Do β-tubulin mutations have a role in resistance to chemotherapy?

Nogales, 2001, Structural insights into microtubule function, Annu Rev Biophys Biomol Struct, 30, 397, 10.1146/annurev.biophys.30.1.397 Fojo, 2000, Taxol and other microtubule-interactive agents, Curr Opin in Oncol Endocrine Metabolic Investig Drugs, 2, 293 Blagosklonny, 1999, Molecular effects of paclitaxel: myths and reality: a critical review, Int J Cancer, 83, 151, 10.1002/(SICI)1097-0215(19991008)83:2<151::AID-IJC1>3.0.CO;2-5 Dumontet, 1999, Mechanisms of action and resistance to antitubulin agents: microtubule dynamics, drug transport and cell death, J Clin Oncol, 17, 1061, 10.1200/JCO.1999.17.3.1061 Rao, 1994, 3′-(p-Azidobenzamido)taxol photolabels the N-terminal 31 amino acids of β-tubulin, J Biol Chem, 269, 3132, 10.1016/S0021-9258(17)41836-9 Rao, 1995, Characterization of the taxol binding site on the microtubule, J Biol Chem, 270, 20235, 10.1074/jbc.270.35.20235 Rao, 1999, Characterization of the taxol binding site on the microtubule, J Biol Chem, 274, 37990, 10.1074/jbc.274.53.37990 Nogales, 1998, Structure of the αβ-tubulin dimer by electron crystallography, Nature, 391, 199, 10.1038/34465 Löwe, 2001, Refined structure of αβ-tubulin at 3·5 Å resolution, J Mol Biol, 313, 1045, 10.1006/jmbi.2001.5077 Rai, 1996, Localization of the vinblastine-binding site on β-tubulin, J Biol Chem, 271, 14707, 10.1074/jbc.271.25.14707 Sullivan, 1986, Identification of conserved isotypedefining variable region sequences for four vertebrate β-tubulin polypeptide classes, Proc Natl Acad Sci USA, 83, 4327, 10.1073/pnas.83.12.4327 Nicoletti, 2001, Expression of β-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-anticancer drug screen: correlation with sensitivity to microtubule active agents, Clin Cancer Res, 7, 2912 NCBI Lee, 1983, Evolutionary history of a multigene family: an expressed human β-tubulin gene and three processed pseudogenes, Cell, 33, 477, 10.1016/0092-8674(83)90429-4 Kelley, 2001, Genetic analysis of the β-tubulin gene, TUBB, in non-small-cell lung cancer, J Natl Cancer Inst, 93, 1886, 10.1093/jnci/93.24.1886 Hasegawa, 2002, Mutational analysis of the class I β-tubulin gene in human breast cancer, Int J Cancer, 101, 46, 10.1002/ijc.10575 Wilde, 1982, Diverse mechanisms in the generation of human β-tubulin pseudogenes, Science, 217, 549, 10.1126/science.6178164 Wilde, 1982, Evidence that a human β-tubulin pseudogene is derived from its corresponding mRNA, Nature, 297, 83, 10.1038/297083a0 Pichuantes, 1982, Structure of the eukaryotic genome: a unique pseudogenes lacking introns and poly A tail as a member of the human β-tubulin gene family, Arch Biol Med Exp, 15, 381 Tsurutani, 2002, Mutational analysis of the β-tubulin gene in lung cancer, Lung Cancer, 35, 11, 10.1016/S0169-5002(01)00291-4 Kavallaris, 1999, Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to taxol, Br J Cancer, 80, 1020, 10.1038/sj.bjc.6690507 Ranganathan, 1998, Altered β-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells, Br J Cancer, 77, 562, 10.1038/bjc.1998.91 Ranganathan, 1996, Increase of βIII-and βIVa-tubulin isotypes in human prostate carcinoma cells as a result of estramustine resistance, Cancer Res, 56, 2584 Kavallaris, 1997, Taxol-resistant epithelial ovarian tumours are associated with altered expression of specific β-tubulin isotypes, J Clin Invest, 100, 1282, 10.1172/JCI119642 Ranganathan, 1998, Cloning and sequencing of human βIII-tubulin cDNA by acute exposure to antimicrotubule agents, Biochim Biophys Acta, 1395, 237, 10.1016/S0167-4781(97)00168-1 Giannakakou, 1997, Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization, J Biol Chem, 272, 17118, 10.1074/jbc.272.27.17118 He, 2001, Mutations in β-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines, Mol Cancer Ther, 1, 3 Šale, 2002, Conservation of the class I β-tubulin gene in human populations and lack of mutations in lung cancers and paclitaxel-resistant ovarian cancers, Mol Cancer Ther, 1, 215 Kavallaris, 2001, Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukaemia cells, Cancer Res, 61, 5803 Giannakakou, 2000, A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells, Proc Natl Acad Sci USA, 97, 2904, 10.1073/pnas.040546297 Hua, 2001, Biochemical genetic analysis of indanocine resistance in human leukemia, Cancer Res, 61, 7248 Nogales, 1999, High-resolution model of the microtubule, Cell, 96, 79, 10.1016/S0092-8674(00)80961-7 Warnick, 2001, Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells, J Biol Chem, 276, 27363, 10.1074/jbc.M103088200 Monzó, 1999, Paclitaxel resistance in nonsmall-cell lung cancer associated with beta-tubulin gene mutations, J Clin Oncol, 17, 1786, 10.1200/JCO.1999.17.6.1786 McDaid, 2002, Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study, Clin Cancer Res, 8, 2035 Kohonen-Corish, 2002, Lack of β-tubulin gene mutations in early stage lung cancer, Int J Cancer, 101, 398, 10.1002/ijc.10601 de Castro, 2003, New insights in β-tubulin sequence analysis in non-small cell lung cancer, Lung Cancer, 41, 41, 10.1016/S0169-5002(03)00123-5 Monzó, 2002, Re: Genetic analysis of the β-tubulin gene, TUBB, in non-small-cell lung cancer, J Natl Cancer Inst, 94, 774, 10.1093/jnci/94.10.774 Kelley, 2002, Genetic analysis of the β-tubulin gene, TUBB, in nonsmall-cell lung cancer, J Natl Cancer Inst, 94, 777, 10.1093/jnci/94.10.777 Šale, 2002, Re: Genetic analysis of the β-tubulin gene, TUBB, in non-small-cell lung cancer, J Natl Cancer Inst, 94, 776, 10.1093/jnci/94.10.776 Lamendola, 2003, β-tubulin mutations are rare in human ovarian carcinoma, Anticancer Res, 23, 681