Drug discovery efforts at George Mason University

SLAS Discovery - Tập 28 - Trang 270-274 - 2023
Ali Andalibi1, Remi Veneziano2, Mikell Paige3, Michael Buschmann2, Amanda Haymond4, Virginia Espina4, Alessandra Luchini4,1, Lance Liotta4,1, Barney Bishop3, Monique Van Hoek1
1School for Systems Biology, George Mason University, Manassas, VA, USA
2Department of Biomedical Engineering, College of Engineering and Computing, George Mason University, Manassas, VA, USA
3Department of Chemistry, College of Science, George Mason University, Fairfax, VA, USA
4Center for Applied Proteomics and Molecular Medicine; George Mason University; Manassas, VA USA

Tài liệu tham khảo

Ke, 2018, Structural DNA nanotechnology: artificial nanostructures for biomedical research, Annu Rev Biomed Eng, 20, 375, 10.1146/annurev-bioeng-062117-120904 Rothemund, 2006, Folding DNA to create nanoscale shapes and patterns, Nature, 440, 297, 10.1038/nature04586 Zhang, 2018, Programmable and multifunctional DNA-based materials for biomedical applications, Adv Mater, 30 Hu, 2019, From DNA nanotechnology to material systems engineering, Adv Mater, 31 Jahanban-Esfahlan, 2019, Static DNA nanostructures for cancer theranostics: recent progress in design and applications, Nanotechnol Sci Appl, 12, 25, 10.2147/NSA.S227193 Zhao, 2021, A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis, Nat Commun, 12, 358, 10.1038/s41467-020-20638-7 Zhao, 2012, DNA origami delivery system for cancer therapy with tunable release properties, ACS Nano, 6, 8684, 10.1021/nn3022662 Veneziano, 2016, Designer nanoscale DNA assemblies programmed from the top down, Science, 352, 1534, 10.1126/science.aaf4388 Bush, 2020, Synthesis of DNA Origami Scaffolds: Current and Emerging Strategies, Molecules, 25, 3386, 10.3390/molecules25153386 Veneziano, 2018, In vitro synthesis of gene-length single-stranded DNA, Sci Rep, 8, 6548, 10.1038/s41598-018-24677-5 Chiriboga, 2022, Rapid DNA origami nanostructure detection and classification using the YOLOv5 deep convolutional neural network, Sci Rep, 12, 3871, 10.1038/s41598-022-07759-3 Veneziano, 2020, Role of nanoscale antigen organization on B-cell activation probed using DNA origami, Nat Nanotechnol, 15, 716, 10.1038/s41565-020-0719-0 Hu, 2022, Controlled release in hydrogels using DNA nanotechnology, Biomedicines, 10, 213, 10.3390/biomedicines10020213 Buschmann, 2021, Nanomaterial delivery systems for mRNA vaccines, Vaccines (Basel), 9, 65, 10.3390/vaccines9010065 Akinc, 2019, The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs, Nat Nanotechnol, 14, 1084, 10.1038/s41565-019-0591-y Carrasco, 2021, Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration, Commun Biol, 4, 956, 10.1038/s42003-021-02441-2 Cheng, 2020, Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing, Nat Nanotechnol, 15, 313, 10.1038/s41565-020-0669-6 Leung, 2015, Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems, J Phys Chem B, 119, 8698, 10.1021/acs.jpcb.5b02891 Luchini, 2014, Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces, Nat Commun, 5, 4413, 10.1038/ncomms5413 Haymond, 2019, Protein painting, an optimized MS-based technique, reveals functionally relevant interfaces of the PD-1/PD-L1 complex and the YAP2/ZO-1 complex, J Biol Chem, 294, 11180, 10.1074/jbc.RA118.007310 Dailing, 2021, Characterization and Validation of Arg286 Residue of IL-1RAcP as a Potential Drug Target for Osteoarthritis, Front Chem, 8, 10.3389/fchem.2020.601477 Günther, 2017, IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor, Immunity., 47, 510, 10.1016/j.immuni.2017.08.004 Kaushal, 2016, Antimicrobial activity of mosquito cecropin peptides against Francisella, Dev Comp Immunol, 63, 171, 10.1016/j.dci.2016.05.018 Kaushal, 2016, Characterization of Cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora, Biochem Biophys Res Commun, 470, 955, 10.1016/j.bbrc.2016.01.100 Amer, 2010, Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella, Biochem Biophys Res Commun, 396, 246, 10.1016/j.bbrc.2010.04.073 de Latour, 2010, Antimicrobial activity of the Naja atra cathelicidin and related small peptides, Biochem Biophys Res Commun, 396, 825, 10.1016/j.bbrc.2010.04.158 Dean, 2011, Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37, Front Microbiol, 2, 128, 10.3389/fmicb.2011.00128 Dean, 2011, Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus, BMC Microbiol, 11, 114, 10.1186/1471-2180-11-114 Blower, 2015, Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis, PLoS Negl Trop Dis, 9, 10.1371/journal.pntd.0003862 Bishop, 2017, Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry, J Proteome Res, 16, 1470, 10.1021/acs.jproteome.6b00857 Bishop, 2015, Bioprospecting the American alligator (Alligator mississippiensis) host defense peptidome, PLoS One, 10, 10.1371/journal.pone.0117394 Juba, 2015, Large Scale Discovery and De Novo-Assisted Sequencing of Cationic Antimicrobial Peptides (CAMPs) by Microparticle Capture and Electron-Transfer Dissociation (ETD) Mass Spectrometry, J Proteome Res, 14, 4282, 10.1021/acs.jproteome.5b00447 Wang, 2016, APD3: the antimicrobial peptide database as a tool for research and education, Nucleic Acids Res, 44, D1087, 10.1093/nar/gkv1278 Wang, 2022, The evolution of the antimicrobial peptide database over 18 years: Milestones and new features, Protein Sci, 31, 92, 10.1002/pro.4185 Barksdale, 2016, Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii, BMC Microbiol, 16, 189, 10.1186/s12866-016-0799-z Barksdale, 2017, Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae, Dev Comp Immunol, 70, 135, 10.1016/j.dci.2017.01.011 Chung, 2017, Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound, NPJ Biofilms Microbiomes, 3, 9, 10.1038/s41522-017-0017-2 Hitt, 2020, Komodo-dragon cathelicidin-inspired peptides are antibacterial against carbapenem-resistant Klebsiella pneumoniae, J Med Microbiol, 69, 1262, 10.1099/jmm.0.001260 van Hoek, 2019, The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters, BMC Genomics, 20, 684, 10.1186/s12864-019-6029-y Bobde, 2021, Ab initio designed antimicrobial peptides against gram-negative bacteria, Front Microbiol, 12, 10.3389/fmicb.2021.715246 Wang, 2022, Machine learning prediction of antimicrobial peptides, Methods Mol Biol, 2405, 1, 10.1007/978-1-0716-1855-4_1 Dean, 2015, Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase Dependent Activity in Francisella novicida, Virulence, 6, 487, 10.1080/21505594.2015.1046029 Dean, 2015, Burkholderia Diffusible Signal Factor Signals to Francisella novicida To Disperse Biofilm and Increase Siderophore Production, Appl Environ Microbiol, 81, 7057, 10.1128/AEM.02165-15