Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

Acta Pharmaceutica Sinica B - Tập 13 - Trang 2747-2764 - 2023
Shenghua Gao1,2,3, Letian Song1, Yusen Cheng1, Fabao Zhao1, Dongwei Kang1,2, Shu Song1, Mianling Yang1, Bing Ye1, Wei Zhao4, Yajie Tang4, Erik De Clercq5, Christophe Pannecouque5, Peng Zhan1,2, Xinyong Liu6,2
1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China
2China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Ji'nan, 250012, China
3Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District of Shenzhen, Shenzhen 518057, China
4State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China
5Rega Institute for Medical Research, K.U.Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium
6Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China

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