Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung

European Journal of Pharmaceutical Sciences - Tập 26 - Trang 414-420 - 2005
Fergus Manford1, Ann Tronde2, Ann-Britt Jeppsson2, Nilesh Patel1, Fredrik Johansson2, Ben Forbes1
1King's College London, Pharmaceutical Science Research Division, 150 Stamford Street, London SE1 9NH, UK
2AstraZeneca R&D Lund, SE-221 87 Lund, Sweden

Tài liệu tham khảo

Ahsan, 2003, Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-[beta]-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-), Eur. J. Pharm. Sci., 20, 27, 10.1016/S0928-0987(03)00163-5 Artursson, 1996, Caco-2 monolayers in experimental and theoretical prediction of drug transport, Adv. Drug Deliv. Rev., 22, 67, 10.1016/S0169-409X(96)00415-2 Artursson, 1997, Intestinal drug absorption and metabolism in cell cultures: caco-2 and beyond, Pharm. Res., 14, 1655, 10.1023/A:1012155124489 Ballard, 1994, Bioelectric properties of proximal bronchiolar epithelium, Am. J. Physiol., 267, 79 Bhat, 1993, Regulation of tight junction permeability by calcium mediators and cell cytoskeleton in rabbit tracheal epithelium, Pharm. Res., 10, 991, 10.1023/A:1018906504944 Borchard, 2002, Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3), J. Pharm. Sci., 91, 1561, 10.1002/jps.10151 Braun, 2000, Cell cultures as tools in biopharmacy, Eur. J. Pharm. Sci., 11, 51, 10.1016/S0928-0987(00)00164-0 Cozens, 1994, CFTR expression and chloride secretion in polarized immortal human bronchial epithelial-cells, Am. J. Respir. Cell Mol. Biol., 10, 38, 10.1165/ajrcmb.10.1.7507342 Egan, 2002, Prediction of intestinal permeability, Adv. Drug Deliv. Rev., 54, 273, 10.1016/S0169-409X(02)00004-2 Ehrhardt, 2002, Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies, Cell Tissue Res., 308, 391, 10.1007/s00441-002-0548-5 Ehrhardt, 2003, 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1, Pharm. Res., 20, 545, 10.1023/A:1023230328687 Florea, 2003, Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3, J. Control. Release, 87, 131, 10.1016/S0168-3659(02)00356-5 Forbes, 2000, Human airway epithelial cell lines for in vitro drug transport and metabolism studies, PSTT, 3, 18 Forbes, 2003, The human bronchial epithelial cell line 16HBE14o- as a model system of the airways for studying drug transport, Int. J. Pharm., 257, 161, 10.1016/S0378-5173(03)00129-7 Foster, 2000, Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery, Int. J. Pharm., 208, 1, 10.1016/S0378-5173(00)00452-X Gonda, 2000, The ascent of pulmonary drug delivery, J. Pharm. Sci., 89, 940, 10.1002/1520-6017(200007)89:7<940::AID-JPS11>3.0.CO;2-B Gramatte, 1999, Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil, Clin. Pharmacol. Ther., 66, 239, 10.1016/S0009-9236(99)70031-7 Groneberg, 2003, Fundamentals of pulmonary delivery, Respir. Med., 97, 382, 10.1053/rmed.2002.1457 Groneberg, 2004, Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport, Am. J. Respir. Cell Mol. Biol., 30, 251, 10.1165/rcmb.2003-0315TR Hamilton, 2001, Modulation of P-gp activity in Calu-3 cells using steroids and β-ligands, Int. J. Pharm., 228, 171, 10.1016/S0378-5173(01)00836-5 Hamilton, 2002, Contribution of efflux pump activity to the delivery of pulmonary therapeutics, Curr. Drug Metab., 3, 1, 10.2174/1389200023338170 Hemberger, 1983, Mechanism of pulmonary absorption of quaternary ammonium compounds in the rat, Drug Metab. Dispos., 11, 73 Irvine, 1999, MDCK (Madin-Darby canine kidney) cells: a tool for membrane permeability screening, J. Pharm. Sci., 88, 28, 10.1021/js9803205 Koepsell, 2004, Polyspecific organic cation transporters: their functions and interactions with drugs, TIPS, 25, 375 Labiris, 2003, Pulmonary drug delivery. Part I. Physiological factors affecting therapeutic effectiveness of aerosolized medications, Br. J. Clin. Pharmacol., 56, 588, 10.1046/j.1365-2125.2003.01892.x Mathias, 2002, Permeability characteristics of calu-3 human bronchial epithelial cells: in vitro–in vivo correlation to predict lung absorption in rats, J. Drug Target, 10, 31, 10.1080/10611860290007504 Mathias, 1996, Respiratory epithelial cell culture models for the evaluation of ion and drug transport, Adv. Drug Del. Rev., 22, 215, 10.1016/S0169-409X(96)00420-6 Patton, 1996, Mechanisms of macromolecular absorption by the lungs, Adv. Drug Deliv. Rev., 19, 3, 10.1016/0169-409X(95)00113-L Soldner, 2000, Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers, Br. J. Pharmacol., 129, 1235, 10.1038/sj.bjp.0703150 Tavelin, 2003, Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers, Pharm. Res., 20, 397, 10.1023/A:1022699920043 Tronde, A., 2002. Pulmonary Drug Absorption: In Vitro and In Vivo Investigations of Drug Absorption Across the Lung Barrier and its Relation to Drug Physicochemical Properties. Doctor's Dissertation Thesis. Uppsala University, Uppsala, Sweden (http://publications.uu.se/theses/fulltext/91-554-5373-2.pdf). Tronde, 2003, Drug absorption from the isolated perfused rat lung—correlations with drug physicochemical properties and epithelial permeability, J. Drug Target, 11, 61, 10.1080/1061186031000086117 Tronde, 2003, Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure–absorption relationships and physicochemical profiling of inhaled drugs, J. Pharm. Sci., 92, 1216, 10.1002/jps.10386 Turner, 2004, Bioavailability prediction based on molecular structure for a diverse series of drugs, Pharm. Res., 21, 68, 10.1023/B:PHAM.0000012154.09631.26 Wan, 2000, Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o-, Eur. Respir. J., 15, 1058, 10.1034/j.1399-3003.2000.01514.x Winton, 1998, Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability, Clin. Exp. Allergy, 28, 1273, 10.1046/j.1365-2222.1998.00354.x