Dissolvable layered microneedles with core-shell structures for transdermal drug delivery

Kim, 2012, Microneedles for drug and vaccine delivery, Adv. Drug Deliv. Rev., 64, 1547, 10.1016/j.addr.2012.04.005 Loh, 2007, Biodegradable thermosensitive copolymer hydrogels for drug delivery, Expert Opin. Ther. Pat., 17, 965, 10.1517/13543776.17.8.965 Li, 2008, Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery, Adv. Drug Deliv. Rev., 60, 1000, 10.1016/j.addr.2008.02.011 Larraneta, 2016, Microneedles: a new frontier in nanomedicine delivery, Pharm. Res., 33, 1055, 10.1007/s11095-016-1885-5 Loh, 2013, Co-delivery of drug and DNA from cationic dual-responsive micelles derived from poly(DMAEMA-co-PPGMA), Mater. Sci. Eng. C, 33, 4545, 10.1016/j.msec.2013.07.011 Dou, 2014, Biodegradable thermogelling polymers: working towards clinical applications, Adv. Healthc. Mater., 3, 977, 10.1002/adhm.201300627 Kai, 2014, Biodegradable polymers for electrospinning: towards biomedical applications, Mater. Sci. Eng. C, 45, 659, 10.1016/j.msec.2014.04.051 Kersten, 2007, Needle-free vaccine delivery, Expert Opin. Drug Deliv., 4, 459, 10.1517/17425247.4.5.459 Ye, 2016, Sebacate-based supramolecular hydrogel as an injectable drug delivery matrix, Polymer, 8 Xiang, 2017, Recent development of synthetic nonviral systems for sustained gene delivery, Drug Discov. Today, 22, 1318, 10.1016/j.drudis.2017.04.001 DeMuth, 2010, Nano-layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA, Adv. Mater., 22, 4851, 10.1002/adma.201001525 McCrudden, 2015, Microneedle applications in improving skin appearance, Exp. Dermatol., 24, 561, 10.1111/exd.12723 Bariya, 2012, Microneedles: an emerging transdermal drug delivery system, J. Pharm. Pharmacol., 64, 11, 10.1111/j.2042-7158.2011.01369.x Pushpamalar, 2016, Biodegradable polysaccharides for controlled drug delivery, Chem. Aust., 81, 504 Liow, 2017, Long-term real-time in vivo drug release monitoring with AIE thermogelling polymer, Small, 13 DeMuth, 2013, Vaccine delivery with microneedle skin patches in nonhuman primates, Nat. Biotechnol., 31, 1082, 10.1038/nbt.2759 Liu, 2016, Improvement of transdermal delivery of exendin-4 using novel tip-loaded microneedle arrays fabricated from hyaluronic acid, Mol. Pharm., 13, 272, 10.1021/acs.molpharmaceut.5b00765 Gill, 2007, Coated microneedles for transdermal delivery, J. Control. Release, 117, 227, 10.1016/j.jconrel.2006.10.017 Andrianov, 2009, Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization, Proc. Natl. Acad. Sci. U. S. A., 106, 18936, 10.1073/pnas.0908842106 Sullivan, 2008, Minimally invasive protein delivery with rapidly dissolving polymer microneedles, Adv. Mater., 20, 933, 10.1002/adma.200701205 Lee, 2011, Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose, Biomaterials, 32, 3134, 10.1016/j.biomaterials.2011.01.014 Lahiji, 2015, A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery, Sci. Rep., 5, 7914, 10.1038/srep07914 Vrdoljak, 2016, Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods, J. Control. Release, 225, 192, 10.1016/j.jconrel.2016.01.019 Vrdoljak, 2012, Coated microneedle arrays for transcutaneous delivery of live virus vaccines, J. Control. Release, 159, 34, 10.1016/j.jconrel.2011.12.026 DeMuth, 2012, Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery, ACS Nano, 6, 8041, 10.1021/nn302639r Martin, 2012, Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications, J. Control. Release, 158, 93, 10.1016/j.jconrel.2011.10.024 Zhu, 2016, Rapidly separating microneedles for transdermal drug delivery, Acta Biomater., 41, 312, 10.1016/j.actbio.2016.06.005 Yu, 2015, Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery, Proc. Natl. Acad. Sci. U. S. A., 112, 8260, 10.1073/pnas.1505405112 Raja, 2013, Transdermal delivery devices: fabrication, mechanics and drug release from silk, Small, 9, 3704, 10.1002/smll.201202075 Ling, 2013, Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats, Acta Biomater., 9, 8952, 10.1016/j.actbio.2013.06.029 Qi, 2016, A fabrication method of microneedle molds with controlled microstructures, Mater. Sci. Eng. C, 65, 135, 10.1016/j.msec.2016.03.097 Chen, 2012, Chitosan microneedle patches for sustained transdermal delivery of macromolecules, Biomacromolecules, 13, 4022, 10.1021/bm301293d Chen, 2016, Near-infrared light-activatable microneedle system for treating superficial tumors by combination of chemotherapy and photothermal therapy, ACS Nano, 10, 93, 10.1021/acsnano.5b05043 Ye, 2014, Current treatment options and drug delivery systems as potential therapeutic agents for ovarian cancer: a review, Mater. Sci. Eng. C, 45, 609, 10.1016/j.msec.2014.06.002 Li, 2015, Water soluble polyhydroxyalkanoates: future materials for therapeutic applications, Chem. Soc. Rev., 44, 2865, 10.1039/C5CS00089K Barouti, 2016, New linear and star-shaped thermogelling poly(R-3-hydroxybutyrate) copolymers, Chem. Eur. J., 22, 10501, 10.1002/chem.201601404 Li, 2016, Recent advances of using hybrid nanocarriers in remotely controlled therapeutic delivery, Small, 12, 4782, 10.1002/smll.201601129 Raphael, 2010, Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays, Small, 6, 1785, 10.1002/smll.201000326 Mistilis, 2015, Development of a thermostable microneedle patch for influenza vaccination, J. Pharm. Sci., 104, 740, 10.1002/jps.24283 Esser, 2016, Tetanus vaccination with a dissolving microneedle patch confers protective immune responses in pregnancy, J. Control. Release, 236, 47, 10.1016/j.jconrel.2016.06.026 Loh, 2016, Utilising inorganic nanocarriers for gene delivery, Biomater. Sci., 4, 70, 10.1039/C5BM00277J Fukushima, 2011, Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats, Pharm. Res., 28, 7, 10.1007/s11095-010-0097-7 Chen, 2015, Poly-gamma-glutamic acid microneedles with a supporting structure design as a potential tool for transdermal delivery of insulin, Acta Biomater., 24, 106, 10.1016/j.actbio.2015.06.021 Chu, 2011, Separable arrowhead microneedles, J. Control. Release, 149, 242, 10.1016/j.jconrel.2010.10.033 Chen, 2013, Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination, Biomaterials, 34, 3077, 10.1016/j.biomaterials.2012.12.041