Drosophila TRPML Forms PI(3,5)P2-activated Cation Channels in Both Endolysosomes and Plasma Membrane

Cheng, 2010, Mucolipins: Intracellular TRPML1–3 channels, FEBS Letters, 584, 2013, 10.1016/j.febslet.2009.12.056

Bargal, 2000, Identification of the gene causing mucolipidosis type IV, Nat. Genet, 26, 118, 10.1038/79095

Bassi, 2000, Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV, Am. J. Hum. Genet, 67, 1110, 10.1016/S0002-9297(07)62941-3

Sun, 2000, Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel, Hum. Mol. Genet, 9, 2471, 10.1093/hmg/9.17.2471

Altarescu, 2002, The neurogenetics of mucolipidosis type IV, Neurology, 59, 306, 10.1212/WNL.59.3.306

Chen, 1998, Abnormal transport along the lysosomal pathway in Mucolipidosis, type IV disease, Proc. Natl. Acad. Sci. U.S.A, 95, 6373, 10.1073/pnas.95.11.6373

Bach, 2005, Mucolipin 1: endocytosis and cation channel–a review, Pflugers Archiv, 451, 313, 10.1007/s00424-004-1361-7

Venugopal, 2007, Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV, Am. J. Hum. Genet, 81, 1070, 10.1086/521954

Micsenyi, 2009, Neuropathology of the Mcoln1−/− knockout mouse model of mucolipidosis type IV, J. Neuropathol. Exp. Neurol, 68, 125, 10.1097/NEN.0b013e3181942cf0

Chandra, 2011, A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice, Gastroenterology, 140, 857, 10.1053/j.gastro.2010.11.040

Kim, 2009, The Ca2+ channel TRPML3 regulates membrane trafficking and autophagy, Traffic, 10, 1157, 10.1111/j.1600-0854.2009.00924.x

Grimm, 2012, Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules, J. Biol. Chem, 287, 22701, 10.1074/jbc.M112.369876

Kim, 2007, Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype, J. Biol. Chem, 282, 36138, 10.1074/jbc.C700190200

Kim, 2008, A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype, EMBO J, 27, 1197, 10.1038/emboj.2008.56

Lev, 2010, Constitutive activity of the human TRPML2 channel induces cell degeneration, J. Biol. Chem, 285, 2771, 10.1074/jbc.M109.046508

Xu, 2007, Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice, Proc. Natl. Acad. Sci. U.S.A, 104, 18321, 10.1073/pnas.0709096104

Grimm, 2007, A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse, Proc. Natl. Acad. Sci. U.S.A, 104, 19583, 10.1073/pnas.0709846104

Nagata, 2008, The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration, Proc. Natl. Acad. Sci. U.S.A, 105, 353, 10.1073/pnas.0707963105

Di Palma, 2002, Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice, Proc. Natl. Acad. Sci. U.S.A, 99, 14994, 10.1073/pnas.222425399

Dong, 2009, Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis, J. Biol. Chem, 284, 32040, 10.1074/jbc.M109.037184

Dong, 2008, The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel, Nature, 455, 992, 10.1038/nature07311

Dong, 2010, PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome, Nat. Commun, 1, 38, 10.1038/ncomms1037

Zhang, 2012, Phosphoinositide isoforms determine compartment-specific ion channel activity, Proc. Natl. Acad. Sci. U.S.A, 109, 11384, 10.1073/pnas.1202194109

Treusch, 2004, Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis, Proc. Natl. Acad. Sci. U.S.A, 101, 4483, 10.1073/pnas.0400709101

Sun, 2011, CUP-5, the C. elegans ortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes, Autophagy, 7, 1308, 10.4161/auto.7.11.17759

Venkatachalam, 2008, Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells, Cell, 135, 838, 10.1016/j.cell.2008.09.041

Wong, 2012, Drosophila TRPML is required for TORC1 activation, Curr. Biol, 22, 1616, 10.1016/j.cub.2012.06.055

Venkatachalam, 2013, Feast or famine: role of TRPML in preventing cellular amino acid starvation, Autophagy, 9, 98, 10.4161/auto.22260

Rohács, 1999, Distinct specificities of inwardly rectifying K+ channels for phosphoinositides, J. Biol. Chem, 274, 36065, 10.1074/jbc.274.51.36065

Xiao, 2008, Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations, J. Biol. Chem, 283, 6162, 10.1074/jbc.M706535200

Boussif, 1995, A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine, Proc. Natl. Acad. Sci. U.S.A, 92, 7297, 10.1073/pnas.92.16.7297

Thomas, 2002, Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells, Proc. Natl. Acad. Sci. U.S.A, 99, 14640, 10.1073/pnas.192581499

Bischof, 2007, An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases, Proc. Natl. Acad. Sci. U.S.A, 104, 3312, 10.1073/pnas.0611511104

Vaithianathan, 2008, Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway, J. Gen. Physiol, 132, 13, 10.1085/jgp.200709913

Zhu, 1998, Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry, J. Biol. Chem, 273, 133, 10.1074/jbc.273.1.133

Shen, 2012, Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release, Nat. Commun, 3, 731, 10.1038/ncomms1735

Swetha, 2011, Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells, Traffic, 12, 1037, 10.1111/j.1600-0854.2011.01214.x

Mellman, 1986, Acidification of the endocytic and exocytic pathways, Annu. Rev. Biochem, 55, 663, 10.1146/annurev.bi.55.070186.003311

Cang, 2013, mTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state, Cell, 152, 778, 10.1016/j.cell.2013.01.023

Rusten, 2006, Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors, Mol. Biol. Cell, 17, 3989, 10.1091/mbc.e06-03-0239