EFFECTS OF CORTICOSTEROIDS ON ASTHMA PATHOLOGY

Adcock, 1996, Glucocorticoid receptor localization in normal and asthmatic lung, Am J Respir Crit Care Med, 154, 771, 10.1164/ajrccm.154.3.8810618 Adcock, 1995, Abnormal glucocorticoid receptor/AP-1 interaction in steroid resistant asthma, J Exp Med, 182, 1951, 10.1084/jem.182.6.1951 Adkins, 1998, Glucocorticoid regulation of GM-CSF: Evidence for transcriptional mechanisms in airway epithelial cells, Am J Physiol, 275, L372 Agnew, 1984, Peripheral airways mucus clearance in stable asthma is improved by oral corticosteroid therapy, Bulletin Europeen de Physiopathologie Respiratoire, 20, 295 Aikawa, 1992, Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack, Chest, 101, 916, 10.1378/chest.101.4.916 Amishima, 1998, Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway, Am J Respir Crit Care Med, 157, 1907, 10.1164/ajrccm.157.6.9609040 Arya, 1984, Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA, J Immunol, 133, 273 Athens, 1961, The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects, J Clin Invest, 40, 989, 10.1172/JCI104338 Aubert, 1997, Expression of endothelin-1 in human broncho-epithelial and monocytic cell lines: Influence of tumor necrosis factor alpha and dexamethasone, Biochem Pharmacol, 53, 547, 10.1016/S0006-2952(96)00771-X Aubert, 1994, Transforming growth factor β1 gene expression in human airways, Thorax, 49, 225, 10.1136/thx.49.3.225 Austen, 1975, Bronchial asthma: The possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute chronic disease, American Review of Respiratory Diseases, 112, 423 Bascom, 1988, The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of systemic steroid pretreatment, American Review of Respiratory Diseases, 138, 406, 10.1164/ajrccm/138.2.406 Bascom, 1988, Basophil influx occurs after nasal antigen challenge: Effects of topical corticosteroid pretreatment, J Allergy Clin Immunol, 81, 580, 10.1016/0091-6749(88)90198-4 Bentley, 1996, Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5 and interferon-gamma cytokine gene expression within the bronchial mucosa, Am J Respir Crit Care Med, 153, 551, 10.1164/ajrccm.153.2.8564096 Bentley, 1993, Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics, Am J Respir Cell Mol Biol, 8, 35, 10.1165/ajrcmb/8.1.35 Beutler, 1986, Control of cachectin (tumor necrosis factor) synthesis: Mechanisms of endotoxin resistance, Science, 232, 977, 10.1126/science.3754653 Blotta, 1997, Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes, J Immunol, 158, 5589 Blyth, 1998, Induction, duration, and resolution of airway goblet cell hyperplasia in a murine model of atopic asthma: Effect of concurrent infection with respiratory syncytial virus and response to dexamethasone, Am J Respir Cell Mol Biol, 19, 38, 10.1165/ajrcmb.19.1.2930 Boulet, 1997, Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine, Chest, 112, 45, 10.1378/chest.112.1.45 Boulet, 1995, Increased maximal airway response to methacholine during seasonal allergic rhinitis in nonasthmatic subjects: Relationships with airway wall thickness and inflammation, Eur Resp J, 8, 913 Bousquet, 1990, Eosinophilic inflammation in asthma, N Engl J Med, 323, 1033, 10.1056/NEJM199010113231505 Brewster, 1990, Myofibroblasts and subepithelial fibrosis in bronchial asthma, Am J Respir Cell Mol Biol, 3, 507, 10.1165/ajrcmb/3.5.507 Broekelmann, 1991, Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis, Proc Natl Acad Sci USA, 88, 6642, 10.1073/pnas.88.15.6642 Burke, 1996, Relative effects of inhaled corticosteroids on immunopathology and physiology in asthma: A controlled study, Thorax, 51, 993, 10.1136/thx.51.10.993 Butcher, 1991, Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity, Cell, 67, 1033, 10.1016/0092-8674(91)90279-8 Campbell, 1987, Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5), Proc Natl Acad Sci USA, 84, 6629, 10.1073/pnas.84.19.6629 Cartier, 1982, Allergen-induced increase in bronchial responsiveness to histamine: Relationship to the late asthmatic responses and change in airway caliber, J Allergy Clin Immunol, 70, 170, 10.1016/0091-6749(82)90038-0 Chakir J, in press Chalmers, 1997, Endothelin-1-induced bronchoconstriction in asthma, Am J Respir Crit Care Med, 156, 382, 10.1164/ajrccm.156.2.9702066 Chetta, 1997, Airways remodeling is a distinctive feature of asthma and is related to severity of disease, Chest, 111, 852, 10.1378/chest.111.4.852 Christodoulopoulos, 1999, Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: Effect of topical corticosteroids, J Allergy Clin Immunol, 103, 1036, 10.1016/S0091-6749(99)70176-4 Christodoulopoulos, 1998, The expression of monocyte chemotactic proteins in allergen-induced rhinitis, J Allergy Clin Immunol, 101, 622 Cohan, 1989, Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine or skin, American Review of Respiratory Diseases, 140, 951, 10.1164/ajrccm/140.4.951 Corrigan, 1991, Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro, American Review of Respiratory Diseases, 144, 1016, 10.1164/ajrccm/144.5.1016 Corrigan, 1991, Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A, American Review of Respiratory Diseases, 144, 1026, 10.1164/ajrccm/144.5.page Corrigan, 1993, CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Effect of glucocorticoid therapy, American Review of Respiratory Diseases, 147, 540, 10.1164/ajrccm/147.3.540 Corrigan, 1995, Peripheral blood CD4 but not CD8 T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy, Am J Respir Cell Mol Biol, 12, 567, 10.1165/ajrcmb.12.5.7742019 Davies, 1984, Regulation of β-adrenergic receptor by steroid hormones, Annu Rev Physiol, 46, 119, 10.1146/annurev.ph.46.030184.001003 Davis, 1984, Eosinophil-mediated injury to lung parenchymal cells and interstitial matrix. A possible role for eosinophils in chronic inflammatory disorders of the lower respiratory tract, J Clin Invest, 74, 269, 10.1172/JCI111411 Darby, 1990, Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing, Lab Invest, 63, 21 Daynes, 1989, Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4, Eur J Immunol, 19, 2319, 10.1002/eji.1830191221 Desmoulière, 1993, Transforming growth factor-β1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts, J Cell Biol, 122, 103, 10.1083/jcb.122.1.103 Djukanovic, 1992, Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma, American Review of Respiratory Diseases, 145, 669, 10.1164/ajrccm/145.3.669 Dunnill, 1960, The pathology of asthma, with special reference to changes in the bronchial mucosa, J Clin Pathol, 13, 27, 10.1136/jcp.13.1.27 Ebina, 1993, Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study, American Review of Respiratory Diseases, 148, 720, 10.1164/ajrccm/148.3.720 Ebisawa, 1997, Corticosteroids inhibit cytokine production but not histamine release from cultured human mast cells, J Allergy Clin Immunol, 99, S123 Ellul-Micallef, 1975, Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness, Lancet, 2, 1269, 10.1016/S0140-6736(75)90608-X Elsner, 1994, C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils, Eur J Immunol, 24, 518, 10.1002/eji.1830240304 Enerbäck, 1986, Intraepithelial migration of nasal mucosal mast cells in hay fever, Int Arch Allergy Appl Immunol, 80, 44, 10.1159/000234024 Eschenbacher, 1987, A technique for isolated airway segment lavage, Chest, 92, 105, 10.1378/chest.92.1.105 Filley, 1982, Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma, Lancet, 2, 11, 10.1016/S0140-6736(82)91152-7 Fischer, 1995, Tumor necrosis factor alpha (TNFα) stimulates mucin secretion and gene expression in airway epithelium in vitro, Chest, 107, 133S, 10.1378/chest.107.3_Supplement.133S Fox, 1981, Mast cells in the human alveolar wall: An electron microscopic study, J Clin Pathol, 34, 1333, 10.1136/jcp.34.12.1333 Geddes, 1974, Interaction of glucocorticoids and bronchodilators on isolated guinea-pig tracheal and human bronchial smooth muscle, American Review of Respiratory Diseases, 110, 420 Ghaffar, 1999, Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells, Am J Respir Crit Care Med, 159, 1933, 10.1164/ajrccm.159.6.9805039 Ghaffar, 1997, IL-13 mRNA and immunoreactivity in allergen-induced rhinitis: Comparison with IL-4 expression and modulation by topical glucocorticoid therapy, Am J Respir Cell Mol Biol, 17, 17, 10.1165/ajrcmb.17.1.2696 Gerblich, 1991, Dynamic T-cell changes in peripheral blood and bronchoalveolar lavage after antigen bronchoprovocation in asthmatics, American Review of Respiratory Diseases, 143, 533, 10.1164/ajrccm/143.3.533 Giaid, 1991, Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung, Am J Respir Cell Mol Biol, 4, 50, 10.1165/ajrcmb/4.1.50 Gillis, 1979, Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation, J Immunol, 123, 1624 Gomez, 1988, Effect of topical corticosteroids on seasonally induced increases in nasal mast cells, BMJ, 296, 1572, 10.1136/bmj.296.6636.1572-a Gosset, 1991, Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction, J Allergy Clin Immunol, 88, 561, 10.1016/0091-6749(91)90149-I Grünig, 1998, Requirement for IL-13 independently of IL-4 in experimental asthma, Science, 282, 2261, 10.1126/science.282.5397.2261 Gundel, 1991, Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys, J Clin Invest, 88, 1407, 10.1172/JCI115447 Gundel, 1992, The role of intercellular adhesion molecule-1 in chronic airway inflammation, Clin Exp Allergy, 22, 569, 10.1111/j.1365-2222.1992.tb00167.x Haahtela, 1994, Effects of reducing or discontinuing inhaled budenoside in patients with mild asthma, N Engl J Med, 331, 700, 10.1056/NEJM199409153311103 Hallsworth, 1992, Glucocorticoids inhibit granulocyte-macrophage colony-stimulating factor-1 and interleukin-5 enhanced in vitro survival of human eosinophils, Immunology, 75, 382 Hallsworth, 1998, Cultured human airway smooth muscle cells stimulated by IL-1β enhance eosinophil survival, Am J Respir Cell Mol Biol, 19, 910, 10.1165/ajrcmb.19.6.3275 Hamaguchi, 1987, Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells, J Exp Med, 165, 268, 10.1084/jem.165.1.268 Hamid, 1991, Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma, J Clin Invest, 87, 1541, 10.1172/JCI115166 Hamid, 1992, Human eosinophils synthesize and secrete interleukin-6, in vitro, Blood, 80, 1496, 10.1182/blood.V80.6.1496.1496 Hamid, 1997, Inflammation of small airways in asthma, J Allergy Clin Immunol, 100, 44, 10.1016/S0091-6749(97)70193-3 Hamid, 1993, Induction of nitric oxide synthase in asthma, Lancet, 342, 1510, 10.1016/S0140-6736(05)80083-2 Hamid, 1999, Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma, Am J Respir Crit Care Med, 159, 1600, 10.1164/ajrccm.159.5.9804131 Hardy, 1996, Regulation of histamine H1 receptor coupling by dexamethasone in human cultured airway smooth muscle, Br J Pharmacol, 118, 1079, 10.1111/j.1476-5381.1996.tb15509.x Hay, 1996, Is endothelin-1 a mediator in asthma?, Am J Respir Crit Care Med, 154, 1594, 10.1164/ajrccm.154.6.8970340 Henderson, 1978, Immunologic and nonimmunologic generation of superoxide from mast cells and basophils, J Clin Invest, 61, 187, 10.1172/JCI108917 Herrick, 1996, Induced expression of IL-6 and IL-8 cytokines in human bronchial smooth muscle cells exposed to asthmatic serum or cytokines, Am J Respir Crit Care Med, 153, A614 Hirata, 1989, Endothelin is a potent mitogen for rat vascular smooth muscle cells, Atherosclerosis, 78, 225, 10.1016/0021-9150(89)90227-X Huang, 1999, Enhanced proteoglycan deposition in the airway wall of atopic asthmatics, Am J Respir Crit Care Med, 160, 725, 10.1164/ajrccm.160.2.9809040 Ihle, 1983, J Immunol, 131, 282 Jaffe, 1995, Human lung mast cell IL-5 gene and protein expression: Temporal analysis of upregulation following IgE-mediated activation, Am J Respir Cell Mol Biol, 13, 665, 10.1165/ajrcmb.13.6.7576704 Jeffery, 1992, Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopy study, American Review of Respiratory Diseases, 145, 890, 10.1164/ajrccm/145.4_Pt_1.890 John, 1998, Expression and release of interleukin-8 by human airway smooth cells: Inhibition by Th-2 cytokines and corticosteroids, Am J Respir Cell Mol Biol, 18, 84, 10.1165/ajrcmb.18.1.2813 John, 1997, Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: Regulation by T helper 2 cytokines and corticosteroids, J Immunol, 158, 1841 John, 1998, Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1α, granulocyte-macrophage colony-stimulating factor, and interferon-γ release from alveolar macrophages in asthma, Am J Respir Crit Care Med, 157, 256, 10.1164/ajrccm.157.1.9703079 Johnson, 1997, Synthetic functions of airway smooth muscle in asthma, Trends Pharmacol Sci, 18, 288, 10.1016/S0165-6147(97)01092-4 Joseph, 1983, Involvement of IgE in the secretory processes of alveolar macrophages from asthmatic patients, J Clin Invest, 71, 221, 10.1172/JCI110762 Kaiser, 1993, The effects of the potent glucocorticoid budesonide on adhesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules, J Pharmacol Exp Ther, 267, 245 Kaliner, 1989, Asthma and mast cell activation, J Allergy Clin Immunol, 83, 510, 10.1016/0091-6749(89)90031-6 Kam, 1993, Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids, J Immunol, 151, 3460 Kay, 1991, Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects, J Exp Med, 173, 775, 10.1084/jem.173.3.775 Kern, 1988, Dexamethasone inhibition of interleukin 1 beta production by monocytes. Posttranscriptional mechanisms, J Clin Invest, 81, 237, 10.1172/JCI113301 Khalil, 1991, Increased production and immunohistochemical localization of transforming growth factor-β in idiopathic pulmonary fibrosis, Am J Respir Cell Mol Biol, 5, 155, 10.1165/ajrcmb/5.2.155 Kung, 1994, Mechanisms of allergic pulmonary eosinophilia in the mouse, J Allergy Clin Immunol, 94, 1217, 10.1016/0091-6749(94)90335-2 Kwon, 1994, Tumor necrosis factor-induced interleukin-8 expression in cultured human airway epithelial cells, Am J Physiol, 267, L398 Kwon, 1995, Glucocorticoid inhibition of RANTES expression in human lung epithelial cells, Am J Respir Cell Mol Biol, 12, 488, 10.1165/ajrcmb.12.5.7537968 Laberge, 1997, Expression of IL-16 in allergen-induced late-phase nasal responses and relation to topical glucocorticosteroid treatment, J Allergy Clin Immunol, 100, 569, 10.1016/S0091-6749(97)70152-0 Laberge, 1997, Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma, Am J Respir Cell Mol Biol, 17, 193, 10.1165/ajrcmb.17.2.2750 Laitinen, 1985, Damage of the airway epithelium and bronchial reactivity in patients with asthma, American Review of Respiratory Diseases, 131, 599, 10.1164/arrd.1985.131.4.599 Laitinen, 1995, Inhaled corticosteroid treatment and extracellular matrix in the airways in asthma, Int Arch Allergy Immunol, 107, 215, 10.1159/000236981 Laitinen, 1996, Remodeling of asthmatic airways by glucocorticosteroids, J Allergy Clin Immunol, 97, 153, 10.1016/S0091-6749(96)80215-6 Laitinen, 1992, A comparative study of the effects of an inhaled corticosteroid, budesonide, and beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomized, double blind, parallel-group controlled trial, J Allergy Clin Immunol, 90, 32, 10.1016/S0091-6749(06)80008-4 Lamas, 1991, Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor, J Immunol, 147, 254 Lamkhioued, 1997, Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation, J Immunol, 159, 4593 Lee, 1988, Glucocorticoids selectively inhibit the transcription of the interleukin 1β gene and decrease the stability of interleukin 1β mRNA, Proc Natl Acad Sci USA, 85, 1204, 10.1073/pnas.85.4.1204 Leung, 1987, Regulation of the human IgE antibody response, Int Rev Immunol, 2, 75, 10.3109/08830188709044748 Leung, 1997, Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor β, J Exp Med, 186, 1567, 10.1084/jem.186.9.1567 Leung, 1995, Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma, J Exp Med, 181, 33, 10.1084/jem.181.1.33 Levine, 1993, Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line, Am J Physiol, 265, L360 Lilly, 1997, Expression of eotaxin by human lung epithelial cells: Induction by cytokines and inhibition by glucocorticoids, J Clin Invest, 99, 1767, 10.1172/JCI119341 Lou, 1998, Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways, Am J Respir Crit Care Med, 157, 1927, 10.1164/ajrccm.157.6.9709113 Lundgren, 1977, Scanning electron microscopic studies of bronchial mucosa before and during treatment with beclomethasone dipropionate inhalations, Scandinavian Journal of Respiratory Diseases Supplementum, 101, 179 Lundgren, 1988, Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids, Eur Resp J, 1, 883 Marom, 1985, Human monocyte-derived mucus secretagogue, J Clin Invest, 75, 191, 10.1172/JCI111674 Marsh, 1985, Increases in airway hyperreactivity to histamine and inflammatory cells in bronchoalveolar lavage after the late asthmatic response in an animal model, American Review of Respiratory Diseases, 131, 875 Masuyama, 1994, Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis, Immunology, 82, 192 Mattoli, 1991, Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction, J Allergy Clin Immunol, 88, 376, 10.1016/0091-6749(91)90100-3 Melewicz, 1981, Increased peripheral blood monocytes with Fc receptors for IgE in patients with severe allergic disorders, J Immunol, 126, 1592 Messer, 1960, Causes of death and pathologic findings in 304 cases of bronchial asthma, Chest, 38, 616, 10.1378/chest.38.6.616 Metcalf, 1986, Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor, Blood, 67, 37, 10.1182/blood.V67.1.37.37 Metzger, 1985, Late asthmatic responses: Inquiry into mechanisms and significance, Clinical Reviews in Allergy, 3, 145, 10.1007/BF02992980 Michael, 1996, Endothelins and the lung, Am J Respir Crit Care Med, 154, 555, 10.1164/ajrccm.154.3.8810589 Minshall, 1998, Assessment by nasal biopsy of long-term use of mometasone furoate aqueous nasal spray (Nasonex) in the treatment of perennial rhinitis, Otolaryngol Head Neck Surg, 118, 648 Minshall, 1998, Cytokine mRNA expression in asthma is not restricted to the large airways, J Allergy Clin Immunol, 101, 386, 10.1016/S0091-6749(98)70252-0 Minshall, 1997, Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma, Am J Respir Cell Mol Biol, 17, 326, 10.1165/ajrcmb.17.3.2733 Mishler, 1977, Development of neutrophilia by serially increasing doses of dexamethasone, Br J Haematol, 36, 249, 10.1111/j.1365-2141.1977.tb00646.x Moqbel, 1994, Cytokine generation by eosinophils, J Allergy Clin Immunol, 94, 1183, 10.1016/0091-6749(94)90330-1 Munck, 1994, Glucocorticoids and stress: Permissive and suppressive actions, Ann N Y Acad Sci, 746, 115, 10.1111/j.1749-6632.1994.tb39221.x Murphy, 1986, The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened airways reactivity in an animal model, American Review of Respiratory Diseases, 134, 62 Nabishah, 1991, Effect of steroid hormones on muscarinic receptors of bronchial smooth muscle, Gen Pharmacol, 22, 389, 10.1016/0306-3623(91)90469-M Nabishah, 1990, Effect of acetylcholine on bronchial smooth muscle contraction and its modulation by steroid hormones, Clin Exp Pharmacol Physiol, 17, 841, 10.1111/j.1440-1681.1990.tb01287.x Nadel, 1989, Roles of mast cell proteases in airways, Drugs, 37, 51, 10.2165/00003495-198900371-00011 Naseer, 1997, Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy, Am J Respir Crit Care Med, 155, 845, 10.1164/ajrccm.155.3.9117015 O'Byrne, 1995, Neutrophil dynamics in airway disease, 389 Olivieri, 1997, Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: A placebo-controlled study, Am J Respir Crit Care Med, 155, 1864, 10.1164/ajrccm.155.6.9196087 Paliogianni, 1993, Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT, J Clin Invest, 91, 1481, 10.1172/JCI116353 Plaut, 1989, Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores, Nature, 339, 64, 10.1038/339064a0 Poiani, 1994, Effect of glucocorticoids on collagen accumulation in pulmonary vascular remodeling in the rat, Am J Respir Crit Care Med, 149, 994, 10.1164/ajrccm.149.4.8143066 Poston, 1992, Immunohistochemical characterization of the cellular infiltration in asthmatic bronchi, American Review of Respiratory Diseases, 145, 918, 10.1164/ajrccm/145.4_Pt_1.918 Rak, 1994, Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge, Clin Exp Allergy, 24, 930, 10.1111/j.1365-2222.1994.tb02724.x Ramirez, 1996, Glucocorticoids promote a Th2 cytokine response by CD4− T cells in vitro, J Immunol, 156, 2406 Reed, 1986, Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression, J Immunol, 137, 150 Robbins, 1994, Expression of inducible nitric oxide in human lung epithelial cells, Biochem Biophys Res Commun, 203, 209, 10.1006/bbrc.1994.2169 Roberts, 1995, Is asthma a fibrotic disease?, Chest, 107, 111S, 10.1378/chest.107.3_Supplement.111S Robinson, 1993, Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression, American Review of Respiratory Diseases, 148, 401, 10.1164/ajrccm/148.2.401 Robinson, 1992, Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma, N Engl J Med, 326, 298, 10.1056/NEJM199201303260504 Roche, 1989, Subepithelial fibrosis in the bronchi of asthmatics, Lancet, 1, 520, 10.1016/S0140-6736(89)90067-6 Roche, 1991, Fibroblasts and asthma, Clin Exp Allergy, 21, 545, 10.1111/j.1365-2222.1991.tb00845.x Rolfe, 1992, Inhibition of interleukin-5 gene expression by dexamethasone, Immunology, 77, 494 Sanderson, 1985, Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin-3, and functional properties of eosinophils produced in culture, J Exp Med, 162, 60, 10.1084/jem.162.1.60 Saunders, 1997, Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: Suppression by dexamethasone, Br J Pharmacol, 120, 545, 10.1038/sj.bjp.0700998 Schleimer, 1992, The effects of anti-inflammatory steroids on mast cells, 483 Schramm, 1996, Corticosteroid modulation of Na+-K+ pump-mediated relaxation in maturing airway smooth muscle, Br J Pharmacol, 119, 807, 10.1111/j.1476-5381.1996.tb15744.x Schuster, 1990, Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355, Am J Physiol, 262, L86 Schwiebert, 1996, The epithelium as a target of glucocorticoid action in the treatment of asthma, Am J Respir Crit Care Med, 154, S16, 10.1164/ajrccm/154.2_Pt_2.S16 Sekizawa, 1989, Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs, J Clin Invest, 83, 175, 10.1172/JCI113855 Seltzer, 1986, O3-induced change in bronchial reactivity to metacholine and airway inflammation in humans, J Appl Physiol, 60, 1321, 10.1152/jappl.1986.60.4.1321 Shelhamer, 1980, Immunologic and neuropharmacologic stimulation of mucous glycoprotein release from human airways in vitro, J Clin Invest, 66, 1400, 10.1172/JCI109993 Shelhamer, 1981, The effects of arachinoids and leukotrienes on the release of mucous from human airways, Chest, 81S, 36 Snyder, 1982, Corticosteroids inhibit murine macrophages Ia expression and interleukin 1 production, J Immunol, 129, 1803 Sommerhoff, 1990, Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells, J Clin Invest, 85, 682, 10.1172/JCI114492 Sousa, 1993, Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids, American Review of Respiratory Diseases, 147, 1557, 10.1164/ajrccm/147.6_Pt_1.1557 Springall, 1991, Endothelin immunoreactivity of airway epithelium in asthmatic patients, Lancet, 337, 697, 10.1016/0140-6736(91)90279-X Springall, 1995, Inducible nitric oxide synthase in asthmatic airway epithelium is reduced by corticosteroid therapy, Am J Respir Crit Care Med, 151, A833 Staruch, 1985, Reduction of serum interleukin-1-like activity after treatment with dexamethasone, J Leukoc Biol, 37, 193, 10.1002/jlb.37.2.193 Stellato, 1995, Expression of the chemokine RANTES by a human bronchial epithelial cell line. Modulation by cytokines and glucocorticoids, J Immunol, 155, 410 Stellato, 1995, Differential regulation by glucocorticoids (GC) of RANTES production in human epithelial and endothelial cells, J Allergy Clin Immunol, 95, 338A Stellato, 1997, Production of the novel C-C chemokine MCP-4 by airway epithelial cells and comparison of its biological activity to other C-C chemokines, J Clin Invest, 99, 926, 10.1172/JCI119257 Stewart, 1995, The effect of glucocorticoids on proliferation of human cultured airway smooth muscle, Br J Pharmacol, 116, 3219, 10.1111/j.1476-5381.1995.tb15127.x Svensjö, 1985, Time-dependent inhibition of bradykinin and histamine-induced increase in microvascular permeability by local glucocorticoid treatment, 136 Takayasu-Okishio, 1990, Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosynthesis in rat vascular smooth muscle cells, Biochem Pharmacol, 40, 2713, 10.1016/0006-2952(90)90592-9 Takuwa, 1989, A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts, J Biol Chem, 264, 7856, 10.1016/S0021-9258(18)83121-0 Tanaka, 1995, Arachidonic acid metabolites and glucocorticoid regulatory mechanism in cultured porcine tracheal smooth muscle cells, Lung, 173, 347, 10.1007/BF00172142 Thompson, 1970, The effect of glucocorticosteroids on the kinetics of mononuclear phagocytes, J Exp Med, 131, 429, 10.1084/jem.131.3.429 Thomson, 1996, Airway smooth muscle stereology: Implications for increased shortening in asthma, Am J Respir Crit Care Med, 154, 749, 10.1164/ajrccm.154.3.8810615 Thomson, 1998, Increased amount of airway smooth muscle does not account for excessive bronchoconstriction in asthma, Can Respir J, 5, 61 Tobler, 1992, Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts, Blood, 79, 45, 10.1182/blood.V79.1.45.45 Tomioka, 1984, Mast cells in bronchoalveolar lumen of patients with bronchial asthma, American Review of Respiratory Diseases, 129, 1000 Trigg, 1994, Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma, Am J Respir Crit Care Med, 150, 17, 10.1164/ajrccm.150.1.8025745 Van De Stolpe, 1993, Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines, Am Rev Respir Cell Mol Biol, 8, 340, 10.1165/ajrcmb/8.3.340 Villaschi, 1994, Paracrine interactions between fibroblasts and endothelial cells in a serum-free coculture model. Modulation of angiogenesis and collagen gel contraction, Lab Invest, 71, 291 Vittori, 1992, Increased expression of endothelin in bronchial epithelial cells of asthmatic patients and effect of corticosteroids, American Review of Respiratory Diseases, 146, 1320, 10.1164/ajrccm/146.5_Pt_1.1320 Walker, 1991, Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity, J Allergy Clin Immunol, 88, 935, 10.1016/0091-6749(91)90251-I Werb, 1978, Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions, J Exp Med, 147, 1695, 10.1084/jem.147.6.1695 Wills-Karp, 1998, Interleukin-13: central mediator of allergic asthma, Science, 282, 2258, 10.1126/science.282.5397.2258 Wu, 1991, Glucocorticoids suppress the production of interleukin 4 by human lymphocytes, Eur J Immunol, 21, 2645, 10.1002/eji.1830211053 Yang-Yen, 1990, Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction, Cell, 62, 1205, 10.1016/0092-8674(90)90396-V Young, 1995, Effects of glucocorticoids and beta-adrenoreceptor agonists on the proliferation of airway smooth muscle, Eur J Pharmacol, 273, 137, 10.1016/0014-2999(94)00679-2 Zheutlin, 1985, Donor sensitivity to basophil activation by eosinophil granule major basic protein, Int Arch Allergy Appl Immunol, 77, 216, 10.1159/000233791 Zweiman, 1976, Histologic studies of human skin test responses to ragweed and compound 48/80. III. Effects of alternate-day steroid therapy, J Allergy Clin Immunol, 58, 657, 10.1016/0091-6749(76)90177-9