E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9

Robim M. Rodrigues1,2, Yong He1, Seonghwan Hwang1, Adeline Bertola1, Bryan Mackowiak1, Yeni Ait Ahmed1, Wonhyo Seo1, Jing Ma1, Xiaolin Wang1, Seol Hee Park1, Yukun Guan1, Yaojie Fu1, Tamara Vanhaecke2, Dechun Feng1, Bin Gao1
1Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
2Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium

Tài liệu tham khảo

Friedman, 2018, Mechanisms of NAFLD development and therapeutic strategies, Nat Med, 24, 908, 10.1038/s41591-018-0104-9 Zhou, 2020, Epidemiological features of NAFLD from 1999 to 2018 in China, Hepatology, 71, 1851, 10.1002/hep.31150 Estes, 2018, Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease, Hepatology, 67, 123, 10.1002/hep.29466 Younossi, 2016, Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes, Hepatology, 64, 73, 10.1002/hep.28431 Chang, 2015, Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1, Hepatology, 62, 1070, 10.1002/hep.27921 Hwang, 2020, Interleukin-22 ameliorates neutrophil-driven nonalcoholic steatohepatitis through multiple targets, Hepatology, 72, 412, 10.1002/hep.31031 He, 2019, MicroRNA-223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes, Hepatology, 70, 1150, 10.1002/hep.30645 Tran, 2013, Non-alcoholic steatohepatitis in morbidly obese patients, Clin Res Hepatol Gastroenterol, 37, 17, 10.1016/j.clinre.2012.07.005 Du Plessis, 2015, Association of adipose tissue inflammation with histologic severity of nonalcoholic fatty liver disease, Gastroenterology, 149, 635, 10.1053/j.gastro.2015.05.044 Ley, 2007, Getting to the site of inflammation: the leukocyte adhesion cascade updated, Nat Rev Immunol, 7, 678, 10.1038/nri2156 Vestweber, 1999, Mechanisms that regulate the function of the selectins and their ligands, Physiol Rev, 79, 181, 10.1152/physrev.1999.79.1.181 Luscinskas, 1996, Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment, Ann Rev Med, 47, 413, 10.1146/annurev.med.47.1.413 Katayama, 2005, CD44 is a physiological E-selectin ligand on neutrophils, J Exp Med, 201, 1183, 10.1084/jem.20042014 Bertola, 2013, Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin, Hepatology, 58, 1814, 10.1002/hep.26419 Wang, 2018, S100A8/A9 in inflammation, Front Immunol, 9, 1298, 10.3389/fimmu.2018.01298 Kraakman, 2017, Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes, J Clin Invest, 127, 2133, 10.1172/JCI92450 Pruenster, 2016, S100A8/A9: from basic science to clinical application, Pharmacol Ther, 167, 120, 10.1016/j.pharmthera.2016.07.015 Ryckman, 2003, Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion, J Immunol, 170, 3233, 10.4049/jimmunol.170.6.3233 Nacken, 2003, S100A9/S100A8: myeloid representatives of the S100 protein family as prominent players in innate immunity, Microsc Res Tech, 60, 569, 10.1002/jemt.10299 Schiopu, 2013, S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease, Mediat Inflamm, 2013, 10.1155/2013/828354 Catalán, 2011, Increased levels of calprotectin in obesity are related to macrophage content: Impact on inflammation and effect of weight loss, Mol Med, 17, 1157, 10.2119/molmed.2011.00144 Serhal, 2015, Nonalcoholic steatohepatitis: Involvement of the telomerase and proinflammatory mediators, Biomed Res Int, 2015, 10.1155/2015/850246 Björk, 2009, Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides, PLoS Biol, 7, e97, 10.1371/journal.pbio.1000097 McDonald, 2008, Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids, J Exp Med, 205, 915, 10.1084/jem.20071765 Lake, 2011, Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease, Drug Metab Dispos, 39, 1954, 10.1124/dmd.111.040592 Feldstein, 2003, Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis, Gastroenterology, 125, 437, 10.1016/S0016-5085(03)00907-7 Ait Ahmed, 2021, Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners, Cell Mol Immunol, 10.1038/s41423-021-00731-7 Guillot, 2021, Bile acid–activated macrophages promote biliary epithelial cell proliferation through integrin αvβ6 upregulation following liver injury, J Clin Invest, 131, 10.1172/JCI132305 Rada, 2020, Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?, Cell Death Dis, 11, 1, 10.1038/s41419-020-03003-w Bijnen, 2018, Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice, Gut, 67, 1317, 10.1136/gutjnl-2016-313654 Kim, 2019, Adipocyte death preferentially induces liver injury and inflammation through the activation of chemokine (C-C motif) receptor 2-positive macrophages and lipolysis, Hepatology, 69, 1965, 10.1002/hep.30525 Frühbeck, 2014, Regulation of adipocyte lipolysis, Nutr Res Rev, 27, 63, 10.1017/S095442241400002X Polyzos, 2009, Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines, Curr Mol Med, 9, 299, 10.2174/156652409787847191 Kucukoglu, 2021, Hepatokines and adipokines in NASH-related hepatocellular carcinoma, J Hepatol, 74, 442, 10.1016/j.jhep.2020.10.030 Rodríguez, 2013, Metabolism and satiety, 75 Singh, 2015, Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies, Clin Gastroenterol Hepatol, 13, 643, 10.1016/j.cgh.2014.04.014 Schuster, 2018, Triggering and resolution of inflammation in NASH, Nat Rev Gastroenterol Hepatol, 15, 349, 10.1038/s41575-018-0009-6 Hwang, 2020, Protective and detrimental roles of p38α mitogen-activated protein kinase in different stages of nonalcoholic fatty liver disease, Hepatology, 72, 873, 10.1002/hep.31390 Simons, 2020, The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease, Liver Int, 40, 1079, 10.1111/liv.14384 Flach, 2013, β3-adrenergic receptor stimulation induces e-selectin-mediated adipose tissue inflammation, J Biol Chem, 288, 2882, 10.1074/jbc.M112.412346 Musso, 2008, Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects, Diabetes Care, 31, 562, 10.2337/dc07-1526 Velázquez, 2019, Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice, World J Hepatol, 11, 619, 10.4254/wjh.v11.i8.619 Ivetic, 2019, L-selectin: a major regulator of leukocyte adhesion, migration and signaling, Front Immunol, 10, 1068, 10.3389/fimmu.2019.01068 Liu, 2017, L-selectin mechanochemistry restricts neutrophil priming in vivo, Nat Commun, 8, 1 Drescher, 2020, L-selectin/CD62L is a key driver of non-alcoholic steatohepatitis in mice and men, Cells, 9, 1106, 10.3390/cells9051106 Yilmaz, 2009, Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance, Eur J Gastroenterol Hepatol, 21, 1247, 10.1097/MEG.0b013e32832b77ae Martínez-Castillo, 2020, Differential production of insulin-like growth factor-binding proteins in liver fibrosis progression, Mol Cell Biochem, 469, 65, 10.1007/s11010-020-03728-4 Hagström, 2017, IGFBP-1 and IGF-I as markers for advanced fibrosis in NAFLD–a pilot study, Scand J Gastroenterol, 52, 1427, 10.1080/00365521.2017.1379556 Hessian, 1993, MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes, J Leukoc Biol, 53, 197, 10.1002/jlb.53.2.197 Zhang, 2014, Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study, Sci Rep, 4, 1 Malhi, 2008, Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease, Semin Liver Dis, 28, 360, 10.1055/s-0028-1091980 Alkhouri, 2009, Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal, Exp Rev Gastroenterol Hepatol, 3, 445, 10.1586/egh.09.32 Huebert, 2010, Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis, Lab Invest, 90, 1770, 10.1038/labinvest.2010.132