Dopaminergic dysfunction in attention deficit hyperactivity disorder (ADHD), differences between pharmacologically treated and never treated young adults: A 3,4-dihdroxy-6-[18F]fluorophenyl-l-alanine PET study

Biederman, 1995, Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity, Am. J. Psychiatry, 152, 1652, 10.1176/ajp.152.11.1652 Biederman, 1999, Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder, Pediatrics, 104, e20, 10.1542/peds.104.2.e20 Brandon, 2003, Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons, Biol. Psychiatry, 54, 1338, 10.1016/S0006-3223(03)00787-X Brix, 1997, Performance evaluation of a whole-body PET scanner using the NEMA protocol National Electrical Manufacturers Association, J. Nucl. Med., 38, 1614 Brooks, 1990, The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET, Brain, 113, 1539, 10.1093/brain/113.5.1539 Cattell, 1960 Dougherty, 1999, Dopamine transporter density in patients with attention deficit hyperactivity disorder, Lancet, 354, 2132, 10.1016/S0140-6736(99)04030-1 Ernst, 1998, DOPA decarboxylase activity in attention deficit hyperactivity disorder adults A [fluorine-18]fluorodopa positron emission tomographic study, J. Neurosci., 18, 5901, 10.1523/JNEUROSCI.18-15-05901.1998 Ernst, 1999, High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder, Am. J. Psychiatry, 156, 1209, 10.1176/ajp.156.8.1209 Feron, 2005, Dopamine transporter in attention-deficit hyperactivity disorder normalizes after cessation of methylphenidate, Pediatr. Neurol., 33, 179, 10.1016/j.pediatrneurol.2005.04.008 Forssberg, 2006, Altered pattern of brain dopamine synthesis in male adolescents with attention deficit hyperactivity disorder, Behav. Brain Funct., 2, 40, 10.1186/1744-9081-2-40 Genovese, 2002, Thresholding of statistical maps in functional neuroimaging using the false discovery rate, NeuroImage, 15, 870, 10.1006/nimg.2001.1037 Giedd, 2004, Structural magnetic resonance imaging of the adolescent brain, Ann. N. Y. Acad. Sci., 1021, 77, 10.1196/annals.1308.009 Gilbert, 2007, Atomoxetine treatment of ADHD in Tourette syndrome: reduction in motor cortex inhibition correlates with clinical improvement, Clin. Neurophysiol., 118, 1835, 10.1016/j.clinph.2007.05.065 Gjedde, 1982, Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination, Brain Res., 257, 237, 10.1016/0165-0173(82)90018-2 Grace, 2001, Psychostimulant actions on dopamine and limbic system function: relevance to the pathophysiology and treatment of ADHD, 134 Gron, 2000, Brain activation during human navigation: gender-different neural networks as substrate of performance, Nat. Neurosci., 3, 404, 10.1038/73980 Hartvig, 1991, Positron emission tomography of L-dopa utilization in the brains of rhesus monkeys and human volunteers, Acta. Radiol. Suppl., 376, 149 Hoffman, 1992, The effects of carbidopa administration on 6-[18F]fluoro-L-dopa kinetics in positron emission tomography, J. Nucl. Med., 33, 1472 Hoshi, 1993, 6-[18F]fluoro-L-dopa metabolism in living human brain: a comparison of six analytical methods, J. Cereb. Blood Flow Metab., 13, 57, 10.1038/jcbfm.1993.8 Ito, 1999, Statistical parametric mapping with 18F-dopa PET shows bilaterally reduced striatal and nigral dopaminergic function in early Parkinson's disease, J. Neurol. Neurosurg. Psychiatry, 66, 754, 10.1136/jnnp.66.6.754 Jackson, 2001, Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex, J. Neurosci., 21, 676, 10.1523/JNEUROSCI.21-02-00676.2001 Jucaite, 2005, Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity, Biol. Psychiatry, 57, 229, 10.1016/j.biopsych.2004.11.009 Kessler, 2006, The prevalence and correlates of adult ADHD in the United States: Results from the national comorbidity survey replication, Am. J. Psychiatry, 163, 716, 10.1176/ajp.2006.163.4.716 Kish, 1995, Striatal 3,4-dihydroxyphenylalanine decarboxylase in aging: disparity between postmortem and positron emission tomography studies?, Ann. Neurol., 38, 260, 10.1002/ana.410380220 Krause, 2000, Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography, Neurosci. Lett., 285, 107, 10.1016/S0304-3940(00)01040-5 Kumakura, 2005, PET studies of net blood-brain clearance of F-DOPA to human brain: age-dependent decline of [18F]fluorodopamine storage capacity, J. Cereb. Blood Flow Metab., 25, 807, 10.1038/sj.jcbfm.9600079 Lou, 2004, ADHD: increased dopamine receptor availability linked to attention deficit and low neonatal cerebral blood flow, Dev. Med. Child Neurol., 46, 179, 10.1111/j.1469-8749.2004.tb00469.x Ludolph, 2006, No neurotoxic but neuroprotective effects of methylphenidate in primary mesencephalic cultures, J. Neural transmission, 113, 1927, 10.1007/s00702-006-0487-5 Maldjian, 2003, An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets, NeuroImage, 19, 1233, 10.1016/S1053-8119(03)00169-1 Moore, 2003, Monoamine neuron innervation of the normal human brain: an 18F-DOPA PET study, Brain Res., 982, 137, 10.1016/S0006-8993(03)02721-5 Patlak, 1983, Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data, J. Cereb Blood Flow Metab., 3, 1, 10.1038/jcbfm.1983.1 Patlak, 1985, Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations, J. Cereb. Blood Flow Metab., 5, 584, 10.1038/jcbfm.1985.87 Plessen, 2006, Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder, Arch. Gen. Psychiatry, 63, 795, 10.1001/archpsyc.63.7.795 Rakshi, 1999, Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study, Brain, 122, 1637, 10.1093/brain/122.9.1637 Sandoval, 2002, Methylphenidate redistributes vesicular monamine transporter-2: role of dopamine receptors, J. Neurosci., 22, 8705, 10.1523/JNEUROSCI.22-19-08705.2002 Sawada, 2000, Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons, Neurosci. Biobehav. Rev., 24, 143, 10.1016/S0149-7634(99)00059-7 Talairach, 1988 van Dyck, 2002, Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder, Am. J. Psychiatry, 159, 309, 10.1176/appi.ajp.159.2.309 van Dyck, 2002, Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries, Am. J. Geriatr Psychiatry, 10, 36, 10.1097/00019442-200201000-00005 Vles, 2003, Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD), Neuropediatrics, 34, 77, 10.1055/s-2003-39602 Vogg, 1999, Low Budget Remotely Controlled Synthesis Unit for Electrophilic Fluorinations: Production of [F-18]6-Fluoro-L-Dopa and [F-18]5-Fluoro-2′-deoxyuridin, J Labelled Cpd Radiopharm, 42, 903 Volkow, 1998, Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate, Am. J. Psychiatry, 155, 1325, 10.1176/ajp.155.10.1325 Volkow, 2001, Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain, J. Neurosci., 21, RC121, 10.1523/JNEUROSCI.21-02-j0001.2001 Volkow, 2002, Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications, Synapse, 43, 181, 10.1002/syn.10038 Volkow, 2007, Brain dopamine transporter levels in treatment and drug naïve adults with ADHD, NeuroImage, 34, 1182, 10.1016/j.neuroimage.2006.10.014 Volkow, 2007, Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-defici/hyperactivity disorder, Arch. Gen. Psychiatry, 64, 932, 10.1001/archpsyc.64.8.932 Walter, 2003, MARINA: An easy to use tool for the creation of masks for region of interest analyses, NeuroImage, 19, S47 Ward, 1993, The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder, Am. J. Psychiatry, 150, 885 Whalen, 2003, Is there a link between adolescent cigarette smoking and pharmacotherapy for ADHD?, Psychol. Addict Behav., 17, 332, 10.1037/0893-164X.17.4.332 Whone, 2003, Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study, Ann. Neurol., 54, 93, 10.1002/ana.10609 Wilens, 2004, Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues, Psychiatr. Clin North Am., 27, 283, 10.1016/S0193-953X(03)00113-8