EAACI Molecular Allergology User's Guide

Pediatric Allergy and Immunology - Tập 27 Số S23 - Trang 1-250 - 2016
Paolo Maria Matricardi1,2, Jörg Kleine‐Tebbe3,2, Hans Jürgen Hoffmann4, Rudolf Valenta5, Christiane Hilger6, Stephanie Hofmaier1, Rob C. Aalberse7,8, Ioana Agache9, R. Asero10, Barbara Ballmer‐Weber11, Domingo Barber12, Kirsten Beyer1, Tilo Biedermann13, Maria Beatrice Bilò14, Simon Blank15, Barbara Bohle16, Philipp P. Bosshard11, Heimo Breiteneder17, Helen A. Brough18, Luis Caraballo19, Jean‐Christoph Caubet20, Reto Crameri21, Janet M. Davies22, Nikolaos Douladiris23, Motohiro Ebisawa24, Philippe Eigenmann20, Montserrat Fernández‐Rivas25, Fátima Ferreira26, Gabriele Gadermaier26, Martin Glatz11,27, Robert G. Hamilton28, T. Hawranek29, Peter W. Hellings30,31, Karin Hoffmann‐Sommergruber17, Thilo Jakob32, Uta Jappe33,34, Marek Jutel35, Sandip D. Kamath36, Edward F. Knol37, Peter Korošec38, Annette Kuehn6, Gideon Lack39,40, Andreas L. Lopata35, Mika J. Mäkelä41, M. Morisset42, Verena Niederberger43, Anna Nowak‐Węgrzyn44, Nikolaos G. Papadopoulos45, Elide A. Pastorello46, G. Pauli47, Thomas A.E. Platts‐Mills48, Daniela Posa1, Lars K. Poulsen49, Monika Raulf50, J. Sastre51, Enrico Scala52, Johannes Martin Schmid4, Peter Schmid‐Grendelmeier11,27, Marianne van Hage53, Ronald van Ree54, Stefan Vieths55, Richard W. Weber56,57, Magnus Wickman58, Antonella Muraro59, Markus Ollert60,6
1Paediatric Pneumology and Immunology Charitè Medical University Berlin Germany
2These authors contributed equally as first authors.
3Allergy & Asthma Center Westend Outpatient Clinic Ackermann, Hanf, & Kleine‐Tebbe Berlin Germany
4Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark
5Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
6Department of Infection & Immunity Luxembourg Institute of Health Esch‐sur‐Alzette Luxembourg
7Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
8Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands
9Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania
10Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
11Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland
12IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain
13Department of Dermatology and Allergology, Technical University Munich, Munich, Germany
14Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona, Italy
15Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany
16Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria
17Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria
18Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, UK
19Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia
20Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland
21Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland
22School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia
23Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, Greece
24Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan
25Allergy Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain
26Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria
27Christine Kühne Center for Allergy Research and Education (CK Care), Davos, Switzerland
28Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md. USA
29Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria
30Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The Netherlands
31Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium
32Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany
33Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel, Germany
34Interdisciplinary Allergy Division Department of Pneumology University of Lübeck Lübeck Germany
35Department of Clinical Immunology ‘ALL‐MED’ Medical Research Institute Wrocław Medical University Wrocław Poland
36Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld, Australia
37Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands
38University clinic of respiratory and allergic diseases, Golnik, Slovenia
39Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, UK
40King's College London MRC & Asthma UK Centre in Allergic Mechanisms of Asthma London UK
41Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
42National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg, UK
43Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
44Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
45Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK
46Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy
47Service de pneumologie, hôpitaux universitaires de Strasbourg, Strasbourg, France
48Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA
49Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark
50Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany
51Allergy Division, Fundación Jimenez Díaz, Madrid, Spain
52Experimental Allergy Unit, IDI-IRCCS, Rome, Italy
53Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
54Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
55Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany
56Department of Medicine, National Jewish Health Service, Denver, CO, USA
57School of Medicine, University of Colorado, Denver, CO, USA
58Sachs' Children's Hospital, Karolinska Institutet, Stockholm, Sweden
59The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy
60Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark

Tóm tắt

AbstractThe availability of allergen molecules (‘components’) from several protein families has advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled ‘component‐resolved diagnosis’ (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options usingCRD. Part A of theEAACI MAUGintroduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low‐abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross‐reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE‐mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted forCRD. Part C covers protein families containing ubiquitous, highly cross‐reactive panallergens from plant (lipid transfer proteins, polcalcins,PR‐10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE‐mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. TheEAACI MAUGdocuments the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

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