EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Cell Chemical Biology - Tập 27 Số 1 - Trang 41-46.e17 - 2020
Jessie Hao-Ru Hsu1, Timothy Rasmusson2, James Robinson3, Fiona Pachl2, Jon Read3, Sameer Kawatkar1, Daniel H. O’Donovan4, Sharan K. Bagal4, Erin Code2, Philip B. Rawlins3, Argyrides Argyrou3, Ronald Tomlinson2, Ning Gao2, Xiahui Zhu2, Elisabetta Chiarparin4, Kelly Jacques1, Minhui Shen1, Haley Woods1, Emma Bednarski1, David M. Wilson4, Lisa Drew1, M. Paola Castaldi2, Stephen E. Fawell1, Andrew Bloecher1
1Oncology R&D, AstraZeneca, Waltham, MA 02451, USA
2Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA 02451, USA
3Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0FZ, UK
4Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, UK

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