Does elevation of serum creatinine in patients with chronic hepatitis C under therapy of telaprevir mean renal impairment?

Nephrology - Tập 20 Số 11 - Trang 843-848 - 2015
Katsuomi Matsui1, Atsuko Kamijo‐Ikemori2,1, Takeshi Sugaya1, Hiroki Ikeda3, Chiaki Okuse3, Yugo Shibagaki1, Takashi Yasuda1, Kenjiro Kimura1
1Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, Miyamae-Ku, Kanagawa, Japan
2Department of Anatomy, St. Marianna University School of Medicine, Miyamae-Ku, Kanagawa, Japan
3Department of Gastroenterology and Hepatology, Internal Medicine, St. Marianna University School of Medicine, Miyamae-Ku, Kanagawa, Japan

Tóm tắt

AbstractAimTreatment with telaprevir (TVR) entails adverse side‐effects including anaemia and elevation of serum creatinine (SCr) level. Our purpose was to evaluate the effects of treatment with TVR on renal function in adults with chronic hepatitis C.MethodsThirteen adult patients with HCV genotype 1b who were scheduled to be treated with TVR, pegylated interferon (PEG IFN), and ribavirin (RBV) were prospectively followed. Patients were divided into two groups: (i) patients with an increase in SCr during the treatment (n = 8), and (ii) patients without an increase in SCr (n = 5). Urine and serum parameters were evaluated.ResultsAlthough there was no difference in SCr level between the two groups before HCV therapy, the SCr level was persistently high in the patients in the increase‐in‐SCr group during the triple therapy. The SCr level returned to the pre‐treatment level after cessation of TVR. There were no differences in urinary L‐FABP, NAG, serum cystatin C level and eGFRcys throughout the study between the two groups. The serum cystatin C level at pre‐treatment tended to be higher in the increase‐in‐SCr group. Urinary L‐FABP and NAG levels in these groups remained within normal limits during treatment. We found that the increase in SCr was not associated with the degree of renal impairment. The increase in SCr may have been induced as a result of a decrease in creatinine secretion from proximal tubules via inhibition of transporters of creatinine induced by TVR.ConclusionElevation of SCr levels with TVR therapy may not suggest renal impairment.

Từ khóa


Tài liệu tham khảo

10.1002/hep.1840360704

10.1056/NEJMoa1013086

10.1056/NEJMoa0908014

10.1002/hep.26602

10.1111/hepr.12229

10.1002/hep.26730

10.1016/j.bcp.2012.07.032

10.1681/ASN.2007010097

10.1111/j.1440-1797.2011.01469.x

10.1038/sj.ki.5002721

10.2353/ajpath.2006.060131

10.1053/j.ajkd.2005.11.006

10.1253/circj.CJ-11-0342

10.1007/s10157-010-0384-y

10.1093/ndt/gfn573

10.1016/j.ajpath.2010.12.002

10.1023/B:PHAM.0000029286.45788.ad

10.2133/dmpk.DMPK-13-RG-118

10.1038/clpt.2011.36

10.7326/0003-4819-113-7-501

10.1111/hepr.12020

Thông tin
Thông tin xuất bản

Nephrology

Tập 20 Số 11

843-848

Thông tin tác giả