Durable clinical response to the multidisciplinary management of neurosurgery, radiation and chemoimmunotherapy in a patient with PD-L1/PD-L2/JAK2 (PDJ)-amplified, refractory triple-negative breast cancer

Journal of the National Cancer Center - Tập 1 - Trang 115-121 - 2021
Hongyuan Zhao1,2, Weijie Ma1, Ruben C. Fragoso3, Griffith R. Harsh IV4, Arya Ashok5, Tianhong Li1
1Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis School of Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, USA
2Current address: Department of Thyroid & Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China
3Department of Radiation Oncology, University of California Davis School of Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, USA
4Department of Neurological Surgery, University of California Davis School of Medicine, Sacramento, USA
5Tempus Labs, Inc., Chicago, USA

Tài liệu tham khảo

Pellerino, 2020, Management of Brain and Leptomeningeal Metastases from Breast Cancer, Int J Mol Sci, 21, 8534, 10.3390/ijms21228534 Lin, 2008, Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases, Cancer, 113, 2638, 10.1002/cncr.23930 Murthy, 2020, Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer, N Engl J Med, 382, 597, 10.1056/NEJMoa1914609 Eguren-Santamaria I, Sanmamed MF, Goldberg SB, et al. PD-1/PD-L1 blockers in NSCLC brain metastases: challenging paradigms and clinical practice. 2020;26(16):4186-4197. Daly MB, Pilarski R, Yurgelun MB, et al. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020. 2020;18(4):380. Beaubier N, Tell R, Lau D, et al. Clinical validation of the tempus xT next-generation targeted oncology sequencing assay. 2019;10(24):2384. Beaubier N, Bontrager M, Huether R, et al. Integrated genomic profiling expands clinical options for patients with cancer. 2019;37(11):1351-60. Ma, 2016, Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy, J Hematol Oncol, 9, 47, 10.1186/s13045-016-0277-y Chen, 2020, Translational Biomarkers and Rationale Strategies to Overcome Resistance to Immune Checkpoint Inhibitors in Solid Tumors, Cancer Treat Res, 180, 251, 10.1007/978-3-030-38862-1_9 Goodman, 2018, Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors, JAMA Oncol, 4, 1237, 10.1001/jamaoncol.2018.1701 Curtis, 2012, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups, Nature, 486, 346, 10.1038/nature10983 Pereira, 2016, The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes, Nat Commun, 7, 11479, 10.1038/ncomms11479 Gupta, 2019, Next-Generation Sequencing-Based Assessment of JAK2, PD-L1, and PD-L2 Copy Number Alterations at 9p24.1 in Breast Cancer: Potential Implications for Clinical Management, J Mol Diagn, 21, 307, 10.1016/j.jmoldx.2018.10.006 Roesler, 2020, Abstract 1790: PDJ amplicon heterogeneity in triple negative breast cancers, Cancer Res, 80, 1790, 10.1158/1538-7445.AM2020-1790 Barrett, 2015, Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer, Oncotarget, 6, 26483, 10.18632/oncotarget.4494 Balko, 2016, Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence, Sci Transl Med, 8, 10.1126/scitranslmed.aad3001 Oechsle, 2010, Prognostic factors and treatment options in patients with leptomeningeal metastases of different primary tumors: a retrospective analysis, J Cancer Res Clin Oncol, 136, 1729, 10.1007/s00432-010-0831-x Cohen, 2016, Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment, Cancer Immunol Res, 4, 179, 10.1158/2326-6066.CIR-15-0160 Kluger, 2019, Long-Term Survival of Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab on a Phase II Trial, J Clin Oncol, 37, 52, 10.1200/JCO.18.00204 Hendriks, 2019, Outcome of Patients with Non-Small Cell Lung Cancer and Brain Metastases Treated with Checkpoint Inhibitors, J Thorac Oncol, 14, 1244, 10.1016/j.jtho.2019.02.009 Hubbeling, 2018, Safety of Combined PD-1 Pathway Inhibition and Intracranial Radiation Therapy in Non-Small Cell Lung Cancer, J Thorac Oncol, 13, 550, 10.1016/j.jtho.2018.01.012 Goldberg, 2020, Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial, Lancet Oncol, 21, 655, 10.1016/S1470-2045(20)30111-X Eguren-Santamaria, 2020, PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice, Clin Cancer Res, 26, 4186, 10.1158/1078-0432.CCR-20-0798 Nakashima, 2020, Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival, Intern Med, 59, 1433, 10.2169/internalmedicine.4232-19 Schmid, 2018, Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer, N Engl J Med, 379, 2108, 10.1056/NEJMoa1809615 Schmid, 2020, Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial, Lancet Oncol, 21, 44, 10.1016/S1470-2045(19)30689-8 Schmid, 2017, Abstract 2986: Atezolizumab in metastatic TNBC (mTNBC): Long-term clinical outcomes and biomarker analyses, Cancer Res, 77, 2986, 10.1158/1538-7445.AM2017-2986 Duchnowska, 2016, Immune response in breast cancer brain metastases and their microenvironment: the role of the PD-1/PD-L axis, Breast Cancer Res, 18, 43, 10.1186/s13058-016-0702-8 Dirix LY, Takacs I, Jerusalem G, et al. Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study. Breast Cancer Res Treat. 2018;167(3):671-86. Nanda R, Chow LQ, Dees EC, et al. Pembrolizumab in patients with advanced triple-negative breast cancer: phase Ib KEYNOTE-012 study. J Clin Oncol. 2016;34(21):2460. Rugo HS, Delord JP, Im SA, et al. Safety and antitumor activity of pembrolizumab in patients with estrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer. Clin Cancer Res. 2018;24(12):2804-11. Tolaney, 2020, A phase Ib/II study of eribulin (ERI) plus pembrolizumab (PEMBRO) in metastatic triple-negative breast cancer (mTNBC)(ENHANCE 1), J Clin Oncol, 38, 1015, 10.1200/JCO.2020.38.15_suppl.1015 Adams, 2017, Phase 2 study of pembrolizumab as first-line therapy for PD-L1–positive metastatic triple-negative breast cancer (mTNBC): Preliminary data from KEYNOTE-086 cohort B, J Clin Oncol, 35, 1088, 10.1200/JCO.2017.35.15_suppl.1088 Cortés J, Lipatov O, Im SA, et al. KEYNOTE-119: Phase III study of pembrolizumab (pembro) versus single-agent chemotherapy (chemo) for metastatic triple negative breast cancer (mTNBC). Ann Oncol. 2019;30:v859-v60. Miles D, Gligorov J, André F, et al. LBA15 Primary results from IMpassion131, a double-blind placebo-controlled randomised phase III trial of first-line paclitaxel (PAC)±atezolizumab (atezo) for unresectable locally advanced/metastatic triple-negative breast cancer (mTNBC). Ann Oncol. 2020;31:S1147-S1148. Cortes, 2020, KEYNOTE-355: Randomized, double-blind, phase III study of pembrolizumab+ chemotherapy versus placebo+ chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer, J Clin Oncol, 35, 1000, 10.1200/JCO.2020.38.15_suppl.1000 Cortes, 2020, Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial, Lancet, 396, 1817, 10.1016/S0140-6736(20)32531-9