Distribution of Exposure Concentrations and Doses for Constituents of Environmental Tobacco Smoke
Tóm tắt
The ultimate goal of the research reported in this series of three articles is to derive distributions of doses of selected environmental tobacco smoke (ETS)-related chemicals for nonsmoking workers. This analysis uses data from the 16-City Study collected with personal monitors over the course of one workday in workplaces where smoking occurred. In this article, we describe distributions of ETS chemical concentrations and the characteristics of those distributions (e.g., whether the distribution was log normal for a given constituent) for the workplace exposure. Next, we present population parameters relevant for estimating dose distributions and the methods used for estimating those dose distributions. Finally, we derive distributions of doses of selected ETS-related constituents obtained in the workplace for people in smoking work environments. Estimating dose distributions provided information beyond the usual point estimate of dose and showed that the preponderance of individuals exposed to ETS in the workplace were exposed at the low end of the dose distribution curve. The results of this analysis include estimations of hourly maxima and time-weighted average (TWA) doses of nicotine from workplace exposures to ETS (extrapolated from 1 day to 1 week) and doses derived from modeled lung burdens of ultraviolet-absorbing particulate matter (UVPM) and solanesol resulting from workplace exposures to ETS (extrapolated from 1 day to 1 year).
Tài liệu tham khảo
R. A. Jenkins, M. R. Guerin, A. Palausky, R. W. Counts, C. K. Bayne, and A. B. Dindal, “Determination of Human Exposure to Environmental Tobacco Smoke (ETS): A Study Conducted in 16 U.S. Cities,” draft final report by Oak Ridge National Laboratory for Center for Indoor Air Research, Lin-thicum, Maryland (1996a).
R. A. Jenkins, A. Palausky, R. W. Counts, C. K. Bayne, A. B. Dindal, and M. R. Guerin, “Exposure to Environmental To-bacco Smoke in Sixteen Cities in the United States as Deter-mined by Personal Breathing Zone Air Sampling,” J.Exposure Anal.Environ.Epidemiol. 6(4), 473–502(1996b).
W. R. Ott, “A Physical Explanation of the Lognormality of Pollutant Concentrations,” J.Air Waste Manage.Assoc. 401378–1383(1990).
U.S. EPA (U.S. Environmental Protection Agency), “Guiding Principles for Monte Carlo Analysis,” Risk Assessment Fo-rum, Washington, D.C., EPA/630/R-97/001 (March 1997).
J. Brainard and D. E. Burmaster, “Bivariate Distributions for Height and Weight of Men and Women in the United States,” Risk Anal. 12(2), 267–275(1992).
American Industrial Health Council (AIHC), Exposure Fac-tors Sourcebook. Washington, D.C. (1994).
U.S. Environmental Protection Agency (EPA), “Exposure Factors Handbook” Exposure Assessment Group, Office of Research and Development, Washington, D.C., EPA/600/P-95/ 002Ba (August 1996a).
T. R. Johnson, J. E. Capel, E. Olaguer, and L. Wijnberg, “Estimation of Carbon Monoxide Exposures by Urban Resi-dents Using a Probabilistic Version of NEM,” report by IT Air Quality Services for the U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, Re-search Triangle Park, North Carolina (1992).
T. R. Johnson, “A Study of Human Activity Patterns in Cincin-nati, Ohio,” report by PEI Associates, Inc., for Electric Power Research Institute, available from Ted R. Johnson, IT Corpo-ration, 3710 University Drive, Durham, NC 27707 (1987).
U.S. Environmental Protection Agency (EPA), Air Quality Criteria for Particulate Matter: Vols.I, II, and IIIOffice of Research and Development, Washington, D.C., EPA/600/P-95/ 001aF (April 1996b).
A. C. James, A. M. Jarabek, P. E. Morrow, R. B. Schlesinger, M. B. Snipes, and C. P. Yu, “Dosimetry of Inhaled Particles in the Respiratory Tract,” in Air Quality Criteria for Particulate Matter, Vol.IIU.S. Environmental Protection Agency, Office of Research and Development, Washington, D.C., EPA/600/ P-95/001bF (April 1996).
D. J. Eatough, L. D. Hansen, and E. A. Lewis, “Assessing Exposure to Environmental Tobacco Smoke,” in R. Perry and P. W. Kirk (eds.), Indoor and Ambient Air Qualitypp. 131–140. (Selper Ltd., Chiswick, London, United Kingdom, 1988).
N. L. Benowitz and P. Jacob III, “Metabolism, Pharmacokinet-ics, and Pharmacodynamics of Nicotine in Man,” in W. R. Martin, G. R. van Loon, E. T. Iwamoto, and D. L. Davis (eds.), Advances in Behavioral Biology—Tobacco Smoking and Nicotine: A Neurobiological Approachpp. 357–373, (Plenum Press, New York, 1987).
M. A. H. Russell and C. Feyerabend, “Cigarette Smoking: A Dependence on High-Nicotine Boli,” Drug Metab.Rev. 8(1), 29–57(1978).
L. Molander, E. Lunell, S. B. Andersson, and F. Kuylenstierna, “Dose Released and Absolute Bioavailability of Nicotine from a Nicotine Vapor Inhaler,” Clin.Pharmacol.Ther. 59(4), 394–400 (1996).
A. Iwase, M. Aiba, and S. Kira, “Respiratory Nicotine Absorp-tion in Non-smoking Females During Passive Smoking,” Int. Arch.Occup.Environ.Health 63139–143(1991).
A. K. Armitage, C. T. Dollery, C. F. George, T. H. Houseman, P. J. Lewis, and D. M. Turner, “Absorption and Metabolism of Nicotine from Cigarettes,” Br.Med.J. 4313–316(1975).
D. E. Robinson, N. J. Balter, and S. L. Schwartz, “A Physiologi-cally Based Pharmacokinetic Model for Nicotine and Cotinine in Man,” J.Pharmacokin.Biopharmaceut. 20(6), 591–609 (1992).
S. Zevin, P. Jacob III, and N. Benowitz, “Cotinine Effects on Nicotine Metabolism,” Clin.Pharmacol.Ther. 61649–654 (1997).
N. L. Benowitz, P. Jacob III, R. T. Jones, and J. Rosenberg, “Interindividual Variability in the Metabolism and Cardiovas-cular Effects of Nicotine in Man,” J.Pharmacol.Exp.Ther. 221(2), 368–372(1982).
C. Feyerabend, R. M. J. Ings, and M. A. H. Russell, “Nicotine Pharmacokinetics and Its Application to Intake from Smok-ing,” Br.J.Clin.Pharmacol. 19239–247(1985).
D. R. Plowchalk, M. E. Andersen, and J. D. deBethizy, “A Physiologically Based Pharmacokinetic Model for Nicotine Disposition in the Sprague-Dawley Rat,” Toxicol.Appl.Phar-macol. 116(2), 177–188(1992).
G. A. Kyerematen, G. F. Owens, B. Chattopadhyay, and J. D. deBethizy, “Sexual Dimorphism of Nicotine Metabolism and Distribution in the Rat: Studies in Vivoand in Vitro” Drug Metab.Dispos. 16(6), 823–828(1988).
K. S. Rotenberg and J. Adir, “Pharmacokinetics of Nicotine in Rats After Multiple-Cigarette Smoke Exposure,” Toxicol. Appl.Pharmacol. 691–11(1983).
H. D. Goodfellow, S. Eyre, and J. A. S. Wyatt, “Assessing Exposures to Environmental Tobacco Smoke,” in Environ-mental Tobacco Smoke: Proceeding of International Sympo-sium at McGill Universitypp. 53–67. D. J. Ecobichon and J. M. Wu, editors. (Lexington Books, Lexington, Massachusetts/Toronto, Canada, 1989).
D. J. Ecobichon, L. C. Holcomb, R. A. Jenkins, Y. S. Kim, S. Liao, T. Malmfors, D. Moschandreas, R. Perry, and J. M. Wu, “Panel Discussion on Exposure and Dose,” in D. J. Ecobi-chon and J. M. Wu (eds.), Environmental Tobacco Smoke: Proceeding of International Symposium at McGill Universitypp. 79–96(Lexington Books, Lexington, Massachusetts/ Toronto, Canada, 1989).
C. P. Yu, L. Zhang, M. H. Becquemin, M. Roy, and A. Bou-chikhi, “Algebraic Modeling of Total and Regional Deposition of Inhaled Particles in the Human Lung of Various Ages, J. Aerosol.Sci. 23(1), 73–79(1992).
L. Koblinger and W. Hofmann, “Monte Carlo Modeling of Aerosol Deposition in Human Lungs. Part I: Simulation of Particle Transport in a Stochastic Lung Structure,” J.Aerosol. Sci. 21(5), 661–674(1990).
International Commission on Radiological Protection (ICRP), “Human Respiratory Tract Model for Radiological Protection. ICRP Publication 66,” Ann.ICRP 24(1- 4), 1–482(1994).
N. S. Jarvis, A. Birchall, A. C. James, M. R. Bailey, and M. D. Dorrian, “LUDEP 2.0. Personal Computer Program for Calculating Internal Doses Using the ICRP Publication 66 Respiratory Tract Model,” National Radiological Protection Board, Oxon, United Kingdom, NRPB-SR287 (1996).
J. J. McAughey, D. A. Knight, A. Black, and C. J. Dickens, “Environmental Tobacco Smoke Retention in Humans from Measurements of Exhaled Smoke Composition,” Inhal.Tox-icol. 6(6), 615–631(1994).
J. C. Strong, A. Black, D. A. Knight, C. J. Dickens, and J. J. McAughey, “The Regional Lung Deposition of Thoron Prog-eny Attached to the Particulate Phase of Environmental To-bacco Smoke,” Radiat.Prot.Dosim. 54(1), 47–56(1994).
J. J. McAughey, “Regional Lung Deposition and Dose of Ambient Particulate in Humans by Particle Mass and Num-be,” in Proceedings of the Particles in Health Symposium, Prague, 1997(Air and Waste Management Association, Wash-ington, D.C., 1997).
U.S. Department of Labor (DOL), Occupation Safety and Health Administration (OSHA), “Proposed Rule Indoor Air Quality,” Fed.Reg. 59(65), 15969–16039(April 5, 1994).