Dynamic epidermal cooling in conjunction with laser treatment of port-wine stains: Theoretical and preliminary clinical evaluations

Lasers in Medical Science - Tập 10 - Trang 105-112 - 1995
Bahman Anvari1,2, Thomas E. Milner1,3, B. Samuel Tanenbaum2, Sol Kimel4, Lars O. Svaasand5, J. Stuart Nelson1
1Beckman Laser Institute and Medical Clinic, Department of Surgery, University of California, Irvine, USA
2Department of Engineering, Harvey Mudd College, Claremont, USA
3Department of Physics, Harvey Mudd College, Claremont, USA
4Department of Chemistry, Technion-Israel Institute of Technology, Haifa, Israel
5Division of Physical Electronics, University of Trondheim, Norwegian Institute of Technology, Norway

Tóm tắt

The clinical objective in laser treatment of port-wine stains (PWS) is to induce selective photothermolysis of subsurface blood vessels without damaging the overlying epidermis. This paper investigates the effectiveness of ‘dynamic’ cooling, where a cryogen is sprayed on the skin surface for an appropriately short period of time, to eliminate epidermal thermal injury during laser treatment of PWS. Comparative measurements of radiometric surface temperature from cooled and uncooled laser irradiated (585 nm) PWS sites, and theoretical predictions of temperature distributions within skin in response to dynamic cooling in conjunction with laser irradiation are presented. Rapid reduction of skin surface temperature and localization of cooling the epidermis are obtained when a cryogen is sprayed on skin prior to laser irradiation. Successful blanching of the PWS without thermal injury to the overlying epidermis is accomplished.

Tài liệu tham khảo

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