Do senescence markers correlate in vitro and in situ within individual human donors?

Aging - Tập 10 Số 2 - Trang 278-289 - 2018
M.E.C. Waaijer1, David A. Gunn2, Diana van Heemst1,3, P. Eline Slagboom4,3, John M. Sedivy5, Roeland W. Dirks6, Hans J. Tanke6, Rudi G. J. Westendorp7, Andrea B. Maier8,9
1Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
2Unilever Discover, Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK
3Netherlands Consortium for Healthy Aging, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
4Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
5Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912 USA
6Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
7Department of Public Health and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 1123 Copenhagen, Denmark
8Department of Medicine and Aged Care, Royal Melbourne Hospital, University of Melbourne, Parkville VIC 3050, Australia
9MOVE Research Institute Amsterdam, Department of Human Movement Sciences, VU University of Amsterdam, 1007 MB Amsterdam, The Netherlands

Tóm tắt

Từ khóa


Tài liệu tham khảo

Hayflick, 1965, The limited in vitro lifetime of human diploid cell strains., Exp Cell Res, 3, 614, 10.1016/0014-4827(65)90211-9

Moorhead, 1961, The serial cultivation of human diploid cell strains., Exp Cell Res, 2, 585, 10.1016/0014-4827(61)90192-6

Krizhanovsky, 2014, Physiological and pathological consequences of cellular senescence., Cell Mol Life Sci, 7, 4373, 10.1007/s00018-014-1691-3

van Deursen, 2011, Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders., Nature, 47, 232, 10.1038/nature10600

Keyes, 2013, Senescence is a developmental mechanism that contributes to embryonic growth and patterning., Cell, 15, 1119, 10.1016/j.cell.2013.10.041

Serrano, 2013, Programmed cell senescence during mammalian embryonic development., Cell, 15, 1104, 10.1016/j.cell.2013.10.019

Campisi, 2008, Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor., PLoS Biol, 6, 2853, 10.1371/journal.pbio.0060301

Lowe, 2008, Senescence of activated stellate cells limits liver fibrosis., Cell, 13, 657, 10.1016/j.cell.2008.06.049

Campisi, 1995, A biomarker that identifies senescent human cells in culture and in aging skin in vivo., Proc Natl Acad Sci USA, 9, 9363, 10.1073/pnas.92.20.9363

Stewart, 2008, Senescence: the good the bad and the dysfunctional., Curr Opin Genet Dev, 1, 42, 10.1016/j.gde.2007.12.002

Hwang, 2006, Senescence-associated beta-galactosidase is lysosomal beta-galactosidase., Aging Cell, 5, 187, 10.1111/j.1474-9726.2006.00199.x

Ferbeyre, 2009, Mitochondrial dysfunction contributes to oncogene-induced senescence., Mol Cell Biol, 2, 4495, 10.1128/MCB.01868-08

Sherr, 2015, Forging a signature of in vivo senescence., Nat Rev Cancer, 1, 397, 10.1038/nrc3960

Boege, 2014, The hallmarks of fibroblast ageing., Mech Ageing Dev, 13, 26, 10.1016/j.mad.2014.03.004

Maier, 2011, Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro., J Gerontol A Biol Sci Med Sci, 6, 45, 10.1093/gerona/glq159

Peeper, 2010, The essence of senescence., Genes Dev, 2, 2463, 10.1101/gad.1971610

Maier, 2009, Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts., Cytometry A, 7, 910, 10.1002/cyto.a.20796

Sedivy, 2004, Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)., Mol Cell, 1, 501, 10.1016/S1097-2765(04)00256-4

Passos, 2010, Quantitative assessment of markers for cell senescence., Exp Gerontol, 4, 772, 10.1016/j.exger.2010.01.018

Giovannelli, 2016, Long-term Neuroglial Cocultures as a Brain Aging Model: Hallmarks of Senescence, MicroRNA Expression Profiles, and Comparison With In Vivo Models., J Gerontol A Biol Sci Med Sci, 7, 50, 10.1093/gerona/glu231

Allen, 2002, Effects of establishing cell cultures and cell culture conditions on the proliferative life span of human fibroblasts isolated from different tissues and donors of different ages., Exp Cell Res, 27, 275, 10.1006/excr.2002.5485

Macieira-Coelho, 1982, Heterogeneity of the kinetics of proliferation within human skin fibroblastic cell populations., J Cell Sci, 5, 177

Grove, 1979, Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro., Science, 20, 526, 10.1126/science.432659

Jendrach, 2007, Identification of cultivation-independent markers of human endothelial cell senescence in vitro., Biogerontology, 8, 383, 10.1007/s10522-007-9082-x

Rubin, 1997, Cell aging in vivo and in vitro., Mech Ageing Dev, 9, 1, 10.1016/S0047-6374(97)00067-5

Schmitt, 2014, In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells., PLoS One, 9, e88071, 10.1371/journal.pone.0088071

King, 2008, Low oxygen delays fibroblast senescence despite shorter telomeres., Biogerontology, 9, 19, 10.1007/s10522-007-9113-7

Sharpless, 2013, Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model., Cell, 15, 340, 10.1016/j.cell.2012.12.010

Sharpless, 2014, p16INK4a reporter mice reveal age-promoting effects of environmental toxicants., J Clin Invest, 12, 169, 10.1172/JCI70960

Sharpless, 2009, INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis., PLoS One, 4, e5027, 10.1371/journal.pone.0005027

Westendorp, 2002, Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population., J Am Geriatr Soc, 5, 1405, 10.1046/j.1532-5415.2002.50363.x

van Heemst, 2007, Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians., Aging Cell, 6, 27, 10.1111/j.1474-9726.2006.00263.x

Westendorp, 2006, Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study., Eur J Hum Genet, 1, 79, 10.1038/sj.ejhg.5201508

Maier, 2012, Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts., Mech Ageing Dev, 13, 498, 10.1016/j.mad.2012.06.002

Maier, 2012, Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age., J Gerontol A Biol Sci Med Sci, 6, 456, 10.1093/gerona/glr196

Maier, 2016, DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age., Aging (Albany NY), 8, 147, 10.18632/aging.100890

Westendorp, 2009, Stress-induced responses of human skin fibroblasts in vitro reflect human longevity., Aging Cell, 8, 595, 10.1111/j.1474-9726.2009.00506.x

Maier, 2012, The number of p16INK4a positive cells in human skin reflects biological age., Aging Cell, 1, 722, 10.1111/j.1474-9726.2012.00837.x