Sự tương tác động giữa các khoáng Ca–P đang phát triển và nanofiber cellulose vi khuẩn trong quá trình khoáng hóa sinh học ban đầu

Springer Science and Business Media LLC - Tập 17 - Trang 365-373 - 2009
Chuan Gao1, Guang Yao Xiong2, Hong Lin Luo1, Kai Jing Ren3, Yuan Huang1, Yi Zao Wan1
1School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, People’s Republic of China
2School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang, People’s Republic of China
3Department of Joint Surgery, Tianjin Hospital, Tianjin, People’s Republic of China

Tóm tắt

Xương là một hợp chất của pha hữu cơ (sợi nano collagen) và khoáng Ca–P (hydroxylapatite) và là một cấu trúc sinh học quan trọng trong lĩnh vực khoáng hóa sinh học, nhưng sự tương tác giữa ma trận hữu cơ và khoáng vô cơ vẫn còn quá mơ hồ. Để nghiên cứu sự tương tác giữa các khoáng Ca–P đang phát triển và các sợi nano hữu cơ trong quá trình khoáng hóa sinh học ban đầu, các sợi nano cellulose vi khuẩn (BC) đã được sử dụng như các mẫu để mô phỏng các sợi nano collagen cho sự lắng đọng khoáng Ca–P thông qua quá trình khoáng hóa sinh học trong khoảng thời gian từ 4 đến 72 giờ. Kết quả nghiên cứu của chúng tôi chỉ ra rằng các khoáng Ca–P hình thành trên các sợi nano BC là dạng hình bản, tương tự với các khoáng thiếu canxi HAp trong mô xương tự nhiên. Đặc biệt, chúng tôi phát hiện rằng sự phát triển của các khoáng Ca–P có ảnh hưởng đến cấu trúc và tính chất của các mẫu nano BC trong quá trình khoáng hóa sinh học.

Từ khóa

#Biomineralization #Ca–P minerals #bacterial cellulose #collagen nanofibers #hydroxylapatite

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