Does desensitization to hexarelin occur?

Growth Hormone & IGF Research - Tập 8 - Trang 141-143 - 1998
A. Rahim1, S.M. Shalet1
1Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK

Tài liệu tham khảo

Ghigo, 1994, Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administrationin man, J Clin Endocrinol Metab, 78, 693, 10.1210/jc.78.3.693 Cella, 1996, Sixteen weeks of hexarelin therapy in aged dogs: effects on the somatotropic axis, muscle morphology, and bone metabolism, J Gerontol A Biol Sci Med Sci, 51, B439, 10.1093/gerona/51A.6.B439 Klinger, 1996, Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children, Eur J Endocrinol, 134, 716, 10.1530/eje.0.1340716 Ghigo, 1996, Short-term administration of intranasal or oral hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness inhuman aging, Eur J Endocrinol, 135, 407, 10.1530/eje.0.1350407 Massoud, 1995, Hexarelin induced growth hormone release is influenced by exogenous growth hormone, Clin Endocrinol (Oxf), 43, 617, 10.1111/j.1365-2265.1995.tb02927.x Arvat, 1997, Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man, Metabolism, 46, 83, 10.1016/S0026-0495(97)90173-6 Ceda, 1987, The growth hormone (GH)-releasing hormone (GHRH)-GH-somatomedin axis: evidence for rapid inhibition of GHRH-elicited GH release by insulin-likegrowth factors I and II, Endocrinology, 120, 1658, 10.1210/endo-120-4-1658 Ceda, 1986, Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin, J Clin Endocrinol Metab, 60, 1204, 10.1210/jcem-60-6-1204 Yamashita, 1986, Insulin-like growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells, J Clin Invest, 79, 449, 10.1172/JCI112832 Yamashita, 1986, Insulin-like growth factor I regulates growth hormone secretion and messenger ribonucleic acid levels in human pituitary tumor cells, J Clin Endocrinol Metab, 63, 730, 10.1210/jcem-63-3-730 Berelowitz, 1981, Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary, Science, 212, 1279, 10.1126/science.6262917 Davis, 1986, Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusionof GRF 1-29 amide in man, Clin Endocrinol (Oxf), 24, 135, 10.1111/j.1365-2265.1986.tb00755.x Huhn, 1993, Twenty-fourhour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to asubsequent GHRP bolus, J Clin Endocrinol Metab, 76, 1202, 10.1210/jc.76.5.1202