature, 548, 352, 10.1038/nature23314 Kumazaki, 2014, Structural basis of Sec-independent membrane protein insertion by YidC, Nature, 509, 516, 10.1038/nature13167 Rodriguez, 2013, Structural model for the protein-translocating element of the twin-arginine transport system, Proc. Natl. Acad. Sci. U. S. A., 110, E1092, 10.1073/pnas.1219486110