Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite

Abraham, 2006, Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder, Clin. Cancer Res., 12, 353, 10.1158/1078-0432.CCR-05-1505 Albanell, 2002, Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition, J. Clin. Oncol., 20, 110, 10.1200/JCO.20.1.110 Arnold, 2005, Cyclin D1 in breast cancer pathogenesis, J. Clin. Oncol., 23, 4215, 10.1200/JCO.2005.05.064 Baldi, 2001, A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes, Bioinformatics, 17, 509, 10.1093/bioinformatics/17.6.509 Barton, 2004, Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: direct STAT3 inhibition induces apoptosis in prostate cancer lines, Mol. Cancer Ther., 3, 11, 10.1186/1476-4598-3-11 Bashyam, 2005, Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer, Neoplasia, 7, 556, 10.1593/neo.04586 Basu, 2001, Genetic toxicology of a paradoxical human carcinogen, arsenic: a review, Mutation Research, 488, 171, 10.1016/S1383-5742(01)00056-4 Bates, 1995, Case–control study of bladder cancer and arsenic in drinking water, Am. J. Epidemiol., 141, 523, 10.1093/oxfordjournals.aje.a117467 Belmont, 1996, Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules, Cell, 84, 623, 10.1016/S0092-8674(00)81037-5 Bergsagel, 2005, Molecular pathogenesis and a consequent classification of multiple myeloma, J. Clin. Oncol., 23, 6333, 10.1200/JCO.2005.05.021 Bhatia, 2005, Activation of Wnt/beta-catenin/Tcf signaling in mouse skin carcinogenesis, Mol. Carcinog., 42, 213, 10.1002/mc.20077 Bieche, 1998, Overexpression of the stathmin gene in a subset of human breast cancer, Br. J. Cancer, 78, 701, 10.1038/bjc.1998.565 Bourcier, 2006, p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis, Cancer Res., 66, 2700, 10.1158/0008-5472.CAN-05-3129 Brantley-Sieders, 2006, Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice, Cancer Res., 66, 10315, 10.1158/0008-5472.CAN-06-1560 Brantley, 2002, Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo, Oncogene, 21, 7011, 10.1038/sj.onc.1205679 Bromberg, 1999, Stat3 as an oncogene, Cell, 99, 295, 10.1016/S0092-8674(00)81959-5 Burnworth, 2006, Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation, Oncogene, 25, 4399, 10.1038/sj.onc.1209474 Callanan, 1996, Implication of cyclin D1 in malignant lymphoma, Crit. Rev. Oncog., 7, 191, 10.1615/CritRevOncog.v7.i3-4.30 Calo, 2003, STAT proteins: from normal control of cellular events to tumorigenesis, J. Cell. Physiol., 197, 157, 10.1002/jcp.10364 Centeno, 2002, Pathology related to chronic arsenic exposure, Environ. Health Perspect., 110, 883, 10.1289/ehp.02110s5883 Chen, 1998, Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and shc, Mol. Cell. Biol., 18, 5178, 10.1128/MCB.18.9.5178 Chen, 2000, K6/ODC transgenic mice as a sensitive model for carcinogen identification, Toxicol. Lett., 116, 27, 10.1016/S0378-4274(00)00196-X Chen, 2003, Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b, Mol. Cell. Biol., 23, 5594, 10.1128/MCB.23.16.5594-5605.2003 Chiou, 1995, Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan, Cancer Res., 55, 1296 Chow, 2006, Identification of RASSF1A modulated genes in nasopharyngeal carcinoma, Oncogene, 25, 310, 10.1038/sj.onc.1209001 Chowdhury, 2000, Groundwater arsenic contamination in Bangladesh and West Bengal, India, Environ. Health Perspect., 108, 393, 10.1289/ehp.00108393 Creighton, C.J., 2007. A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors. In Oncogene, pp. Epub ahead of print. D'Cruz, 2002, Persistent parity-induced changes in growth factors, TGF-beta3 and differentiation in the rodent mammary gland, Mol. Endocrinol., 16, 2034, 10.1210/me.2002-0073 Dai, 2005, Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases, J. Clin. Oncol., 23, 1473, 10.1200/JCO.2005.07.168 Dang, 1999, c-Myc target genes involved in cell growth, apoptosis, and metabolism, Mol. Cell. Biol., 19, 1, 10.1128/MCB.19.1.1 De Strooper, 1999, A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain, Nature, 398, 518, 10.1038/19083 Deane, 2001, Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice, Cancer Res., 61, 5389 Dodelet, 2002, Eph receptors and ephrin ligands: embryogenesis to tumorigenesis, Oncogene, 19, 5614, 10.1038/sj.onc.1203856 Duncan, 2005, Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance, Nat. Immunol., 6, 234, 10.1038/ni1164 Easty, 1995, Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression, Cancer Res., 55, 2528 Easty, 1999, Up-regulation of ephrin-A1 during melanoma progression, Int. J. Cancer, 84, 494, 10.1002/(SICI)1097-0215(19991022)84:5<494::AID-IJC8>3.0.CO;2-O Ewen, 2004, The activities of cyclin D1 that drive tumorigenesis, Trends Mol. Med., 10, 158, 10.1016/j.molmed.2004.02.005 Fernandez-Salas, 1999, p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein, J. Biol. Chem., 274, 36488, 10.1074/jbc.274.51.36488 Fernandez-Salas, 2002, mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53, Mol. Cell. Biol., 22, 3610, 10.1128/MCB.22.11.3610-3620.2002 Ferreccio, 2000, Lung cancer and arsenic concentrations in drinking water in Chile, Epidemiology, 11, 673, 10.1097/00001648-200011000-00010 Flowers, 2005, A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells, Oncogene, 24, 2114, 10.1038/sj.onc.1208437 Frame, 1998, Epithelial carcinogenesis in the mouse: correlating the genetics and the biology, Philos. Trans. R. Soc. Lond., B Biol. Sci., 353, 839, 10.1098/rstb.1998.0248 Friedrich, 1995, Differentiation-stage specific expression of oncoprotein 18 in human and rat prostatic adenocarcinoma, Prostate, 27, 102, 10.1002/pros.2990270207 Galm, 2003, SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma, Blood, 102, 1554 Gansauge, 1997, Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis, Cancer Res., 57 Gautschi, 2007, Cyclin D1 in non-small cell lung cancer: A key driver of malignant transformation, Lung Cancer, 55, 1, 10.1016/j.lungcan.2006.09.024 Grandis, 2000, Epidermal growth factor receptor-mediated Stat3 signaling blocks apoptosis in head and neck cancer, Laryngoscope, 110, 868, 10.1097/00005537-200005000-00016 Grandori, 2000, The Myc/Max/Mad network and the transcriptional control of cell behavior, Annu. Rev. Cell Dev. Biol., 16, 653, 10.1146/annurev.cellbio.16.1.653 Han, 2006, RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization, J. Leukoc. Biol., 79, 1357, 10.1189/jlb.1105693 Hanada, 2006, INFgama-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice, J. Exp. Med., 203, 1391, 10.1084/jem.20060436 Haque, 2003, Arsenic in drinking water and skin lesions: dose–response data from West Bengal, India, Epidemiology, 14, 174, 10.1097/01.EDE.0000040361.55051.54 Hayashi, 1998, Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice, Cancer Lett., 125, 83, 10.1016/S0304-3835(97)00484-9 Hebenstreit, 2005, JAK/STAT-dependent gene regulation by cytokines, Drug News Perspect., 18, 243, 10.1358/dnp.2005.18.4.908658 Himanen, 2003, Eph receptors and ephrins, Int. J. Biochem. Cell Biol., 35, 130, 10.1016/S1357-2725(02)00096-1 Hopenhayn-Rich, 1998, Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina, Int. J. Epidemiol., 27, 561, 10.1093/ije/27.4.561 Howell, 1999, Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo, J. Cell Sci., 112, 3713, 10.1242/jcs.112.21.3713 Hu, 2004, From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies, Cancer Res., 64, 7748, 10.1158/0008-5472.CAN-04-1827 Huang, 2004, Molecular mechanisms of arsenic carcinogenesis, Mol. Cell. Biochem., 255, 57, 10.1023/B:MCBI.0000007261.04684.78 Huang, 1999, Requirement of Erk, but not JNK, for arsenite-induced cell transformation, J. Biol. Chem., 274, 14595, 10.1074/jbc.274.21.14595 Iancu-Rubin, 2005, p27Kip1 and stathmin share the stage for the first time, Trends Cell Biol., 15, 346, 10.1016/j.tcb.2005.05.008 IARC, 1980. Monographs on the evaluation of carcinogenic risk of chemicals to man, some metals and metallic compounds. Lyon: International Agency for Research on Cancer. IARC, 2004. Some drinking water disinfectants and contaminants, including arsenic. Kann, 2005, Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status, Toxicol. Sci., 87, 365, 10.1093/toxsci/kfi253 Kawakami, 2001, Analysis of p53, p21 (Waf1/Cip1) and TGF-beta (3) immunohistochemical staining in Bowen's disease, Dermatology, 202, 9, 10.1159/000051577 Kawakami, 2001, Overexpression of tranforming growth favtor-beta3 immunohistochemical staining in extramammary Paget's disease but downregulated expression in Bowen's disease, Int. J. Dermatol., 40, 262, 10.1046/j.1365-4362.2001.01026.x Khan, 2003, Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature, Asian Pac. J. Cancer Prevention, 4, 7 Kim, 2006, Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment if F344 rats, Toxicol. Appl. Pharmacol., 214, 144, 10.1016/j.taap.2005.12.009 Kitchin, 2001, Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites, Toxicol. Appl. Pharmacol., 172, 249, 10.1006/taap.2001.9157 Kitchin, 2003, Oxidative stress as a possible mode of action for arsenic carcinogenesis, Toxicol. Lett., 137, 3, 10.1016/S0378-4274(02)00376-4 Kligerman, 2006, Insights into the carcinogenic mode of action of arsenic, Toxicol. Appl. Pharmacol., 222, 281, 10.1016/j.taap.2006.10.006 Koga, 2004, Identification of differentially expressed molecules in adult T-cell leukemia cells proliferating in vivo, Cancer Sci., 95, 411, 10.1111/j.1349-7006.2004.tb03224.x Kouzu, 2006, Overexpression stathmin in oral squamous-cell carcinoma: correlation with tumour progress and poor prognosis, Br. J. Cancer, 94, 717, 10.1038/sj.bjc.6602991 Krebs, 2001, SOCS proteins: negative regulators of cytokine signaling, Stem Cells, 19, 378, 10.1634/stemcells.19-5-378 Lai, 2004, Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression, J. Biol. Chem., 279, 13383, 10.1074/jbc.M313356200 Lee, 2006, Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas, Mol. Cancer Ther., 5, 8, 10.1158/1535-7163.MCT-05-0069 Lejeune, 2002, Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability, J. Clin. Invest., 110, 433, 10.1172/JCI0216493 Li, 2005, Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers, Proteomics, 5, 1125, 10.1002/pmic.200401141 Liang, 2002, Cooperativity between DNA methyltransferase in the maintenance methylation of repetitive elements, Mol. Cell. Biol., 22, 480, 10.1128/MCB.22.2.480-491.2002 Ludwig, 1998, The stress inducer arsenite activates mitogen-activated protein kinase extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway, J. Biol. Chem., 273, 1917, 10.1074/jbc.273.4.1917 Ma, 2006, Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3 mediated apoptosis in squamous cell carcinoma cells, Cancer Res., 66, 8131, 10.1158/0008-5472.CAN-06-1333 Majumder, 2005, Akt-regulated pathways in prostate cancer, Oncogene, 24, 7465, 10.1038/sj.onc.1209096 Mangone, 2005, Overexpression of Fos-related antigen-1 in head and neck squamous cell carcinoma, Int. J. Exp. Pathol., 86, 205, 10.1111/j.0959-9673.2005.00423.x Marini, 2006, Epigenetic inactivation of tumor supressor genes in serum of patients with cutaneous melanoma, J. Invest. Dermatol., 126, 422, 10.1038/sj.jid.5700073 Marklund, 1996, Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics, EMBO J., 15, 5290, 10.1002/j.1460-2075.1996.tb00914.x Masuda, 2002, Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma, Cancer Res., 62, 3351 Michl, 2005, Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers, Z. Gastroenterol., 43, 1133, 10.1055/s-2005-858638 Milde-Langosch, 2005, The Fos family of transcription factors and their role in tumourigenesis, Eur. J. Cancer, 41, 2449, 10.1016/j.ejca.2005.08.008 Mistry, 1999, Stathmin expression in immortalized and oncogene transformed cells, Anticancer Res., 19, 573 Mistry, 2001, Stathmin inhibition enhances okadaic acid-induced mitotic arrest: a potential role for stathmin in mitotic exit, J. Biol. Chem., 276, 31209, 10.1074/jbc.M011654200 Mistry, 2002, Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy, Mt. Sinai J. Med., 69, 299 Mizoi, 2005, The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: tumor-promoting action through the induction of oxidative stress, Toxicol. Lett., 158, 87, 10.1016/j.toxlet.2005.03.009 Morikawa, 2000, Promotion of skin carcinogenesis by dimethylarsenic acid in keratin (K6)/ODC transgenic mice, Jpn. J. Cancer Res., 91, 579, 10.1111/j.1349-7006.2000.tb00984.x Motiwale, 2005, Mouse skin tumor promotion by sodium arsenate is associated with enhanced PCNA expression, Cancer Lett., 223, 27, 10.1016/j.canlet.2004.10.020 Nakashima, 2005, Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands, Int. J. Cancer, 118, 704, 10.1002/ijc.21318 Nelson, 2007, Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin, Toxicology, 241, 134, 10.1016/j.tox.2007.08.094 NRC, 2000 O'Brien, 1997, Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin, Cancer Res., 57, 2630 Ouyang, 2006, Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 C141 cells, Carcinogenesis, 27, 864, 10.1093/carcin/bgi321 Parada, 2004, Transforming growth factor-beta2 and beta3 expression in carcinoma of the prostate, Arch. Esp. Urol., 57, 93 Pedranzini, 2004, Stat3 is required for the development of skin cancer, J. Clin. Invest., 114, 720, 10.1172/JCI22800 Pegg, 2003, Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth, Biochem Soc Trans., 31, 356, 10.1042/bst0310356 Pillai, 2005, Marginal zone B cells, Annu. Rev. Immunol., 23, 161, 10.1146/annurev.immunol.23.021704.115728 Price, 2000, The phosphoprotein Op18/stathmin is differentially expressed in ovarian cancer, Cancer Investig., 18, 722, 10.3109/07357900009012204 Proweller, 2006, Impaired notch signaling promotes de novo squamous cell carcinoma formation, Cancer Res., 66, 7438, 10.1158/0008-5472.CAN-06-0793 Quan, 2002, Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo, J. Invest. Dermatol., 119, 499, 10.1046/j.1523-1747.2002.01834.x Radtke, 2003, The role of Notch in tumorigenesis: oncogene or tumour supressor?, Nat. Rev. Cancer, 3, 756, 10.1038/nrc1186 Rangel, 2003, Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas, Clin. Cancer Res., 9, 2567 Rauhala, 2005, Dual-specificity phosphatase 1 and serum/glucocorticoid-regulated kinase are downregulated in prostate cancer, Int. J. Cancer, 117, 738, 10.1002/ijc.21270 Reichard, 2007, Long term low-dose arsenic exposure induces loss of DNA methylation, Biochem. Biophys. Res. Commun., 352, 188, 10.1016/j.bbrc.2006.11.001 Robertson, 2005, Functional and therapeutic significance of Akt deregulation in malignant melanoma, Cancer Metastasis Rev, 24, 273, 10.1007/s10555-005-1577-9 Robles, 1995, Early overexpression of cyclin D1 protein in mouse skin carcinogenesis, Carcinogenesis, 16, 781, 10.1093/carcin/16.4.781 Rodriguez-Puebla, 1999, Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development, Cell Growth Differ., 10, 467 Rodriguez-Puebla, 2000, Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia, Am. J. Pathol., 157, 1039, 10.1016/S0002-9440(10)64616-0 Rodriguez-Viciana, 2005, Cancer targets in the Ras pathway, Cold Spring Harbor Symp. Quant. Biol., 70, 461, 10.1101/sqb.2005.70.044 Rossman, 2003, Mechanism of arsenic carcinogenesis: an integrated approach, Mutat. Res., 533, 37, 10.1016/j.mrfmmm.2003.07.009 Rossman, 2004, Evidence that arsenite acts as a cocarcinogen in skin cancer, Toxicol. Appl. Pharmacol., 198, 394, 10.1016/j.taap.2003.10.016 Rossman, 2002, Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies, Environ. Health Perspect., 110, 749, 10.1289/ehp.02110s5749 Sancho, 2004, Signaling pathways in intestinal development and cancer, Annu. Rev. Cell Dev. Biol., 20, 695, 10.1146/annurev.cellbio.20.010403.092805 Schweisguth, 2004, Regulation of notch signaling activity, Curr. Biol., 14, 129, 10.1016/j.cub.2004.01.023 Sherrington, 1995, Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature, 375, 754, 10.1038/375754a0 Song, 2000, STAT signaling in head and neck cancer, Oncogene, 19, 2489, 10.1038/sj.onc.1203483 Sosman, 2006, Molecular targets in melanoma from angiogenesis to apoptosis, Clin. Cancer Res., 12, 2376, 10.1158/1078-0432.CCR-05-2558 Soufla, 2006, Transcriptional deregulation of VEGF, FGF2, TGF-beta1, 2, 3 and cognate receptors in breast tumorigenesis, Cancer Lett., 235, 100, 10.1016/j.canlet.2005.04.022 Suh, 2005, Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor alpha-induced apoptosis, and inhibits tumor growth, Cancer Res., 65, 562, 10.1158/0008-5472.562.65.2 Suh, 2004, The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis, J. Biol. Chem., 279, 4632, 10.1074/jbc.M311632200 Sun, 2004, Arsenic contamination and arsenicosis in China, Toxicol. Appl. Pharmacol., 198, 268, 10.1016/j.taap.2003.10.017 Suzuki, 2001, Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes, J. Hum. Genet., 46, 155, 10.1007/s100380170105 Swisshelf, 2005, Role of claudins in tumorigenesis, Adv. Drug Deliv. Rev., 57, 919, 10.1016/j.addr.2005.01.006 Szyf, 2004, DNA demethylation and cancer: therapeutic implications, Cancer Lett., 211, 133, 10.1016/j.canlet.2004.04.009 Takata, 2005, Early cancers of the skin: clinical, histopathological, and molecular characteristics, Int. J. Clin. Oncol., 10, 391, 10.1007/s10147-005-0532-7 Tapio, 2006, Arsenic in the aetiology of cancer, Mutat. Res., 612, 215, 10.1016/j.mrrev.2006.02.001 Terry, 2002, Oral contraceptive use and cyclin D1 overexpression in breast cancer among young women, Cancer Epidemiol. Biomarkers Prev., 11, 1100 Tian, 2005, External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras, Ann. N. Y. Acad. Sci., 1059, 106, 10.1196/annals.1339.038 Tokes, 2005, Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study, Breast Cancer Res., 7, R296, 10.1186/bcr983 Tomioka, 2006, Gene expression analysis by cDNA microarray in oral squamous cell carcinoma, J. Oral Pathol. Med., 35, 206, 10.1111/j.1600-0714.2006.00410.x Tseng, 1968, Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan, J. Natl. Cancer Inst., 40, 453 Uchikado, 2006, Gene expression profiling of lymph node metastasis by oligomicroarray analysis using laser microdissection in esophageal squamous cell carcinoma, Int. J. Oncol., 29, 1337 Uddin, 2005, Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin, Carcinogenesis, 26, 2179, 10.1093/carcin/bgi180 Unoki, 2001, Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway, Oncogene, 20, 4457, 10.1038/sj.onc.1204608 Vogt, 2001, Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts—a possible mechanism for arsenite's comutagenicity, Mutat. Res., 478, 159, 10.1016/S0027-5107(01)00137-3 Waalkes, 2004, Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero, J. Natl. Cancer Inst., 96, 466, 10.1093/jnci/djh070 Waalkes, 2006, Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen, Toxicol. Appl. Pharmacol., 215, 295, 10.1016/j.taap.2006.03.010 Wang, 1998, NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation, Science, 281, 1680, 10.1126/science.281.5383.1680 Willert, 1998, Beta-catenin: a key mediator of Wnt signaling, Curr. Opin. Genet. Dev., 8, 95, 10.1016/S0959-437X(98)80068-3 Wilson, 2006, Multiple function of Notch signaling in self-renewing organs and cancer, FEBS Lett., 580, 2860, 10.1016/j.febslet.2006.03.024 Wittman, 2004, Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1, J. Biol. Chem., 279, 6196, 10.1074/jbc.M307261200 Wong, 2006, Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray, Int. J. Cancer, 118, 2461, 10.1002/ijc.21660 Wu, 2004, Preprocessing of oligonucleotide array data, Nat. Biotechnol., 22, 656, 10.1038/nbt0604-656b Xia, 2001, Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis, Proc. Natl. Acad. Sci. U. S. A., 98, 10863, 10.1073/pnas.191284198 Yamamoto, 2004, Expression of transforming growth factor beta isoforms and their receptors in malignant fibrous histiocytoma of soft tissue, Clin. Cancer Res., 10, 5804, 10.1158/1078-0432.CCR-0770-03 Yin, 2006, Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions, Mol. Cancer, 5, 15, 10.1186/1476-4598-5-15 Yoeli-Lerner, 2006, Akt/PKB signaling in cancer: a function in cell motility and invasion, Cell Cycle, 5, 603, 10.4161/cc.5.6.2561 Yoshida, 2004, Chronic health effects in people exposed to arsenic via the drinking water: dose–response relationships in review, Toxicol. Appl. Pharmacol., 198, 243, 10.1016/j.taap.2003.10.022 Yoshikawa, 2001, SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity, Nat. Genet., 28, 29, 10.1038/ng0501-29 Young, 2006, Fra-1 a target for cancer prevention or intervention, Gene, 379, 1, 10.1016/j.gene.2006.05.001 Zheng, 2003, Low-level arsenite induced gene expression in HEK293 cells, Toxicol. Appl. Pharmacol., 187, 39