EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in <i>C. elegans</i>

Development (Cambridge) - Tập 125 Số 6 - Trang 1083-1093 - 1998
Rebecca D. Burdine1, Catherine Branda2, Michael Stern2
1Departments of Cell Biology, Genetics, Yale University School of Medicine, PO Box 208005, New Haven, Connecticut 06520-8005, USA
2Yale University School of Medicine 2 Department of Cell Biology and Genetics , , PO Box 208005, New Haven, Connecticut 06520-8005, USA

Tóm tắt

ABSTRACT During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are involved in the gonadal signals that guide the migrations of the sex myoblasts. Here we show that EGL-17(FGF) can act as an instructive guidance cue to direct the sex myoblasts to their final destinations. We find that egl-17 reporter constructs are expressed in the primary vulval cell and that EGL-17(FGF) expression in this cell correlates with the precise positioning of the sex myoblasts. We postulate that EGL-17(FGF) helps to coordinate the development of a functional egg-laying system, linking vulval induction with proper sex myoblast migration.

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