Donor-Derived Mesenchymal Stem Cells Suppress Alloreactivity of Kidney Transplant Patients

Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells., Science, 284, 143, 10.1126/science.284.5411.143

Di Nicola, 2002, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli., Blood, 99, 3838, 10.1182/blood.V99.10.3838

Krampera, 2003, Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide., Blood, 101, 3722, 10.1182/blood-2002-07-2104

Aggarwal, 2005, Human mesenchymal stem cells modulate allogeneic immune cell responses., Blood, 105, 1815, 10.1182/blood-2004-04-1559

Nauta, 2006, Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells., J Immunol, 177, 2080, 10.4049/jimmunol.177.4.2080

Batten, 2006, Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: Relevance to tissue engineering human heart valves., Tissue Eng, 12, 2263, 10.1089/ten.2006.12.2263

Ringden, 2006, Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease., Transplantation, 81, 1390, 10.1097/01.tp.0000214462.63943.14

Dazzi, 2007, Cell therapy for autoimmune diseases., Arthritis Res Ther, 9, 206, 10.1186/ar2128

Bartholomew, 2002, Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo., Exp Hematol, 30, 42, 10.1016/S0301-472X(01)00769-X

Inoue, 2006, Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model., Transplantation, 81, 1589, 10.1097/01.tp.0000209919.90630.7b

Le Blanc, 2003, Immunomodulatory effects of fetal and adult mesenchymal stem cells., Cytotherapy, 5, 485, 10.1080/14653240310003611

Maccario, 2005, Human mesenchymal stem cells and cyclosporin a exert a synergistic suppressive effect on in vitro activation of alloantigen-specific cytotoxic lymphocytes., Biol Blood Marrow Transplant, 11, 1031, 10.1016/j.bbmt.2005.08.039

Hoogduijn, 2007, Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities., Stem Cells Dev, 16, 597, 10.1089/scd.2006.0110

Hoogduijn, 2008, Donor-derived mesenchymal stem cells remain present and functional in the transplanted human heart., Am J Transplant, 9, 222, 10.1111/j.1600-6143.2008.02450.x

Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method., Methods, 25, 402, 10.1006/meth.2001.1262

Le Blanc, 2003, Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex., Scand J Immunol, 57, 11, 10.1046/j.1365-3083.2003.01176.x

Klyushnenkova, 2005, T cell responses to allogeneic human mesenchymal stem cells: Immunogenicity, tolerance, and suppression., J Biomed Sci, 12, 47, 10.1007/s11373-004-8183-7

Krampera, 2006, Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells., Stem Cells, 24, 386, 10.1634/stemcells.2005-0008

Rasmusson, 2003, Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells., Transplantation, 76, 1208, 10.1097/01.TP.0000082540.43730.80

Maccario, 2005, Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype., Haematologica, 90, 516

Sotiropoulou, 2006, Interactions between human mesenchymal stem cells and natural killer cells., Stem Cells, 24, 74, 10.1634/stemcells.2004-0359

Corcione, 2006, Human mesenchymal stem cells modulate B-cell functions., Blood, 107, 367, 10.1182/blood-2005-07-2657

Hendrikx, 2007, Sequential analysis of CD4+CD25bright+ FoxP3+ T-cells in renal allograft patients reveals no intrinsic defect in their regulatory capacity [abstract]., Am J Transplant, 7, S2

Bestard, 2007, Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates., J Immunol, 179, 4901, 10.4049/jimmunol.179.7.4901

Allan, 2007, Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production., Int Immunol, 19, 345, 10.1093/intimm/dxm014

Benvenuto, 2007, Human mesenchymal stem cells promote survival of T cells in a quiescent state., Stem Cells, 25, 1753, 10.1634/stemcells.2007-0068

Casiraghi, 2008, Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells., J Immunol, 181, 3933, 10.4049/jimmunol.181.6.3933

Tse, 2003, Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation., Transplantation, 75, 389, 10.1097/01.TP.0000045055.63901.A9

Le Blanc, 2003, HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells., Exp Hematol, 31, 890, 10.1016/S0301-472X(03)00110-3

Nauta, 2006, Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a non-myeloablative setting., Blood, 108, 2114, 10.1182/blood-2005-11-011650

Sbano, 2008, Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model., Arch Dermatol Res, 300, 115, 10.1007/s00403-007-0827-9