Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications

Benhayon, 2003, Binding of purified reelin to apoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1, Mol Brain Res, 112, 33, 10.1016/S0169-328X(03)00032-9 Bhat, 2004, Glycogen synthase kinase 3: a drug target for CNS therapies, J Neurochem, 89, 1313, 10.1111/j.1471-4159.2004.02422.x Bock, 2003, Reelin activates Src family tyrosine kinases in neurons, Curr Biol, 13, 18, 10.1016/S0960-9822(02)01403-3 Casey, 2003, Effect of divalproex combined with olanzapine or risperidone in patients with an acute exacerbation of schizophrenia, Neuropsychopharmacology, 28, 182, 10.1038/sj.npp.1300023 Cooper, 1999, Lipoprotein receptors: signaling functions in the brain?, Cell, 97, 671, 10.1016/S0092-8674(00)80778-3 Costa, 2002, Reelin and schizophrenia: a disease at the interface of the genome and epigenome, Mol Interv, 2, 47, 10.1124/mi.2.1.47 Costa, 2002, The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics, Curr Opin Pharmacol, 2, 56, 10.1016/S1471-4892(01)00121-7 D'Arcangelo, 1999, Reelin is a ligand for lipoprotein receptors, Neuron, 24, 471, 10.1016/S0896-6273(00)80860-0 Dunn, 2005, Does lithium therapy protect against the onset of dementia?, Alzheimer Dis Assoc Disord, 19, 20, 10.1097/01.wad.0000155068.23937.9b Feyt, 2005, Lithium chloride increases the production of amyloid-β-peptide independently from its inhibition of glycogen synthase kinase 3, J Biol Chem, 280, 33220, 10.1074/jbc.M501610200 Grundke-Iqbal, 1986, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc Natl Acad Sci U S A, 83, 4913, 10.1073/pnas.83.13.4913 Guidotti, 2000, Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder, Arch Gen Psychiatry, 57, 1061, 10.1001/archpsyc.57.11.1061 Hiesberger, 1999, Direct binding of reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation, Neuron, 24, 481, 10.1016/S0896-6273(00)80861-2 Hong, 1997, Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons, J Biol Chem, 272, 19547, 10.1074/jbc.272.31.19547 Hong, 1997, Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3, J Biol Chem, 272, 25326, 10.1074/jbc.272.40.25326 Lee, 1998, Tau interacts with src-family non-receptor tyrosine kinases, J Cell Sci, 111, 3167, 10.1242/jcs.111.21.3167 Liu, 2001, Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient hetereozygous reeler mouse, Proc Natl Acad Sci U S A, 98, 3477, 10.1073/pnas.051614698 Ohkubo, 2003, Apolipoprotein E and reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3β cascade, FASEB J, 17, 295, 10.1096/fj.02-0434fje Phiel, 2003, GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides, Nature, 423, 392, 10.1038/nature01640 Rice, 1999, Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS, Genes Dev, 13, 2758, 10.1101/gad.13.21.2758 Ryder, 2003, Divergent roles of GSK3 and CDK5 in APP processing, Biochem Biophys Res Commun, 312, 922, 10.1016/j.bbrc.2003.11.014 Schneider, 2003, LDL receptor relatives at the crossroad of endocytosis and signaling, Cell Mol Life Sci, 60, 892, 10.1007/s00018-003-2183-Z Shirazi, 1993, The protein tyrosine kinase, fyn, in Alzheimer's disease pathology, Neuroreport, 4, 435, 10.1097/00001756-199304000-00024 Su, 2004, Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing, Biochemistry, 43, 6899, 10.1021/bi035627j Sun, 2002, Glycogen synthase kinase-3β is complexed with tau protein in brain microtubules, J Biol Chem, 277, 11933, 10.1074/jbc.M107182200 Sun, 2002, Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100, Neurosci Lett, 321, 61, 10.1016/S0304-3940(01)02583-6 Tesseur, 2000, Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice, Am J Pathol, 156, 951, 10.1016/S0002-9440(10)64963-2 Tremolizzo, 2005, Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice, Biol Psychiatry, 57, 500, 10.1016/j.biopsych.2004.11.046 Trommsdorff, 1999, Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and apoE receptor 2, Cell, 97, 689, 10.1016/S0092-8674(00)80782-5 Weeber, 2002, Reelin and apoE receptors cooperate to enhance hippocampal synaptic plasticity and learning, J Biol Chem, 277, 39944, 10.1074/jbc.M205147200 Weinberger, 1987, Implications of normal brain development for the pathogenesis of schizophrenia, Arch Gen Psychiatry, 44, 660, 10.1001/archpsyc.1987.01800190080012