Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer’s disease?

Molecular Medicine Today - Tập 6 - Trang 54-59 - 2000
Brian H Anderton1, Rejith Dayanandan1, Richard Killick1, Simon Lovestone1
1Department of Neuroscience, Institute of Psychiatry, King’s College London, De Crespigny Park, London, UK SE5 8AF

Tài liệu tham khảo

Ray, 1998, Molecular pathogenesis of sporadic and familial forms of Alzheimer’s disease, Mol. Med. Today, 4, 151, 10.1016/S1357-4310(98)01229-5 Mandelkow, 1998, Tau in Alzheimer’s disease, Trends Cell Biol., 8, 425, 10.1016/S0962-8924(98)01368-3 Hanger, 1998, New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer’s disease brain using nanoelectrospray mass spectrometry, J. Neurochem., 71, 2465, 10.1046/j.1471-4159.1998.71062465.x Lovestone, 1994, Alzheimer’s disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells, Curr. Biol., 4, 1077, 10.1016/S0960-9822(00)00246-3 Lovestone, 1997, The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes, Neuroscience, 78, 309 Lovestone, 1999, Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations, Biol. Psychiatry, 45, 995, 10.1016/S0006-3223(98)00183-8 Cohen, 1999, The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction, Philos. Trans. R. Soc. Lond. B. Biol. Sci., 354, 485, 10.1098/rstb.1999.0399 Hong, 1997, Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons, J. Biol. Chem., 272, 19547, 10.1074/jbc.272.31.19547 Dale, 1998, Signal transduction by the Wnt family of ligands, Biochem. J., 329, 209, 10.1042/bj3290209 Cook, 1996, Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C, EMBO J., 15, 4526, 10.1002/j.1460-2075.1996.tb00830.x Doornbos, 1999, Protein kinase Czeta is a negative regulator of protein kinase B activity, J. Biol. Chem., 274, 8589, 10.1074/jbc.274.13.8589 Behrens, 1998, Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β, Science, 280, 596, 10.1126/science.280.5363.596 Hart, 1998, Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β, Curr. Biol., 8, 573, 10.1016/S0960-9822(98)70226-X Smalley, 1999, Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription, EMBO J., 18, 2823, 10.1093/emboj/18.10.2823 Artavanis-Tsakonas, 1999, Notch signaling: cell fate control and signal integration in development, Science, 284, 770, 10.1126/science.284.5415.770 De Strooper, 1999, Presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain, Nature, 398, 518, 10.1038/19083 Shen, 1997, Skeletal and CNS defects in Presenilin-1-deficient mice, Cell, 89, 629, 10.1016/S0092-8674(00)80244-5 Song, 1999, Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations, Proc. Natl. Acad. Sci. U. S. A., 96, 6959, 10.1073/pnas.96.12.6959 Steiner, 1999, A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signalling, J. Biol. Chem., 40, 28669, 10.1074/jbc.274.40.28669 Wong, 1997, Presenilin 1 is required for Notch1 DII1 expression in the paraxial mesoderm, Nature, 387, 288, 10.1038/387288a0 Axelrod, 1996, Interaction between wingless and notch signaling pathways mediated by dishevelled, Science, 271, 1826, 10.1126/science.271.5257.1826 Levesque, 1999, Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin, J. Neurochem., 72, 999, 10.1046/j.1471-4159.1999.0720999.x Stahl, 1999, Direct interaction of Alzheimer’s disease-related presenilin 1 with armadillo protein p0071, J. Biol. Chem., 274, 9141, 10.1074/jbc.274.14.9141 Tanahashi, 1999, Isolation of human delta-catenin and its binding specificity with presenilin 1, Neuroreport, 10, 563, 10.1097/00001756-199902250-00022 Zhou, 1997, Presenilin 1 interaction in the brain with a novel member of the Armadillo family, Neuroreport, 8, 2085, 10.1097/00001756-199705260-00054 Kang, 1999, Presenilin 1 facilitates the constitutive turnover of β-catenin: differential activity of Alzheimer’s disease-linked PS1 mutants in the β-catenin-signaling pathway, J. Neurosci., 19, 4229, 10.1523/JNEUROSCI.19-11-04229.1999 Zhang, 1998, Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis, Nature, 395, 698, 10.1038/27208 Murayama, 1998, Direct association of presenilin-1 with β-catenin, FEBS Lett., 433, 73, 10.1016/S0014-5793(98)00886-2 Weihl, 1999, Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB, J. Neurosci., 19, 5360, 10.1523/JNEUROSCI.19-13-05360.1999 Yu, 1998, The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin, J. Biol. Chem., 273, 16470, 10.1074/jbc.273.26.16470 Ray, 1999, Evidence for a physical interaction between presenilin and Notch, Proc. Natl. Acad. Sci. U. S. A., 96, 3263, 10.1073/pnas.96.6.3263 Nishimura, 1999, Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex, Nat. Med., 5, 164, 10.1038/5526 Bursztajn, 1998, Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis, J. Neurosci., 18, 9790, 10.1523/JNEUROSCI.18-23-09790.1998 Irving, 1997, Tau phosphorylation in cells transfected with wild-type or an Alzheimer’s disease mutant presenilin 1, Neurosci. Lett., 222, 71, 10.1016/S0304-3940(97)13343-2 Takashima, 1998, Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau, Proc. Natl. Acad. Sci. U. S. A., 95, 9637, 10.1073/pnas.95.16.9637