Dose-Independent Pharmacokinetics of Metformin in Rats: Hepatic and Gastrointestinal First-Pass Effects

Scheen, 1996, Clinical pharmacokinetics of metformin, Clin Pharmacokinet, 30, 359, 10.2165/00003088-199630050-00003

Sirtori, 1978, Disposition of metformin (N,N-dimethylbiguanide) in man, Clin Pharmacol Ther, 24, 683, 10.1002/cpt1978246683

Tucker, 1981, Metformin kinetics in healthy subjects and in patients with diabetes mellitus, Br J Clin Pharmacol, 12, 235, 10.1111/j.1365-2125.1981.tb01206.x

Yu, 2003, Dose-independent pharmacokinetics of a new reversible proton pump inhibitor, KR-60436, after intravenous and oral administration to rats: Gastrointestinal first-pass effect, J Pharm Sci, 92, 1592, 10.1002/jps.10427

Lee, 1981, Pharmacokinetics of drugs in blood II. Unusual distribution and storage effect of furosemide, Res Commun Chem Pathol Pharmacol, 34, 17

Shim, 2000, Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique, Biopharm Drug Dispos, 21, 285, 10.1002/bdd.238

Litterst, 1975, Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species, Drug Metab Dispos, 3, 259

Hale, 2002, Transfer of metformin into human milk, Diabetologia, 45, 1509, 10.1007/s00125-002-0939-x

Kim, 1993, Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition, J Pharmacokinet Biopharm, 21, 1, 10.1007/BF01061772

Shin, 2004, Dose-dependent pharmacokinetics of itraconazole after intravenous or oral administration to rats: Intestinal first-pass effect, Antimicrob Agents Chemother, 48, 1756, 10.1128/AAC.48.5.1756-1762.2004

Murakami, 2003, Separate assessment of intestinal and hepatic first-pass effects using a rat model with double cannulation of the portal and jugular veins, Drug Metab Pharmacokinet, 18, 242, 10.2133/dmpk.18.252

Chiou, 1978, Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve, J Pharmacokinet Biopharm, 6, 539, 10.1007/BF01062108

Gibaldi, 1982

Chiou, 1980, New calculation method of mean total body clearance of drugs and its application to dosage regimens, J Pharm Sci, 69, 90, 10.1002/jps.2600690125

Eatman, 1977, Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects, J Pharmacokinet Biopharm, 5, 481, 10.1007/BF01061729

Chiou, 1979, New calculation method for mean apparent drug volume of distribution and application to rational dosage regimen, J Pharm Sci, 68, 1067, 10.1002/jps.2600680843

Bae, 2004, Pharmacokinetics, blood partition and protein binding of DA-7867, a new oxazolidinone, Biopharm Drug Dispos, 25, 127, 10.1002/bdd.394

Wilkinson, 1975, A physiological approach to hepatic drug clearance, Clin Pharmacol Ther, 18, 377, 10.1002/cpt1975184377

Choi, 2006, Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: Involvement of CYP2C11, 2D1, and 3A1/2 for the metabolism of metformin, Br J Pharmacol, 10.1038/sj.bjp.0706875

Davies, 1993, Physiological parameters in laboratory animals and humans, Pharm Res, 10, 1093, 10.1023/A:1018943613122

Mitruka, 1982

Lee, 1983, Evaluation of potential causes for the incomplete bioavailability of furosemide: Gastric first-pass metabolism, J Pharmacokinet Biopharm, 11, 623, 10.1007/BF01059061