Doxorubicin induces apoptosis in Jurkat cells by mitochondria-dependent and mitochondria-independent mechanisms under normoxic and hypoxic conditions

Anti-Cancer Drugs - Tập 26 Số 6 - Trang 583-598 - 2015
Miguel Mendivil‐Perez1, Carlos Velez‐Pardo1, Marlene Jiménez-Del-Río1,2,3,4
1Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Medellin, Colombia
2e-mail: [email protected]
3fax: +574 219 6444
4to Marlene Jimenez-Del-Rio, MSc, DSc, Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia(UdeA), Calle 70 no. 52-21, and Calle 62 # 52-59, Building 1, Room 412, SIU Medellin, Colombia Tel: +574 291 6457

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Tài liệu tham khảo

Kantarjian, 2004, . Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia., Cancer, 101, 2788, 10.1002/cncr.20668

Lowas, 2009, Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia., Pediatr Blood Cancer, 52, 814, 10.1002/pbc.21980

Weng, 2004, . Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia., Science, 306, 269, 10.1126/science.1102160

Rohwer, 2011, Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways., Drug Resist Updat, 14, 191, 10.1016/j.drup.2011.03.001

Frolova, 2012, . Regulation of HIF-1 signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment., Cancer Biol Ther, 13, 858, 10.4161/cbt.20838

Cui, 2013, Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells., Blood Cells Mol Dis, 51, 177, 10.1016/j.bcmd.2013.05.003

Wu, 2011, The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy., Mol Pharm, 8, 1996, 10.1021/mp200261n

Breier, 2013, New insight into p-glycoprotein as a drug target., Anticancer Agents Med Chem, 13, 159, 10.2174/187152013804487380

Hanahan, 2011, Hallmarks of cancer: the next generation., Cell, 144, 646, 10.1016/j.cell.2011.02.013

Fuchs, 2011, Programmed cell death in animal development and disease., Cell, 147, 742, 10.1016/j.cell.2011.10.033

Kroemer, 2009, . Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009., Cell Death Differ, 16, 3, 10.1038/cdd.2008.150

Galluzzi, 2012, . Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012., Cell Death Differ, 19, 107, 10.1038/cdd.2011.96

Gewirtz, 1999, A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin., Biochem Pharmacol, 57, 727, 10.1016/S0006-2952(98)00307-4

Denard, 2012, Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1., Elife (Cambridge), 1, e00090

Mizutani, 2005, Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide., Life Sci, 76, 1439, 10.1016/j.lfs.2004.05.040

Gamen, 2000, . Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells., Exp Cell Res, 258, 223, 10.1006/excr.2000.4924

Brantley-Finley, 2003, . The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide., Biochem Pharmacol, 66, 459, 10.1016/S0006-2952(03)00255-7

van Delft, 2010, Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases., Cell Death Differ, 17, 821, 10.1038/cdd.2009.166

Lopez-Royuela, 2010, . Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells., Biochem Pharmacol, 79, 1746, 10.1016/j.bcp.2010.02.010

Tsang, 2003, Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis., Life Sci, 73, 2047, 10.1016/S0024-3205(03)00566-6

Aguilo, 2012, . Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications., Chem Biol Interact, 198, 18, 10.1016/j.cbi.2012.05.001

Ashikawa, 2004, Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues., Biochem Pharmacol, 67, 353, 10.1016/j.bcp.2003.08.039

Campbell, 2004, Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B., Mol Cell, 13, 853, 10.1016/S1097-2765(04)00131-5

Ho, 2005, Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells., Cancer Res, 65, 4273, 10.1158/0008-5472.CAN-04-3494

Bednarski, 2009, Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin., PLoS One, 4, e6992, 10.1371/journal.pone.0006992

Tacar, 2013, Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems., J Pharm Pharmacol, 65, 157, 10.1111/j.2042-7158.2012.01567.x

Mendivil-Perez, 2012, TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways., Oxid Med Cell Longev, 2012, 313275, 10.1155/2012/313275

Mendivil-Perez, 2014, Response to rotenone is glucose-sensitive in a model of human acute lymphoblastic leukemia: involvement of oxidative stress mechanism, DJ-1, Parkin, and PINK-1 proteins., Oxid Med Cell Longev, 2014, 457154, 10.1155/2014/457154

Mendivil-Perez, 2013, Glucose starvation induces apoptosis in a model of acute T leukemia dependent on caspase-3 and apoptosis-inducing factor: a therapeutic strategy., Nutr Cancer, 65, 99, 10.1080/01635581.2013.741751

Jimenez-Del-Rio, 2012, The bad, the good, and the ugly about oxidative stress., Oxid Med Cell Longev, 2012, 163913, 10.1155/2012/163913

Winklhofer, 2014, Parkin and mitochondrial quality control: toward assembling the puzzle., Trends Cell Biol, 24, 332, 10.1016/j.tcb.2014.01.001

Yang, 2006, Induction of parkin expression in the presence of oxidative stress., Eur J Neurosci, 24, 1366, 10.1111/j.1460-9568.2006.04998.x

Wilson, 2011, The role of cysteine oxidation in DJ-1 function and dysfunction., Antioxid Redox Signal, 15, 111, 10.1089/ars.2010.3481

Cookson, 2012, Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways., Cold Spring Harb Perspect Med, 2, a009415, 10.1101/cshperspect.a009415

Liu, 2008, . Expression and role of DJ-1 in leukemia., Biochem Biophys Res Commun, 375, 477, 10.1016/j.bbrc.2008.08.046

Agirre, 2006, . Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia., Int J Cancer, 118, 1945, 10.1002/ijc.21584

Zhang, 2011, . Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect., Proc Natl Acad Sci USA, 108, 16259, 10.1073/pnas.1113884108

Henn, 2007, . Parkin mediates neuroprotection through activation of IkappaB kinasenuclear factor-kappaB signaling., J Neurosci, 27, 1868, 10.1523/JNEUROSCI.5537-06.2007

Sha, 2010, Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling., Hum Mol Genet, 19, 352, 10.1093/hmg/ddp501

Fiegl, 2009, CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure., Blood, 113, 1504, 10.1182/blood-2008-06-161539

Ke, 2006, Hypoxia-inducible factor-1 (HIF-1)., Mol Pharmacol, 70, 1469, 10.1124/mol.106.027029

Wu, 2011, Induction and testing of hypoxia in cell culture., J Vis Exp, 12, ii

Marinho, 2014, Hydrogen peroxide sensing, signaling and regulation of transcription factors., Redox Biol, 2, 535, 10.1016/j.redox.2014.02.006

Leite, 1999, Critical evaluation of techniques to detect and measure cell death - study in a model of UV radiation of the leukaemic cell line HL60., Anal Cell Pathol, 19, 139, 10.1155/1999/176515

Mikami, 2006, . C-jun N-terminal kinase activation is required for apoptotic cell death induced by TNF-related apoptosis-inducing ligand plus DNA-damaging agents in sarcoma cell lines., Anticancer Res, 26, 1153

Inanami, 1999, Hydrogen peroxide-induced activation of SAPKJNK regulated by phosphatidylinositol 3-kinase in Chinese hamster V79 cells., Antioxid Redox Signal, 1, 113, 10.1089/ars.1999.1.1-113

Kamata, 2002, Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops., FEBS Lett, 519, 231, 10.1016/S0014-5793(02)02712-6

Takada, 2003, Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase., J Biol Chem, 278, 24233, 10.1074/jbc.M212389200

Yang, 2013, . Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway., Cell Physiol Biochem, 32, 1072, 10.1159/000354507

McNeill-Blue, 2006, Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporine., Brain Res, 1112, 1, 10.1016/j.brainres.2006.07.024

Hangen, 2010, Life with or without AIF., Trends Biochem Sci, 35, 278, 10.1016/j.tibs.2009.12.008

Greene, 2012, . Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment., EMBO Rep, 13, 378, 10.1038/embor.2012.14

Okatsu, 2012, . PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria., Nat Commun, 3, 1016, 10.1038/ncomms2016

Kondapalli, 2012, . PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65., Open Biol, 2, 120080, 10.1098/rsob.120080

Chan, 2011, Parkin uses the UPS to ship off dysfunctional mitochondria., Autophagy, 7, 771, 10.4161/auto.7.7.15453

Benito, 2011, . Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104., PLoS One, 6, e23108, 10.1371/journal.pone.0023108

Rohwer, 2010, . Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB., PLoS One, 5, e12038, 10.1371/journal.pone.0012038