Does bone marrow aspirate help enhance the integration of gamma irradiated allograft bone?

Bae H, Kanim LEA, Spayde E, Wong P, Zhao L, Pradhan BZ, Delamarter R (2006) Does autologous bone marrow aspirate enhance graft effectiveness for spinal fusion? Semin Spine Surg 18(1):2–11. https://doi.org/10.1053/j.semss.2006.01.002

Batista MA, Leivas TP, Rodriguez CJ, Arenas CF, Belitardo DR, Guarniero R (2011) Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia. Clinics 66(10):1787–1792. https://doi.org/10.1590/s1807-593220110007000018

Blokhuis TJ, Arts JJ (2011) Bioactive and osteoinductive bone graft substitutes: definitions, facts and myths. Injury 42(Suppl 2):S26–S29. https://doi.org/10.1016/j.injury.2011.06.010

Boyce T, Edwards J, Scarborough N (1999) Allograft bone. The influence of processing on safety and performance. Orthop Clin North Am 30(4):571–581

Braly HL, O’Connor DP, Brinker MR (2013) Percutaneous autologous bone marrow injection in the treatment of distal meta-diaphyseal tibial nonunions and delayed unions. J Orthop Trauma 27(9):527–533. https://doi.org/10.1097/BOT.0b013e31828bf077

Burwell RG (1985) The function of bone marrow in the incorporation of a bone graft. Clin Orthop Relat Res 200:125–141

Cancedda R, Bianchi G, Derubeis A, Quarto R (2003) Cell therapy for bone disease: a review of current status. Stem Cells 21(5):610–619. https://doi.org/10.1634/stemcells.21-5-610

Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9(5):641–650. https://doi.org/10.1002/jor.1100090504

Carter G (1999) Harvesting and implanting allograft bone. AORN J 70(4):660–670 (quiz 672–666)

Close B, Banister K, Baumans V, Bernoth EM, Bromage N, Bunyan J, Warwick C (1997) Recommendations for euthanasia of experimental animals: part 2. DGXT of the European Commission. Lab Anim 31(1):1–32

Conrad EU, Gretch DR, Obermeyer KR, Moogk MS, Sayers M, Wilson JJ, Strong DM (1995) Transmission of the hepatitis-C virus by tissue transplantation. J Bone Joint Surg Am 77(2):214–224

Cummine J, Nade S (1977) Osteogenesis after bone and bone-marrow transplantation. I. Studies with combined myelo-osseous grafts in the guinea pig. Acta Orthop Scand 48(1):15–24

den Boer FC, Bramer JA, Patka P, Bakker FC, Barentsen RH, Feilzer AJ, Haarman HJ (1998) Quantification of fracture healing with three-dimensional computed tomography. Arch Orthop Trauma Surg 117(6–7):345–350

Dimitriou R, Mataliotakis GI, Angoules AG, Kanakaris NK, Giannoudis PV (2011) Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury 42(Suppl 2):S3–S15. https://doi.org/10.1016/j.injury.2011.06.015

Dodd CA, Fergusson CM, Freedman L, Houghton GR, Thomas D (1988) Allograft versus autograft bone in scoliosis surgery. J Bone Joint Surg Br 70(3):431–434

Enneking WF, Mindell ER, Burchardt H, Tomford W (2005) Editorial comment. Clin Orthop Rel Res 435:2–4. https://doi.org/10.1097/01.blo.0000165720.29782.49

Faour O, Dimitriou R, Cousins CA, Giannoudis PV (2011) The use of bone graft substitutes in large cancellous voids: any specific needs? Injury 42(Suppl 2):S87–S90. https://doi.org/10.1016/j.injury.2011.06.020

Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA (2003) Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88(5):873–884. https://doi.org/10.1002/jcb.10435

Giannoudis PV, Dinopoulos H, Tsiridis E (2005) Bone substitutes: an update. Injury 36(Suppl 3):S20–S27. https://doi.org/10.1016/j.injury.2005.07.029

Grigoryan M, Lynch JA, Fierlinger AL, Guermazi A, Fan B, MacLean DB, Genant HK (2003) Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography1. Acad Radiol 10(11):1267–1273. https://doi.org/10.1016/s1076-6332(03)00467-7

Hart R, Komzak M, Okal F, Nahlik D, Jajtner P, Puskeiler M (2013) Allograft alone versus allograft with bone marrow concentrate for the healing of the instrumented posterolateral lumbar fusion. Spine J. https://doi.org/10.1016/j.spine.2013.12.014

Heiple KG, Goldberg VM, Powell AE, Bos GD, Zika JM (1987) Biology of cancellous bone grafts. Orthop Clin North Am 18(2):179–185

Hernigou P, Delepine G, Goutallier D, Julieron A (1993) Massive allografts sterilised by irradiation. Clinical results. J Bone Joint Surg Br 75(6):904–913

Hernigou P, Poignard A, Beaujean F, Rouard H (2005) Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 87(7):1430–1437. https://doi.org/10.2106/jbjs.d.02215

Ilan DI, Ladd AL (2003) Bone graft substitues. Oper Tech Plast Reconstr Surg 9(4):151–160. https://doi.org/10.1016/s1071-0949(03)00072-6

Jamsa T, Koivukangas A, Kippo K, Hannuniemi R, Jalovaara P, Tuukkanen J (2000) Comparison of radiographic and pQCT analyses of healing rat tibial fractures. Calcif Tissue Int 66(4):288–291

Kaminski A, Jastrzebska A, Grazka E, Marowska J, Gut G, Wojciechowski A, Uhrynowska-Tyszkiewicz I (2012) Effect of gamma irradiation on mechanical properties of human cortical bone: influence of different processing methods. Cell Tissue Bank 13(3):363–374. https://doi.org/10.1007/s10561-012-9308-2

Kooistra BW, Sprague S, Bhandari M, Schemitsch EH (2010) Outcomes assessment in fracture healing trials: a primer. J Orthop Trauma 24(Suppl 1):S71–S75. https://doi.org/10.1097/BOT.0b013e3181ca3fbd

Lane JM, Sandhu HS (1987) Current approaches to experimental bone grafting. Orthop Clin North Am 18(2):213–225

Lee CY, Prasad HS, Suzuki JB, Stover JD, Rohrer MD (2011) The correlation of bone mineral density and histologic data in the early grafted maxillary sinus: a preliminary report. Implant Dent 20(3):202–214. https://doi.org/10.1097/ID.0b013e318211f72e

Lichte P, Pape HC, Pufe T, Kobbe P, Fischer H (2011) Scaffolds for bone healing: concepts, materials and evidence. Injury 42(6):569–573. https://doi.org/10.1016/j.injury.2011.03.033

Lindholm TS, Urist MR (1980) A quantitative analysis of new bone formation by induction in compositive grafts of bone marrow and bone matrix. Clin Orthop Relat Res 150:288–300

Lucarelli E, Fini M, Beccheroni A, Giavaresi G, Di Bella C, Aldini NN, Donati D (2005) Stromal stem cells and platelet-rich plasma improve bone allograft integration. Clin Orthop Relat Res 435:62–68. https://doi.org/10.1097/01.blo.0000165736.87628.12

Mankin HJ, Hornicek FJ, Raskin KA, Kevin A (2005) Infection in massive bone allografts. Clin Orthop Relat Res 432:210–216. https://doi.org/10.1097/01.blo.0000150371.77314.52

Marsell R, Einhorn TA (2010) Emerging bone healing therapies. J Orthop Trauma 24(Suppl 1):S4–S8. https://doi.org/10.1097/BOT.0b013e3181ca3fab

McAuliffe JA (2003) Bone graft substitutes. J Hand Ther 16(2):180–187

Nade S, Burwell RG (1977) Decalcified bone as a substrate for osteogenesis. J Bone Joint Surg [Br] 59(2):189–196

Nather A (2005) Structure of bone. Bone grafts and bone substitutes. World Scientific, Singapore, pp 3–17

Nather A, David V, Teng JWH, Lee CW, Pereira BP (2010) Effect of autologous mesenchymal stem cells on biological healing of allografts in critical-sized tibial defects simulated in adult rabbits. Ann Acad Med Singap 39:599–606

Nguyen H, Morgan DA, Forwood MR (2007a) Sterilization of allograft bone: effects of gamma irradiation on allograft biology and biomechanics. Cell Tissue Bank 8(2):93–105. https://doi.org/10.1007/s10561-006-9020-1

Nguyen H, Morgan DA, Forwood MR (2007b) Sterilization of allograft bone: is 25 kGy the gold standard for gamma irradiation? Cell Tissue Bank 8(2):81–91. https://doi.org/10.1007/s10561-006-9019-7

Nicklas W, Baneux P, Boot R, Decelle T, Deeny AA, Fumanelli M et al (2002) Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 36(1):20–42

Nyman JS, Munoz S, Jadhav S, Mansour A, Yoshii T, Mundy GR, Gutierrez GE (2009) Quantitative measures of femoral fracture repair in rats derived by micro- computed tomography. J Biomech 42(7):891–897. https://doi.org/10.1016/j.jbiomech.2009.01.016

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143–147

Russell NA, Pelletier MH, Bruce WJ, Walsh WR (2012) The effect of gamma irradiation on the anisotropy of bovine cortical bone. Med Eng Phys 34(8):1117–1122. https://doi.org/10.1016/j.medengphy.2011.11.021

Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Bianco P (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131(2):324–336. https://doi.org/10.1016/j.cell.2007.08.025

Sandhu HS, Grewal HS, Parvataneni H (1999) Bone grafting for spinal fusion. Orthop Clin North Am 30(4):685–698

Spruit M, Meijers H, Obradov M, Anderson PG (2004) CT density measurement of bone graft within an intervertebral lumbar cage: increase of hounsfield units as an indicator for increasing bone mineral content. J Spinal Disord Tech 17(3):232–235

Sundberg RD, Hodgson RE (1949) Aspiration of bone marrow in laboratory animals. Blood 4(5):557–561

Tang TT, Lu H, Dai KR (2002) Osteogenesis of freeze-dried cancellous bone allograft loaded with autologous marrow-derived mesenchymal cells. Mater Sci Eng C 20:57–61

Wientroub S, Goodwin D, Khermosh O, Salama R (1989) The clinical use of autologous marrow to improve osteogenic potential of bone grafts in pediatric orthopedics. J Pediatr Orthop 9(2):186–190