Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

Annals of Hepatology - Tập 25 - Trang 100538 - 2021
Yue-fan Wang1, Chun-mei Ge1, Hao-zan Yin1, Zhi-hui Dai1, Jun-peng Dong1, Man Ji1, Fu Yang1
1The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.

Tài liệu tham khảo

Huang, 2020, mA Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer[J], Cancer Cell, 37, 270, 10.1016/j.ccell.2020.02.004 Forner, 2018, Hepatocellular carcinoma[J], Lancet (London, England), 391, 1301, 10.1016/S0140-6736(18)30010-2 Zhao, 2017, mA-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition[J], Nature, 542, 475, 10.1038/nature21355 Ma, 2020, IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease[J], J Hepatol, 72, 946, 10.1016/j.jhep.2019.12.016 Wang, 2018, Novel insights on mA RNA methylation in tumorigenesis: a double-edged sword[J], Mol Cancer, 17, 101, 10.1186/s12943-018-0847-4 DESROSIERS, 1974, Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells[J], PNAS, 71, 3971, 10.1073/pnas.71.10.3971 Dai, 2018, N6-methyladenosine links RNA METABOLISM TO CANCER progression[J], Cell Death Dis, 9, 124, 10.1038/s41419-017-0129-x Huang, 2018, Structural Insights into N-methyladenosine (mA) Modification in the Transcriptome[J], Genomics Proteomics Bioinformatics, 16, 85, 10.1016/j.gpb.2018.03.001 Zhou, 2017, Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs[J], Cell Rep, 20, 2262, 10.1016/j.celrep.2017.08.027 Ke, 2015, A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation[J], Genes Dev, 29, 2037, 10.1101/gad.269415.115 Roignant, 2017, mA in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression[J], Trends Genet, 33, 380, 10.1016/j.tig.2017.04.003 Liu, 2014, A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation[J], Nat Chem Biol, 10, 93, 10.1038/nchembio.1432 Wang, 2020, The potential role of RNA N6-methyladenosine in Cancer progression[J], Mol Cancer, 19, 88, 10.1186/s12943-020-01204-7 Knuckles, 2018, Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the mA machinery component Wtap/Fl(2)d[J], Genes Dev, 32, 415, 10.1101/gad.309146.117 Schwartz, 2014, Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites[J], Cell Rep, 8, 284, 10.1016/j.celrep.2014.05.048 Zheng, 2013, ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility[J], Mol Cell, 49, 18, 10.1016/j.molcel.2012.10.015 Zhao, 2014, FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis[J], Cell Res, 24, 1403, 10.1038/cr.2014.151 Fu, 2013, FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA[J], Nat Commun, 4, 1798, 10.1038/ncomms2822 Ueda, 2017, AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells[J], Sci Rep, 7, 42271, 10.1038/srep42271 Wang, 2014, N6-methyladenosine-dependent regulation of messenger RNA stability[J], Nature, 505, 117, 10.1038/nature12730 Wang, 2015, N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency[J], Cell, 161, 1388, 10.1016/j.cell.2015.05.014 Meyer, 2015, 5′ UTR m(6)A Promotes Cap-Independent Translation[J], Cell, 163, 999, 10.1016/j.cell.2015.10.012 Shi, 2017, YTHDF3 facilitates translation and decay of N-methyladenosine-modified RNA[J], Cell Res, 27, 315, 10.1038/cr.2017.15 Wojtas, 2017, Regulation of mA Transcripts by the 3′→5′ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline[J], Mol Cell, 68, 10.1016/j.molcel.2017.09.021 Kasowitz, 2018, Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development[J], PLos Genet, 14, 10.1371/journal.pgen.1007412 Zhao, 2020, mA-binding proteins: the emerging crucial performers in epigenetics[J], J Hematol Oncol, 13, 35, 10.1186/s13045-020-00872-8 Guichard, 2012, Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma[J], Nat Genet, 44, 694, 10.1038/ng.2256 Alarcón, 2015, HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events[J], Cell, 162, 1299, 10.1016/j.cell.2015.08.011 Bell, 2013, Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?[J], Cellular and molecular life sciences: CMLS, 70, 2657, 10.1007/s00018-012-1186-z HUANG, 2018, Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation[J], Nat Cell Biol, 20, 285, 10.1038/s41556-018-0045-z Qiao, 2019, Human apolipoprotein E promotes hepatitis B virus infection and production[J], PLoS Pathog, 15, 10.1371/journal.ppat.1007874 Jones, 2013, Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention[J], Emerging microbes & infections, 2, e56 Imam, 2018, N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle[J], PNAS, 115, 8829, 10.1073/pnas.1808319115 Xu, 2019, Role of identified RNA N6-methyladenosine methylation in liver[J], Anal Biochem, 578, 45, 10.1016/j.ab.2019.05.005 Petta, 2020, Extrahepatic Manifestations of Chronic Viral C Hepatitis[J], Gastroenterol Clin North Am, 49, 347, 10.1016/j.gtc.2020.01.012 Tan, 2018, RNA epitranscriptomics: Regulation of infection of RNA and DNA viruses by N -methyladenosine (m A)[J], Rev Med Virol, 28, e1983, 10.1002/rmv.1983 Gokhale, 2016, N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection[J], Cell host & microbe, 20, 654, 10.1016/j.chom.2016.09.015 Durbin, 2016, RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling[J], mBio, 7, 10.1128/mBio.00833-16 Wang, 2020, Quantifying and monitoring fibrosis in non-alcoholic fatty liver disease using dual-photon microscopy[J], Gut, 69, 1116, 10.1136/gutjnl-2019-318841 Chen, 2020, The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis[J], Mol Cancer, 19, 44, 10.1186/s12943-020-01172-y Chen, 2017, FTO Promotes Adipogenesis through Inhibition of the Wnt/β-catenin Signaling Pathway in Porcine Intramuscular Preadipocytes[J], Anim Biotechnol, 28, 268, 10.1080/10495398.2016.1273835 Merkestein, 2015, FTO influences adipogenesis by regulating mitotic clonal expansion[J], Nat Commun, 6, 6792, 10.1038/ncomms7792 Wu, 2018, FTO regulates adipogenesis by controlling cell cycle progression via mA-YTHDF2 dependent mechanism[J], Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863, 1323, 10.1016/j.bbalip.2018.08.008 HU, 2020, GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m(6)A on lipogenic mRNAs[J], RNA Biol, 17, 930, 10.1080/15476286.2020.1736868 Zhou, 2020, N -methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes[J], Hepatology MA, 2017, METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6) -methyladenosine-dependent primary MicroRNA processing[J], Hepatology, 65, 529, 10.1002/hep.28885 Chen, 2018, RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2[J], Hepatology, 67, 2254, 10.1002/hep.29683 He, 2019, Functions of N6-methyladenosine and its role in cancer[J], Mol Cancer, 18, 176, 10.1186/s12943-019-1109-9 Yu, 2019, A Novel RNA Imprint in Human Cancer[J], Front Oncol, 9, 1407, 10.3389/fonc.2019.01407 Li, 2020, N6-Methyladenosine Regulates the Expression and Secretion of TGFβ1 to Affect the Epithelial-Mesenchymal Transition of Cancer Cells[J], Cells, 9, 10.3390/cells9020296 Lin, 2020, RNA m A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy[J], EMBO J, 10.15252/embj.2019103181 CHEN, 2019, WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1[J], Mol Cancer, 18, 127, 10.1186/s12943-019-1053-8 Cheng, 2019, KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA[J], OncoTargets and therapy, 12, 3421, 10.2147/OTT.S180954 LI, 2019, m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation[J], Am J Transl Res, 11, 6084 CHEN, 2020, ALKBH5 suppresses malignancy of hepatocellular carcinoma via m(6)A-guided epigenetic inhibition of LYPD1[J], Mol Cancer, 19, 123, 10.1186/s12943-020-01239-w Zhao, 2018, Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma[J], Cancer biomarkers: section A of Disease markers, 21, 859, 10.3233/CBM-170791 LIU, 2020, YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner[J], Molecular therapy. Nucleic acids, 22, 750, 10.1016/j.omtn.2020.09.036 Du, 2016, YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex[J], Nat Commun, 7, 12626, 10.1038/ncomms12626 Yang, 2017, NMicroRNA-145 Modulates -Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of the -Methyladenosine Binding YTH Domain Family 2 Protein[J], J Biol Chem, 292, 3614, 10.1074/jbc.M116.749689 ZHANG, 2020, YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation[J], Oncogene, 39, 4507, 10.1038/s41388-020-1303-7 ZHONG, 2019, YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma[J], Cancer Lett, 442, 252, 10.1016/j.canlet.2018.11.006 HOU, 2019, YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma[J], Mol Cancer, 18, 163, 10.1186/s12943-019-1082-3 Huang, 2018, Recognition of RNA N-methyladenosine by IGF2BP proteins enhances mRNA stability and translation[J], Nat Cell Biol, 20, 285, 10.1038/s41556-018-0045-z Qu, 2020, Multiple mA RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis[J], BMC Cancer, 20, 165, 10.1186/s12885-020-6638-5 Taketo, 2018, The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells[J], Int J Oncol, 52, 621 Visvanathan, 2018, Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance[J], Oncogene, 37, 522, 10.1038/onc.2017.351 Yang, 2019, mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade[J], Nat Commun, 10, 2782, 10.1038/s41467-019-10669-0 Han, 2019, Anti-tumour immunity controlled through mRNA mA methylation and YTHDF1 in dendritic cells[J], Nature, 566, 270, 10.1038/s41586-019-0916-x Huang, 2015, Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5[J], Nucleic Acids Res, 43, 373, 10.1093/nar/gku1276 Su, 2018, R-2HG Exhibits Anti-tumor Activity by Targeting FTO/mA/MYC/CEBPA Signaling[J], Cell, 172, 10.1016/j.cell.2017.11.031 Huang, 2019, Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia[J], Cancer Cell, 35, 10.1016/j.ccell.2019.03.006