Dysregulation of the expression of HLA-DR, costimulatory molecule, and chemokine receptors on immune cells in children with autism

International Immunopharmacology - Tập 65 - Trang 360-365 - 2018
Sheikh F. Ahmad1, Mushtaq A. Ansari1, Ahmed Nadeem1, Saleh A. Bakheet1, Laila Y. AL-Ayadhi2, Moureq R. Alotaibi1, Ali R. Alhoshani1, Khaled A. Al-Hosaini1, Sabry M. Attia1,3
1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
2Autism Research and Treatment Center, AL-Amodi Autism Research Chair, Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
3Department of Pharmacology and Toxicology, College of Pharmacy, Al-Azhar University, Cairo, Egypt

Tài liệu tham khảo

American Psychiatric Association, 2015 Cohen, 2005, Specific genetic disorders and autism: clinical contribution towards their identification, J. Autism Dev. Disord., 35, 103, 10.1007/s10803-004-1038-2 Meltzer, 2017, The role of the immune system in autism spectrum disorder, Neuropsychopharmacology, 42, 284, 10.1038/npp.2016.158 Torres, 2002, The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder, Hum. Immunol., 63, 311, 10.1016/S0198-8859(02)00374-9 Varga, 2009, The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly, Genet. Med., 11, 111, 10.1097/GIM.0b013e31818fd762 Morgan, 2010, Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism, Biol. Psychiatry, 68, 368, 10.1016/j.biopsych.2010.05.024 Onore, 2011, The role of immune dysfunction in the pathophysiology of autism, Brain Behav. Immun., 26, 383, 10.1016/j.bbi.2011.08.007 Vargas, 2005, Neuroglial activation and neuroinflammation in the brain of patients with autism, Ann. Neurol., 57, 67, 10.1002/ana.20315 Ahmad, 2017, Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 79, 472, 10.1016/j.pnpbp.2017.08.002 Ahmad, 2018, Upregulation of peripheral CXC and CC chemokine receptor expression on CD4+ T cells is associated with immune dysregulation in children with autism, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 81, 211, 10.1016/j.pnpbp.2017.10.001 Ahmad, 2017, Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children, Mol. Immunol., 82, 57, 10.1016/j.molimm.2016.12.019 Ahmad, 2017, Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism, Mol. Neurobiol., 54, 4390, 10.1007/s12035-016-9977-0 Hamza, 2010, Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease, Nat. Genet., 42, 781, 10.1038/ng.642 Lee, 2006, HLA-DR4 in families with autism, Pediatr. Neurol., 35, 303, 10.1016/j.pediatrneurol.2006.06.006 Torres, 2006, The association and linkage of the HLA-A2 class I allele with autism, Hum. Immunol., 67, 346, 10.1016/j.humimm.2006.01.001 Comi, 1999, Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism, J. Child Neurol., 14, 388, 10.1177/088307389901400608 Levin, 2004, Analysis of HLA genes in families with autoimmune diabetes and thyroiditis, Hum. Immunol., 65, 640, 10.1016/j.humimm.2004.02.026 Garay, 2010, Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders, Front Synaptic Neurosci., 2, 136, 10.3389/fnsyn.2010.00136 Patterson, 2009, Immune involvement in schizophrenia and autism: etiology, pathology and animal models, Behav. Brain Res., 204, 313, 10.1016/j.bbr.2008.12.016 Ashwood, 2011, Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders, J. Neuroimmunol., 232, 196, 10.1016/j.jneuroim.2010.10.025 Ahmad, 2018, Downregulation in Helios transcription factor signaling is associated with immune dysfunction in blood leukocytes of autistic children, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 85, 98, 10.1016/j.pnpbp.2018.04.011 Filiano, 2016, Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour, Nature, 535, 425, 10.1038/nature18626 Hsiao, 2012, Modeling an autism risk factor in mice leads to permanent immune dysregulation, Proc. Natl. Acad. Sci. U. S. A., 109, 12776, 10.1073/pnas.1202556109 Schopler, 1986 Noster, 2014, IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells, Sci. Transl. Med., 6, 241ra80, 10.1126/scitranslmed.3008706 Chen, 2007, Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-kappaB, Br. J. Pharmacol., 150, 298, 10.1038/sj.bjp.0706987 Enstrom, 2009, Autoimmunity in autism, Curr. Opin. Investig. Drugs, 10, 463 Ashwood, 2004, Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10, J. Clin. Immunol., 24, 664, 10.1007/s10875-004-6241-6 Enstrom, 2010, Differential monocyte responses to TLR ligands in children with autism spectrum disorders, Brain Behav. Immun., 24, 64, 10.1016/j.bbi.2009.08.001 Boulanger, 2009, Immune proteins in brain development and synaptic plasticity, Neuron, 64, 93, 10.1016/j.neuron.2009.09.001 Deverman, 2009, Cytokines and CNS development, Neuron, 64, 61, 10.1016/j.neuron.2009.09.002 Hsiao, 2013, Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders, Cell, 155, 1451, 10.1016/j.cell.2013.11.024 Guerini, 2006, A family based linkage analysis of HLA and 5-HTTLPR gene polymorphisms in Sardinian children with autism spectrum disorder, Hum. Immunol., 67, 108, 10.1016/j.humimm.2006.02.033 Ferrante, 2003, Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children, Biomed. Pharmacother., 57, 372, 10.1016/S0753-3322(03)00099-4 Johnson, 2009, HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy, Arch. Pediatr. Adolesc. Med., 163, 542, 10.1001/archpediatrics.2009.74 Sadeharju, 2003, The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens, Diabetologia, 46, 1100, 10.1007/s00125-003-1157-x Balashov, 1999, CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions, Proc. Natl. Acad. Sci. U. S. A., 96, 6873, 10.1073/pnas.96.12.6873 Bagaeva, 2006, Segal B. CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis, J. Immunol., 176, 7676, 10.4049/jimmunol.176.12.7676 Schönemeier, 2008, Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain, J. Neuroimmunol., 198, 39, 10.1016/j.jneuroim.2008.04.010 Li, 2009, Elevated immune response in the brain of autistic patients, J. Neuroimmunol., 207, 111, 10.1016/j.jneuroim.2008.12.002 Goines, 2011, Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: a case-control study, Mol. Autism, 2, 13, 10.1186/2040-2392-2-13 Korn, 2007, IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells, Nature, 448, 484, 10.1038/nature05970 Ouyang, 2008, The biological functions of T helper 17 cell effector cytokines in inflammation, Immunity, 28, 454, 10.1016/j.immuni.2008.03.004 Tzartos, 2011, IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain, Am. J. Pathol., 178, 794, 10.1016/j.ajpath.2010.10.043 Safari, 2017, FOXP3 gene variations and susceptibility to autism: a case-control study, Gene, 596, 119, 10.1016/j.gene.2016.10.019