Dose-escalated simultaneously integrated boost photon or proton therapy in pancreatic cancer in an in-silico study: Gastrointestinal organs remain critical

Clinical and Translational Radiation Oncology - Tập 27 - Trang 24-31 - 2021
Sarah Stefanowicz1,2,3, Waldemar Wlodarczyk4, Susanne Frosch1,2, Sebastian Zschaeck4,5, Esther G.C. Troost1,2,3,6,7
1OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden – Rossendorf, Dresden, Germany
2Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
3Helmholtz-Zentrum Dresden – Rossendorf, Institute of Radiooncology - OncoRay, Dresden, Germany
4Department of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, Germany
5Berlin Institute of Health (BIH), Berlin, Germany
6German Cancer Consortium (DKTK), partner site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany
7National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and; Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany

Tài liệu tham khảo

Campbell, 2009, Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumor involvement within 1 mm of a resection margin, Histopathology, 55, 277, 10.1111/j.1365-2559.2009.03376.x Versteijne, 2020, Preoperative chemoradiotherapy versus immediate surgery of resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III PREOPANC trial, J Clin Oncol, 38, 1763, 10.1200/JCO.19.02274 Hammel, 2016, Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib: the LAP07 randomized clinical trial, JAMA, 315, 1844, 10.1001/jama.2016.4324 Ben-Josef, 2012, A phase I/II trial of intensity modulated radiation (IMRT) dose escalation with concurrent fixed-dose rate gemcitabine (FDR-G) in patients with unresectable pancreatic cancer, Int J Radiat Oncol*Biol*Phys, 84, 1166, 10.1016/j.ijrobp.2012.02.051 Wo, 2014, Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer, Radiother Oncol, 110, 160, 10.1016/j.radonc.2013.10.027 Herman, 2015, Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma, Cancer, 121, 1128, 10.1002/cncr.29161 Shaib, 2016, A phase 1 study of stereotactic body radiotherapy dose escalation for borderline resectable pancreatic cancer after modified FOLFIRINOX (NCT01446458), Int J Radiat Oncol Biol Phys, 96, 296, 10.1016/j.ijrobp.2016.05.010 Zschaeck, 2017, Dose-escalated radiotherapy for unresectable or locally recurrent pancreatic cancer: Dose volume analysis, toxicity and outcome of 28 consecutive patients, PLoS One, 12, 10.1371/journal.pone.0186341 Huguet, 2017, Chemotherapy and intensity-modulated radiation therapy for locally advanced pancreatic cancer achieves a high rate of R0 resection*, Acta Oncol, 56, 384, 10.1080/0284186X.2016.1245862 Krishnan, 2016, Focal radiation therapy dose escalation improves overall survival in locally advanced pancreatic cancer patients receiving induction chemotherapy and consolidative chemoradiation, Int J Radiat Oncol*Biol*Phys, 94, 755, 10.1016/j.ijrobp.2015.12.003 Terashima, 2012, A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis, Radiother Oncol, 103, 25, 10.1016/j.radonc.2011.12.029 Sachsman, 2014, Proton therapy and concomitant caspecitabine for non-metastatic unresectable pancreatic adenocarcinoma, Int J Particle Ther, 1, 692, 10.14338/IJPT.14-00006.1 Nichols, 2013, Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity, Acta Oncol, 52, 498, 10.3109/0284186X.2012.762997 Murphy, 2018, Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial, JAMA Oncol, 4, 963, 10.1001/jamaoncol.2018.0329 Murphy, 2019, Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical trial, JAMA Oncol, 5, 1020, 10.1001/jamaoncol.2019.0892 Zurlo, 2000, The role of proton therapy in the treatment of large irradiation volumes: a comparative planning study of pancreatic and biliary tumors, Int J Radiat Oncol*Biol*Phys, 48, 277, 10.1016/S0360-3016(00)00522-8 Nichols, 2012, Protons offer reduced normal-tissue exposure for patients receiving postoperative radiotherapy for resected pancreatic head cancer, Int J Radiat Oncol*Biol*Phys, 83, 158, 10.1016/j.ijrobp.2011.05.045 Ding, 2014, Med Dosim, 39, 139, 10.1016/j.meddos.2013.11.005 Thompson, 2014, A dosimetric comparison of proton and photon therapy in unresectable cancers of the head of pancreas: Proton dosimetry in pancreatic cancer, Med Phys, 41, 081711, 10.1118/1.4887797 Lomax, 2008, Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculation uncertainties, Phys Med Biol, 53, 1027, 10.1088/0031-9155/53/4/014 Lomax, 2008, Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: the potential effects of inter-fraction and inter-field motions, Phys Med Biol, 53, 1043, 10.1088/0031-9155/53/4/015 Lens, 2016, Abdominal organ motion during inhalation and exhalation breath-holds: pancreatic motion at different lung volumes compared, Radiother Oncol, 121, 268, 10.1016/j.radonc.2016.09.012 Dolde, 2019, Comparison of pancreatic motion management with three abdominal corsets for particle radiation therapy: case study, J Appl Clin Med Phys, 20, 111, 10.1002/acm2.12613 Stefanowicz, 2018, Comparison of different treatment planning approaches for intensity-modulated proton therapy with simultaneous integrated boost for pancreatic cancer, Radiat Oncol, 13, 228, 10.1186/s13014-018-1165-0 Marks, 2010, Use of normal tissue complication probability models in the clinic, Int J Radiat Oncol Biol Phys, 76, 10, 10.1016/j.ijrobp.2009.07.1754 Paddick, 2000, A simple scoring ratio to index conformity of radiosurgical treatment plans, J Neurosurg, 93, 219, 10.3171/jns.2000.93.supplement_3.0219 Hsiung-Stripp, 2001, Comparative treatment planning between proton and x-ray therapy in pancreatic cancer, Med Dosim, 26, 255, 10.1016/S0958-3947(01)00072-3 Ben-Josef, 2004, Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer, Int J Radiat Oncol Biol Phys, 59, 454, 10.1016/j.ijrobp.2003.11.019 Chuong, 2018, Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer, J Gastrointest Oncol, 9, 687, 10.21037/jgo.2018.03.14 Stefanowicz, 2020, PO – 1063: Do we need a PTV around the boost in simultaneously integrated boost approaches of abdominal tumors?, Radiother Oncol, 152, S564, 10.1016/S0167-8140(21)01080-X Huang, 2012, Dose-volume analysis of predictors for gastrointestinal toxicity after concurrent full-dose gemcitabine and radiotherapy for locally advanced pancreatic cancer, Int J Radiat Oncol Biol Phys, 83, 1120, 10.1016/j.ijrobp.2011.09.022 Olsen, 2017, Predictors of radiation therapy-related gastrointestinal toxicity from anal cancer dose-painted intensity modulated radiation therapy: secondary analysis of NRG Oncology RTOG 0529, Int J Radiat Oncol Biol Phys, 98, 400, 10.1016/j.ijrobp.2017.02.005 Rao, 2017, A novel absorbable radiopaque hydrogel spacer to separate the head of the pancreas and duodenum in radiation therapy for pancreatic cancer, Int J Radiat Oncol Biol Phys, 99, 1111, 10.1016/j.ijrobp.2017.08.006 Komatsu, 2019, Validation of combination treatment with surgical spacer placement and subsequent particle radiotherapy for unresectable hepatocellular carcinoma, J Surg Oncol, 120, 214, 10.1002/jso.25495 Eekers, 2019, Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial, Acta Oncol, 58, 57, 10.1080/0284186X.2018.1529424