Do mutations in Plasmodium falciparum dihydropteroate synthase and dihydrofolate reductase confer resistance to sulfadoxine-pyrimethamine in Iran?

Abbas-Ali Eskandarian1, Hossein Keshavarz1, Leonardo K. Basco2, Fereidoun Mahboudi3
1Department of Medical Parasitology and Mycology, School of Health and Institute for Health Researches, University of Medical Sciences of Tehran, Tehran, Iran
2Unité de Recherche ‘Paludologie Afro-tropicale’, Institut de Recherche pour le Développement-Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon
3Biotechnology Department, Pasteur Institute of Iran, Tehran, 13164, Iran

Tài liệu tham khảo

Barker, 1994, Plasmodium falciparum and P. vivax: factors affecting sensitivity and specificity of PCR-based diagnosis of malaria, Experimental Parasitology, 79, 41, 10.1006/expr.1994.1057 Basco, 2000, Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria, Journal of Infectious Diseases, 182, 624, 10.1086/315731 Brooks, 1994, Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase:dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine, European Journal of Biochemistry, 2, 397, 10.1111/j.1432-1033.1994.00397.x Edrissian, 1985, Preliminary study of the response of Plasmodium falciparum to chloroquine in Sistan and Bluchistan province of Iran [Correspondence], Transactions of the Royal Society of Tropical Medicine and Hygiene, 79, 563, 10.1016/0035-9203(85)90101-4 Edrissian, 1993, Assessment of the response in vivo and in vitro of Plasmodium falciparum to sulfadoxine-pyrimethamine in the malarious areas of Iran, Journal of Tropical Medicine and Hygiene, 96, 237 Edrissian, 1999, Monitoring the response of Plasmodium falciparum and P. vivax to antimalarial drugs in the malarious areas in south-east Iran, Archives of Internal Medicine, 2, 61 Nzila, 2000, Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites, Antimicrobial Agents and Chemotherapy, 44, 991, 10.1128/AAC.44.4.991-996.2000 Plowe, 1998, P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and role in clinical resistance to antifolates, Drug Resistance Updates, 1, 389, 10.1016/S1368-7646(98)80014-9 Triglia, 1994, Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum, 91, 7149 Wang, 1994, A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthase gene of Plasmodium falciparum, Molecular and Biochemical Parasitology, 71, 115, 10.1016/0166-6851(95)00041-X Wang, 1997, Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins, Molecular and Biochemical Parasitology, 89, 161, 10.1016/S0166-6851(97)00114-X Wu, 1996, Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine, 93, 1130