Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Cell - Tập 145 Số 4 - Trang 529-542 - 2011
Katharina Schlacher1,2, Nicole Christ2, Nicolas Siaud2, Akinori Egashira2, Hong Wu1,3, Maria Jasin2
1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 USA
2Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
3Institute for Molecular Medicine, University of California, Los Angeles, CA 90095, USA

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Ayoub, 2009, The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry, Curr. Biol., 19, 1075, 10.1016/j.cub.2009.05.057

Benson, 1994, Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA, EMBO J., 13, 5764, 10.1002/j.1460-2075.1994.tb06914.x

Bryant, 2005, Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase, Nature, 434, 913, 10.1038/nature03443

Budzowska, 2009, Mechanisms of dealing with DNA damage-induced replication problems, Cell Biochem. Biophys., 53, 17, 10.1007/s12013-008-9039-y

Cheng, 2004, Linkage between Werner syndrome protein and the Mre11 complex via Nbs1, J. Biol. Chem., 279, 21169, 10.1074/jbc.M312770200

Cotta-Ramusino, 2005, Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells, Mol. Cell, 17, 153, 10.1016/j.molcel.2004.11.032

Davies, 2007, Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats, Nat. Struct. Mol. Biol., 14, 475, 10.1038/nsmb0707-680a

Davies, 2001, Role of BRCA2 in control of the RAD51 recombination and DNA repair protein, Mol. Cell, 7, 273, 10.1016/S1097-2765(01)00175-7

Donoho, 2003, Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice, Genes Chromosomes Cancer, 36, 317, 10.1002/gcc.10148

Dupre, 2008, A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex, Nat. Chem. Biol., 4, 119, 10.1038/nchembio.63

Edwards, 2008, Resistance to therapy caused by intragenic deletion in BRCA2, Nature, 451, 1111, 10.1038/nature06548

Esashi, 2005, CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair, Nature, 434, 598, 10.1038/nature03404

Esashi, 2007, Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2, Nat. Struct. Mol. Biol., 14, 468, 10.1038/nsmb1245

Essers, 1997, Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination, Cell, 89, 195, 10.1016/S0092-8674(00)80199-3

Farmer, 2005, Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy, Nature, 434, 917, 10.1038/nature03445

Fishman-Lobell, 1992, Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated, Mol. Cell. Biol., 12, 1292, 10.1128/MCB.12.3.1292

Foiani, 2000, DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae, Mutat. Res., 451, 187, 10.1016/S0027-5107(00)00049-X

Franchitto, 2004, Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery, Cell Cycle, 3, 1331, 10.4161/cc.3.10.1185

Goggins, 1996, Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas, Cancer Res., 56, 5360

Gu, 1997, Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination, Proc. Natl. Acad. Sci. USA, 94, 8076, 10.1073/pnas.94.15.8076

Gudmundsdottir, 2006, The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability, Oncogene, 25, 5864, 10.1038/sj.onc.1209874

Hanada, 2007, The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks, Nat. Struct. Mol. Biol., 14, 1096, 10.1038/nsmb1313

Hashimoto, 2010, Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis, Nat. Struct. Mol. Biol., 17, 1305, 10.1038/nsmb.1927

Hay, 2005, DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data, Biochem. Soc. Trans., 33, 715, 10.1042/BST0330715

Heyer, 2006, Rad54: the Swiss Army knife of homologous recombination?, Nucleic Acids Res., 34, 4115, 10.1093/nar/gkl481

Jackson, 1998, Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells, J. Cell Biol., 140, 1285, 10.1083/jcb.140.6.1285

Jensen, 2010, Purified human BRCA2 stimulates RAD51-mediated recombination, Nature, 467, 678, 10.1038/nature09399

Kass, 2010, Collaboration and competition between DNA double-strand break repair pathways, FEBS Lett., 584, 3703, 10.1016/j.febslet.2010.07.057

Lomonosov, 2003, Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein, Genes Dev., 17, 3017, 10.1101/gad.279003

Mazloum, 2009, Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis, Mol. Cell, 36, 620, 10.1016/j.molcel.2009.09.033

McAllister, 2002, Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene, Cancer Res., 62, 990

Mimitou, 2009, DNA end resection: many nucleases make light work, DNA Repair (Amst.), 8, 983, 10.1016/j.dnarep.2009.04.017

Morimatsu, 1998, Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence, Cancer Res., 58, 3441

Morrison, 1999, The essential functions of human Rad51 are independent of ATP hydrolysis, Mol. Cell. Biol., 19, 6891, 10.1128/MCB.19.10.6891

Moynahan, 2002, The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans, Oncogene, 21, 8994, 10.1038/sj.onc.1206177

Moynahan, 2010, Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis, Nat. Rev. Mol. Cell Biol., 11, 196, 10.1038/nrm2851

Moynahan, 2001, BRCA2 is required for homology-directed repair of chromosomal breaks, Mol. Cell, 7, 263, 10.1016/S1097-2765(01)00174-5

Nagaraju, 2007, Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks, DNA Repair (Amst.), 6, 1018, 10.1016/j.dnarep.2007.02.020

Navarro, 2006, Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1, Mol. Ther., 14, 525, 10.1016/j.ymthe.2006.05.018

Negrini, 2010, Genomic instability–an evolving hallmark of cancer, Nat. Rev. Mol. Cell Biol., 11, 220, 10.1038/nrm2858

Petermann, 2010, Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair, Mol. Cell, 37, 492, 10.1016/j.molcel.2010.01.021

Pierce, 2001, Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells, Genes Dev., 15, 3237, 10.1101/gad.946401

Postow, 2001, Topological challenges to DNA replication: conformations at the fork, Proc. Natl. Acad. Sci. USA, 98, 8219, 10.1073/pnas.111006998

Saeki, 2006, Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions, Proc. Natl. Acad. Sci. USA, 103, 8768, 10.1073/pnas.0600298103

Sakai, 2008, Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers, Nature, 451, 1116, 10.1038/nature06633

Schlacher, 2007, Lessons from 50 years of SOS DNA-damage-induced mutagenesis, Nat. Rev. Mol. Cell Biol., 8, 587, 10.1038/nrm2198

Sogo, 2002, Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects, Science, 297, 599, 10.1126/science.1074023

Stark, 2002, ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair, J. Biol. Chem., 277, 20185, 10.1074/jbc.M112132200

Su, 2008, Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51, Nat. Struct. Mol. Biol., 15, 1049, 10.1038/nsmb.1490

van Mameren, 2009, Counting RAD51 proteins disassembling from nucleoprotein filaments under tension, Nature, 457, 745, 10.1038/nature07581

Wang, 2000, BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures, Genes Dev., 14, 927, 10.1101/gad.14.8.927

Wiegant, 2006, Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function, Mutat. Res., 600, 79, 10.1016/j.mrfmmm.2006.03.001

Williams, 2008, Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair, Cell, 135, 97, 10.1016/j.cell.2008.08.017

Budzowska, M., and Kanaar, R. (2009). Mechanisms of Dealing with DNA Damage-Induced Replication Problems. Cell Biochem. Biophys. 53, 17–31.

Jackson, D.A., and Pombo, A. (1998). Replicon Clusters are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells. J. Cell Biol. 140, 1285–1295.

Lee, E.C., Yu, D., Martinez de Velasco, J., Tessarollo, L., Swing, D.A., Court, D.L., Jenkins, N.A., and Copeland, N.G. (2001). A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73, 56–65.

Liu, P., Jenkins, N.A., and Copeland, N.G. (2003). A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res. 13, 476–484.

Pierce, A.J., and Jasin, M. (2005). Measuring recombination proficiency in mouse embryonic stem cells. Methods Mol. Biol. 291, 373–384.

Saeki, H., Siaud, N., Christ, N., Wiegant, W.W., van Buul, P.P., Han, M., Zdzienicka, M.Z., Stark, J.M., and Jasin, M. (2006). Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Proc. Natl. Acad. Sci. USA 103, 8768–8773.

Scully, R., Puget, N., and Vlasakova, K. (2000). DNA polymerase stalling, sister chromatid recombination and the BRCA genes. Oncogene 19, 6176–6183.

Sharan, S.K., Pyle, A., Coppola, V., Babus, J., Swaminathan, S., Benedict, J., Swing, D., Martin, B.K., Tessarollo, L., Evans, J.P., et al. (2004). BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development 131, 131–142.

Warming, S., Costantino, N., Court, D.L., Jenkins, N.A., and Copeland, N.G. (2005). Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res. 33, e36.