Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge Cryptosporidium parvum infection

Aguirre, 1994, Susceptibility of major histocompatibility complex (MHC) class I- and MHC class II-deficient mice to Cryptosporidium parvum infection, Infect. Immun., 62, 697, 10.1128/IAI.62.2.697-699.1994 Ball, 2003, Improved mRNA quantitation in LightCycler RT-PCR, Int. Arch. Allergy Immunol., 130, 82, 10.1159/000068372 Barner, 1998, Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses, Curr. Biol., 8, 669, 10.1016/S0960-9822(98)70256-8 Chatelain, 1992, IL-4 induces a Th2 response in Leishmania major-infected mice, J. Immunol., 148, 1182, 10.4049/jimmunol.148.4.1182 Chen, 1993, Requirements for CD4+ cells and gamma interferon in resolution of established Cryptosporidium parvum infection in mice, Infect. Immun., 61, 3928, 10.1128/IAI.61.9.3928-3932.1993 Chen, 1993, Gamma interferon functions in resistance to Cryptosporidium parvum infection in severe combined immunodeficient mice, Infect. Immun., 61, 3548, 10.1128/IAI.61.8.3548-3551.1993 Chomarat, 1998, Interleukin-4 and interleukin-13: their similarities and discrepancies, Int. Rev. Immunol., 17, 1, 10.3109/08830189809084486 Dalton, 1993, Multiple defects of immune cell function in mice with disrupted interferon-gamma genes, Science, 259, 1739, 10.1126/science.8456300 Dinarello, 1999, IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family, J. Allergy Clin. Immunol., 103, 11, 10.1016/S0091-6749(99)70518-X Ehigiator, 2005, Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice, Parasite Immunol., 27, 17, 10.1111/j.1365-3024.2005.00736.x Ehigiator, 2007, Cryptosporidium parvum: the contribution of Th1-inducing pathways to the resolution of infection in mice, Exp. Parasitol., 115, 107, 10.1016/j.exppara.2006.07.001 Enriquez, 1993, Role of CD4+ TH1- and TH2-cell-secreted cytokines in cryptosporidiosis, Folia Parasitol. Praha., 40, 307 Guk, 2007, Role of murine Peyer's patch lymphocytes against primary and challenge infections with Cryptosporidium parvum, Korean J. Parasitol., 45, 175, 10.3347/kjp.2007.45.3.175 Guk, 2003, Role of murine intestinal intraepithelial lymphocytes and lamina propria lymphocytes against primary and challenge infections with Cryptosporidium parvum, J. Parasitol., 89, 270, 10.1645/0022-3395(2003)089[0270:ROMIIL]2.0.CO;2 Harp, 1994, In vitro proliferation and production of gamma interferon by murine CD4+ cells in response to Cryptosporidium parvum antigen, J. Parasitol., 80, 67, 10.2307/3283347 Hayward, 2000, Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice, J. Infect. Dis., 182, 1001, 10.1086/315802 Helmby, 2001, Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13, J. Exp. Med., 194, 355, 10.1084/jem.194.3.355 Huang, 1996, Alterations of the mucosal immune system due to Cryptosporidium parvum infection in normal mice, Cell Immunol., 173, 176, 10.1006/cimm.1996.0265 Huang, 2002, IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production, J. Immunol., 168, 5756, 10.4049/jimmunol.168.11.5756 Jakobi, 2008, Humoral immune response in interleukin-12 and interferon-g deficient mice after infection with Cryptosporidium parvum, Parasite Immunol., 30, 151, 10.1111/j.1365-3024.2007.01013.x Kapel, 1996, Kinetics of mucosal ileal gamma-interferon response during cryptosporidiosis in immunocompetent neonatal mice, Parasitol. Res., 82, 664, 10.1007/s004360050182 Kawakami, 2000, IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells, J. Immunol., 165, 941, 10.4049/jimmunol.165.2.941 Kinjo, 2002, Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40, J. Immunol., 169, 323, 10.4049/jimmunol.169.1.323 Lacroix, 2001, Cryptosporidium parvum-specific mucosal immune response in C57BL/6 neonatal and gamma interferon-deficient mice: role of tumor necrosis factor alpha in protection, Infect. Immun., 69, 1635, 10.1128/IAI.69.3.1635-1642.2001 Leav, 2005, An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice, Infect. Immun., 73, 8425, 10.1128/IAI.73.12.8425-8428.2005 Liu, 2006, IL-18 stimulates IL-13-mediated IFN-gamma-sensitive host resistance in vivo, Eur. J. Immunol., 36, 1187, 10.1002/eji.200535668 Lochner, 2002, Generation of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivo, J. Immunol. Methods, 259, 149, 10.1016/S0022-1759(01)00505-1 Magram, 1996, IL-12-deficient mice are defective in IFNg production and type 1 cytokine responses, Immunity, 4, 471, 10.1016/S1074-7613(00)80413-6 McDonald, 1994, Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in SCID mice, Parasite Immunol., 16, 315, 10.1111/j.1365-3024.1994.tb00354.x McDonald, 1992, Immune responses to Cryptosporidium muris and Cryptosporidium parvum in adult immunocompetent or immunocompromised (nude and SCID) mice, Infect. Immun., 60, 3325, 10.1128/IAI.60.8.3325-3331.1992 McDonald, 2004, Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines, J. Infect. Dis., 190, 1019, 10.1086/422761 McDonald, 2006, A potential role for interleukin-18 in inhibition of the development of Cryptosporidium parvum, Clin. Exp. Immunol., 145, 555, 10.1111/j.1365-2249.2006.03159.x McKenzie, 1998, A distinct role for interleukin-13 in Th2-cell-mediated immune responses, Curr. Biol., 8, 339, 10.1016/S0960-9822(98)70134-4 Mead, 1998, Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice, J. Parasitol., 84, 1045, 10.2307/3284643 Mead, 1991, Cryptosporidial infections in SCID mice reconstituted with human or murine lymphocytes, J. Protozool., 38, 59S Nakanishi, 2001, Interleukin-18 regulates both Th1 and Th2 responses, Annu. Rev. Immunol., 19, 423, 10.1146/annurev.immunol.19.1.423 Okamura, 1995, Cloning of a new cytokine that induces IFN-gamma production by T cells, Nature, 378, 88, 10.1038/378088a0 Okamura, 1998, Interleukin-18: a novel cytokine that augments both innate and acquired immunity, Adv. Immunol., 70, 281, 10.1016/S0065-2776(08)60389-2 Okazawa, 2004, Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes, Clin. Exp. Immunol., 136, 269, 10.1111/j.1365-2249.2004.02431.x Perryman, 1994, Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice, Infect. Immun., 62, 1474, 10.1128/IAI.62.4.1474-1477.1994 Rozen, 2000, Primer3 on the WWW for general users and for biologist programmers, 365 Singh, 2005, Kinetics of Cryptosporidium parvum-specific cytokine responses in healing and nonhealing murine models of C. parvum infection, Parasitol. Res., 97, 309, 10.1007/s00436-005-1436-1 Smith, 2000, Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice, J. Parasitol., 86, 300 Smith, 2001, Exogenous interleukin-12 (IL-12) exacerbates Cryptosporidium parvum infection in gamma interferon knockout mice, Exp. Parasitol., 98, 123, 10.1006/expr.2001.4627 Sonobe, 2005, Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations, Brain Res., 1040, 202, 10.1016/j.brainres.2005.01.100 Ungar, 1991, Cryptosporidium infection in an adult mouse model. Independent roles for IFN-gamma and CD4+ T lymphocytes in protective immunity, J. Immunol., 147, 1014, 10.4049/jimmunol.147.3.1014 Urban, 1996, IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum, J. Immunol., 156, 263, 10.4049/jimmunol.156.1.263 Urban, 1998, IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis, Immunity, 8, 255, 10.1016/S1074-7613(00)80477-X Wakeham, 2000, Genetically determined disparate innate and adaptive cell-mediated immune responses to pulmonary Mycobacterium bovis BCG infection in C57BL/6 and BALB/c mice, Infect. Immun., 68, 6946, 10.1128/IAI.68.12.6946-6953.2000 White, 2000, Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion, J. Infect. Dis., 181, 701, 10.1086/315261 Wyatt, 2001, Evidence for the emergence of a type-1-like immune response in intestinal mucosa of calves recovering from cryptosporidiosis, J. Parasitol., 87, 90 Wyatt, 2005, Response of T lymphocytes from previously infected calves to recombinant Cryptosporidium parvum P23 vaccine antigen, J. Parasitol., 91, 1239, 10.1645/GE-3446RN.1 You, 1998, Characterization of experimental Cryptosporidium parvum infection in IFN-gamma knockout mice, Parasitology, 117, 525, 10.1017/S0031182098003424