Double-strand breaks and tumorigenesis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Vogelstein, 1998
Jasin, 2001, Double-strand break repair and homologous recombination in mammalian cells, III, 207
Johnson, 2001, Double-strand-break-induced homologous recombination in mammalian cells, Biochem. Soc. Trans., 29, 196, 10.1042/bst0290196
van Gent, 2001, Chromosomal stability and the DNA double-stranded break connection, Nat. Rev. Genet., 2, 196, 10.1038/35056049
Lim, 1996, A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53, Mol. Cell. Biol., 16, 7133, 10.1128/MCB.16.12.7133
Tsuzuki, 1996, Targeted disruption of the Rad51 gene leads to lethality in embryonic mice, Proc. Natl. Acad. Sci. U. S. A., 93, 6236, 10.1073/pnas.93.13.6236
Deans, 2000, Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice, EMBO J., 19, 6675, 10.1093/emboj/19.24.6675
Gu, 2000, Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice, Proc. Natl. Acad. Sci. U. S. A., 97, 2668, 10.1073/pnas.97.6.2668
Wang, 2001, Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group, Oncogene, 20, 2212, 10.1038/sj.onc.1204350
Thompson, 1999, The contribution of homologous recombination in preserving genome integrity in mammalian cells, Biochimie, 81, 87, 10.1016/S0300-9084(99)80042-X
Paull, 2000, A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage, Curr. Biol., 10, 886, 10.1016/S0960-9822(00)00610-2
Mirzoeva, 2001, DNA damage-dependent nuclear dynamics of the Mre11 complex, Mol. Cell. Biol., 21, 281, 10.1128/MCB.21.1.281-288.2001
Scully, 2000, In search of the tumour-suppressor functions of BRCA1 and BRCA2, Nature, 408, 429, 10.1038/35044000
Welcsh, 2000, Insights into the functions of BRCA1 and BRCA2, Trends Genet., 16, 69, 10.1016/S0168-9525(99)01930-7
Yu, 2000, Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation, Genes Dev., 14, 1400, 10.1101/gad.14.11.1400
Moynahan, 2001, Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation, Cancer Res., 61, 4842
Cox, 1999, Recombinational DNA repair in bacteria and the RecA protein, Prog. Nucleic Acids Res. Mol. Biol., 63, 311, 10.1016/S0079-6603(08)60726-6
Yuan, 1999, BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo, Cancer Res., 59, 3547
Bhattacharyya, 2000, The breast cancer-susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA crosslinking agent cisplatin, J. Biol. Chem., 275, 23899, 10.1074/jbc.C000276200
Huber, 2001, Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci, Mol. Cell. Biol., 21, 4005, 10.1128/MCB.21.12.4005-4015.2001
Moynahan, 1999, Brca1 controls homology-directed repair, Mol. Cell, 4, 511, 10.1016/S1097-2765(00)80202-6
Moynahan, 2001, BRCA2 is required for homology-directed repair of chromosomal breaks, Mol. Cell. Biol., 7, 263
Mak, 2000, Brcal required for T cell lineage development but not TCR loci rearrangement, Nat. Immun., 1, 77, 10.1038/76950
Paull, 2001, Direct DNA binding by Brca1, Proc. Natl. Acad. Sci. U. S. A., 98, 6086, 10.1073/pnas.111125998
Davies, 2001, Role of BRCA2 in control of the RAD51 recombination and DNA repair protein, Mol. Cell, 7, 273, 10.1016/S1097-2765(01)00175-7
Xu, 2001, Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation, Mol. Cell. Biol., 21, 3445, 10.1128/MCB.21.10.3445-3450.2001
Kuschel, 2001, Apparent human BRCA1 knockout caused by mispriming during polymerase chain reaction: implications for genetic testing, Genes Chromosomes Cancer, 31, 96, 10.1002/gcc.1122
Hohenstein, 2001, A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage, Oncogene, 20, 2544, 10.1038/sj.onc.1204363
Ludwig, 2001, Tumorigenesis in mice carrying a truncating Brca1 mutation, Genes Dev., 15, 1188, 10.1101/gad.879201
Xu, 1999, Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation, Nat. Genet., 22, 37, 10.1038/8743
Ludwig, 2001, Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice, Oncogene, 20, 3937, 10.1038/sj.onc.1204512
Phillips, 1999, Breast carcinomas arising in carriers of mutations in BRCA1 or BRCA2: are they prognostically different?, J. Clin. Oncol., 17, 3653, 10.1200/JCO.1999.17.11.3653
Hedenfalk, 2001, Gene-expression profiles in hereditary breast cancer, New Engl. J. Med., 344, 539, 10.1056/NEJM200102223440801
Bell, 1999, Common nonsense mutations in RAD52, Cancer Res., 59, 3883
Kato, 2000, Identification of Rad51 alteration in patients with bilateral breast cancer, J. Hum. Genet., 45, 133, 10.1007/s100380050199
Wang, 2001, A single nucleotide polymorphism in the 5′ untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers, Cancer Epidemiol. Biomarkers Prev., 10, 955
Levy-Lahad, 2001, A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers, Proc. Natl. Acad. Sci. U. S. A., 98, 3232, 10.1073/pnas.051624098
Takata, 2001, Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs, Mol. Cell. Biol., 21, 2858, 10.1128/MCB.21.8.2858-2866.2001
Tanaka, 2000, A novel human rad54 homologue, Rad54B, associates with Rad51, J. Biol. Chem., 275, 26316, 10.1074/jbc.M910306199
Dronkert, 2000, Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange, Mol. Cell. Biol., 20, 3147, 10.1128/MCB.20.9.3147-3156.2000
Johnson, 1999, Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination, Nature, 401, 397, 10.1038/43932
Pierce, 1999, XRCC3 promotes homology-directed repair of DNA damage in mammalian cells, Genes Dev., 13, 2633, 10.1101/gad.13.20.2633
Shu, 1999, Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can be partially rescued in a p53(−/−) background, Mol. Cell. Biol., 19, 8686, 10.1128/MCB.19.12.8686
Pittman, 2000, Midgestation lethality in mice deficient for the RecA-related gene, Rad51d/Rad51l3, Genesis, 26, 167, 10.1002/(SICI)1526-968X(200003)26:3<167::AID-GENE1>3.0.CO;2-M
Essers, 1997, Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination, Cell, 89, 195, 10.1016/S0092-8674(00)80199-3
Rijkers, 1998, Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation, Mol. Cell. Biol., 18, 6423, 10.1128/MCB.18.11.6423
Matsuda, 1999, Mutations in the RAD54 recombination gene in primary cancers, Oncogene, 18, 3427, 10.1038/sj.onc.1202692
Shen, 1998, Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans, Cancer Res., 58, 604
Winsey, 2000, A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer, Cancer Res., 60, 5612
Matullo, 2001, DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study, Int. J. Cancer, 92, 562, 10.1002/ijc.1228
Butkiewicz, 2001, Genetic polymorphisms in DNA repair genes and risk of lung cancer, Carcinogenesis, 22, 593, 10.1093/carcin/22.4.593
Schoenmakers, 1999, Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas, Cancer Res., 59, 19
Vessey, 1999, Genetic disorders associated with cancer predisposition and genomic instability, Prog. Nucleic Acids Res. Mol. Biol., 63, 189, 10.1016/S0079-6603(08)60723-0
Petrini, 2000, The Mre11 complex and ATM: collaborating to navigate S phase, Curr. Opin. Cell Biol., 12, 293, 10.1016/S0955-0674(00)00091-0
Mohaghegh, 2001, DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders, Hum. Mol. Genet., 10, 741, 10.1093/hmg/10.7.741
Wu, 2000, ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response, Nature, 405, 477, 10.1038/35013089
Garcia-Higuera, 2001, Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway, Mol. Cell, 7, 249, 10.1016/S1097-2765(01)00173-3
Wang, 2000, BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures, Genes Dev., 14, 927, 10.1101/gad.14.8.927
Moshous, 2001, Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency, Cell, 105, 177, 10.1016/S0092-8674(01)00309-9
Difilippantonio, 2000, DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation, Nature, 404, 510, 10.1038/35006670
Ferguson, 2000, The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations, Proc. Natl. Acad. Sci. U. S. A., 97, 6630, 10.1073/pnas.110152897
Frank, 2000, DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway, Mol. Cell, 5, 993, 10.1016/S1097-2765(00)80264-6
Gao, 2000, Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development, Nature, 404, 897, 10.1038/35009138
Vanasse, 1999, Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase, J. Clin. Invest., 103, 1669, 10.1172/JCI6658
Lim, 2000, Analysis of ku80-mutant mice and cells with deficient levels of p53, Mol. Cell. Biol., 20, 3772, 10.1128/MCB.20.11.3772-3780.2000
Yu, 2001, Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent proteinkinase catalytic subunit) gene, Cancer Res., 61, 1820
Riballo, 2001, Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity, J. Biol. Chem., 276, 31124, 10.1074/jbc.M103866200