Drug resistance analysis by next generation sequencing in Leishmania
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Akopyants, 2009, Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector, Science, 324, 265, 10.1126/science.1169464
Ali, 2013, Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines, Mol. Pharmacol, 83, 439, 10.1124/mol.112.082321
Alvar, 2012, Leishmaniasis worldwide and global estimates of its incidence, PloS One, 7, e35671, 10.1371/journal.pone.0035671
Arrebola, 1994, Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells, J. Biol. Chem, 269, 10590, 10.1016/S0021-9258(17)34100-5
Ashutosh, 2012, Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance, Antimicrob. Agents Chemother, 56, 518, 10.1128/AAC.00736-11
Bahassi, 2014, Next-generation sequencing technologies: breaking the sound barrier of human genetics, Mutagenesis, 29, 303, 10.1093/mutage/geu031
Berman, 1998, Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries, Bull World Health Organ, 76, 25
Bern, 2006, Liposomal amphotericin B for the treatment of visceral leishmaniasis, Clin. Infect. Dis, 43, 917, 10.1086/507530
Beverley, 1991, Gene amplification in Leishmania, Annu. Rev. Microbiol, 45, 417, 10.1146/annurev.mi.45.100191.002221
Beverley, 1990, Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species, Mol. Biochem. Parasitol, 42, 133, 10.1016/0166-6851(90)90121-2
Beverley, 1984, Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization, Cell, 38, 431, 10.1016/0092-8674(84)90498-7
Boisvert, 2010, Ray: simultaneous assembly of reads from a mix of high-throughput sequencing technologies, J. Comput. Biol.: J. Comput. Mol. Cell Biol, 17, 1519, 10.1089/cmb.2009.0238
Britto, 1998, Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes, Gene, 222, 107, 10.1016/S0378-1119(98)00472-7
Brotherton, 2013, Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant, PloS ONE, 8, 10.1371/journal.pone.0081899
Buermans, 2014, Next generation sequencing technology: advances and applications, Biochimica et biophysica acta, 10.1016/j.bbadis.2014.06.015
Castanys-Munoz, 2008, Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement, Antimicrob. Agents Chemother, 52, 3573, 10.1128/AAC.00587-08
Chen, 2012, Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy, Nature, 482, 246, 10.1038/nature10795
Coderre, 1983, Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica, Proc. Natl. Acad. Sci. U. S. A., 80, 2132, 10.1073/pnas.80.8.2132
Coelho, 2012, Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing, PLoS Negl. Trop. Dis, 6, e1512, 10.1371/journal.pntd.0001512
Croft, 1987, The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani, Biochem. Pharmacol, 36, 2633, 10.1016/0006-2952(87)90543-0
Cruz, 1993, Plasticity in chromosome number and testing of essential genes in Leishmania by targeting, Proc. Natl. Acad. Sci. U. S. A., 90, 1599, 10.1073/pnas.90.4.1599
DePristo, 2011, A framework for variation discovery and genotyping using next-generation DNA sequencing data, Nat. Genet, 43, 491, 10.1038/ng.806
do Monte-Neto, 2011, Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis, PLoS Negl. Trop. Dis, 5, e1167, 10.1371/journal.pntd.0001167
Downing, 2011, Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance, Genome Res, 21, 2143, 10.1101/gr.123430.111
Downing, 2012, Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex, Infect. Genet. Evol.: J. Mol. Epidemiol. Evol. Genet. Infect. Dis, 12, 149, 10.1016/j.meegid.2011.11.005
Dubessay, 2001, Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania, Nucl. Acids Res, 29, 3231, 10.1093/nar/29.15.3231
Dumas, 1997, Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages, Embo. J., 16, 2590, 10.1093/emboj/16.10.2590
El-Halfawy, 2013, Chemical communication of antibiotic resistance by a highly resistant subpopulation of bacterial cells, PloS One, 8, e68874, 10.1371/journal.pone.0068874
Fonseca, 2012, Tools for mapping high-throughput sequencing data, Bioinformatics, 28, 3169, 10.1093/bioinformatics/bts605
Garcia-Hernandez, 2012, Leishmania donovani develops resistance to drug combinations, PLoS Negl. Trop. Dis, 6, e1974, 10.1371/journal.pntd.0001974
Garvey, 1986, Stable amplified DNA in drug-resistant Leishmania exists as extrachromosomal circles, Science, 233, 535, 10.1126/science.3726545
Gnerre, 2011, High-quality draft assemblies of mammalian genomes from massively parallel sequence data, Proc. Natl. Acad. Sci. U. S. A., 108, 1513, 10.1073/pnas.1017351108
Gonzalez, U., Pinart, M., Rengifo-Pardo, M., Macaya, A., Alvar, J., Tweed, J.A., 2009. Interventions for American cutaneous and mucocutaneous leishmaniasis. The Cochrane database of systematic reviews, CD004834.
Gourbal, 2004, Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin, J. Biol. Chem, 279, 31010, 10.1074/jbc.M403959200
Grondin, 1993, Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania, Nucl. Acids Res, 21, 1895, 10.1093/nar/21.8.1895
Grondin, 1998, Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae, Nucl. Acids Res, 26, 3372, 10.1093/nar/26.14.3372
Guimond, 2003, Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays, Nucl. Acids Res, 31, 5886, 10.1093/nar/gkg806
Haile, 2007, Developmental regulation of gene expression in trypanosomatid parasitic protozoa, Curr. Opin. Microbiol, 10, 569, 10.1016/j.mib.2007.10.001
Hailu, 2010, Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial, PLoS Negl. Trop. Dis, 4, e709, 10.1371/journal.pntd.0000709
Haimeur, 1998, Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate, Antimicrob. Agents Chemother, 42, 1689, 10.1128/AAC.42.7.1689
Hammond, 1982, UMP synthesis in the kinetoplastida, Biochim. Biophys. Acta, 718, 1, 10.1016/0304-4165(82)90002-2
Henry, V.J., Bandrowski, A.E., Pepin, A.S., Gonzalez, B.J., Desfeux, A., 2014. OMIC tools: an informative directory for multi-omic data analysis. Database: J. Biol. Databases Curation 2014.
Ivens, 2005, The genome of the kinetoplastid parasite, Leishmania major, Science, 309, 436, 10.1126/science.1112680
Jha, 1998, Randomised controlled trial of aminosidine (paromomycin) v sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India, Bmj, 316, 1200, 10.1136/bmj.316.7139.1200
Jha, 1999, Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis, N. Engl. J. Med, 341, 1795, 10.1056/NEJM199912093412403
Katakura, 2004, Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis, FEBS Lett, 561, 207, 10.1016/S0014-5793(04)00130-9
Koren, 2012, Hybrid error correction and de novo assembly of single-molecule sequencing reads, Nat. Biotechnol, 30, 693, 10.1038/nbt.2280
Kumar, 2013, Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes, Mol. Microbiol, 89, 565, 10.1111/mmi.12298
Lachaud, 2014, Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus, Microbes Infect./Institut Pasteur, 16, 61, 10.1016/j.micinf.2013.09.005
Laurent, 2007, Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal, Infect. Genet. Evol.: J. Mol. Epidemiol. Evol. Genet. Infect. Dis, 7, 206, 10.1016/j.meegid.2006.08.005
Lee, 2010, Bacterial charity work leads to population-wide resistance, Nature, 467, 82, 10.1038/nature09354
Leprohon, 2009, Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials, Antimicrob. Agents Chemother, 53, 2646, 10.1128/AAC.01474-08
Leprohon, 2009, Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum, Nucl. Acids Res, 37, 1387, 10.1093/nar/gkn1069
Li, 2009, Fast and accurate short read alignment with Burrows-Wheeler transform, Bioinformatics, 25, 1754, 10.1093/bioinformatics/btp324
Li, 2008, Mapping short DNA sequencing reads and calling variants using mapping quality scores, Genome Res, 18, 1851, 10.1101/gr.078212.108
Li, 2008, SOAP: short oligonucleotide alignment program, Bioinformatics, 24, 713, 10.1093/bioinformatics/btn025
Lira, 1999, Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani, J Infect Dis, 180, 564, 10.1086/314896
Liu, 2012, Comparison of next-generation sequencing systems, J. Biomed. Biotechnol, 2012, 251364, 10.1155/2012/251364
Luo, 2012, SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler, GigaScience, 1, 18, 10.1186/2047-217X-1-18
Lye, 2010, Retention and loss of RNA interference pathways in trypanosomatid protozoans, PLoS Pathog, 6, e1001161, 10.1371/journal.ppat.1001161
Maretti-Mira, 2012, Transcriptome patterns from primary cutaneous Leishmania braziliensis infections associate with eventual development of mucosal disease in humans, PLoS Negl. Trop. Dis, 6, e1816, 10.1371/journal.pntd.0001816
Marquis, 2005, Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania, Mol. Microbiol, 57, 1690, 10.1111/j.1365-2958.2005.04782.x
Martin, 2014, Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani, PLoS Pathog, 10, e1003938, 10.1371/journal.ppat.1003938
Martinez-Calvillo, 2003, Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region, Mol. Cell, 11, 1291, 10.1016/S1097-2765(03)00143-6
Martinez-Calvillo, 2004, Transcription initiation and termination on Leishmania major chromosome 3, Eukaryot. Cell, 3, 506, 10.1128/EC.3.2.506-517.2004
Martinez-Calvillo, 2005, Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1, Int. J. Parasitol, 35, 419, 10.1016/j.ijpara.2004.12.014
McKenna, 2010, The genome analysis toolkit: a mapreduce framework for analyzing next-generation DNA sequencing data, Genome Res, 20, 1297, 10.1101/gr.107524.110
Meheus, 2010, Cost-effectiveness analysis of combination therapies for visceral leishmaniasis in the Indian subcontinent, PLoS Negl. Trop. Dis, 4, 10.1371/journal.pntd.0000818
Mehta, 2006, Mechanism of metalloid-induced death in Leishmania spp.: role of iron, reactive oxygen species, Ca2+, and glutathione, Free Radic. Biol. Med, 40, 1857, 10.1016/j.freeradbiomed.2006.01.024
Mittra, 2013, Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels, J. Exp. Med, 210, 401, 10.1084/jem.20121368
Mohamed-Ahmed, 2012, Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis, Curr. Opin. Infect. Dis, 25, 695, 10.1097/QCO.0b013e328359eff2
Monte-Neto, R., Laffitte, M.C., Leprohon, P., Reis, P., Frézard, F., Ouellette, M., Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis, submitted.
Moreira, 2011, Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania, Cell Death Dis, 2, e201, 10.1038/cddis.2011.83
Mottram, 1996, Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana, Mol. Microbiol, 22, 573, 10.1046/j.1365-2958.1996.00136.x
Mukherjee, 2011, Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania, Nucl. Acids Res, 39, 7499, 10.1093/nar/gkr494
Mukherjee, 2013, Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania, Mol. Microbiol, 88, 189, 10.1111/mmi.12178
Muller, 2010, Selective inactivation of SIDER2 retroposon-mediated mRNA decay contributes to stage- and species-specific gene expression in Leishmania, Mol. Microbiol, 77, 471, 10.1111/j.1365-2958.2010.07226.x
Muller, 2010, Rapid decay of unstable Leishmania mRNAs bearing a conserved retroposon signature 3′-UTR motif is initiated by a site-specific endonucleolytic cleavage without prior deadenylation, Nucl. Acids Res, 38, 5867, 10.1093/nar/gkq349
Musa, 2010, Paromomycin for the treatment of visceral leishmaniasis in Sudan: a randomized, open-label, dose-finding study, PLoS Negl. Trop. Dis, 4, e855, 10.1371/journal.pntd.0000855
Navarro, 1994, Inverted repeat structure and homologous sequences in the LD1 amplicons of Leishmania spp, Mol. Biochem. Parasitol, 68, 69, 10.1016/0166-6851(94)00147-2
Ning, 2001, SSAHA: a fast search method for large DNA databases, Genome Res, 11, 1725, 10.1101/gr.194201
Nowrousian, 2010, Next-generation sequencing techniques for eukaryotic microorganisms: sequencing-based solutions to biological problems, Eukaryot. Cell, 9, 1300, 10.1128/EC.00123-10
Olliaro, 2010, Drug combinations for visceral leishmaniasis, Curr. Opin. Infect. Dis, 23, 595, 10.1097/QCO.0b013e32833fca9d
Olmo, 1995, Co-existence of circular and multiple linear amplicons in methotrexate-resistant Leishmania, Nucl. Acids Res, 23, 2856, 10.1093/nar/23.15.2856
Ouameur, 2008, Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania, Mol. Biochem. Parasitol, 162, 155, 10.1016/j.molbiopara.2008.08.007
Ouellette, 1993, Mechanisms of drug resistance in Leishmania, Parasitol. Today, 9, 150, 10.1016/0169-4758(93)90135-3
Ouellette, 1991, Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania, Embo. J, 10, 1009, 10.1002/j.1460-2075.1991.tb08035.x
Ouellette, 1998, Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption, Methods Enzymol, 292, 182, 10.1016/S0076-6879(98)92015-8
Palatnik-de-Sousa, 2008, Vaccines for leishmaniasis in the fore coming 25 years, Vaccine, 26, 1709, 10.1016/j.vaccine.2008.01.023
Papadopoulou, 1993, Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania, Nucl. Acids Res, 21, 4305, 10.1093/nar/21.18.4305
Pathak, 2001, Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines, J. Immunol, 167, 3391, 10.4049/jimmunol.167.6.3391
Peacock, 2007, Comparative genomic analysis of three Leishmania species that cause diverse human disease, Nat. Genet, 39, 839, 10.1038/ng2053
Perez-Victoria, 2003, Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance, J. Biol. Chem, 278, 49965, 10.1074/jbc.M308352200
Perez-Victoria, 2006, Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites, J. Biol. Chem, 281, 23766, 10.1074/jbc.M605214200
Petrillo-Peixoto, 1988, Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major, Mol. Cell. Biol, 8, 5188, 10.1128/MCB.8.12.5188
Rando, 2007, Chromatin structure in the genomics era, Trends Genet.: TIG, 23, 67, 10.1016/j.tig.2006.12.002
Rastrojo, 2013, The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq, BMC Genomics, 14, 223, 10.1186/1471-2164-14-223
Raymond, 2012, Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species, Nucl. Acids Res, 40, 1131, 10.1093/nar/gkr834
Real, F., Vidal, R.O., Carazzolle, M.F., Mondego, J.M., Costa, G.G., Herai, R.H., Wurtele, M., de Carvalho, L.M., RC, E.F., Mortara, R.A., Barbieri, C.L., Mieczkowski, P., da Silveira, J.F., Briones, M.R., Pereira, G.A., Bahia, D., 2013. The genome sequence of Leishmania (Leishmania) amazonensis: functional annotation and extended analysis of gene models. DNA Res.: Int. J. Rapid Publ. Reports Genes Genomes.
Reithinger, 2007, Cutaneous leishmaniasis, Lancet Infect. Dis, 7, 581, 10.1016/S1473-3099(07)70209-8
Rijal, 2003, Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stibogluconate and need for a policy to limit further decline, Trans. Roy. Soc. Trop. Med. Hyg, 97, 350, 10.1016/S0035-9203(03)90167-2
Rijal, 2013, Increasing failure of miltefosine in the treatment of kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance, Clin. Infect. Dis, 56, 1530, 10.1093/cid/cit102
Ritt, 2013, Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum, PLoS Negl. Trop. Dis, 7, e2564, 10.1371/journal.pntd.0002564
Rogers, 2011, Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania, Genome Res, 21, 2129, 10.1101/gr.122945.111
Salzberg, 2012, GAGE: A critical evaluation of genome assemblies and assembly algorithms, Genome Res, 22, 557, 10.1101/gr.131383.111
Sanchez-Canete, 2009, Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug, Antimicrob. Agents Chemother, 53, 1305, 10.1128/AAC.01694-08
Selmecki, 2006, Aneuploidy and isochromosome formation in drug-resistant Candida albicans, Science, 313, 367, 10.1126/science.1128242
Selmecki, 2008, An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1, Mol. Microbiol, 68, 624, 10.1111/j.1365-2958.2008.06176.x
Selmecki, 2010, Genomic plasticity of the human fungal pathogen Candida albicans, Eukaryot. Cell, 9, 991, 10.1128/EC.00060-10
Siegel, 2009, Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei, Genes Dev, 23, 1063, 10.1101/gad.1790409
Simpson, 2012, Efficient de novo assembly of large genomes using compressed data structures, Genome Res, 22, 549, 10.1101/gr.126953.111
Simpson, 2009, ABySS: a parallel assembler for short read sequence data, Genome Res, 19, 1117, 10.1101/gr.089532.108
Singh, 2007, Differential gene expression analysis in antimony-unresponsive Indian kala azar (visceral leishmaniasis) clinical isolates by DNA microarray, Parasitology, 134, 777, 10.1017/S0031182007002284
Singh, 2010, Overexpression of histone H2A modulates drug susceptibility in Leishmania parasites, Int. J. Antimicrob. Agents, 36, 50, 10.1016/j.ijantimicag.2010.03.012
Sionov, 2010, Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes, PLoS Pathog, 6, e1000848, 10.1371/journal.ppat.1000848
Soto, 2001, Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent, Clin. Infect. Dis, 33, E57, 10.1086/322689
Soto, 2004, Miltefosine for new world cutaneous leishmaniasis, Clin. Infect. Dis, 38, 1266, 10.1086/383321
Soto, 2008, Efficacy of miltefosine for bolivian cutaneous leishmaniasis, Am. J. Trop. Med. Hyg, 78, 210, 10.4269/ajtmh.2008.78.210
Sterkers, 2011, FISH analysis reveals aneuploidy and continual generation of chromosomal mosaicism in Leishmania major, Cell. Microbiol, 13, 274, 10.1111/j.1462-5822.2010.01534.x
Sundar, 2000, Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic, Clin. Infect. Dis, 31, 1104, 10.1086/318121
Sundar, 2002, Oral miltefosine for Indian visceral leishmaniasis, N. Engl. J. Med, 347, 1739, 10.1056/NEJMoa021556
Sundar, 2007, Injectable paromomycin for visceral leishmaniasis in India, N. Engl. J. Med, 356, 2571, 10.1056/NEJMoa066536
Sundar, 2010, Single-dose liposomal amphotericin B for visceral leishmaniasis in India, N. Engl. J. Med, 362, 504, 10.1056/NEJMoa0903627
Thomas, 2009, Histone acetylations mark origins of polycistronic transcription in Leishmania major, BMC Genomics, 10, 152, 10.1186/1471-2164-10-152
Torres, 2007, Effects of aneuploidy on cellular physiology and cell division in haploid yeast, Science, 317, 916, 10.1126/science.1142210
Tripp, 1991, A DNA sequence (LD1) which occurs in several genomic organizations in Leishmania, Mol. Biochem. Parasitol, 47, 151, 10.1016/0166-6851(91)90174-5
Ubeda, 2008, Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy, Genome Biol, 9, R115, 10.1186/gb-2008-9-7-r115
Ubeda, 2014, Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania, PLoS Biol, 12, e1001868, 10.1371/journal.pbio.1001868
van Dijk, 2014
van Griensven, 2010, Combination therapy for visceral leishmaniasis, Lancet Infect. Dis, 10, 184, 10.1016/S1473-3099(10)70011-6
van Luenen, 2012, Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania, Cell, 150, 909, 10.1016/j.cell.2012.07.030
Vanaerschot, 2012, Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent, J. Infect. Dis, 206, 752, 10.1093/infdis/jis424
Vasudevan, 1998, Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant, Proc. Natl. Acad. Sci. U. S. A., 95, 9873, 10.1073/pnas.95.17.9873
Vasudevan, 2001, Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity, Proc. Natl. Acad. Sci. U. S. A., 98, 6092, 10.1073/pnas.101537298
Vega, 2012, Signaling-mediated bacterial persister formation, Nat. Chem. Biol, 8, 431, 10.1038/nchembio.915
White, 1988, The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance, J. Biol. Chem, 263, 16977, 10.1016/S0021-9258(18)37486-6
Yardley, 2005, The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine, Am. J. Trop. Med. Hyg, 73, 272, 10.4269/ajtmh.2005.73.272