Drug transport by Organic Anion Transporters (OATs)

Pharmacology & Therapeutics - Tập 136 Số 1 - Trang 106-130 - 2012
Gerhard Burckhardt1
1Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Universitätsmedizin Göttingen, Humboldtallee 23, 37073, Göttingen, Germany

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Aherne, 1978, The interaction between methotrexate and probenecid in man, Br J Pharmacol, 63, 369P

Ahn, 2009, Interaction of organic cations with organic anion transporters, J Biol Chem, 284, 31422, 10.1074/jbc.M109.024489

Aleboyeh, 2003, Expression of human organic anion transporter in the choroid plexus and their interactions with neurotransmitter metabolites, J Pharmacol Sci, 93, 430, 10.1254/jphs.93.430

Aleksunes, 2008, Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment, Toxicology, 250, 82, 10.1016/j.tox.2008.06.009

Anzai, 2005, Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules, J Pharmacol Exp Ther, 315, 534, 10.1124/jpet.105.088583

Anzai, 2004, The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus, J Biol Chem, 279, 45942, 10.1074/jbc.M406724200

Apiwattanakul, 1999, Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes, Mol Pharmacol, 55, 847

Asif, 2005, Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells, Pflügers Arch. - Eur J Physiol, 450, 88, 10.1007/s00424-004-1373-3

Augustine, 2005, Xenobiotic and endobiotic transporter mRNA expression in the blood–testis barrier, Drug Metab Dispos, 33, 182, 10.1124/dmd.104.001024

Babu, 2002, Role of human organic anion transporter 4 in the transport of ochratoxin A, Biochim Biophys Acta, 1590, 64, 10.1016/S0167-4889(02)00187-8

Babu, 2002, Human organic anion transporters mediate the transport of tetracycline, Jpn J Pharmacol, 88, 69, 10.1254/jjp.88.69

Bahn, 2004, Expression studies and functional characterization of renal human organic anion transporter 1 isoforms, Drug Metab Dispos, 32, 424, 10.1124/dmd.32.4.424

Bahn, 2008, Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13), J Biol Chem, 283, 16332, 10.1074/jbc.M800737200

Bahn, 2002, Interaction of the metal chelator 2,3-dimercapto-1-propane sulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1), Mol Pharmacol, 62, 1128, 10.1124/mol.62.5.1128

Bahn, 2005, Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites, Am J Physiol Cell Physiol, 289, C1075, 10.1152/ajpcell.00619.2004

Bahn, 2000, Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene, Biochem Biophys Res Commun, 275, 623, 10.1006/bbrc.2000.3230

Bakhiya, 2003, Human organic anion transporter 3 (hOAT3) can operate as an exchanger accepting urate as a substrate, Cell Physiol Biochem, 13, 249, 10.1159/000074539

Barros, 2009, Activation of protein kinase Cζ increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport, J Biol Chem, 284, 2672, 10.1074/jbc.M808078200

Bleasby, 2006, Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition, Xenobiotica, 36, 963, 10.1080/00498250600861751

Bleasby, 2005, Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6), J Pharmacol Exp Ther, 314, 923, 10.1124/jpet.105.084301

Bow, 2006, The impact of plasma protein binding on the renal transport of organic anions, J Pharmacol Exp Ther, 316, 349, 10.1124/jpet.105.093070

Brady, 1999, A novel putative transporter maps top the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse, Genomics, 56, 254, 10.1006/geno.1998.5722

Brandoni, 2006, Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3, Biochim Biophys Acta, 1762, 673, 10.1016/j.bbadis.2006.05.011

Brandoni, 2003, Compensation increase in organic anion excretion in rats with acute biliary obstruction: role of the renal organic anion transporter 1, Pharmacology, 68, 57, 10.1159/000069529

Brandoni, 2006, Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction, Hepatology, 43, 1092, 10.1002/hep.21142

Buist, 2002, Gender-specific and developmental influences on the expression of rat organic anion transporters, J Pharmacol Exp Ther, 301, 145, 10.1124/jpet.301.1.145

Buist, 2003, Endocrine regulation of rat organic anion transporters, Drug Metab Dispos, 31, 559, 10.1124/dmd.31.5.559

Buist, 2004, Rat and mouse differences in gender-predominant expression of organic anion transporter (OAT1-3, SLC22A6-8) mRNA levels, Drug Metab Dispos, 32, 620, 10.1124/dmd.32.6.620

Burckhardt, 2003, Transport of cimetidine by flounder and human renal organic anion transporter 1, Am J Physiol Renal Physiol, 284, F503, 10.1152/ajprenal.00290.2002

Burckhardt, 2003, Transport of organic anions across the basolateral membrane of proximal tubule cells, Rev Physiol Biochem Pharmacol, 146, 95, 10.1007/s10254-002-0003-8

Burckhardt, 2011, In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy, 29

Cha, 2001, Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney, Mol Pharmacol, 59, 1277, 10.1124/mol.59.5.1277

Cha, 2000, Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta, J Biol Chem, 275, 4507, 10.1074/jbc.275.6.4507

Chen, 2008, Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis, Am J Physiol Renal Physiol, 295, F247, 10.1152/ajprenal.00139.2008

Cheng, 2012, Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs, Drug Metab Dispos, 40, 618, 10.1124/dmd.111.042036

Cheong, 2005, Mutational analysis of idiopathic renal hypouricemia, Pediatr Nephrol, 20, 886, 10.1007/s00467-005-1863-3

Chu, 2007, Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein, J Pharmacol Exp Ther, 321, 673, 10.1124/jpet.106.116517

Cihlar, 2000, Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1, Anal Biochem, 283, 49, 10.1006/abio.2000.4633

Cihlar, 1999, The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1, Mol Pharmacol, 56, 570, 10.1124/mol.56.3.570

Cropp, 2008, Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP, Mol Pharmacol, 73, 1151, 10.1124/mol.107.043117

Cundy, 1995, Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients, Antimicrob Agents Chemother, 39, 1247, 10.1128/AAC.39.6.1247

Cunningham, 2007, Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport, J Am Soc Nephrol, 18, 1419, 10.1681/ASN.2006090980

Deguchi, 2004, Characterization of uremic toxin transport by organic anion transporters in the kidney, Kidney Int, 65, 162, 10.1111/j.1523-1755.2004.00354.x

Di Giusto, 2008, Elimination of organic anions in response to an early stage of renal ischemia–reperfusion in the rat: role of basolateral plasma transporters and cortical renal blood flow, Pharmacology, 81, 127, 10.1159/000110555

Di Giusto, 2009, Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury, J Histochem Cytochem, 57, 17, 10.1369/jhc.2008.951582

Dinour, 2011, URAT1 mutations cause renal hypouricemia type 1 in Iraqui Jews, Nephrol Dial Transplant, 26, 2175, 10.1093/ndt/gfq722

Ekaratanawong, 2004, Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules, J Pharmacol Sci, 94, 297, 10.1254/jphs.94.297

Enomoto, 2005, Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human diseases, Clin Exp Nephrol, 9, 195, 10.1007/s10157-005-0368-5

Enomoto, 2002, Molecular identification of a renal urate-anion exchanger that regulates blood urate levels, Nature, 417, 447, 10.1038/nature742

Enomoto, 2002, Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors, J Pharmacol Exp Ther, 301, 797, 10.1124/jpet.301.3.797

Enomoto, 2003, Interactions of human organic anion as well as cation transporters with indoxyl sulfate, Eur J Pharmacol, 466, 13, 10.1016/S0014-2999(03)01530-9

Enomoto, 2002, Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity, J Am Soc Nephrol, 13, 1711, 10.1097/01.ASN.0000022017.96399.B2

Eraly, 2003, Novel aspects of renal organic anion transporters, Curr Opin Nephrol Hypertens, 12, 551, 10.1097/00041552-200309000-00011

Eraly, 2003, Organic anion and cation transporters occur in pairs of similar and similarly expressed genes, Biochem Biophys Res Commun, 300, 333, 10.1016/S0006-291X(02)02853-X

Eraly, 2002, Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters, Biochem Biophys Res Commun, 297, 1159, 10.1016/S0006-291X(02)02343-4

Eraly, 2006, Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice, J Biol Chem, 281, 5072, 10.1074/jbc.M508050200

Erdman, 2005, The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics, Am J Physiol Renal Physiol, 290, 905, 10.1152/ajprenal.00272.2005

Feng, 2001, Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3, Biochemistry, 40, 5511, 10.1021/bi002841o

Feng, 2002, Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition, Biochemistry, 41, 8941, 10.1021/bi0200615

Fork, 2011, OAT2 catalysis efflux of glutamate and uptake of orotic acid, Biochem J, 436, 305, 10.1042/BJ20101904

Frenia, 1992, Methotrexate and non-steroidal antiinflammatory drug interactions, Ann Pharmacother, 26, 234, 10.1177/106002809202600219

Fujita, 2005, Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1), Pharmacogenet Genomics, 15, 201, 10.1097/01213011-200504000-00003

Gopal, 2004, Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate, J Biol Chem, 279, 44522, 10.1074/jbc.M405365200

Groves, 2006, Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules, J Pharmacol Exp Ther, 316, 743, 10.1124/jpet.105.094979

Habu, 2005, Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney, Biochem Pharmacol, 69, 993, 10.1016/j.bcp.2004.12.004

Hagos, 2002, Cloning of the pig renal organic anion transporter 1 (pOAT1), Biochimie, 84, 1221, 10.1016/S0300-9084(02)00022-6

Hagos, 2007, Torasemide transport by organic anion transporters contributes to hyperuricemia, J Am Soc Nephrol, 18, 3101, 10.1681/ASN.2007010106

Hagos, 2005, Functional expression of pig renal organic anion transporter 3 (pOAT3), Biochimie, 87, 421, 10.1016/j.biochi.2005.01.006

Hagos, 2007, Human renal organic anion transporter 4 (hOAT4) operates as an asymmetric urate transporter, J Am Soc Nephrol, 18, 430, 10.1681/ASN.2006040415

Hasannejad, 2003, Interactions of human organic anion transporters with diuretics, J Pharmacol Exp Ther, 308, 1021, 10.1124/jpet.103.059139

Hasegawa, 2003, Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat, J Pharmacol Exp Ther, 305, 1087, 10.1124/jpet.102.046847

Hasegawa, 2002, Functional involvement of rat organic anion transporter 3 (rOAT3; Slc22a8) in the uptake of organic anions, J Pharmacol Exp Ther, 300, 746, 10.1124/jpet.300.3.746

Hashimoto, 2004, Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters, Drug Metab Dispos, 32, 1096, 10.1124/dmd.32.10.1096

Hediger, 2005, Molecular physiology of urate transport, Physiology, 20, 125, 10.1152/physiol.00039.2004

Hilgendorf, 2007, Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines, Drug Metab Dispos, 35, 1333, 10.1124/dmd.107.014902

Ho, 2000, Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1, J Am Soc Nephrol, 11, 383, 10.1681/ASN.V113383

Höcherl, 2009, COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the renal cortex, Kidney Int, 75, 373, 10.1038/ki.2008.557

Homeida, 1977, Influence of probenecid and spironolacton on furosemide clearance and dynamics in man, Clin Pharmacol Ther, 22, 402, 10.1002/cpt1977224402

Honari, 1977, Effects of probenecid on furosemide kinetics and natriuresis in man, Clin Pharmacol Ther, 22, 395, 10.1002/cpt1977224395

Hosoyamada, 2004, Function and localization of urate transporter 1 in mouse kidney, J Am Soc Nephrol, 15, 261, 10.1097/01.ASN.0000107560.80107.19

Hosoyamada, 1999, Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney, Am J Physiol Renal Physiol, 276, F122, 10.1152/ajprenal.1999.276.1.F122

Hu, 2008, Interaction of imatinib with human organic ion carriers, Clin Cancer Res, 14, 3141, 10.1158/1078-0432.CCR-07-4913

Huang, 2001, Assessmant of cisplatin-induced nephrotoxicity by microarray technology, Toxicol Sci, 63, 196, 10.1093/toxsci/63.2.196

Ichida, 2004, Clinical and molecular analysis of patients with renal hypouricemia in Japan — influence of URAT1 gene on urinary urate excretion, J Am Soc Nephrol, 15, 164, 10.1097/01.ASN.0000105320.04395.D0

Ichida, 2003, Urate transport via human PAH transporter hOAT1 and its gene structure, Kidney Int, 63, 143, 10.1046/j.1523-1755.2003.00710.x

Imaoka, 2004, The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules, J Am Soc Nephrol, 15, 2012, 10.1097/01.ASN.0000135049.20420.E5

Iwanaga, 2005, Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone, Drug Metab Dispos, 33, 1791

Iwanaga, 2007, Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter, J Pharmacol Exp Ther, 320, 211, 10.1124/jpet.106.112755

Jacobsson, 2007, Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family, Genomics, 90, 595, 10.1016/j.ygeno.2007.03.017

Jariyawat, 1999, The interaction and transport of β-lactam antibiotics with the cloned rat renal organic anion transporter 1, J Pharmacol Exp Ther, 290, 672

Ji, 2002, Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy, Kidney Int, 62, 514, 10.1046/j.1523-1755.2002.00464.x

Jigorel, 2006, Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes, Drug Metab Dispos, 34, 1756, 10.1124/dmd.106.010033

Jung, 2001, Characterization of ochratoxin A transport by human organic anion transporters, Life Sci, 69, 2123, 10.1016/S0024-3205(01)01296-6

Jung, 2002, Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1, Life Sci, 70, 1861, 10.1016/S0024-3205(02)01500-X

Jutabha, 2010, Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate, J Biol Chem, 285, 35123, 10.1074/jbc.M110.121301

Kaler, 2007, Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members, J Biol Chem, 282, 23841, 10.1074/jbc.M703467200

Kaler, 2007, Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions, Biochem Biophys Res Commun, 351, 872, 10.1016/j.bbrc.2006.10.136

Kato, 2002, Gender difference in the urinary excretion of organic anions in rats, J Pharmacol Exp Ther, 302, 483, 10.1124/jpet.102.033878

Kato, 2004, Screening of the interaction between xenobiotic transporters and PDZ proteins, Pharm Res, 21, 1886, 10.1023/B:PHAM.0000045244.83999.43

Kaufhold, 2011, Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3, Am J Physiol Renal Physiol, 301, F1026, 10.1152/ajprenal.00169.2011

Khamdang, 2003, Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics, Eur J Pharmacol, 465, 1, 10.1016/S0014-2999(03)01381-5

Khamdang, 2002, Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs, J Pharmacol Exp Ther, 303, 534, 10.1124/jpet.102.037580

Khamdang, 2004, Interaction of human- and rat-organic anion transporters with pravastatin and cimetidine, J Pharmacol Sci, 94, 197, 10.1254/jphs.94.197

Kikuchi, 2007, Regulation of the tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1α/β and DNA methylation, Mol Pharmacol, 72, 619, 10.1124/mol.107.039701

Kikuchi, 2006, Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1α/β and DNA methylation, Mol Pharmacol, 70, 887, 10.1124/mol.106.025494

Kikuchi, 2003, Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier, J Pharmacol Exp Ther, 306, 51, 10.1124/jpet.103.049197

Kim, 2003, Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney, Nephrol Dial Transplant, 18, 1505, 10.1093/ndt/gfg186

Kimura, 2005, Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1, Drug Metab Pharmacokinet, 20, 379, 10.2133/dmpk.20.379

Kimura, 2007, Development and characterization of immobilized human organic anion transporter based liquid chromatography stationary phase: hOAT1 and hOAT2, J Chromatogr B, 15, 267, 10.1016/j.jchromb.2007.09.039

Kimura, 2002, Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins, J Pharmacol Exp Ther, 301, 293, 10.1124/jpet.301.1.293

Klein, 2010, The human organic anion transporter genes OAT5 and OAT7 are trans-activated by hepatocyte nuclear factor-1α (HNF-1α), Mol Pharmacol, 78, 1079, 10.1124/mol.110.065201

Kobayashi, 2005, Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediated the renal transport of bumetanide, Eur J Pharmacol, 524, 44, 10.1016/j.ejphar.2005.09.054

Kobayashi, 2005, Transport mechanism and substrate specificity of human organic anion transporter 2 (hOAT2[SLC22A7]), J Pharm Pharmacol, 57, 573, 10.1211/0022357055966

Kobayashi, 2002, Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice, Mol Pharmacol, 62, 7, 10.1124/mol.62.1.7

Kobayashi, 2004, Renal transport of organic compounds mediated by mouse organic anion transporter 3 (MOAT3): further substrate specificity of MOAT3, Drug Metab Dispos, 32, 479, 10.1124/dmd.32.5.479

Kobayashi, 2005, Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver, Drug Metab Dispos, 33, 619, 10.1124/dmd.104.003301

Koepsell, 2004, The SLC22 drug transporter family, Pflügers Arch. - Eur J Physiol, 447, 666, 10.1007/s00424-003-1089-9

Kojima, 2002, Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney, J Am Soc Nephrol, 13, 848, 10.1681/ASN.V134848

Komoda, 2004, The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia, Pediatr Nephrol, 19, 728, 10.1007/s00467-004-1424-1

Kusuhara, 1999, Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain, J Biol Chem, 274, 13675, 10.1074/jbc.274.19.13675

Kuze, 1999, Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells, J Biol Chem, 274, 1519, 10.1074/jbc.274.3.1519

Kwak, 2005, Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter, J Steroid Biochem Mol Biol, 97, 369, 10.1016/j.jsbmb.2005.06.028

Li, 2006, Drug–drug interactions involving membrane transporters in the human kidney, Expert Opin Drug Metab Toxicol, 2, 505, 10.1517/17425255.2.4.505

Li, 2008, Effects of angiotensin II receptor blockers on renal handling of uric acid in rats, Drug Metab Pharmacokinet, 23, 263, 10.2133/dmpk.23.263

Ljubojevic, 2007, Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones, Am J Physiol Renal Physiol, 292, F361, 10.1152/ajprenal.00207.2006

Ljubojevic, 2004, Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition, Am J Physiol Renal Physiol, 287, F124, 10.1152/ajprenal.00029.2004

Lopez-Nieto, 1997, Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney, J Biol Chem, 272, 6471, 10.1074/jbc.272.10.6471

Lu, 1999, Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C, Am J Physiol Renal Physiol, 276, F295, 10.1152/ajprenal.1999.276.2.F295

Maher, 2006, Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α, Biochem Pharmacol, 72, 512, 10.1016/j.bcp.2006.03.016

Manautou, 2008, Renal and hepatic transporter expression in type 2 diabetic rats, Drug Metab Lett, 2, 11, 10.2174/187231208783478425

Masereeuw, 2010, Therapeutic implications of renal anionic drug transporters, Pharmacol Ther, 126, 200, 10.1016/j.pharmthera.2010.02.007

Matsumoto, 2007, Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride], J Pharmacol Exp Ther, 322, 1246, 10.1124/jpet.107.123323

Matsuzaki, 2007, Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure, Kidney Int, 71, 539, 10.1038/sj.ki.5002104

Minematsu, 2008, Role of the organic anion transporters in the pharmacokinetics of Zonampanel, and α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats, Drug Metab Dispos, 36, 1496, 10.1124/dmd.107.019828

Miyazaki, 2005, Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins, J Am Soc Nephrol, 16, 3498, 10.1681/ASN.2005030306

Mizuno, 2003, Impact of drug transporter studies on drug discovery and development, Pharmacol Rev, 55, 425, 10.1124/pr.55.3.1

Mizuno, 2007, Human organic anion transporter 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate, Drug Metab Dispos, 35, 1429, 10.1124/dmd.106.013912

Monte, 2004, Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa, Biochem Biophys Res Commun, 323, 429, 10.1016/j.bbrc.2004.08.112

Mori, 1997, Kidney-specific expression of a novel mouse organic cation transporter-like protein, FEBS Lett, 417, 371, 10.1016/S0014-5793(97)01325-2

Mori, 2004, Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs, J Neurochem, 90, 931, 10.1111/j.1471-4159.2004.02552.x

Mori, 2003, Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells, J Cereb Blood Flow Metab, 23, 432, 10.1097/00004647-200304000-00007

Morita, 2001, Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells, J Pharmacol Exp Ther, 298, 1179

Motohashi, 2002, Gene expression levels and immunolocalization of organic ion transporters in human kidney, J Am Soc Nephrol, 13, 866, 10.1681/ASN.V134866

Motohashi, 2004, Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A), Eur J Pharmacol, 503, 25, 10.1016/j.ejphar.2004.09.032

Motojima, 2002, Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake, Br J Pharmacol, 135, 555, 10.1038/sj.bjp.0704482

Mulato, 2000, Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1, J Pharmacol Exp Ther, 295, 10

Nagata, 2002, Expression and functional characterization of rat organic anion transporter 3 (rOAT3) in the choroid plexus, Mol Pharmacol, 61, 982, 10.1124/mol.61.5.982

Nakajima, 2000, Developmental changes in multispecific organic anion transporter 1 expression in rat kidney, Kidney Int, 57, 1608, 10.1046/j.1523-1755.2000.00005.x

Nishimura, 2005, Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies, Drug Metab Pharmacokinet, 20, 452, 10.2133/dmpk.20.452

Nishizato, 2003, Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics, Clin Pharmacol Ther, 73, 554, 10.1016/S0009-9236(03)00060-2

Nomura, 2012, Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein, Am J Physiol Renal Physiol, 302, F1640, 10.1152/ajprenal.00525.2011

Nozaki, 2004, Quantitative evaluation of the drug–drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporter and reduced folate transporter, J Pharmacol Exp Ther, 309, 226, 10.1124/jpet.103.061812

Nozaki, 2007, Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices, J Pharmacol Exp Ther, 322, 1162, 10.1124/jpet.107.121491

Ogasawara, 2006, Human organic anion transporter 3 gene is regulated constitutively and inducibly via a cAMP-responsive element, J Pharmacol Exp Ther, 319, 317, 10.1124/jpet.106.108233

Ogasawara, 2007, Hepatocyte nuclear factor-4α regulates the human organic anion transporter 1 gene in the kidney, Am J Physiol Renal Physiol, 292, F1819, 10.1152/ajprenal.00017.2007

Ogasawara, 2008, Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney, J Hum Genet, 53, 607, 10.1007/s10038-008-0288-9

Ohtsuki, 2004, Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood–brain barrier, J Pharmacol Exp Ther, 309, 1273, 10.1124/jpet.103.063370

Overbosch, 1988, The effect of probenecid on the renal tubular excretion of benzylpenicillin, Br J Clin Pharmacol, 25, 51, 10.1111/j.1365-2125.1988.tb03281.x

Pajor, 2006, Molecular properties of the SCL13 family of dicarboxylate and sulfate transporters, Pflügers Arch Eur J Physiol, 451, 597, 10.1007/s00424-005-1487-2

Perry, 2006, A three-dimensional model of human organic anion transporter 1. Aromatic amino acids required for substrate transport, J Biol Chem, 281, 38071, 10.1074/jbc.M608834200

Popowski, 2005, The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids, Mol Pharmacol, 67, 1629, 10.1124/mol.104.010223

Price, 2006, Human vascular smooth muscle cells express a urate transporter, J Am Soc Nephrol, 17, 1791, 10.1681/ASN.2006030264

Prueksaritanont, 2004, Renal elimination of a novel and potent αvβ3 integrin antagonist in animals, Xenobiotica, 34, 1059, 10.1080/00498250400015277

Race, 1999, Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3), Biochem Biophys Res Commun, 255, 508, 10.1006/bbrc.1998.9978

Reid, 1998, Cloning of a human renal p-aminohippurate transporter, hROAT1, Kidney Blood Press Res, 21, 233, 10.1159/000025863

Rizwan, 2007, Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles, Pharm Res, 24, 450, 10.1007/s11095-006-9181-4

Sabolic, 2007, Gender differences in kidney function, Pflügers Arch Eur J Physiol, 455, 397, 10.1007/s00424-007-0308-1

Saji, 2008, Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 α/β, J Pharmacol Exp Ther, 324, 784, 10.1124/jpet.107.128249

Sakurai, 2004, Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases, Pharm Res, 21, 61, 10.1023/B:PHAM.0000012153.71993.cb

Sato, 2008, Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers, Pharm Res, 25, 639, 10.1007/s11095-007-9401-6

Sato, 2010, Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human, Biol Pharm Bull, 33, 498, 10.1248/bpb.33.498

Sauvant, 2004, Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells, Am J Physiol Renal Physiol, 286, F774, 10.1152/ajprenal.00326.2003

Sauvant, 2002, Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA2, and COX1, J Am Soc Nephrol, 13, 1981, 10.1097/01.ASN.0000024437.62046.AF

Sauvant, 2003, Short-term regulation of basolateral organic anion uptake in proximal tubular opossum kidney cells: prostaglandin E2 acts via receptor-mediated activation of protein kinase A, J Am Soc Nephrol, 14, 3017, 10.1097/01.ASN.0000099376.87890.71

Sauvant, 2006, Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3, J Am Soc Nephrol, 17, 46, 10.1681/ASN.2005070727

Schnabolk, 2010, Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles, J Pharmacol Exp Ther, 334, 927, 10.1124/jpet.110.168765

Schnabolk, 2006, Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20), Am J Physiol Renal Physiol, 291, F314, 10.1152/ajprenal.00497.2005

Schneider, 2007, Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats, Am J Physiol Renal Physiol, 292, F1599, 10.1152/ajprenal.00473.2006

Sekine, 1998, Identification of multispecific organic anion transporter 2 expressed predominantly in the liver, FEBS Lett, 429, 179, 10.1016/S0014-5793(98)00585-7

Sekine, 1997, Expression cloning and characterization of a novel multispecific organic anion transporter, J Biol Chem, 272, 18526, 10.1074/jbc.272.30.18526

Shibayama, 2006, Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats, Cancer Sci, 97, 1260, 10.1111/j.1349-7006.2006.00304.x

Shin, 2007, Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate, Hepatology, 45, 1046, 10.1002/hep.21596

Shitara, 2005, Evaluation of drug–drug interaction in the hepatobiliary and renal transport of drugs, Annu Rev Pharmacol Toxicol, 45, 689, 10.1146/annurev.pharmtox.44.101802.121444

Simonson, 1994, Molecular cloning and characterization of a novel liver-specific transport protein, J Cell Sci, 107, 1065, 10.1242/jcs.107.4.1065

Soodvilai, 2004, Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules, Am J Physiol Renal Physiol, 287, F1021, 10.1152/ajprenal.00080.2004

Soodvilai, 2005, Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules, Am J Physiol Renal Physiol, 289, F1057, 10.1152/ajprenal.00185.2005

Srimaroeng, 2008, Physiology, structure, and regulation of the cloned organic anion transporters, Xenobiotica, 38, 889, 10.1080/00498250801927435

Sugawara, 2005, Structure-activity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites, Biochim Biophys Acta, 1714, 85, 10.1016/j.bbamem.2005.06.006

Sun, 2001, Isolation of a family of organic anion transporters from human liver and kidney, Biochem Biophys Res Commun, 283, 417, 10.1006/bbrc.2001.4774

Sweet, 2005, Organic anion transporter (Slc22a) family members as mediators of toxicity, Toxicol Appl Pharmacol, 204, 198, 10.1016/j.taap.2004.10.016

Sweet, 2003, Organic anion transporter 3 [Slc22a8] is a dicarboxylate exchanger indirectly coupled to the Na+ gradient, Am J Physiol Renal Physiol, 284, F763, 10.1152/ajprenal.00405.2002

Sweet, 2002, Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice, J Biol Chem, 277, 26934, 10.1074/jbc.M203803200

Sweet, 1997, Expression cloning and characterization of ROAT1, J Biol Chem, 272, 30088, 10.1074/jbc.272.48.30088

Sykes, 2004, Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice, Am J Physiol Renal Physiol, 286, F972, 10.1152/ajprenal.00356.2003

Tahara, 2006, Is the monkey an appropriate animal model to examine drug–drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists, J Pharmacol Exp Ther, 316, 1187, 10.1124/jpet.105.094052

Tahara, 2005, A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters, J Pharmacol Exp Ther, 315, 337, 10.1124/jpet.105.088104

Tahara, 2005, Molecular cloning and functional analysis of OAT1 and OAT3 from Cynomolgus monkey kidney, Pharm Res, 22, 647, 10.1007/s11095-005-2503-0

Takeda, 2002, Corrigendum to “Interaction of human organic anion transporters with various cephalosporin antibiotics”, Eur J Pharmacol, 450, 111, 10.1016/S0014-2999(02)02054-X

Takeda, 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics, Eur J Pharmacol, 438, 137, 10.1016/S0014-2999(02)01306-7

Takeda, 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters, J Pharmacol Exp Ther, 302, 666, 10.1124/jpet.102.034330

Takeda, 2002, Human organic anion transporters and human organic cation transporters mediate renal antiviral transport, J Pharmacol Exp Ther, 300, 918, 10.1124/jpet.300.3.918

Takeda, 2004, Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors, Eur J Pharmacol, 483, 133, 10.1016/j.ejphar.2003.10.017

Takeda, 1999, Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity, Kidney Int, 56, 2128, 10.1046/j.1523-1755.1999.00789.x

Tanaka, 2004, Role of glycosylation in the organic anion transporter OAT1, J Biol Chem, 279, 14961, 10.1074/jbc.M400197200

Taylor, 2011, Angiotensin receptor blockers: pharmacology, efficacy, and safety, J Clin Hypertens, 13, 677, 10.1111/j.1751-7176.2011.00518.x

Thyss, 1986, Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen, Lancet, 1, 256, 10.1016/S0140-6736(86)90786-5

Tojo, 1999, Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney, J Am Soc Nephrol, 10, 464, 10.1681/ASN.V103464

Torres, 2011, Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury, J Biol Chem, 286, 26391, 10.1074/jbc.M111.249292

Truong, 2008, Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination, J Biol Chem, 283, 8654, 10.1074/jbc.M708615200

Tsuchida, 2010, Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney, Cell Physiol Biochem, 25, 511, 10.1159/000303060

Ueo, 2007, Cl-dependent up-regulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3, Am J Physiol Renal Physiol, 293, F391, 10.1152/ajprenal.00376.2006

Ueo, 2005, Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1, Biochem Pharmacol, 70, 1104, 10.1016/j.bcp.2005.06.024

Ugele, 2003, Characterization and identification of steroid sulfate transporters in human placenta, Am J Physiol Endocrinol Metab, 284, E390, 10.1152/ajpendo.00257.2002

Urban, 2006, Functional genomics of membrane transporters in human populations, Genome Res, 16, 223, 10.1101/gr.4356206

Uwai, 2007, Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2), Pharm Res, 24, 811, 10.1007/s11095-006-9196-x

Uwai, 2007, Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3, Biochem Pharmacol, 74, 161, 10.1016/j.bcp.2007.03.024

Uwai, 2000, Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1, Eur J Pharmacol, 398, 193, 10.1016/S0014-2999(00)00324-1

Uwai, 2000, Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1, J Pharmacol Exp Ther, 295, 261

Uwai, 2002, Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone, Drug Metab Pharmacokinet, 17, 125, 10.2133/dmpk.17.125

Uwai, 2004, Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3, Drug Metab Dispos, 19, 369, 10.2133/dmpk.19.369

Vallon, 2008, Organic anion transporter 3 contributes to the regulation of blood pressure, J Am Soc Nephrol, 19, 1732, 10.1681/ASN.2008020180

Vallon, 2008, Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics, Am J Physiol Renal Physiol, 294, F867, 10.1152/ajprenal.00528.2007

Van Wert, 2007, Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G, Am J Physiol Renal Physiol, 293, F1332, 10.1152/ajprenal.00319.2007

Van Wert, 2010, Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology, Biopharm Drug Dispos, 31, 1, 10.1002/bdd.693

Van Wert, 2008, Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin, Mol Pharmacol, 74, 122, 10.1124/mol.107.042853

Van Wert, 2008, Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact on reduced folates, Pharm Res, 25, 453, 10.1007/s11095-007-9407-0

Vázquez-Mellado, 2007, Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout, Rheumatology, 46, 215, 10.1093/rheumatology/kel205

Villar, 2005, Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction, Kidney Int, 68, 2704, 10.1111/j.1523-1755.2005.00741.x

Villar, 2008, Time course of organic anion excretion in rats with bilateral ureteral obstruction: role of organic anion transporters (Oat1 and Oat3), Nephron Physiol, 110, 45, 10.1159/000166996

Vree, 1995, Probenecid inhibits the renal clearance of frusemide and its acyl glucuronide, Br J Clin Pharmacol, 39, 692

Wada, 2000, Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs, J Pharmacol Exp Ther, 294, 844

Wegner, 2012, Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6, PLoS One, 7, e35556, 10.1371/journal.pone.0035556

Windass, 2007, The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin, J Pharmacol Exp Ther, 322, 1221, 10.1124/jpet.107.125831

Wolff, 2007, Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of human kidney, Nephrol Dial Transplant, 22, 2497, 10.1093/ndt/gfm219

Wolff, 2003, Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization, J Am Soc Nephrol, 14, 1959, 10.1097/01.ASN.0000079040.55124.25

Wright, 2004, Molecular and cellular physiology of renal organic cation and anion transport, Physiol Rev, 84, 987, 10.1152/physrev.00040.2003

Xu, 2005, Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT1 (RST)], Kidney Int, 68, 1491, 10.1111/j.1523-1755.2005.00612.x

Yamada, 2007, Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor, Drug Metab Dispos, 35, 2166, 10.1124/dmd.107.017459

Yamashita, 2006, Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4, J Pharm Pharmacol, 58, 1499, 10.1211/jpp.58.11.0011

Yokoyama, 2008, Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct, Cell Physiol Biochem, 21, 269, 10.1159/000129385

Youngblood, 2004, Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney, Am J Physiol Renal Physiol, 287, F236, 10.1152/ajprenal.00012.2004

Yuan, 2009, Renal organic anion transporter-mediated drug–drug interaction between gemcabene and quinapril, J Pharmacol Exp Ther, 330, 191, 10.1124/jpet.108.149476

Zhang, 2004, Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule, Am J Physiol Renal Physiol, 287, F999, 10.1152/ajprenal.00156.2004

Zhang, 2008, Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway, J Biol Chem, 283, 32570, 10.1074/jbc.M800298200

Zhang, 2008, Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury, Am J Nephrol, 28, 772, 10.1159/000129073

Zhou, 2005, The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter OAT4, Mol Pharmacol, 67, 868, 10.1124/mol.104.007583

Zhou, 2007, Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells, Pharm Res, 25, 475, 10.1007/s11095-007-9359-4

Zlender, 2009, Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex, Toxicol Appl Pharmacol, 239, 284, 10.1016/j.taap.2009.06.008