Drugs in the Management of Cute Traumatic Brain Injury

Ramesh Raghupathi1, Tracy K. McIntosh1
1The Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Tài liệu tham khảo

Altura, 1982, The role of magnesium in the etiology of strokes and cerebro-vasospasm, Magnesium, 1, 277 Ashford, 1935, The effect of potassium on the glycolysis of brain tissue with reference to the Pasteur effect, Biochem, 29, 157 Baker, 1993, Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans, J Neurosurg, 79, 369, 10.3171/jns.1993.79.3.0369 Baron, 1994, Ultrastructural features of a brain injury model in the cat. I. Vascular and neurological changes and the prevention of astroglial swelling by L-644,711, Acta Neuropathol, 39, 340 Biagas, 1992, Assessment of post-traumatic polymorphonu-clear leukocyte accumulation in rat brain using tissue myeloperoxidase assay and vinblastine treatment, J Neurotrauma, 9, 363, 10.1089/neu.1992.9.363 Bodie, 1993, A selective N-channel calcium blocker attenuates the injury-induced accumulation of calcium following experimental traumatic brain injury, J Neurotrauma, 10, 161 Bornstein, 1946, Presence and action of acetylcholine in experimental brain trauma, J Neurophysiol (Abstr), 9, 349, 10.1152/jn.1946.9.5.349 Bourke, 1979, Studies on the formation of astroglial swelling and its inhibition by clinically useful agents, 95 Bourke, 1975, The effect of HCO 3 on the swelling and ion uptake of monkey cerebral cortex under conditions of raised extracellular potassium, J Neurochem, 25, 323, 10.1111/j.1471-4159.1975.tb06974.x Braakman, 1983, Megadose steroids in severe head injury, J Neurosurg, 58, 326, 10.3171/jns.1983.58.3.0326 Braughler, 1987, Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation, J Biol Chem, 262, 10434, 10.1016/S0021-9258(18)60979-2 Cavaliere, 1985, Varazioni del magnesio slerico ed urinario in pazienti traumatizzati cranici, Recenti Prog Med, 76, 563 Chan, 1992, Antioxidant-dependent amelioration of brain injury: Role of CuZn-superoxide dismutase, J Neurotrauma, 9, S417 Choi, 1987, Ionic dependence of glutamate neurotoxicity, J Neurosci, 7, 369, 10.1523/JNEUROSCI.07-02-00369.1987 Choi, 1987, Glutamate neurotoxicity in cortical cell culture, J Neurosci, 7, 357, 10.1523/JNEUROSCI.07-02-00357.1987 Choi, 1989, Effects of dynorphin on NMDA-induced neurotoxicity in cortical cell culture, Neurosci Abstr, 2, 11 Clifton, 1981, Neuropathology of early and late deaths after head injury, Neurosurgery, 8, 309, 10.1227/00006123-198103000-00002 Clifton, 1993, A phase II study of moderate hypothermia in severe brain injury, J Neurotrauma, 10, 263, 10.1089/neu.1993.10.263 Clifton, 1991, Marked protection by moderate hypothermia after experimental traumatic brain injury, J Cereb Blood Flow Metab, 11, 114, 10.1038/jcbfm.1991.13 Compton, 1990, A double-blind placebo controlled trial of the calcium entry blocking drug nicardipine in the treatment of vasospasm following severe head injury, Br J Neurosurg, 4, 9, 10.3109/02688699009000676 Corkey, 1986, Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria, J Biol Chem, 261, 2567, 10.1016/S0021-9258(17)35825-8 Cragoe, 1987, Drugs for the treatment of traumatic brain injury, Med Res Rev, 7, 271, 10.1002/med.2610070302 Dail, 1981, Responses to cortical injury. II. Widespread depression of the activity of an enzyme in cortex remote from focal injury, Brain Res, 211, 79, 10.1016/0006-8993(81)90068-8 DeSalles, 1987, Intra- and extracellular pH and extracellular potassium following mechanical brain injury in the cat, J Cereb Blood Flow Metab, 7, S627 DeWitt, 1988, Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats, J Neurotrauma, 5, 303, 10.1089/neu.1988.5.303 Dietrich, 1994, Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat, Acta Neuropathol (Berlin), 87, 250, 10.1007/BF00296740 Ebel, 1980, Magnesium metabolism: A review, Journal of Clinical Chemistry and Clinical Biochemistry, 8, 257 Ellis, 1987, Inhibition of bradykinin-and kallikrein-induced cerebral arteriolar dilation by a specific bradykinin antagonist, Stroke, 18, 792, 10.1161/01.STR.18.4.792 Faden, 1992, Dynorphin increases extracellular levels of excitatory amino acids in the brain through a nonopioid mechanism, J Neurosci, 12, 425, 10.1523/JNEUROSCI.12-02-00425.1992 Faden, 1989, The role of excitatory amino acids and NMDA receptors in traumatic brain injury, Science, 244, 798, 10.1126/science.2567056 Feeney, 1981, Responses to cortical injury. I. Methodology and local effects of contusions in the rat, Brain Res, 211, 67, 10.1016/0006-8993(81)90067-6 Gentile, 1993, Cognitive and neurologic functions and hippocampal neuronal loss after nimodipine in fluid percussion brain injury [abstract], J Neurotrauma, 10, S193 Gianotta, 1984, High dose glucocorticoids in the management of severe head injury, Neurosurgery, 15, 497, 10.1227/00006123-198410000-00004 Goldstein, 1990, Traumatic brain injury: A silent epidemic, Ann Neurol, 27, 327, 10.1002/ana.410270315 Goodman, 1990, Elevation of tumor necrosis factor in head injury, J Neuroimmunol, 30, 213, 10.1016/0165-5728(90)90105-V Hall, 1985, Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: Comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase, J Neurotrauma, 2, 75 Hall, 1988, Effects of the 21-aminosteroid U74006F on post-traumatic spinal cord ischemia in cats, J Neurosurg, 68, 462, 10.3171/jns.1988.68.3.0462 Hall, 1986, A pharmacological analysis of the pathophysiological mechanisms of post-traumatic spinal cord ischemia, J Neurosurg, 64, 951, 10.3171/jns.1986.64.6.0951 Hamill, 1987, Catecholamines predict outcome in traumatic brain injury, Ann Neurol, 212, 438, 10.1002/ana.410210504 Hansen, 1978, The extracellular potassium concentration in brain cortex following ischemia in hypo- and hyperglycemic rats, Acta Physiol Scand, 102, 324, 10.1111/j.1748-1716.1978.tb06079.x Hashimoto, 1979, The role of extracellular potassium in early epilepsy, Neurol Res, 1, 39, 10.1080/01616412.1979.11739540 Hayes, 1987, Pretreatment with phencyclidine (PCP) attenuates long-term behavioral deficits following concussive brain injury in the rat, Society of Neuroscience Abstracts Abstr, 13, 1254 Hayes, 1983, Effects of naloxone on systemic and cerebral responses to experimental concussive brain injury in cats, J Neurosurg, 58, 720, 10.3171/jns.1983.58.5.0720 Hayes, 1988, Pretreatment with phencyclidine, an N-methyl-D-aspartate antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury, J Neurotrauma, 5, 259, 10.1089/neu.1988.5.259 Hayes, 1990, Possible protective effect of endogenous opioids in traumatic brain injury, J Neurosurg, 72, 252, 10.3171/jns.1990.72.2.0252 Hayes, 1986, Metabolic and neurophysiologic sequelae of brain injury: A cholinergic hypothesis, J Neurotrauma, 3, 163 Heizer, 1988, Increased extravascular kininogen following experimental fluid percussion brain injury, FASEB J, 2, A1519 Hicks, 1994, Kynurenate is neuroprotective following experimental brain injury in the rat, Brain Res, 655, 91, 10.1016/0006-8993(94)91601-2 Hovda, 1991, Intracellular calcium accumulates for at least 48 hours following fluid percussion brain injury in the rat, Proc Am Assoc Neurol Surg Abstr, 1, 452 Hylton, 1995, Non-NMDA antagonist GYKI 52466 enhances spatial memory after experimental brain injury [abstract], J Neurotrauma, 12, 124 Isaac, 1989, Dynorphin-induced neurotoxicity is blocked by pretreatment or post-treatment with MK-801, Neurosci Abstr, 15, 762 Isaac, 1990, MK-801 blocks dynorphin A (l-13)-induced loss of the tail-flick reflex in the rat, Brain Res, 531, 83, 10.1016/0006-8993(90)90760-9 Jennett, 1981, Management of Head Injuries, 20 Jiang, 1992, Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat, Acta Neuropathol, 84, 495, 10.1007/BF00304468 Johnson, 1992, Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning, Neurobiol Aging, 13, 641, 10.1016/0197-4580(92)90086-D Kaczorowski, 1993, Effect of sCr-1 on brain polymorphonuclear leukocyte accumulation after brain injury in rats, Presented at the 11th Annual Neurotrauma Symposium Kampfl, 1996, μ Calpain activation and calpain mediated cytoskeletal proteolysis following traumatic brain injury, J Neurochem, 67, 1575, 10.1046/j.1471-4159.1996.67041575.x Katayama, 1990, Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury, J Neurosurg, 73, 889, 10.3171/jns.1990.73.6.0889 Katayama, 1989, Ion fluxes and cell swelling in experimental traumatic brain injury: The role of excitatory amino acids, 584 Kawamata, 1992, Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury, J Cereb Blood Flow Metab, 12, 12, 10.1038/jcbfm.1992.3 Kimelberg, 1979, Glial enzymes and ion transport in brain swelling, 137 Kimelberg, 1982, Swelling of astroglia after injury to the central nervous system, 31 Kimelberg, 1987, Improved recovery from a traumatic hypoxic brain injury in cats by intracisternal injection of an ion transport inhibitor, J Neurotrauma, 4, 3 Kleckner, 1988, Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes, Science, 241, 835, 10.1126/science.2841759 Kontos, 1989, Oxygen radicals in central nervous system damage, Chem Biol Interact, 72, 229, 10.1016/0009-2797(89)90001-X Kontos, 1986, Oxygen radicals in brain injury, Central Nervous System Trauma Report, 3, 257, 10.1089/cns.1986.3.257 Kontos, 1985, Appearance of superoxide radical in cerebral extracellular space during increased prostaglandin synthesis in cats, Circ Res, 57, 142, 10.1161/01.RES.57.1.142 Kostron, 1985, Treatment of cerebrovasospasm following severe head injury with the calcium channel influx blocker nimodipine, Acta Neurochir (Wein), 28, 103 Lemke, 1990, Decrease in tissue levels of ubiquino-9 and -10, ascorbate and α-tocopherol following spinal cord impact trauma in rats, Neurosci Lett, 108, 201, 10.1016/0304-3940(90)90731-N Leslie, 1985, Eicosanoids in the central nervous system, J Neurosurg, 63, 659, 10.3171/jns.1985.63.5.0659 Lyeth, 1988, Effects of anticholinergic treatment on transient behavioral suppression and physiological responses following concussive brain injury to the rat, Brain Res, 488, 88, 10.1016/0006-8993(88)91104-3 Lyeth, 1988, Effects of scopolamine treatment on longterm behavioral deficits following concussive brain injury to the rat, Brain Res, 452, 39, 10.1016/0006-8993(88)90006-6 Lyeth, 1992, Cholinergic and opioid mediation of traumatic brain injury, J Neurotrauma, 9, S463 Lyeth, 1993, Behavioral protection by moderate hypothermia initiated after experimental traumatic brain injury, J Neurotrauma, 10, 57, 10.1089/neu.1993.10.57 Marion, 1993, The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report, J Neurosurg, 79, 354, 10.3171/jns.1993.79.3.0354 McClain, 1991, Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury, J Lab Clin Med, 118, 225 McIntosh, 1988, Opiate antagonists in CNS injury, 89 McIntosh, 1991, The effects of naloxone hydrochloride treatment after experimental traumatic brain injury in the rat, J Cereb Blood Flow Metab, 9, S734 McIntosh, 1987, Endogenous opioids may mediate secondary damage after experimental brain injury, Am J Physiol, 253, E565 McIntosh, 1987, Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat, Brain Res, 425, 225, 10.1016/0006-8993(87)90505-1 McIntosh, 1988, Exacerbation of traumatic brain injury following central administration of kappaopiate receptor agonists [abstract], Neurosci Abstr, 14, 1152 McIntosh, 1992, The novel 21-aminosteroid U74006F attenuates cerebral edema and improves survival after brain injury in the rat, J Neurotrauma, 9, 33, 10.1089/neu.1992.9.33 McIntosh, 1987, Alterations in free magnesium, high-energy phosphates and lactate following traumatic brain injury: Assessment by nuclear magnetic resonance spectroscopy, J Cereb Blood Flow Metab, 7, S620 McIntosh, 1988, Magnesium deficiency exacerbates and pretreatment improves outcome following traumatic brain injury in rats. 31P Magnetic resonance spectroscopy and behavioral studies, J Neurotrauma, 5, 17, 10.1089/neu.1988.5.17 McIntosh, 1989, Magnesium protects against neurological deficit after brain injury, Brain Res, 482, 252, 10.1016/0006-8993(89)91188-8 McIntosh, 1995, Riluzole, a compound that interferes with glutamate neurotransmission, improves cognitive deficits following experimental brain injury in rats [abstract], J Neurotrauma, 12, 379 McIntosh, 1989, Alterations in regional brain catecholamine concentrations after experimental brain injury [abstract], J Cereb Blood Flow Metab, 9, 578 Meldrum, 1992, Reduction of glutamate release and protection against ischemic brain damage by BW1003C87, Brain Res, 593, 1, 10.1016/0006-8993(92)91254-C Miller, 1986, Lamotrigine, 165 Miller, 1990, Excitatory amino acid receptor subtype binding following traumatic brain injury, Brain Res, 526, 103, 10.1016/0006-8993(90)90254-9 Morganti-Kossmann, 1992, Cytokines and neuropathology, Trends Pharmacol Sci, 13, 286, 10.1016/0165-6147(92)90087-M Muizelaar, 1993, Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycolconjugated superoxide dismutase: A phase II trial, J Neurosurg, 78, 375, 10.3171/jns.1993.78.3.0375 Murphy, 1988, Characterization of the binding of [3H]-CGS 19755: A novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain, Br J Pharmacol, 95, 932, 10.1111/j.1476-5381.1988.tb11723.x Nigam, 1986, Alteration of prostanoid metabolism in rats with magnesium deficiency, Prostaglandins Leukot Essent Fatty Acids, 223, 1 Nilsson, 1993, Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats, J Cereb Blood Flow Metab, 13, 183, 10.1038/jcbfm.1993.22 Nilsson, 1990, Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats, J Cereb Blood Flow Metab, 10, 631, 10.1038/jcbfm.1990.115 Nowak, 1984, Magnesium gates glutamate-activated channels in mouse central neurons, Nature, 307, 462, 10.1038/307462a0 Okiyama, 1994, (S)-Emopamil attenuates regional cerebral blood flow reduction following experimental brain injury, J Neurotrauma, 11, 83, 10.1089/neu.1994.11.83 Okiyama, 1995, The sodium channel blocker and glutamate release inhibitor BW1003C87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat, J Neurochem, 64, 802, 10.1046/j.1471-4159.1995.64020802.x Okiyama, 1992, Evaluation of a novel calcium channel blocker (S)-emopamil on regional cerebral edema and neurobehavioral function after experimental brain injury, J Neurosurg, 77, 607, 10.3171/jns.1992.77.4.0607 Olney, 1971, Cytotoxic effects of acidic and sulphurcontaining amino acid on the infant mouse central nervous system, Exp Brain Res, 14, 61, 10.1007/BF00234911 Olney, 1989, Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs, Science, 244, 1360, 10.1126/science.2660263 Palmer, 1993, Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model, J Neurochem, 61, 2015, 10.1111/j.1471-4159.1993.tb07437.x Panter, 1992, Dextrancoupled deferoxamine improves outcome in a murine model of head injury, J Neurotrauma, 9, 47, 10.1089/neu.1992.9.47 Panter, 1992, Pretreatment with the NMDA antagonists limits release of excitatory amino acids following traumatic brain injury, Neurosci Lett, 136, 165, 10.1016/0304-3940(92)90040-E Pappius, 1987, Effects of injury on the indoleamines in cerebral cortex, J Neurochem, 49, 321, 10.1111/j.1471-4159.1987.tb03433.x Pappius, 1983, Effects of indomethacin and ibuprofen on cerebral metabolism and blood flow in traumatized brain, J Cereb Blood Flow Metab, 3, 448, 10.1038/jcbfm.1983.71 Pappius, 1983, Functional disturbances in brain following injury, Neurochem Res, 8, 63, 10.1007/BF00965654 Piek, 1992, Extracranial complications of severe head injury, J Neurosurg, 77, 901, 10.3171/jns.1992.77.6.0901 Prasad, 1992, Decreased alpha-adrenergic receptors after experimental brain injury, J Neurotrauma, 9, 269, 10.1089/neu.1992.9.269 Quattrocchi, 1990, Suppression of cellular immune activity following severe head injury, J Neurotrauma, 7, 77, 10.1089/neu.1990.7.77 Quattrocchi, 1992, Impairment of helper T-cell function following severe head injury, J Neurotrauma, 9, 1, 10.1089/neu.1992.9.1 Robichaud, 1990, Cold injury, blood brain barrier changes and leukotriene synthesis: Inhibition by phenidone, J Neurotrauma Abstr, 7, 193, 10.1089/neu.1990.7.193 Romhanyi, 1990, Catecholaminergic stimulation enhances recovery of function following concussive brain injury, J Neurotrauma, 9, 164 Rothman, 1987, Excitotoxicity and the NMDA receptor, Trends Neurosci, 10, 299, 10.1016/0166-2236(87)90177-9 Ruge, 1945, The use of cholinergic blocking agents in the treatment of craniocerebral injuries, J Neurosurg, 11, 77, 10.3171/jns.1954.11.1.0077 Saatman, 1996, Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat, J Neuropathol Exp Neurol, 55, 850, 10.1097/00005072-199607000-00010 Saatman, 1996, The calpain inhibitor AK295 improves outcome following experimental brain injury, Proc Natl Acad Sci USA, 93, 3428, 10.1073/pnas.93.8.3428 Sadee, 1982, Opiate receptor: Multiple effects of metalions, J Neurochem, 39, 659, 10.1111/j.1471-4159.1982.tb07943.x Saija, 1988, The effect of concussive head injury' on central cholinergic neurons, Brain Res, 452, 303, 10.1016/0006-8993(88)90034-0 Sanada, 1993, Effect of U74006F on neurologic function and brain edema after fluid percussion injury in rats, J Neurotrauma, 10, 65, 10.1089/neu.1993.10.65 Schoettle, 1990, Early polymorphonuclear leukocyte accumulation correlates with the development of post-traumatic cerebral edema in rats, J Neurotrauma, 7, 207, 10.1089/neu.1990.7.207 Shapira, 1993, Ketamine alters calcium and magnesium in brain tissue following experimental head trauma in rats, J Cereb Blood Flow Metab, 13, 962, 10.1038/jcbfm.1993.120 Shapira, 1989, Accumulation of calcium in the brain following head trauma, Neurol Res, 11, 169, 10.1080/01616412.1989.11739885 Shapira, 1990, Protective effect of MK-801 in experimental brain injury, J Neurotrauma, 7, 131, 10.1089/neu.1990.7.131 Shohami, 1996, Inhibition of tumor necrosis factor alpha (TNFa) activity in rat brain is associated with cerebroprotection after closed head injury, J Cereb Blood Flow Metab, 16, 378, 10.1097/00004647-199605000-00004 Shohami, 1993, A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat, J Neurotrauma, 10, 109, 10.1089/neu.1993.10.109 Shohami, 1988, Experimental closed head injury in rats: Prostaglandin production in a noninjured zone, Neurosurgery, 22, 859, 10.1227/00006123-198805000-00007 Siesjö, 1981, Cell damage to the brain: A speculative hypothesis, J Cereb Blood Flow Metab, 1, 155, 10.1038/jcbfm.1981.18 Siesjö, 1985, Brain injury: Neurochemical aspects, 513 Smith, 1993, Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury, Neurosci Lett, 157, 211, 10.1016/0304-3940(93)90739-8 Smith, 1993, Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury, J Neurosci, 13, 5383, 10.1523/JNEUROSCI.13-12-05383.1993 Smith, 1990, Differential effects of competitive and noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists in experimental brain injury [abstract], FASEB J, 4, 773 Sosin, 1995, Trends in death associated with traumatic brain injury, 1979 through 1992, JAMA, 273, 1778, 10.1001/jama.1995.03520460060036 Stein, 1991, Intracerebral administration of a-tocopherol-containing liposomes facilitates behavioral recovery in rats with bilateral lesions of the frontal cortex, J Neurotrauma, 8, 281, 10.1089/neu.1991.8.281 Taft, 1993, Hypothermia attenuates the loss of hippocampal microtubule-associated protein 2 (MAP2) following traumatic brain injury, J Cereb Blood Flow Metab, 13, 796, 10.1038/jcbfm.1993.101 Takahashi, 1981, Changes in extracellular potassium concentration in cortex and brain stem during the acute phase of experimental closed head injury, J Neurosurg, 55, 708, 10.3171/jns.1981.55.5.0708 Takahashi, 1990, Calpain substrate specificity, 55 Tandian, 1990, Amphetamine enhances both behavior and metabolic recovery following fluid percussion brain injury, J Neurotrauma, 9, 174 Teasdale, 1991, A randomized trial of nimodipine in severe head injury: HIT 1, J Neurotrauma, 37, S545 Thomas, 1990, Effects of experimental brain injury on regional cation homeostasis [abstract], Neurosci Abstr, 16, 777 Toulmond, 1995, Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat, Brain Res, 671, 261, 10.1016/0006-8993(94)01343-G Toulmond, 1993, Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window, Brain Res, 620, 32, 10.1016/0006-8993(93)90267-Q Tower, 1948, Acetylcholine and neuronal activity in craniocerebral trauma, J Clin Invest, 27, 558 Vink, 1987, Decrease in total and free magnesium concentration following traumatic brain injury in rats, Biochem Biophys Res Commun, 149, 594, 10.1016/0006-291X(87)90409-8 Vink, 1988, Decline in intracellular free Mg2+ is associated with irreversible tissue injury following brain trauma, J Biol Chem, 263, 757, 10.1016/S0021-9258(19)35418-3 Vink, 1990, Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state and neurological outcome following traumatic brain injury in rats, J Neurosci, 10, 3524, 10.1523/JNEUROSCI.10-11-03524.1990 Vink, 1991, κ-Opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury, Am J Physiol, 261, R1527 Voddi, 1996, The pre-synaptic glutamate release inhibitor BW619C89 attenuates memory dysfunction following experimental brain injury, J Neurotrauma Wei, 1982, Increased phospholipase C activity after experimental brain injury, J Neurosurg, 56, 695, 10.3171/jns.1982.56.5.0695 West, 1981, Cerebral concussion in rats rapidly induces hypothalamic specific effects on opiate and cholinergic receptors, Brain Res, 225, 271, 10.1016/0006-8993(81)90835-0 Wolfe, 1979, The role of prostaglandins in the central nervous system, Ann Rev Physiol, 41, 669, 10.1146/annurev.ph.41.030179.003321 Woodroofe, 1991, Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: Evidence of a role for microglia in cytokine production, J Neuroimmunol, 33, 227, 10.1016/0165-5728(91)90110-S Woolf, 1987, The predictive value of catecholamines in assessing outcome in traumatic brain injury, J Neurosurg, 66, 875, 10.3171/jns.1987.66.6.0875 Yan, 1992, Expression of interleukin (IL)-lß, IL-6 and their respective receptors in the normal rat brain and after injury, Eur J Immunol, 22, 2693, 10.1002/eji.1830221131 Yergey, 1990, Brain eicosanoid formation following acute penetration injury as studied by in vivo microdialysis, J Cereb Blood Flow Metab, 10, 143, 10.1038/jcbfm.1990.20 Young, 1987, The post-injury response in trauma and ischemia. Secondary injury or protective mechanisms?, Central Nervous System Trauma Report, 4, 27, 10.1089/cns.1987.4.27 Young, 1985, The role of calcium in spinal cord injury, Central Nervous System Trauma Report, 2, 109, 10.1089/cns.1985.2.109