Does weight loss improve semen quality and reproductive hormones? results from a cohort of severely obese men

Haslam DW, James WP: Obesity. Lancet. 2005, 366: 1197-1209. 10.1016/S0140-6736(05)67483-1.

Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD: Reduced fertility among overweight and obese men. Epidemiology. 2006, 17: 520-523. 10.1097/01.ede.0000229953.76862.e5.

Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sorensen TIA, Olsen J: Subfecundity in overweight and obese couples. Hum Reprod. 2007, 22: 1634-1637. 10.1093/humrep/dem035.

Nguyen RH, Wilcox AJ, Skjaerven R, Baird DD: Men's body mass index and infertility. Hum Reprod. 2007, 22: 2488-2493. 10.1093/humrep/dem139.

Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH: Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004, 82: 863-870. 10.1016/j.fertnstert.2004.03.056.

Fejes I, Koloszar S, Szollosi J, Zavaczki Z, Pal A: Is semen quality affected by male body fat distribution?. Andrologia. 2005, 37: 155-159. 10.1111/j.1439-0272.2005.00671.x.

Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K: Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005, 20: 208-215.

Koloszar S, Fejes I, Zavaczki Z, Daru J, Szollosi J, Pal A: Effect of body weight on sperm concentration in normozoospermic males. Arch Androl. 2005, 51: 299-304. 10.1080/01485010590919701.

Fejes I, Koloszar S, Zavaczki Z, Daru J, Szollosi J, Pal A: Effect of body weight on testosterone/estradiol ratio in oligozoospermic patients. Arch Androl. 2006, 52: 97-102. 10.1080/01485010500315479.

Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA: Impact of body mass index values on sperm quantity and quality. J Androl. 2006, 27: 450-452. 10.2164/jandrol.05124.

Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW: Male obesity and alteration in sperm parameters. Fertil Steril. 2008, 90: 2222-2225. 10.1016/j.fertnstert.2007.10.011.

Stewart TM, Liu DY, Garrett C, Jorgensen N, Brown EH, Baker HW: Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output. Hum Reprod. 2009, 24: 1561-1568. 10.1093/humrep/dep075.

Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R: Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010, 93: 2222-2231. 10.1016/j.fertnstert.2009.01.100.

Hofny ERM, Ali ME, bdel-Hafez HZ, Kamal EE-D, Mohamed EE, bd El-Azeem HG: Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril. 2010, 94: 581-584. 10.1016/j.fertnstert.2009.03.085.

Qin DD, Yuan W, Zhou WJ, Cui YQ, Wu JQ, Gao ES: Do reproductive hormones explain the association between body mass index and semen quality?. Asian J Androl. 2007, 9: 827-834. 10.1111/j.1745-7262.2007.00268.x.

Aggerholm AS, Thulstrup AM, Toft G, Ramlau-Hansen CH, Bonde JP: Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?. Fertil Steril. 2008, 90: 619-626. 10.1016/j.fertnstert.2007.07.1292.

Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA: Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril. 2008, 90: 346-351. 10.1016/j.fertnstert.2007.06.046.

Ramlau-Hansen CH, Hansen M, Jensen CR, Olsen J, Bonde JP, Thulstrup AM: Semen quality and reproductive hormones according to birthweight and body mass index in childhood and adult life: two decades of follow-up. Fertil Steril. 2010, 94: 610-618. 10.1016/j.fertnstert.2009.01.142.

Wise LA, Rothman KJ, Mikkelsen EM, Sorensen HT, Riis A, Hatch EE: An internet-based prospective study of body size and time-to-pregnancy. Hum Reprod. 2010, 25: 253-264. 10.1093/humrep/dep360.

Martini AC, Tissera A, Estofβn D, Molina RI, Mangeaud A, de Cuneo MF: Overweight and seminal quality: a study of 794 patients. Fertil Steril. 2010, 94: 1739-1743. 10.1016/j.fertnstert.2009.11.017.

MacDonald AA, Herbison GP, Showell M, Farquhar CM: The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010, 16: 293-311. 10.1093/humupd/dmp047.

Schneider G, Kirschner MA, Berkowitz R, Ertel NH: Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979, 48: 633-638. 10.1210/jcem-48-4-633.

Giagulli VA, Kaufman JM, Vermeulen A: Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab. 1994, 79: 997-1000. 10.1210/jc.79.4.997.

Pasquali R: Obesity and androgens: facts and perspectives. Fertil Steril. 2006, 85: 1319-1340. 10.1016/j.fertnstert.2005.10.054.

Hoffer LJ, Beitins IZ, Kyung NH, Bistrian BR: Effects of severe dietary restriction on male reproductive hormones. J Clin Endocrinol Metab. 1986, 62: 288-292. 10.1210/jcem-62-2-288.

Leenen R, van der KK, Seidell JC, Deurenberg P, Koppeschaar HP: Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab. 1994, 78: 1515-1520. 10.1210/jc.78.6.1515.

Kraemer WJ, Volek JS, Clark KL, Gordon SE, Puhl SM, Koziris LP: Influence of exercise training on physiological and performance changes with weight loss in men. Med Sci Sports Exerc. 1999, 31: 1320-1329. 10.1097/00005768-199909000-00014.

Stanik S, Dornfeld LP, Maxwell MH, Viosca SP, Korenman SG: The effect of weight loss on reproductive hormones in obese men. J Clin Endocrinol Metab. 1981, 53: 828-832. 10.1210/jcem-53-4-828.

Strain GW, Zumoff B, Miller LK, Rosner W, Levit C, Kalin M: Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men. J Clin Endocrinol Metab. 1988, 66: 1019-1023. 10.1210/jcem-66-5-1019.

Pasquali R, Casimirri F, Melchionda N, Fabbri R, Capelli M, Plate L: Weight loss and sex steroid metabolism in massively obese man. J Endocrinol Invest. 1988, 11: 205-210.

Bastounis EA, Karayiannakis AJ, Syrigos K, Zbar A, Makri GG, Alexiou D: Sex hormone changes in morbidly obese patients after vertical banded gastroplasty. Eur Surg Res. 1998, 30: 43-47. 10.1159/000008556.

Kaukua J, Pekkarinen T, Sane T, Mustajoki P: Sex hormones and sexual function in obese men losing weight. Obes Res. 2003, 11: 689-694. 10.1038/oby.2003.98.

Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A: Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004, 6: 208-215. 10.1111/j.1462-8902.2004.00335.x.

Anawalt BD, Bebb RA, Matsumoto AM, Groome NP, Illingworth PJ, McNeilly AS: Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab. 1996, 81: 3341-3345. 10.1210/jc.81.9.3341.

Jensen TK, Andersson AM, Hjollund NH, Scheike T, Kolstad H, Giwercman A: Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab. 1997, 82: 4059-4063. 10.1210/jc.82.12.4059.

Pierik FH, Vreeburg JT, Stijnen T, de Jong FH, Weber RF: Serum inhibin B as a marker of spermatogenesis. J Clin Endocrinol Metab. 1998, 83: 3110-3114. 10.1210/jc.83.9.3110.

Pierik FH, Burdorf A, de Jong FH, Weber RF: Inhibin B: a novel marker of spermatogenesis. Ann Med. 2003, 35: 12-20. 10.1080/07853890310004084.

Al-Qahtani A, Muttukrishna S, Appasamy M, Johns J, Cranfield M, Visser JA: Development of a sensitive enzyme immunoassay for anti-Mullerian hormone and the evaluation of potential clinical applications in males and females. Clin Endocrinol (Oxf). 2005, 63: 267-273. 10.1111/j.1365-2265.2005.02336.x.

Muttukrishna S, Yussoff H, Naidu M, Barua J, Arambage K, Suharjono H: Serum anti-Mullerian hormone and inhibin B in disorders of spermatogenesis. Fertil Steril. 2007, 88: 516-518. 10.1016/j.fertnstert.2006.11.110.

Goulis DG, Iliadou PK, Tsametis C, Gerou S, Tarlatzis BC, Bontis IN: Serum anti-Mullerian hormone levels differentiate control from subfertile men but not men with different causes of subfertility. Gynecol Endocrinol. 2008, 24: 158-160. 10.1080/09513590701672314.

Mabeck LM, Jensen MS, Toft G, Thulstrup M, Andersson M, Jensen TK: Fecundability according to male serum inhibin B--a prospective study among first pregnancy planners. Hum Reprod. 2005, 20: 2909-2915. 10.1093/humrep/dei141.

Appasamy M, Muttukrishna S, Pizzey AR, Ozturk O, Groome NP, Serhal P: Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reprod Biomed Online. 2007, 14: 159-165. 10.1016/S1472-6483(10)60783-3.

Tuttelmann F, Dykstra N, Themmen AP, Visser JA, Nieschlag E, Simoni M: Anti-Mullerian hormone in men with normal and reduced sperm concentration and men with maldescended testes. Fertil Steril. 2009, 91: 1812-1819. 10.1016/j.fertnstert.2008.02.118.

Makler A, Zaidise I, Brandes JM: Elimination of errors induced during a routine human sperm motility analysis. Arch Androl. 1979, 3: 201-210. 10.3109/01485017908988406.

Menkveld R, Stander FS, Kotze TJ, Kruger TF, van Zyl JA: The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod. 1990, 5: 586-592.

Evenson DP, Larson KL, Jost LK: Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl. 2002, 23: 25-43.

Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, Erenpreiss J: Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod. 2007, 22: 174-179.

Maldonado G, Greenland S: Interpreting model coefficients when the true model form is unknown. Epidemiology. 1993, 4: 310-318. 10.1097/00001648-199307000-00006.

Paasch U, Grunewald S, Kratzsch J, Glander HJ: Obesity and age affect male fertility potential. Fertility and Sterility. 2010, 94: 2898-2901. 10.1016/j.fertnstert.2010.06.047.

HELLER CG, CLERMONT Y: Spermatogenesis in man: an estimate of its duration. Science. 1963, 140: 184-186. 10.1126/science.140.3563.184.

Bonde JP, Ernst E, Jensen TK, Hjollund NH, Kolstad H, Henriksen TB: Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet. 1998, 352: 1172-1177. 10.1016/S0140-6736(97)10514-1.