Double blinded randomized clinical trial to assess the effectiveness of several preparations for colonoscopy

Journal of Coloproctology - Tập 38 - Trang 302-308 - 2018
Bruno Giusti Werneck Cortes1,2, Raquel Martins Cabral2, Guilherme Augusto Alves do Carmo1, Fábio Lopes de Queiroz2, Sinara Mônica de Oliveira Leite2, Amanda Cristina de Souza Andrade3, Alexandre Silluzio Ferreira1, Marta Eugênia Alcici1, Maria da Conceição Juste Werneck Cortes3
1Hospital Municipal Odilon Behrens, Belo Horizonte, MG, Brazil
2Hospital Governador Israel Pinheiro, Instituto da Previdência dos Servidores do Estado de Minas Gerais, Belo Horizonte, MG, Brazil
3Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

Tóm tắt

Abstract Introduction Colonoscopy is the screening gold standard to investigate several conditions in the colon. The excellence of preparation is a determining factor for a quality colonoscopy. Objective Compare the quality of colon preparations for colonoscopy with different kinds of laxative medications in a public hospital of Belo Horizonte, Brazil. Method A prospective double blind randomized clinical trial was conducted from June 2016 to March 2017. A total of 117 Patients were randomised in four groups to receive a type of preparation (Sodium picosulfate, Mannitol, Lactitol, Lactulose). The patients answered a questionnaire and peripheral blood samples were collected before and after the preparation.The quality of the cleansing was accessed according to the Boston Bowel Preparation Scale. Results 99.1% of patients have taken the recommended dose and 79.5% reported a good tolerability. Endoscopists performed complete colonoscopy in 89.7%, with an polipectomy rate of 47%. The total effectiveness rate of the solutions were 88%. There were no statistically significant differences between groups (p = 0.271). Regarding the laboratory parameters, differences were seen in the pre- and post-test values of sodium, chlorine and creatinine but without exceeding reference values. Conclusion The four preparations were effective for colon cleansing, with good acceptance, differing only as for costs.

Tài liệu tham khảo

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