Dried plum polyphenols attenuate the detrimental effects of TNF-α on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I

Rodan, 2000, Therapeutic approaches to bone diseases, Science, 289, 1508, 10.1126/science.289.5484.1508 Manolagas, 2000, Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis, Endocr Rev, 21, 115 Roodman, 1999, Cell biology of the osteoclast, Exp Hematol, 27, 1229, 10.1016/S0301-472X(99)00061-2 Rodan, 1992, Introduction to Bone Biology, Bone, 13, S3, 10.1016/S8756-3282(09)80003-3 Jones, 2002, Role of RANKL and RANK in bone loss and arthritis, Ann Rheum Dis, 61, 32, 10.1136/ard.61.suppl_2.ii32 Wei, 2005, IL-1 mediates TNF-induced osteoclastogenesis, J Clin Invest, 115, 282, 10.1172/JCI200523394 Zou, 2002, Dual modulation of osteoclast differentiation by lipopolysaccharide, J Bone Miner Res, 17, 1211, 10.1359/jbmr.2002.17.7.1211 Cenci, 2000, Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha, J Clin Invest, 106, 1229, 10.1172/JCI11066 Scharla, 1994, Effect of tumor-necrosis-factor-alpha on the expression of insulin-like growth-factor-I and insulin-like growth-factor binding-protein-4 in mouse osteoblasts, Eur J Endocrinol, 131, 293, 10.1530/eje.0.1310293 Gilbert, 2000, Inhibition of osteoblast differentiation by tumor necrosis factor-alpha, Endocrinology, 141, 3956, 10.1210/endo.141.11.7739 Pischon, 2004, Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts, J Biol Chem, 279, 30060, 10.1074/jbc.M404208200 Lu, 2006, Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways, J Biol Chem, 281, 6297, 10.1074/jbc.M507804200 Gilbert, 2002, Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2 alpha A) is inhibited by tumor necrosis factor-alpha, J Biol Chem, 277, 2695, 10.1074/jbc.M106339200 Pacifici, 1996, Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis, J Bone Miner Res, 11, 1043, 10.1002/jbmr.5650110802 Lean, 2003, A crucial role for thiol antioxidants in estrogen-deficiency bone loss, J Clin Invest, 112, 915, 10.1172/JCI200318859 Muhlbauer, 2003, Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats, J Nutr, 133, 3592, 10.1093/jn/133.11.3592 Woo, 2004, Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts, Biol Pharm Bull, 27, 504, 10.1248/bpb.27.504 Horcajada-Molteni, 2000, Rutin inhibits ovariectomy-induced osteopenia in rats, J Bone Miner Res, 15, 2251, 10.1359/jbmr.2000.15.11.2251 Mizutani, 1998, Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells, Biochem Biophys Res Commun, 253, 859, 10.1006/bbrc.1998.9870 Bai, 2004, Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappa B, Biochem Biophys Res Commun, 314, 197, 10.1016/j.bbrc.2003.12.073 Stacewicz-Sapuntzakis, 2001, Chemical composition and potential health effects of prunes: a functional food?, Crit Rev Food Sci Nutr, 41, 251, 10.1080/20014091091814 Franklin, 2006, Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway, Bone, 39, 1331, 10.1016/j.bone.2006.05.024 Arjmandi, 2002, Dried plums improve indices of bone formation in postmenopausal women, J Women's Health Gend Med, 11, 61, 10.1089/152460902753473471 Arjmandi, 2001, Prune prevents ovariectomy-induced bone loss in rats, JANA, 4, 50 Deyhim, 2005, Dried plum reverses bone loss in an osteopenic rat model of osteoporosis, Menopause, 12, 755, 10.1097/01.gme.0000185486.55758.5b Bu, 2007, Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats, Osteoporos Int, 18, 931, 10.1007/s00198-007-0335-y Picherit, 2001, Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats, J Nutr, 131, 723, 10.1093/jn/131.3.723 Kim, 2003, Quantification of polyphenolics and their antioxidant capacity in fresh plums, J Agric Food Chem, 51, 6509, 10.1021/jf0343074 Singleton, 1999, Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent, Oxid Antioxid, 299, 152, 10.1016/S0076-6879(99)99017-1 Al-Nasiry, 2007, The use of Alamar Blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells, Hum Reprod, 22, 1304, 10.1093/humrep/dem011 Stoscheck, 1990, Quantitation of protein, Methods Enzymol, 182, 50, 10.1016/0076-6879(90)82008-P Stanford, 1995, Rapidly forming apatitic mineral in an osteoblastic cell-line (Umr-106-01 Bsp), J Biol Chem, 270, 9420, 10.1074/jbc.270.16.9420 Schett, 2003, Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice, Arthritis Rheum, 48, 2042, 10.1002/art.11150 Eliseev, 2006, Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NF kappa B, Exp Cell Res, 312, 40, 10.1016/j.yexcr.2005.09.016 Li, 2007, Endogenous TNF alpha loweres maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kB, J Bone Miner Res, 22, 646, 10.1359/jbmr.070121 Kim, 2004, Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2, J Biol Chem, 279, 50773, 10.1074/jbc.M404145200 Wang, 2006, Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells, J Endocrinol Invest, 29, 101, 10.1007/BF03344081 Nakajima, 2002, Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34), J Bone Miner Res, 17, 2038, 10.1359/jbmr.2002.17.11.2038 Pan, 2005, Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture, J Cell Biochem, 94, 307, 10.1002/jcb.20308 Zapf, 1986, Insulin-like growth-factors somatomedins — structure, secretion, biological actions and physiological-role, Horm Res, 24, 121, 10.1159/000180551 Li, 1997, Regulation of myeloid growth and differentiation by the insulin-like growth factor I receptor, Endocrinology, 138, 362, 10.1210/endo.138.1.4847 Patel, 2005, Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD), Bone, 37, 833, 10.1016/j.bone.2005.06.016 Saito, 2006, Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture, Osteoporos Int, 17, 986, 10.1007/s00198-006-0087-0 Ammann, 2003, Bone strength and its determinants, Osteoporos Int, 14, S13, 10.1007/s00198-002-1345-4 Hofbauer, 2000, The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption, J Bone Miner Res, 15, 2, 10.1359/jbmr.2000.15.1.2 Hofbauer, 1999, Interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells, Bone, 25, 255, 10.1016/S8756-3282(99)00162-3 Landis, 1996, Mineral characterization in calcifying tissues: atomic, molecular and macromolecular perspectives, Conn Tissue Res, 35, 1 Frossard, 2000, Potential for increasing the content and bioavailability of Fe, Zn and Ca in plants for human nutrition, J Sci Food Agric, 80, 861, 10.1002/(SICI)1097-0010(20000515)80:7<861::AID-JSFA601>3.0.CO;2-P Cremin, 2001, LC/ES-MS detection of hydroxycinnamates in human plasma and urine, J Agric Food Chem, 49, 1747, 10.1021/jf000764y