Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis

Journal of Cognitive Neuroscience - Tập 25 Số 4 - Trang 571-579 - 2013
Goran Papenberg1,2, Lars Bäckman2, Irene E. Nagel1,3, Wilfried Nietfeld4, Julia Schröder4,5, Lars Bertram4, Hauke R. Heekeren1,3, Ulman Lindenberger1, Shu‐Chen Li1,6
11Max Planck Institute for Human Development, Berlin, Germany
22Karolinska Institute, Stockholm, Sweden
34Freie Universität Berlin
43Max Planck Institute for Molecular Genetics, Berlin, Germany
55Charité Universitätsmedizin, Berlin, Germany
66TU Dresden

Tóm tắt

AbstractEmerging evidence from animal studies suggests that suboptimal dopamine (DA) modulation may be associated with increased forgetting of episodic information. Extending these observations, we investigated the influence of DA-relevant genes on forgetting in samples of younger (n = 433, 20–31 years) and older (n = 690, 59–71 years) adults. The effects of single nucleotide polymorphisms of the DA D2 (DRD2) and D3 (DRD3) receptor genes as well as the DA transporter gene (DAT1; SLC6A3) were examined. Over the course of one week, older adults carrying two or three genotypes associated with higher DA signaling (i.e., higher availability of DA and DA receptors) forgot less pictorial information than older individuals carrying only one or no beneficial genotype. No such genetic effects were found in younger adults. The results are consistent with the view that genetic effects on cognition are magnified in old age. To the best of our knowledge, this is the first report to relate genotypes associated with suboptimal DA modulation to more long-term forgetting in humans. Independent replication studies in other populations are needed to confirm the observed association.

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