Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

Springer Science and Business Media LLC - Tập 6 - Trang 275-279 - 2012
Shuangwei Li1, Diane DiFang Hsu1, Hongyang Wang2, Gen-Sheng Feng1
1Department of Pathology, and Division of Biological Sciences, University of California San Diego, La Jolla, USA
2Laboratory of Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, Shanghai, China

Tóm tắt

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.

Tài liệu tham khảo

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