Diverse Polyphenols from Hypericum faberi

Natural Products and Bioprospecting - Tập 9 Số 3 - Trang 215-221 - 2019
Xin Wen Zhang1,2, Yan Song Ye1,2, F. Xia1, Xing Yang1, Gang Xu1
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, People’s Republic of China
2University of Chinese Academy of Sciences, Beijing, People’s Republic of China

Tóm tắt

Abstract Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A–F (1–6), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B (1/2) and 12–13 were isoprenylated xanthones, hyperfaberols C–E (3–5) and 8–11 were seven isoprenylated acylphloroglucinol derivatives, while 6–7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line (ECA-109) and the pancreatic tumor cell line (PANC-1) in vitro, respectively. Graphical Abstract

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Natural Products and Bioprospecting

Tập 9 Số 3

215-221

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