Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease

Neurobiology of Disease - Tập 40 - Trang 113-119 - 2010
Florian Bayersdorfer1, Aaron Voigt2, Stephan Schneuwly1, José A. Botella1
1Institute of Zoology, Universitaetsstr. 31, University of Regensburg, D-93040 Regensburg, Germany
2Department of Neurology, University Medical Centre, RWTH Aachen, Germany

Tài liệu tham khảo

Alam, 2002, Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats, Behav. Brain Res., 136, 317, 10.1016/S0166-4328(02)00180-8 Ascherio, 2006, Pesticide exposure and risk for Parkinson's disease, Ann. Neurol., 60, 197, 10.1002/ana.20904 Auluck, 2002, Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease, Science, 295, 865, 10.1126/science.1067389 Barolo, 2000, GFP and beta-galactosidase transformation vectors for promoter/enhancer analysis in Drosophila, Biotechniques, 29, 726, 10.2144/00294bm10 Betarbet, 2000, Chronic systemic pesticide exposure reproduces features of Parkinson's disease, Nat. Neurosci., 3, 1301, 10.1038/81834 Botella, 2008, Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease, Neurobiol. Dis., 30, 65, 10.1016/j.nbd.2007.11.013 Bové, 2005, Toxin-induced models of Parkinson's disease, NeuroRx, 2, 484, 10.1602/neurorx.2.3.484 Brown, 2006, Pesticides and Parkinson's disease—is there a link?, Environ. Health Perspect., 114, 156, 10.1289/ehp.8095 Bywood, 2003, Mitochondrial complex inhibitors preferentially damage substantia nigra dopamine neurons in rat brain slices, Exp. Neurol., 179, 47, 10.1006/exnr.2002.8044 Coulom, 2004, Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster, J. Neurosci., 24, 10993, 10.1523/JNEUROSCI.2993-04.2004 Dietzl, 2007, A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila, Nature, 448, 151, 10.1038/nature05954 Dukes, 2005, The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells, Antioxid. Redox Signal., 7, 630, 10.1089/ars.2005.7.630 Feany, 2000, A Drosophila model of Parkinson's disease, Nature, 404, 394, 10.1038/35006074 Friggi-Grelin, 2003, Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase, J. Neurobiol., 54, 618, 10.1002/neu.10185 Kruger, 1998, Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease, Nat. Genet., 18, 106, 10.1038/ng0298-106 Liu, Q., Rand, T.A., Kalidas, S., Du, F., Kim, H.E., Smith, D.P., Wang, X., 2003. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 26, 1921–1925. Liu, 2005, Intracellular dopamine oxidation mediates rotenone-induced apoptosis in PC12 cells, Acta Pharmacol. Sin., 26, 17, 10.1111/j.1745-7254.2005.00003.x Lotharius, 2002, Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease, Hum. Mol. Genet., 11, 2395, 10.1093/hmg/11.20.2395 Neckameyer, 1996, Multiple roles for dopamine in Drosophila development, Dev. Biol., 176, 209, 10.1006/dbio.1996.0128 Outeiro, 2007, Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease, Science, 317, 516, 10.1126/science.1143780 Park, 2007, Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein, Eur. J. Neurosci., 26, 3104, 10.1111/j.1460-9568.2007.05929.x Polymeropoulos, 1997, Mutation in the alpha-synuclein gene identified in families with Parkinson's disease, Science, 276, 2045, 10.1126/science.276.5321.2045 Robinow, 1988, Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development, J. Neurobiol., 22, 443, 10.1002/neu.480220503 Rochet, 2004, Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease, J. Mol. Neurosci., 23, 23, 10.1385/JMN:23:1-2:023 Sakka, 2003, Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone, Neuroreport, 14, 2425, 10.1097/00001756-200312190-00027 Sang, 2007, A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine, J. Neurosci., 27, 981, 10.1523/JNEUROSCI.4810-06.2007 Sherer, 2003, Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation, Exp. Neurol., 179, 9, 10.1006/exnr.2002.8072 Singleton, 2003, alpha-Synuclein locus triplication causes Parkinson's disease, Science, 302, 841, 10.1126/science.1090278 Takeda, 2006, Mechanisms of neuronal death in synucleinopathy, J. Biomed. Biotechnol., 2006, 19365, 10.1155/JBB/2006/19365 Testa, 2005, Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures, Brain Res. Mol. Brain Res., 134, 109, 10.1016/j.molbrainres.2004.11.007 True, 1999, Drosophila wing melanin patterns form by vein-dependent elaboration of enzymatic prepatterns, Curr. Biol., 9, 1382, 10.1016/S0960-9822(00)80083-4 Watabe, 2007, Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells, J. Pharmacol. Exp. Ther., 323, 499, 10.1124/jpet.107.127597 Whitworth, 2005, Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease, Proc. Natl. Acad. Sci. U. S. A., 102, 8024, 10.1073/pnas.0501078102 Xu, 2002, Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease, Nat. Med., 8, 600, 10.1038/nm0602-600 Yu, 2005, Alpha-synuclein and dopamine metabolism, Mol. Neurobiol., 31, 243, 10.1385/MN:31:1-3:243