Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma
Rut Espinosa-Sotelo1,2, Noel P. Fusté1, Irene Peñuelas-Haro1,2, Ania Alay3,4, Gabriel Pons5, Xènia Almodóvar1, Júlia Albaladejo1, Ismael Sánchez-Vera5, Ricard Bonilla-Amadeo1, Francesco Dituri6, Grazia Serino6, Emilio Ramos2,7, Teresa Serrano2,8, Mariona Calvo9, María Luz Martínez-Chantar2,10, Gianluigi Giannelli6, Esther Bertran1,2, Isabel Fabregat1,2
1TGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
2CIBEREHD, ISCIII, Spain
3Unit of Bioinformatics for Precision Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain
4Preclinical and Experimental Research in Thoracic Tumors (PReTT), Oncobell Program, IDIBELL, L'Hospitalet de Llobregat, Spain
5Physiological Sciences Department, University of Barcelona, Oncobell-IDIBELL, Barcelona, Spain
6National Institute of Gastroenterology, IRCCS Saverio De Bellis Research Hospital, Castellana Wrotte, Bari, Italy
7Department of Surgery, Liver Transplant Unit, University Hospital of Bellvitge and Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain
8Pathological Anatomy Service, University Hospital of Bellvitge and Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain
9Oncología Médica, Institut Català d’Oncologia (ICO-IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain
10Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Bizkaia, Spain