Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

BioEssays - Tập 25 Số 6 - Trang 542-553 - 2003
Patrick O. Humbert1, Sarah M. Russell2, Helena E. Richardson3
1Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, St. Andrew's Place, East Melbourne, Victoria 3002, Australia.
2Immune Signaling Laboratory, Peter MacCallum Cancer Institute, Victoria, Australia
3Cell Cycle and Development Laboratory, Peter MacCallum Cancer Institute, Victoria, Australia

Tóm tắt

AbstractDlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been identified as tumour suppressor genes in Drosophila, mutations of which cause similar phenotypes, involving disruption of cell polarity and neoplastic overgrowth of tissues. The molecular mechanisms by which Dlg, Scrib and Lgl proteins regulate cell proliferation are not clear, but there is some evidence that epithelial polarisation is required for this regulation. Dlg, Scrib and Lgl are highly conserved between human and Drosophila, and we discuss evidence that these proteins also play a role in cancer progression in humans. BioEssays 25:542–553, 2003. © 2003 Wiley Periodicals, Inc.

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BioEssays

Tập 25 Số 6

542-553

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