Disfunción endotelial

Revista Española de Cardiología Suplementos - Tập 6 - Trang 21A-30A - 2006
Lina Badimón1, José Martínez-González1
1Centro de Investigación Cardiovascular, CSIC-ICCC. Hospital de la Santa Creu y Sant Pau. Barcelona. España

Tài liệu tham khảo

Badimon L, Martínez-González J, Llorente-Cortés V, Rodríguez C, Padro T. Cell biology and lipoproteins in atherosclerosis. Curr Mol Med. En prensa. Badimon, 1992, Endothelium and atherosclerosis, J Hypertens, 10, S43 Badimon, 2002, Endotelio en la protección vascular: nuevos conocimientos, Rev Esp Cardiol, 55, S17 Badimon, 2003, Estatinas y función endotelial, Rev Esp Cardiol, 3, C25 Dejana, 1996, Cell adhesion in vascular biology, J Clin Invest, 9, 1949, 10.1172/JCI118997 Nordestgaard, 1994, Atherosclerosis and arterial influx of lipoproteins, Curr Opin Lipidol, 5, 252, 10.1097/00041433-199408000-00002 Zhao, 1997, Oxidized low-density lipoprotein increases endothelial intracellular calcium and alters cytoskeletal f-actin distribution, Eur J Clin Invest, 27, 48, 10.1046/j.1365-2362.1997.750628.x Essler, 1999, Midly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase, J Biol Chem, 274, 30361, 10.1074/jbc.274.43.30361 Pillarisetti, 2000, Lipoprotein modulation of subendothelial heparin sulfate proteoglycans (Perlecan) and atherogenicity, Trends Cardiovasc Med, 10, 60, 10.1016/S1050-1738(00)00048-7 Rodríguez, 2002, Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and in the arterial wall, Arterioscler Thromb Vasc Biol, 22, 1409, 10.1161/01.ATV.0000033818.21748.99 Badimón L, Martínez-González J. Bases moleculares y genéticas de las cardiopatías. En: Bayés de Luna A, López Sendon JL, Attie F, Alegría Ezquerra E, editores. Cardiología clínica. Barcelona: Editorial Masson, S.A.;22003.p.30-44. Cybulski, 1991, Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis, Science, 251, 788, 10.1126/science.1990440 Smalley, 1996, Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1, Arterioscler Thromb Vasc Biol, 16, 585, 10.1161/01.ATV.16.4.585 Khan, 1995, Modified low density lipoprotein and its constituents augments cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells, J Clin Invest, 95, 1262, 10.1172/JCI117776 Colomé, 2000, Small oxidative changes in atherogenic LDL concentrations irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A, Atherosclerosis, 149, 295, 10.1016/S0021-9150(99)00338-X Johson-Tidey, 1994, Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. coexpression with intercellular adhesion molecule-1, Am J Pathol, 144, 952 Ikeda, 1995, Increased soluble form of P-selectin in patients with unstable angina, Circulation, 92, 1693, 10.1161/01.CIR.92.7.1693 Hwang, 1997, Circulating adhesion molecules VCAM-1, ICAM-1 and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study, Circulation, 96, 4219, 10.1161/01.CIR.96.12.4219 Abe, 1998, Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion, Arterioscler Thromb Vasc Biol, 18, 723, 10.1161/01.ATV.18.5.723 Frijns, 1997, Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis, Stroke, 28, 2214, 10.1161/01.STR.28.11.2214 Peter, 1997, Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and trombomodulin, Arterioscler Thromb Vasc Biol, 17, 503, 10.1161/01.ATV.17.3.505 Ridker, 1998, Plasma concentration of soluble intercellular adhesion molecule 1 and risk of future myocardial infarction in apparently healthy men, Lancet, 351, 88, 10.1016/S0140-6736(97)09032-6 Alonso, 2001, Sustained long-term improvement of arterial endothelial function in heterozygous familial hypercholesterolemia patients treated with simvastatin, Atherosclerosis, 157, 423, 10.1016/S0021-9150(00)00733-4 Zeiher, 1991, Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis, Circulation, 83, 391, 10.1161/01.CIR.83.2.391 Casino, 1993, The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients, Circulation, 88, 2541, 10.1161/01.CIR.88.6.2541 O’Driscoll, 1997, Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month, Circulation, 95, 1126, 10.1161/01.CIR.95.5.1126 John, 1998, Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients. A randomized, placebo-controlled, double-blind study, Circulation, 98, 211, 10.1161/01.CIR.98.3.211 Liao, 1995, Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase, J Biol Chem, 270, 319, 10.1074/jbc.270.1.319 Vidal, 1998, Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells, Eur J Biochem, 252, 378, 10.1046/j.1432-1327.1998.2520378.x Llorente, 1998, Bases celulares y moleculares de la acumulación de colesterol en la pared vascular y su contribución a la progresión de la lesión aterosclerótica, Rev Esp Cardiol, 51, 633, 10.1016/S0300-8932(98)74802-X Feron, 1999, Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase, J Clin Invest, 103, 897, 10.1172/JCI4829 Martínez-González, 2001, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs. Balance between transcriptional and post-transcriptional regulation, Arterioscler Thromb Vascular Biol, 21, 804, 10.1161/01.ATV.21.5.804 Boger, 1998, Asymmetric dimethylarginine/ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia, Circulation, 98, 1842, 10.1161/01.CIR.98.18.1842 Oemar, 1998, Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis, Circulation, 97, 2494, 10.1161/01.CIR.97.25.2494 Vilahur, 2004, Effects of a novel platelet NO-donor (LA816), aspirin, clopidogrel and combined therapy in inhibiting flow and lesion-dependent thrombosis in the porcine ex vivo model, Circulation, 110, 1686, 10.1161/01.CIR.0000142296.19558.99 Vilahur, 2004, Inhibition of thrombosis by a novel platelet selective S-nitrosothiol compound without hemodynamic side effects, Cardiovasc Res, 61, 806, 10.1016/j.cardiores.2003.11.034 Vilahur, 2004, A novel anti-ischemic nitric oxide donor inhibits thrombosis without modifying haemodynamic parameters, Thrombosis Hemostasis, 91, 1035, 10.1160/TH03-12-0786 Mendelson, 1990, Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine, J Biol Chem, 265, 19028, 10.1016/S0021-9258(17)30619-1 Michelson, 1996, Effects of nitric oxide/EDRF on platelet surface glycoproteins, Am J Physiol, 29, H1640 Ku, 1985, Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress, Arteriosclerosis, 5, 293, 10.1161/01.ATV.5.3.293 Davies, 1995, Flow-mediated endothelial mechanotransduction, Physiol Rev, 75, 519, 10.1152/physrev.1995.75.3.519 Topper, 1996, Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxyde synthase are selectively up-regulated by steady laminar shear stress, Proc Natl Acad Sci USA, 93, 10417, 10.1073/pnas.93.19.10417 Resnick, 2000, Signalling pathways in vascular endothelium activated by shear stress: relevance to atherosclerosis, Curr Opin Lipidol, 11, 167, 10.1097/00041433-200004000-00010 Nagel, 1999, Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors, Arterioscler Thromb Vasc Biol, 19, 1825, 10.1161/01.ATV.19.8.1825 Dimmeler, 1998, Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis, Eur Cytokine Netw, 9, 697 Martínez-González, 2000, Reendotelización, engrosamiento intimal y remodelado vascular. ¿Un denominador común?, Rev Esp Cardiol, 53, 1425, 10.1016/S0300-8932(00)75258-4 Badimon, 1986, Influence of arterial damage and wall shear rate on platelet deposition. Ex vivo study in a swine model, Arteriosclerosis, 6, 312, 10.1161/01.ATV.6.3.312 Badimon, 1992, Thrombus formation on ruptured atherosclerotic plaques and rethrombosis on evolving thrombi, Circulation, 86, III74 Fernández-Ortiz, 1994, Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture, J Am Coll Cardiol, 23, 1562, 10.1016/0735-1097(94)90657-2 Toschi, 1997, Tissue factor modulates the thrombogenicity of human atherosclerotic plaques, Circulation, 95, 594, 10.1161/01.CIR.95.3.594 Badimon, 1999, Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques. Effects of TFPI on plaque thrombogenicity under flow conditions, Circulation, 99, 1780, 10.1161/01.CIR.99.14.1780 Fuster, 1995, The three processes leading to post PTCA restenosis: dependence on the lesion substrate, Thromb Haemostasis, 74, 552, 10.1055/s-0038-1642737 Ip, 1990, Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation, J Am Coll Cardiol, 15, 1667, 10.1016/0735-1097(90)92845-S Van Belle, 1998, Endothelial regrowth after arterial injury: from vascular repair to therapeutics, Cardiovas Res, 38, 54, 10.1016/S0008-6363(97)00326-X Collins, 1993, Endothelial nuclear factor-kB and the initiation of the atherosclerotic lesion, Lab Invest, 68, 499 Thanos, 1995, NF-kB: a lesson in family values, Cell, 80, 529, 10.1016/0092-8674(95)90506-5 Bourcier, 1997, The nuclear factor k-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis, J Biol Chem, 272, 15817, 10.1074/jbc.272.25.15817 Rodríguez-Sinovas, 2001, LDL downregulate CYP51 in vascular endothelial cells and in the arterial wall through a SREBP-2 dependent mechanism, Circ Res, 88, 268, 10.1161/01.RES.88.3.268 Rodríguez, 2003, Modulation of ERG25 expression by LDL in vascular cells, Cardiov Res, 58, 178, 10.1016/S0008-6363(02)00856-8 Yokohama, 1993, SREBP-1, a basic helix-loop-helix leucine zipper protein that controls transcription of the LDL receptor gene, Cell, 75, 187, 10.1016/S0092-8674(05)80095-9 López, 1999, Sterol regulatory element-binding protein- 1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-B1 gene, Endocrinology, 140, 5669, 10.1210/en.140.12.5669 Yang, 1998, Sp1 and Sp3 transactivate the human lipoprotein lipase gene promoter through to a CT element: synergy with the sterol regulatory element binding protein and reduced transactivation of a naturally occurring promoter variant, J Lipid Res, 39, 2054, 10.1016/S0022-2275(20)32504-9 Fajas, 1999, Regulation of peroxisome proliferator-activated receptor (expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism, Mol Cell Biol, 19, 5495, 10.1128/MCB.19.8.5495 Zimmet, 2001, Global and societal implications of the diabetes epidemic, Nature, 414, 782, 10.1038/414782a Sjöholm, 2005, Endothelial inflammation in insulin resistance, Lancet, 365, 610, 10.1016/S0140-6736(05)17912-4 Kashyap, 2005, Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects, J Clin Endocrinol Metab, 90, 1100, 10.1210/jc.2004-0745 Aljada, 2000, Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide, J Clin Endocrinol Metab, 85, 2572, 10.1210/jc.85.7.2572 Schnyder, 2002, Rapid effects of glucose on the insulin signalling of endothelial NO generation and epithelial Na transport, Am J Physiol Endocrinol Metab, 282, E87, 10.1152/ajpendo.00050.2001 Fichtlscherer, 2004, Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes: further evidence for the existence of the «vulnerable» patient, Circulation, 110, 1926, 10.1161/01.CIR.0000143378.58099.8C